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Aliases for MIR187 Gene

Subcategory (RNA class) for MIR187 Gene

miRNA

Quality Score for this RNA gene is

8.2

Aliases for MIR187 Gene

  • MicroRNA 187 2 3
  • MIRN187 3 6
  • Hsa-Mir-187 3
  • MiRNA187 3
  • MiR-187 3

External Ids for MIR187 Gene

Previous HGNC Symbols for MIR187 Gene

  • MIRN187

Previous GeneCards Identifiers for MIR187 Gene

  • GC18M031741
  • GC18M033484

Summaries for MIR187 Gene

Entrez Gene Summary for MIR187 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR187 Gene

MIR187 (MicroRNA 187) is an RNA Gene, and is affiliated with the miRNA class.

fRNAdb sequence ontologies for MIR187 Gene

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

View fRNAdb secondary structures for MIR187

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR187 Gene

Genomics for MIR187 Gene

Genomic Location for MIR187 Gene

Start:
35,904,818 bp from pter
End:
35,904,926 bp from pter
Size:
109 bases
Orientation:
Minus strand

Genomic View for MIR187 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR187 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR187 Gene

ORGUL Member Location for MIR187 Gene

ORGUL Member Location for MIR187 gene

No data available for Regulatory Elements for MIR187 Gene

Proteins for MIR187 Gene

Post-translational modifications for MIR187 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR187 Gene

Domains for MIR187 Gene

Gene Families for MIR187 Gene

HGNC:
  • MIR :ncRNAs / Micro RNAs

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR187: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR187 Gene

Function for MIR187 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MIR187 Gene

Localization for MIR187 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR187 Gene

Pathways for MIR187 Gene

SuperPathways for MIR187 Gene

No Data Available

Interacting Proteins for MIR187 Gene

Gene Ontology (GO) - Biological Process for MIR187 Gene

None

No data available for Pathways by source for MIR187 Gene

Transcripts for MIR187 Gene

fRNAdb Secondary structures for MIR187 Gene

  • FR190602

mRNA/cDNA for MIR187 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MIR187

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR187 Gene

No ASD Table

Relevant External Links for MIR187 Gene

GeneLoc Exon Structure for
MIR187
ECgene alternative splicing isoforms for
MIR187

Expression for MIR187 Gene

mRNA expression in normal human tissues for MIR187 Gene

genes like me logo Genes that share expressions with MIR187: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for MIR187 Gene

Orthologs for MIR187 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR187 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia bta-mir-187 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-187 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir187 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-187 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-187 36
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-187 36
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-187 36
  • 78 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-187-2 36
  • 73 (a)
OneToMany
dre-mir-187-2 36
  • 73 (a)
OneToMany
Species with no ortholog for MIR187:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR187 Gene

ENSEMBL:
Gene Tree for MIR187 (if available)
TreeFam:
Gene Tree for MIR187 (if available)

Paralogs for MIR187 Gene

No data available for Paralogs for MIR187 Gene

Variants for MIR187 Gene

Sequence variations from dbSNP and Humsavar for MIR187 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs12605436 -- 35,906,684(+) tcaaa(C/T)ggtat upstream-variant-2KB
rs12959342 -- 35,905,672(+) TGTGG(A/G)AATGA upstream-variant-2KB
rs41274312 -- 35,904,829(+) CCTGC(A/G)TCCCT nc-transcript-variant
rs74518846 -- 35,905,754(+) ATCTT(C/T)TGGGA upstream-variant-2KB
rs74699517 -- 35,904,745(+) ACCAG(A/G)GCCTG downstream-variant-500B

Relevant External Links for MIR187 Gene

HapMap Linkage Disequilibrium report
MIR187

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MIR187 Gene

Disorders for MIR187 Gene

No disorders were found for MIR187 Gene.

No data available for UniProtKB/Swiss-Prot for MIR187 Gene

Publications for MIR187 Gene

  1. Numerous microRNPs in neuronal cells containing novel microRNAs. (PMID: 12554860) Dostie J. … Dreyfuss G. (RNA 2003) 3
  2. Vertebrate microRNA genes. (PMID: 12624257) Lim L.P. … Bartel D.P. (Science 2003) 3
  3. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3
  4. A mammalian microRNA expression atlas based on small RNA library sequencing. (PMID: 17604727) Landgraf P. … Tuschl T. (Cell 2007) 3
  5. Regulation of ovarian cancer progression by microRNA-187 through targeting Disabled homolog-2. (PMID: 21725366) Chao A. … Lai C.H. (Oncogene 2012) 3

Products for MIR187 Gene

  • QIAGEN qRT-PCR Assays for microRNAs that regulate MIR187
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for MIR187
    • Block miRNA regulation of MIR187 using miScript Target Protectors

    Sources for MIR187 Gene

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