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Aliases for MIR187 Gene

Subcategory (RNA class) for MIR187 Gene

miRNA

Quality Score for this RNA gene is

8.2

Aliases for MIR187 Gene

  • MicroRNA 187 2 3 5
  • Hsa-Mir-187 3
  • MiRNA187 3
  • MiR-187 3
  • MIRN187 3

External Ids for MIR187 Gene

Previous HGNC Symbols for MIR187 Gene

  • MIRN187

Previous GeneCards Identifiers for MIR187 Gene

  • GC18M031741
  • GC18M033484

Summaries for MIR187 Gene

Entrez Gene Summary for MIR187 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR187 Gene

MIR187 (MicroRNA 187) is an RNA Gene, and is affiliated with the miRNA class.

fRNAdb sequence ontologies for MIR187 Gene

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

View fRNAdb secondary structures for MIR187

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR187 Gene

Genomics for MIR187 Gene

Regulatory Elements for MIR187 Gene

Enhancers for MIR187 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH18G035934 0.7 ENCODE 12 -29.3 -29257 0.3 GTF2F1 TBP SREBF2 JUN MAX CEBPG FOSL1 GATA3 POLR3A FOS LOC105372066 MIR187 C18orf21 RPRD1A MIR3929 GC18P035965
GH18G035939 0.5 ENCODE 11.1 -34.5 -34529 0.9 CTCF PRDM1 RAD21 LOC105372066 C18orf21 MIR187 MIR3929 GC18P035965
GH18G035875 0.4 ENCODE 11.8 +29.2 29164 0.1 L3MBTL2 MIR187 ZNF271P NRBF2P1
GH18G035938 0.4 ENCODE 11.1 -33.5 -33467 0.2 FOS TRIM28 C18orf21 MIR187 MIR3929 GC18P035965
GH18G035770 0.3 FANTOM5 11 +134.4 134351 0.2 MIR187 ZNF396 INO80C ZNF24 ENSG00000267397 NRBF2P1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR187 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR187 Gene

Chromosome:
18
Start:
35,904,818 bp from pter
End:
35,904,926 bp from pter
Size:
109 bases
Orientation:
Minus strand

Genomic View for MIR187 Gene

Genes around MIR187 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR187 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR187 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR187 Gene

ORGUL Member Location for MIR187 Gene

ORGUL Member Location for MIR187 gene

Proteins for MIR187 Gene

Post-translational modifications for MIR187 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR187 Gene

Domains & Families for MIR187 Gene

Gene Families for MIR187 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR187: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR187 Gene

Function for MIR187 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR187 Gene

Localization for MIR187 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR187 Gene

Pathways & Interactions for MIR187 Gene

SuperPathways for MIR187 Gene

No Data Available

Interacting Proteins for MIR187 Gene

Gene Ontology (GO) - Biological Process for MIR187 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR187 Gene

Drugs & Compounds for MIR187 Gene

No Compound Related Data Available

Transcripts for MIR187 Gene

fRNAdb Secondary structures for MIR187 Gene

  • FR190602

mRNA/cDNA for MIR187 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR187 Gene

No ASD Table

Relevant External Links for MIR187 Gene

GeneLoc Exon Structure for
MIR187
ECgene alternative splicing isoforms for
MIR187

Expression for MIR187 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR187 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR187 Gene:

MIR187
genes like me logo Genes that share expression patterns with MIR187: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR187 Gene

Orthologs for MIR187 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR187 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia cfa-mir-187 35
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir187 35
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-187 35
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-187 35
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-187 35
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-187 35
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-187 35
  • 78 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-187-2 35 35
  • 73 (a)
OneToMany
Species where no ortholog for MIR187 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR187 Gene

ENSEMBL:
Gene Tree for MIR187 (if available)
TreeFam:
Gene Tree for MIR187 (if available)

Paralogs for MIR187 Gene

No data available for Paralogs for MIR187 Gene

Variants for MIR187 Gene

Sequence variations from dbSNP and Humsavar for MIR187 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs1000749800 -- 35,904,586(+) GCTGT(A/G)TCACC downstream-variant-500B
rs1001388012 -- 35,905,688(+) AAGCG(G/T)CGGTG upstream-variant-2KB
rs1001987636 -- 35,906,740(+) TGGTT(A/G)AACTA upstream-variant-2KB
rs1002216253 -- 35,906,135(+) TACAC(A/T)TTTTT upstream-variant-2KB
rs1002757408 -- 35,906,519(+) ACATG(C/T)CACAT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR187 Gene

Variant ID Type Subtype PubMed ID
nsv1065113 CNV loss 25217958

Relevant External Links for MIR187 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR187

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR187 Gene

Disorders for MIR187 Gene

Relevant External Links for MIR187

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR187

No disorders were found for MIR187 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR187 Gene

Publications for MIR187 Gene

  1. Two lung development-related microRNAs, miR-134 and miR-187, are differentially expressed in lung tumors. (PMID: 26642897) Mirzadeh Azad F. … Mowla S.J. (Gene 2016) 3 64
  2. MicroRNA-187-3p mitigates non-small cell lung cancer (NSCLC) development through down-regulation of BCL6. (PMID: 26845350) Sun C. … Li D. (Biochem. Biophys. Res. Commun. 2016) 3 64
  3. MicroRNAa89187 is an independent prognostic factor in lung cancer and promotes lung cancer cell invasion via targeting of PTRF. (PMID: 27634346) Peng J. … Lei Z.Y. (Oncol. Rep. 2016) 3 64
  4. miR-187-5p Regulates Cell Growth and Apoptosis in Acute Lymphoblastic Leukemia via DKK2. (PMID: 27296949) Lou Y. … Fan H. (Oncol. Res. 2016) 3 64
  5. MicroRNA-187, a downstream effector of TGFI^ pathway, suppresses Smad-mediated epithelial-mesenchymal transition in colorectal cancer. (PMID: 26820227) Zhang F. … Zhao L. (Cancer Lett. 2016) 3 64

Products for MIR187 Gene

Sources for MIR187 Gene

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