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Aliases for MIR186 Gene

Subcategory (RNA class) for MIR186 Gene


Quality Score for this RNA gene is


Aliases for MIR186 Gene

  • MicroRNA 186 2 3 5
  • Hsa-Mir-186 3
  • MiR-186 3
  • MIRN186 3

External Ids for MIR186 Gene

Previous HGNC Symbols for MIR186 Gene

  • MIRN186

Previous GeneCards Identifiers for MIR186 Gene

  • GC01M071305
  • GC01M071533

Summaries for MIR186 Gene

Entrez Gene Summary for MIR186 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR186 Gene

MIR186 (MicroRNA 186) is an RNA Gene, and is affiliated with the miRNA class.

fRNAdb sequence ontologies for MIR186 Gene

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

View fRNAdb secondary structures for MIR186

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR186 Gene

Genomics for MIR186 Gene

Regulatory Elements for MIR186 Gene

Enhancers for MIR186 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around MIR186 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR186 Gene

71,067,631 bp from pter
71,067,716 bp from pter
86 bases
Minus strand

Genomic View for MIR186 Gene

Genes around MIR186 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR186 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR186 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR186 Gene

ORGUL Member Location for MIR186 Gene

ORGUL Member Location for MIR186 gene

Proteins for MIR186 Gene

Post-translational modifications for MIR186 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR186 Gene

Domains & Families for MIR186 Gene

Gene Families for MIR186 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR186: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR186 Gene

Function for MIR186 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR186 Gene

Localization for MIR186 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR186 Gene

Pathways & Interactions for MIR186 Gene

SuperPathways for MIR186 Gene

No Data Available

Interacting Proteins for MIR186 Gene

Gene Ontology (GO) - Biological Process for MIR186 Gene


No data available for Pathways by source and SIGNOR curated interactions for MIR186 Gene

Drugs & Compounds for MIR186 Gene

No Compound Related Data Available

Transcripts for MIR186 Gene

fRNAdb Secondary structures for MIR186 Gene

  • hsa-miR-186-5p_MIMAT0000456_Homo_sapiens_miR-186-5p_mature

mRNA/cDNA for MIR186 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR186 Gene

No ASD Table

Relevant External Links for MIR186 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR186 Gene

mRNA expression in normal human tissues for MIR186 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR186 Gene:

genes like me logo Genes that share expression patterns with MIR186: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR186 Gene

Orthologs for MIR186 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR186 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia bta-mir-186 35
  • 98 (a)
(Canis familiaris)
Mammalia cfa-mir-186 35
  • 98 (a)
(Monodelphis domestica)
Mammalia mdo-mir-186 35
  • 85 (a)
(Mus musculus)
Mammalia Mir186 35
  • 93 (a)
(Ornithorhynchus anatinus)
Mammalia oan-mir-186 35
  • 76 (a)
(Pan troglodytes)
Mammalia ptr-mir-186 35
  • 100 (a)
Species where no ortholog for MIR186 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR186 Gene

Gene Tree for MIR186 (if available)
Gene Tree for MIR186 (if available)

Paralogs for MIR186 Gene

No data available for Paralogs for MIR186 Gene

Variants for MIR186 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR186 Gene

Variant ID Type Subtype PubMed ID
nsv546472 CNV gain 21841781

Relevant External Links for MIR186 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Variation tolerance for MIR186 Gene

Disorders for MIR186 Gene

Relevant External Links for MIR186

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MIR186 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR186 Gene

Publications for MIR186 Gene

  1. miR-186 regulation of Twist1 and ovarian cancer sensitivity to cisplatin. (PMID: 25867064) Zhu X. … Li Y. (Oncogene 2016) 3 65
  2. microRNA-186 inhibits cell proliferation and induces apoptosis in human esophageal squamous cell carcinoma by targeting SKP2. (PMID: 26568291) He W. … Zhao G. (Lab. Invest. 2016) 3 65
  3. Down-Regulation of miR-186 Correlates with Poor Survival in de novo Acute Myeloid Leukemia. (PMID: 27012040) Zhang T.J. … Qian J. (Clin. Lab. 2016) 3 65
  4. miR-186 inhibits cell proliferation in multiple myeloma by repressing Jagged1. (PMID: 26679605) Liu Z. … Peng J. (Biochem. Biophys. Res. Commun. 2016) 3 65
  5. miR-186 and 326 predict the prognosis of pancreatic ductal adenocarcinoma and affect the proliferation and migration of cancer cells. (PMID: 25742499) Zhang Z.L. … Pei H.H. (PLoS ONE 2015) 3 65

Products for MIR186 Gene

Sources for MIR186 Gene

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