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Aliases for MIR186 Gene

Subcategory (RNA class) for MIR186 Gene

miRNA

Quality Score for this RNA gene is

8.2

Aliases for MIR186 Gene

  • MicroRNA 186 2 3 5
  • Hsa-Mir-186 3
  • MiR-186 3
  • MIRN186 3

External Ids for MIR186 Gene

Previous HGNC Symbols for MIR186 Gene

  • MIRN186

Previous GeneCards Identifiers for MIR186 Gene

  • GC01M071305
  • GC01M071533

Summaries for MIR186 Gene

Entrez Gene Summary for MIR186 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR186 Gene

MIR186 (MicroRNA 186) is an RNA Gene, and is affiliated with the miRNA class.

fRNAdb sequence ontologies for MIR186 Gene

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

View fRNAdb secondary structures for MIR186

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR186 Gene

Genomics for MIR186 Gene

Regulatory Elements for MIR186 Gene

Enhancers for MIR186 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F070674 1 ENCODE 10.2 +392.0 391965 1.7 PKNOX1 ATF1 ARNT CBX5 GATA2 NCOA1 MBD2 SMARCA4 PBX2 NBN PTGER3 ZRANB2-AS1 MIR186 ZRANB2 CASP3P1 LINC01788
GH01F071014 0.4 FANTOM5 10.4 +53.2 53215 0.3 FOXP2 MIR186 ZRANB2 GC01M071006 ZRANB2-AS1
GH01F070243 0.4 FANTOM5 9.4 +824.2 824158 0.5 ZNF362 ZRANB2 MIR186 GC01P070230 GC01M070275
GH01F070510 0.2 Ensembl 9.6 +557.0 557016 0.2 MIR186 ZRANB2 GC01M070501 GC01M070486
GH01F071079 1.1 ENCODE 0.4 -13.1 -13052 2.7 PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 SRSF11 ZRANB2 ANKRD13C PTGER3 MIR186
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR186 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR186 Gene

Chromosome:
1
Start:
71,067,631 bp from pter
End:
71,067,716 bp from pter
Size:
86 bases
Orientation:
Minus strand

Genomic View for MIR186 Gene

Genes around MIR186 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR186 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR186 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR186 Gene

ORGUL Member Location for MIR186 Gene

ORGUL Member Location for MIR186 gene

Proteins for MIR186 Gene

Post-translational modifications for MIR186 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR186 Gene

Domains & Families for MIR186 Gene

Gene Families for MIR186 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR186: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR186 Gene

Function for MIR186 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR186 Gene

Localization for MIR186 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR186 Gene

Pathways & Interactions for MIR186 Gene

SuperPathways for MIR186 Gene

No Data Available

Interacting Proteins for MIR186 Gene

Gene Ontology (GO) - Biological Process for MIR186 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR186 Gene

Transcripts for MIR186 Gene

fRNAdb Secondary structures for MIR186 Gene

  • hsa-miR-186-5p_MIMAT0000456_Homo_sapiens_miR-186-5p_mature

mRNA/cDNA for MIR186 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR186 Gene

No ASD Table

Relevant External Links for MIR186 Gene

GeneLoc Exon Structure for
MIR186
ECgene alternative splicing isoforms for
MIR186

Expression for MIR186 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR186 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR186 Gene:

MIR186
genes like me logo Genes that share expression patterns with MIR186: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR186 Gene

Orthologs for MIR186 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR186 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-186 35
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-186 35
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-186 35
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir186 35
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-186 35
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-186 35
  • 76 (a)
OneToOne
Species where no ortholog for MIR186 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR186 Gene

ENSEMBL:
Gene Tree for MIR186 (if available)
TreeFam:
Gene Tree for MIR186 (if available)

Paralogs for MIR186 Gene

No data available for Paralogs for MIR186 Gene

Variants for MIR186 Gene

Sequence variations from dbSNP and Humsavar for MIR186 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1138823 -- 71,068,393(-) TCTTT(G/T)TTTTT intron-variant, upstream-variant-2KB
rs115720755 -- 71,069,073(+) ATTTC(A/G)ATCAT intron-variant, upstream-variant-2KB
rs139418603 -- 71,068,654(+) ATAAA(C/T)GGCAA intron-variant, upstream-variant-2KB
rs139450147 -- 71,069,449(+) ATTAG(A/G)GTTCA intron-variant, upstream-variant-2KB
rs140056018 -- 71,067,736(+) GGGAA(C/G)AATAT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR186 Gene

Variant ID Type Subtype PubMed ID
nsv546472 CNV gain 21841781

Relevant External Links for MIR186 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR186

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR186 Gene

Disorders for MIR186 Gene

Relevant External Links for MIR186

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR186

No disorders were found for MIR186 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR186 Gene

Publications for MIR186 Gene

  1. microRNA-186 inhibits cell proliferation and induces apoptosis in human esophageal squamous cell carcinoma by targeting SKP2. (PMID: 26568291) He W. … Zhao G. (Lab. Invest. 2016) 3 64
  2. miR-186 inhibits cell proliferation in multiple myeloma by repressing Jagged1. (PMID: 26679605) Liu Z. … Peng J. (Biochem. Biophys. Res. Commun. 2016) 3 64
  3. Circulating MiR-19b-3p, MiR-134-5p and MiR-186-5p are Promising Novel Biomarkers for Early Diagnosis of Acute Myocardial Infarction. (PMID: 26939053) Wang K.J. … Chen Z.J. (Cell. Physiol. Biochem. 2016) 3 64
  4. Down-Regulation of miR-186 Correlates with Poor Survival in de novo Acute Myeloid Leukemia. (PMID: 27012040) Zhang T.J. … Qian J. (Clin. Lab. 2016) 3 64
  5. miR-186 regulation of Twist1 and ovarian cancer sensitivity to cisplatin. (PMID: 25867064) Zhu X. … Li Y. (Oncogene 2016) 3 64

Products for MIR186 Gene

Sources for MIR186 Gene

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