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Aliases for MIR185 Gene

Subcategory (RNA class) for MIR185 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR185 Gene

  • MicroRNA 185 2 3 5
  • Hsa-Mir-185 3
  • MiR-185 3
  • MIRN185 3

External Ids for MIR185 Gene

ORGUL Members for MIR185 Gene

Previous HGNC Symbols for MIR185 Gene

  • MIRN185

Previous GeneCards Identifiers for MIR185 Gene

  • GC22P018400
  • GC22P020022
  • GC22P020026

Summaries for MIR185 Gene

Entrez Gene Summary for MIR185 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR185 Gene

MIR185 (MicroRNA 185) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cardiomyocyte hypertrophy.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR185 Gene

Genomics for MIR185 Gene

Regulatory Elements for MIR185 Gene

Enhancers for MIR185 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22F020059 0.5 ENCODE 12.6 +26.4 26434 0.2 YBX3 HDGF ATF1 ARNT CREB3L1 ZBTB40 ZNF766 GATA2 CREM SMARCA5 MIR185 RPL7AP70 ENSG00000268292 GC22P020037
GH22F020076 0.6 ENCODE 12 +43.8 43770 1.1 HDGF PKNOX1 ARNT TBL1XR1 YBX1 GATA2 SMARCA5 ZBTB2 CEBPB ZEB2 ENSG00000243762 RANBP1 TRMT2A MIR185 ZDHHC8 CCDC188 DGCR8 MIR1306 MIR3618 ENSG00000277950
GH22F020078 1.1 FANTOM5 ENCODE 11.9 +48.4 48383 5.2 HDGF PKNOX1 ARNT CREB3L1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 DGCR8 RPL8P5 TRMT2A THAP7-AS1 THAP7 RPL7AP70 SCARF2 LINC01311 ENSG00000243762 RANBP1
GH22F019946 1.5 FANTOM5 Ensembl ENCODE 11.7 -82.8 -82838 8.2 HDGF PKNOX1 MLX WRNIP1 ZFP64 SIN3A ARID4B FEZF1 DMAP1 ZNF2 DGCR8 LINC01311 LOC100420177 ENSG00000273300 RPL8P5 TXNRD2 MIR185 COMT DGCR11 RPL7AP70
GH22F020105 0.7 ENCODE 11.5 +73.3 73274 2.2 TBL1XR1 ZNF740 NR4A1 TSC22D4 MNT ZIC2 RAD21 YY1 POLR2A ATF3 ABHD17AP4 ZDHHC8 MIR185 CCDC188 ENSG00000243762 DGCR8 MIR1306 MIR3618
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR185 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR185 Gene

Chromosome:
22
Start:
20,033,139 bp from pter
End:
20,033,220 bp from pter
Size:
82 bases
Orientation:
Plus strand

Genomic View for MIR185 Gene

Genes around MIR185 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR185 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR185 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR185 Gene

Proteins for MIR185 Gene

Post-translational modifications for MIR185 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR185 Gene

Domains & Families for MIR185 Gene

Gene Families for MIR185 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR185: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR185 Gene

Function for MIR185 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR185 Gene

Localization for MIR185 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR185 Gene

Pathways & Interactions for MIR185 Gene

genes like me logo Genes that share pathways with MIR185: view

Pathways by source for MIR185 Gene

1 BioSystems pathway for MIR185 Gene

Interacting Proteins for MIR185 Gene

Gene Ontology (GO) - Biological Process for MIR185 Gene

None

No data available for SIGNOR curated interactions for MIR185 Gene

Transcripts for MIR185 Gene

mRNA/cDNA for MIR185 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR185 Gene

No ASD Table

Relevant External Links for MIR185 Gene

GeneLoc Exon Structure for
MIR185
ECgene alternative splicing isoforms for
MIR185

Expression for MIR185 Gene

mRNA expression in normal human tissues for MIR185 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR185 Gene:

MIR185
genes like me logo Genes that share expression patterns with MIR185: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR185 Gene

Orthologs for MIR185 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR185 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-185 35
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir185 35
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-185 35
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-185 35
  • 92 (a)
OneToOne
Species where no ortholog for MIR185 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR185 Gene

ENSEMBL:
Gene Tree for MIR185 (if available)
TreeFam:
Gene Tree for MIR185 (if available)

Paralogs for MIR185 Gene

No data available for Paralogs for MIR185 Gene

Variants for MIR185 Gene

Sequence variations from dbSNP and Humsavar for MIR185 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs112637156 -- 20,033,245(+) GGCCA(C/G)AGCCC intron-variant, downstream-variant-500B
rs113031995 -- 20,031,816(+) GGCAG(A/T)GCAGA intron-variant, upstream-variant-2KB
rs113483434 -- 20,032,175(+) TGCGT(C/T)ACCTG intron-variant, upstream-variant-2KB
rs114653890 -- 20,032,483(+) CCTGC(A/C)TGCCT intron-variant, upstream-variant-2KB
rs114783249 -- 20,033,707(+) AGGGA(C/T)TTGTG intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for MIR185 Gene

Variant ID Type Subtype PubMed ID
dgv72n68 CNV loss 17160897
dgv7983n54 CNV gain 21841781
esv3647284 CNV gain 21293372
esv3893434 CNV gain 25118596
nsv3560 CNV insertion 18451855
nsv469641 CNV loss 16826518
nsv471183 CNV loss 18288195
nsv828938 CNV gain 20364138
nsv828939 CNV loss 20364138
nsv834133 CNV loss 17160897
nsv953026 CNV deletion 24416366

Relevant External Links for MIR185 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR185

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR185 Gene

Disorders for MIR185 Gene

Relevant External Links for MIR185

Genetic Association Database (GAD)
MIR185
Human Genome Epidemiology (HuGE) Navigator
MIR185
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR185

No disorders were found for MIR185 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR185 Gene

Publications for MIR185 Gene

  1. Novel genetic variants in miR-191 gene and familial ovarian cancer. (PMID: 20167074) Shen J. … Zhao H. (BMC Cancer 2010) 3 46 64
  2. MicroRNA-185 inhibits angiogenesis in human microvascular endothelial cells through targeting stromal interaction molecule 1. (PMID: 26694763) Hou J. … Li X. (Cell Biol. Int. 2016) 3 64
  3. Increased complexin-1 and decreased miR-185 expression levels in BehAset's disease with and without neurological involvement. (PMID: 26577184) UA9urel E. … Vural B. (Neurol. Sci. 2016) 3 64
  4. STIM1, a direct target of microRNA-185, promotes tumor metastasis and is associated with poor prognosis in colorectal cancer. (PMID: 25531324) Zhang Z. … Fan D. (Oncogene 2015) 3 64
  5. MicroRNA-185 targets SOCS3 to inhibit beta-cell dysfunction in diabetes. (PMID: 25658748) Bao L. … Lv H. (PLoS ONE 2015) 3 64

Products for MIR185 Gene

Sources for MIR185 Gene

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