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microRNA 185
(Previous symbol: MIRN185)
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Aliases
for MIR185 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
Subcategory (RNA class): miRNA
Quality score for this RNA gene is 13
| Aliases |
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| MicroRNA 1851 2 | | MIRN1851 2 | | Hsa-Mir-1851 | | MiR-1851 | | Mir-1851 |
| External Ids: | HGNC: 315561 | Entrez Gene: 4069612 | Ensembl: ENSG000002080237 |
Export aliases for MIR185 gene to outside databasesPrevious GC identifer: GC22P018400
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Summaries
for MIR185 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MIR185:
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of geneexpression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribedby RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be eitherprotein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce anapproximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicerribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporatedinto a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with themiRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeqrepresents the predicted microRNA stem-loop. (provided by RefSeq, Sep 2009)
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Genomic Views
for MIR185 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for MIR185
Other transcription factors
Search SABiosciences Chromatin IP Primers for MIR185
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MIR185 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 22q11.21 Ensembl cytogenetic band: 22q11.21 HGNC cytogenetic band: 22q11.21MIR185 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 22 GeneLoc Exon Structure GeneLoc location for GC22P020022: view genomic region (via miRBase)
(about GC identifiers)
Start:
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20,020,662 bp from pter |
End:
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20,020,743 bp from pter |
Size:
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82 bases |
Orientation:
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plus strand |
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Proteins
for MIR185 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
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UniProtKB: --
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Protein
Domains /
Families
for MIR185 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| -- |
Function
for MIR185 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
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miRNA
Products: | | miRTarBase genes targeted by MIR185:
HMGA2(MIRT004702), CDC42(MIRT004037), CORO2B(MIRT004703), AKT1(MIRT004701), RHOA(MIRT004036), SIX1(MIRT005550), NTRK3(MIRT005963), CCNE1(MIRT004698), CDK6(MIRT004700) |
| |  | Browse 3'-UTR reporter clones for miRNA target validation
Browse MicroRNA Expression Plasmids
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MIR185 | | | Search QIAGEN for miScript miRNA Assays for microRNAs that regulate MIR185 | |  | Browse SwitchGear 3'UTR luciferase reporter plasmids |
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Pathways & Interactions
for MIR185 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MIR185
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Drugs & Compounds
for MIR185 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
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 Browse Tocris compounds for MIR185
Search CenterWatch for drugs/clinical trials and news about MIR185 
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Transcripts
for MIR185 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
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1 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000385288(miRNA)
GeneLoc Exon Structure
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Expression
for MIR185 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| Expression evidence for MIR185:none
MIR185 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image SABiosciences Custom PCR Arrays for MIR185
Primer
Products: | | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat MIR185 | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MIR185 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MIR185 |
Orthologs
for MIR185 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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ENSEMBL Gene Tree for MIR185 (if available)
TreeFam Gene Tree for MIR185 (if available) |
Paralogs
for MIR185 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
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Genomic Variants
for MIR185 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
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Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for MIR185
5 CNVs: 30151 2261 30152 5168 31071 | SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for MIR185 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
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MIR185 for disorders About GeneDecksing
8  diseases for MIR185: About MalaCardskaposi's sarcoma sarcoma cervical cancer cervicitis
colorectal cancer lung cancer hepatitis neuronitis
Human Genome Epidemiology (HuGE) Navigator: MIR185 (2 documents)
Export disorders for MIR185 gene to outside databases
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Publications
for MIR185 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
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PubMed articles for MIR185 gene, integrated from 9 sources (see all 15):
(articles sorted by number of sources associating them with MIR185) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- MiR-185 targets the DNA methyltransferases 1 and regu lates global DNA methylation in human glioma. (PubMed id 21962230)1 Zhang Z....Li G. (2011)
- Autoregulatory suppression of c-Myc by miR-185-3p. (PubMed id 21832077)1 Liao J.M. and Lu H. (2011)
- miR-185 targets RhoA and Cdc42 expression and inhibit s the proliferation potential of human colorectal cells. (PubMed id 21186079)1 Liu M....Bi F. (2011)
- miR-185 and miR-133b deregulation is associated with overall survival and metastasis in colorectal cancer. (PubMed id 21573504)1 AkAsakaya P....Lui W.O. (2011)
- Analysis of deep sequencing microRNA expression profi le from human embryonic stem cells derived mesenchymal stem cells reveals possi ble role of let-7 microRNA family in downstream targeting of hepatic nuclear fa ctor 4 alpha. (PubMed id 20158877)1 Koh W....Tanavde V. (2010)
- Genetic Polymorphisms in the pre-MicroRNA Flanking Re gion and Non-Small-Cell Lung Cancer Survival. (PubMed id 20889907)1 Hu Z....Shen H. (2010)
- MicroRNA-185 suppresses tumor growth and progression by targeting the Six1 oncogene in human cancers. (PubMed id 20603620)1 Imam J.S....Rao M.K. (2010)
- Novel genetic variants in miR-191 gene and familial o varian cancer. (PubMed id 20167074)1 Shen J....Zhao H. (2010)
- MiR-107 and MiR-185 can induce cell cycle arrest in h uman non small cell lung cancer cell lines. (PubMed id 19688090)1 Takahashi Y....Yasuda J. (2009)
- Patterns of known and novel small RNAs in human cervical cancer. (PubMed id 17616659)1 Lui W.O....Fire A. (2007)
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External Searches for MIR185 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing MIR185 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
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Other Databases showing MIR185 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MIR185 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
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| Name | Description |
| PharmGKB entry for MIR185 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for MIR185 gene:
Search GeneIP for patents involving MIR185
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for MIR185 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MIR185 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MIR185 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MIR185 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MIR185 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MIR185 | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MIR185 |
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| | | | Search Tocris compounds for MIR185 |
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 | | | | |  |  |  | | | | Search ThermoFisher Antibodies for MIR185 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MIR185 |
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Last full update: 19 Mar 2013 -
Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013
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