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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MIR184 Gene

RNA gene   GIFtS: 24
GCID: GC15P079502

MicroRNA 184


(Previous symbol: MIRN184)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Subcategory (RNA class): miRNA

Quality score for this RNA gene is 3

Aliases
MicroRNA 1841 2
MIRN1841 2 5
EDICT2
miR-1842
mir-1849

External Ids:    HGNC: 315551   Entrez Gene: 4069602   Ensembl: ENSG000002076957   OMIM: 6131465   
ORGUL members:    fRNAdb10:FR070261 FR103672      

Export aliases for MIR184 gene to outside databases

Previous GC identifer: GC15P077293


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MIR184 Gene:
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of
gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are
transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can
be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme
to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the
cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The
mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through
imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of
the target mRNA. The RefSeq represents the predicted microRNA stem-loop. (provided by RefSeq, Sep 2009)

GeneCards Summary for MIR184 Gene: 
MIR184 (microRNA 184) is an RNA gene, and is affiliated with the miRNA class. Diseases associated with MIR184 include edict syndrome, and keratoconus.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for MIR184
         Other transcription factors

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Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MIR184


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q25.1   Ensembl cytogenetic band:  15q25.1   HGNC cytogenetic band: 15q25.1

MIR184 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MIR184 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P079502:  view genomic region (via miRBase)     (about GC identifiers)

Start:
79,502,130 bp from pter      End:
79,502,213 bp from pter
Size:
84 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB: --


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
MIR: ncRNAs / Micro RNAs

  --

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Animal Models:
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MIR184

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000384962(miRNA)
miRNA
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GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

Expression evidence for MIR184:none

MIR184 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
MIR184 Expression
About this image

    SABiosciences Custom PCR Arrays for MIR184
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for MIR184 gene from 2/8 species (see all 8)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
chicken
(Gallus gallus)
Aves gga-mir-1846
gga-mir-184
82(a)
1 ↔ 1
10(19462850-19462923) ENSGALG00000018259
zebrafish
(Danio rerio)
Actinopterygii mir184-26
mir1846
microRNA 184
75(a)
74(a)
many → 1
many → 1
7(31526100-31526178) ENSDARG00000083498
18(25989792-25989878) ENSDARG00000081763
        Species with no ortholog for MIR184

ENSEMBL Gene Tree for MIR184 (if available)
TreeFam Gene Tree for MIR184 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/53 SNPs in MIR184 are shown (see all 53)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 15 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1149132791,2
F--59539485(+) TTATAA/TACGTG 1 -- us2k11Minor allele frequency- T:0.01WA 118
rs1113865481,2
C,F--59539532(+) TGGGAC/ACTTGG 1 -- us2k12Minor allele frequency- A:0.03NA 122
rs773718881,2
F--59539653(+) GAGGAG/ATTCAG 1 -- us2k11Minor allele frequency- A:0.02WA 118
rs1504711431,2
--59539741(+) ATCTGC/TGATTG 1 -- us2k10--------
rs1120852101,2
C,F--59539755(+) TGACCA/C/GCTCCA 1 -- us2k13CSA WA 122
rs287568221,2
C,F--59539849(+) CAGGAG/TCTGCA 1 -- us2k11Minor allele frequency- T:0.30WA 118
rs1383276621,2
--59539859(+) ATAAGA/CTCTTG 1 -- us2k10--------
rs1846440541,2
--59539877(+) TTGAGA/GAGCTG 1 -- us2k10--------
rs1414594911,2
--59539893(+) CAAAGC/TAATTA 1 -- us2k10--------
rs1890126501,2
--59539918(+) AGTAAC/TCAGTG 1 -- us2k10--------

HapMap Linkage Disequilibrium report for MIR184 (79502130 - 79502213 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for MIR184:    About this table     
Variant IDTypeSubtypePubMed ID
dgv758e1CNV Complex17122850


Human Gene Mutation Database (HGMD): MIR184
SABiosciences Cancer Mutation PCR Assays
Search QIAGEN SeqTarget long-range PCR primers for resequencing MIR184
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 613146    OMIM disorders: --

7 diseases for MIR184:    About MalaCards
edict syndrome    keratoconus    cataract    neuroblastoma
lung cancer    squamous cell carcinoma    neuronitis


MIR184 for disorders           About GeneDecksing

Human Genome Epidemiology (HuGE) Navigator: MIR184 (1 document)

Export disorders for MIR184 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for MIR184 gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with MIR184)
    Utopia: connect your pdf to the dynamic
world of online information

  1. microRNA 184 regulates expression of NFAT1 in umbilic al cord blood CD4+ T cells. (PubMed id 19286996)1, 9 Weitzel R.P....Laughlin M.J. (2009)
  2. A single-base substitution in the seed region of miR-1 84 causes EDICT syndrome. (PubMed id 22131394)1 Iliff B.W....Gottsch J.D. (2012)
  3. Mutation altering the miR-184 seed region causes fami lial keratoconus with cataract. (PubMed id 21996275)1 Hughes A.E....Willoughby C.E. (2011)
  4. [Abnormal expression and significance of MIR-184 in hu man renal carcinoma]. (PubMed id 21844955)1 Leng H.M....Cai Z.M. (2011)
  5. MicroRNA-184 inhibits neuroblastoma cell survival thr ough targeting the serine/threonine kinase AKT2. (PubMed id 20409325)1 Foley N.H....Stallings R.L. (2010)
  6. Genetic Polymorphisms in the pre-MicroRNA Flanking Re gion and Non-Small-Cell Lung Cancer Survival. (PubMed id 20889907)1 Hu Z....Shen H. (2010)
  7. MicroRNA-184 antagonizes microRNA-205 to maintain SHIP2 levels in epithelia. (PubMed id 19033458)1 Yu J....Lavker R.M. (2008)
  8. Mature miR-184 as Potential Oncogenic microRNA of Squamous Cell Carcinoma of Tongue. (PubMed id 18451220)1 Wong T.S....Wei W.I. (2008)
  9. A mammalian microRNA expression atlas based on small RNA library sequencing. (PubMed id 17604727)1 Landgraf P....Tuschl T. (2007)
  10. miRBase: microRNA sequences, targets and gene nomencl ature. (PubMed id 16381832)1 Griffiths-Jones S....Enright A.J. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 406960 HGNC: 31555 Ensembl:ENSG00000207695 miRBase: hsa-mir-184 euGenes: HUgn406960
ECgene: MIR184 H-InvDB: MIR184

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for MIR184 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for MIR184 gene:
Search GeneIP for patents involving MIR184

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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