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Aliases for MIR184 Gene

Subcategory (RNA class) for MIR184 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR184 Gene

  • MicroRNA 184 2 3 5
  • Hsa-Mir-184 3
  • MiR-184 3
  • MIRN184 3
  • EDICT 3

External Ids for MIR184 Gene

ORGUL Members for MIR184 Gene

Previous HGNC Symbols for MIR184 Gene

  • MIRN184

Previous GeneCards Identifiers for MIR184 Gene

  • GC15P077293
  • GC15P079502

Summaries for MIR184 Gene

Entrez Gene Summary for MIR184 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of target mRNAs. This microRNA represents the most abundant miRNA in the corneal and lens epithelia of the eye and has been shown to interfere with target binding by another miRNA, miR-205. Through regulation of the VEGF and Akt signaling pathways, this microRNA may inhibit corneal angiogenesis. Mutations in the seed region of this microRNA cause familial keratoconus with cataract, also known as EDICT syndrome. [provided by RefSeq, Mar 2017]

GeneCards Summary for MIR184 Gene

MIR184 (MicroRNA 184) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR184 include Edict Syndrome and Sebaceous Adenocarcinoma. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins..

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR184 Gene

Genomics for MIR184 Gene

Regulatory Elements for MIR184 Gene

Enhancers for MIR184 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15G079184 0.7 ENCODE 11.1 -25.2 -25225 0.2 CTCF ZNF654 WRNIP1 TRIM22 CEBPB REST ZNF2 RAD21 ZNF324 KLF16 MIR184 ENSG00000177699 CTSH GC15P079181 GC15P079204
GH15G079185 0.6 ENCODE 11.2 -24.5 -24455 0.1 CTCF ZNF366 ZNF512 ZNF662 ETV6 ZBTB40 MIR184 ENSG00000177699 CTSH GC15P079181 GC15P079204
GH15G079035 0.6 ENCODE 10.7 -174.4 -174355 0.2 CTCF EED IKZF1 JUNB RBBP5 EBF1 CREM RASGRF1 MIR184 ENSG00000177699 GC15P079059 LOC105370917
GH15G079039 0.3 FANTOM5 10.7 -170.2 -170209 0.2 RASGRF1 MIR184 ENSG00000177699 GC15P079059 LOC105370917
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR184 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR184 Gene

Chromosome:
15
Start:
79,209,788 bp from pter
End:
79,209,871 bp from pter
Size:
84 bases
Orientation:
Plus strand

Genomic View for MIR184 Gene

Genes around MIR184 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR184 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR184 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR184 Gene

Proteins for MIR184 Gene

Post-translational modifications for MIR184 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR184 Gene

Domains & Families for MIR184 Gene

Gene Families for MIR184 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR184: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR184 Gene

Function for MIR184 Gene

Human Phenotype Ontology for MIR184 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR184 Gene

Localization for MIR184 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR184 Gene

Pathways & Interactions for MIR184 Gene

genes like me logo Genes that share pathways with MIR184: view

Pathways by source for MIR184 Gene

1 BioSystems pathway for MIR184 Gene

Interacting Proteins for MIR184 Gene

Gene Ontology (GO) - Biological Process for MIR184 Gene

None

No data available for SIGNOR curated interactions for MIR184 Gene

Drugs & Compounds for MIR184 Gene

No Compound Related Data Available

Transcripts for MIR184 Gene

mRNA/cDNA for MIR184 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR184 Gene

No ASD Table

Relevant External Links for MIR184 Gene

GeneLoc Exon Structure for
MIR184
ECgene alternative splicing isoforms for
MIR184

Expression for MIR184 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR184 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR184 Gene:

MIR184

Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR184 Gene

Germ Layers:
  • ectoderm
Systems:
  • nervous
Organs:
Head and neck:
  • brain
  • cranial nerve
  • eye
  • eyelid
  • head
General:
  • peripheral nervous system
genes like me logo Genes that share expression patterns with MIR184: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Evidence on tissue expression from TISSUES for MIR184 Gene

Orthologs for MIR184 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR184 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-184 35
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-184 35
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-184 35
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir184 35
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-184 35
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-184 35 35
  • 52 (a)
OneToMany
chicken
(Gallus gallus)
Aves gga-mir-184 35
  • 82 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-184-2 35
  • 75 (a)
OneToMany
dre-mir-184-1 35
  • 74 (a)
OneToMany
Species where no ortholog for MIR184 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR184 Gene

ENSEMBL:
Gene Tree for MIR184 (if available)
TreeFam:
Gene Tree for MIR184 (if available)

Paralogs for MIR184 Gene

No data available for Paralogs for MIR184 Gene

Variants for MIR184 Gene

Sequence variations from dbSNP and Humsavar for MIR184 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1000060083 -- 79,209,697(+) GAGGA(A/G)CTGCA intron-variant, upstream-variant-2KB
rs1000080772 -- 79,210,224(+) TAAAA(A/C)AAAAA intron-variant, downstream-variant-500B
rs1000215928 -- 79,209,952(+) CCCGA(A/G)GACAG intron-variant, downstream-variant-500B
rs1004642144 -- 79,207,879(+) TTTCC(C/G)TTCAG intron-variant, upstream-variant-2KB
rs1006176365 -- 79,208,069(+) TTGAC(C/T)GCTCC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR184 Gene

Variant ID Type Subtype PubMed ID
esv2760042 CNV gain 17122850

Relevant External Links for MIR184 Gene

Human Gene Mutation Database (HGMD)
MIR184
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR184

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR184 Gene

Disorders for MIR184 Gene

MalaCards: The human disease database

(2) MalaCards diseases for MIR184 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, and GeneCards

Disorder Aliases PubMed IDs
edict syndrome
  • horn kolb syndrome
sebaceous adenocarcinoma
  • adenocarcinoma of the sebaceous gland
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for MIR184

Human Genome Epidemiology (HuGE) Navigator
MIR184
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR184
genes like me logo Genes that share disorders with MIR184: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR184 Gene

Publications for MIR184 Gene

  1. microRNA 184 regulates expression of NFAT1 in umbilical cord blood CD4+ T cells. (PMID: 19286996) Weitzel R.P. … Laughlin M.J. (Blood 2009) 3 22 64
  2. The role of microRNAs in myopia. (PMID: 27837278) Jiang B. … Wang J. (Graefes Arch. Clin. Exp. Ophthalmol. 2017) 3 64
  3. miR-184 exhibits angiostatic properties via regulation of Akt and VEGF signaling pathways. (PMID: 27825105) Park J.K. … Lavker R.M. (FASEB J. 2017) 3 64
  4. Inverse relationship between microRNA-155 and -184 expression with increasing conjunctival inflammation during ocular Chlamydia trachomatis infection. (PMID: 26842862) Derrick T. … Holland M.J. (BMC Infect. Dis. 2016) 3 64
  5. Mutational Analysis of Pre-miR-184 and hsa-mir-568 in Greek Patients With Sporadic Keratoconus. (PMID: 26845316) Moschos M.M. … Gazouli M. (Cornea 2016) 3 64

Products for MIR184 Gene

Sources for MIR184 Gene

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