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Aliases for MIR183 Gene

Subcategory (RNA class) for MIR183 Gene


Quality Score for this RNA gene is


Aliases for MIR183 Gene

  • MicroRNA 183 2 3
  • MIRN183 3 6
  • Hsa-Mir-183 3
  • MiRNA183 3
  • MiR-183 3

External Ids for MIR183 Gene

Previous HGNC Symbols for MIR183 Gene

  • MIRN183

Previous GeneCards Identifiers for MIR183 Gene

  • GC07M129204
  • GC07M129415
  • GC07M129416
  • GC07M129420
  • GC07M129429

Summaries for MIR183 Gene

Entrez Gene Summary for MIR183 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. The microRNA encoded by this gene has been shown to inhibit metastasis in lung cancer by down-regulating the expression of ezrin and other genes involved in migration and invasion of cancer cells. [provided by RefSeq, Mar 2010]

GeneCards Summary for MIR183 Gene

MIR183 (MicroRNA 183) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR183 include lung cancer. Among its related pathways are MicroRNAs in cancer.

fRNAdb sequence ontologies for MIR183 Gene - the ORGUL cluster for this gene includes several descriptions:

  • miRNA: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene. Micro RNAs are produced from precursor molecules (SO:0000647) that can form local hairpin structures, which ordinarily are processed (via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors.

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

View fRNAdb secondary structures for MIR183

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR183 Gene

Genomics for MIR183 Gene

Genomic Location for MIR183 Gene

129,774,905 bp from pter
129,775,014 bp from pter
110 bases
Minus strand

Genomic View for MIR183 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR183 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR183 Gene

ORGUL Member Location for MIR183 Gene

ORGUL Member Location for MIR183 gene

No data available for Regulatory Elements for MIR183 Gene

Proteins for MIR183 Gene

Post-translational modifications for MIR183 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR183 Gene

Domains for MIR183 Gene

Gene Families for MIR183 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR183: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR183 Gene

Function for MIR183 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR183 Gene

Localization for MIR183 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR183 Gene

Pathways for MIR183 Gene

SuperPathways for MIR183 Gene

Superpath Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR183: view

Pathways by source for MIR183 Gene

1 KEGG pathway for MIR183 Gene

Interacting Proteins for MIR183 Gene

Gene Ontology (GO) - Biological Process for MIR183 Gene


Transcripts for MIR183 Gene

fRNAdb Secondary structures for MIR183 Gene

  • FR182760

mRNA/cDNA for MIR183 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR183 Gene

No ASD Table

Relevant External Links for MIR183 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR183 Gene

mRNA expression in normal human tissues for MIR183 Gene

genes like me logo Genes that share expressions with MIR183: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for MIR183 Gene

Orthologs for MIR183 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR183 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia bta-mir-183 36
  • 99 (a)
(Canis familiaris)
Mammalia cfa-mir-183 36
  • 99 (a)
(Monodelphis domestica)
Mammalia mdo-mir-183 36
  • 90 (a)
(Mus musculus)
Mammalia Mir183 36
  • 100 (a)
(Ornithorhynchus anatinus)
Mammalia oan-mir-183 36
  • 69 (a)
(Pan troglodytes)
Mammalia ptr-mir-183 36
  • 100 (a)
(Gallus gallus)
Aves gga-mir-183 36
  • 87 (a)
(Danio rerio)
Actinopterygii dre-mir-183 36
  • 89 (a)
sea squirt
(Ciona savignyi)
Ascidiacea csa-mir-183 36
  • 50 (a)
Species with no ortholog for MIR183:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR183 Gene

Gene Tree for MIR183 (if available)
Gene Tree for MIR183 (if available)

Paralogs for MIR183 Gene

No data available for Paralogs for MIR183 Gene

Variants for MIR183 Gene

Sequence variations from dbSNP and Humsavar for MIR183 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs6947908 -- 129,776,863(+) gcgcc(C/T)gaagc upstream-variant-2KB
rs6947939 -- 129,776,930(+) CACCA(C/T)TGCAC upstream-variant-2KB
rs55967489 -- 129,776,980(+) AACAA(-/C)AAAAA upstream-variant-2KB
rs57560217 -- 129,776,980(+) AACAA(A/C)AAAAA upstream-variant-2KB
rs60875326 -- 129,777,003(+) AAAAA(-/AAA)GAATT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR183 Gene

Variant ID Type Subtype PubMed ID
esv23078 CNV Gain 19812545
nsv516024 CNV Gain+Loss 19592680
nsv464721 CNV Loss 19166990

Relevant External Links for MIR183 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MIR183 Gene

Disorders for MIR183 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for MIR183 Gene in MalaCards »

(1) Disease for MIR183 Gene

genes like me logo Genes that share disorders with MIR183: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for MIR183 Gene

Publications for MIR183 Gene

  1. Targeting of integrin beta1 and kinesin 2alpha by microRNA 183. (PMID: 19940135) Li G. … Gonzalez P. (J. Biol. Chem. 2010) 3 23
  2. Numerous microRNPs in neuronal cells containing novel microRNAs. (PMID: 12554860) Dostie J. … Dreyfuss G. (RNA 2003) 3
  3. Vertebrate microRNA genes. (PMID: 12624257) Lim L.P. … Bartel D.P. (Science 2003) 3
  4. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3
  5. MicroRNA (miRNA) transcriptome of mouse retina and identification of a sensory organ-specific miRNA cluster. (PMID: 17597072) Xu S. … Valle D. (J. Biol. Chem. 2007) 3

Products for MIR183 Gene

Sources for MIR183 Gene

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