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Aliases for MIR183 Gene

Subcategory (RNA class) for MIR183 Gene

miRNA

Quality Score for this RNA gene is

9.2

Aliases for MIR183 Gene

  • MicroRNA 183 2 3 5
  • Hsa-Mir-183 3
  • MiRNA183 3
  • MiR-183 3
  • MIRN183 3

External Ids for MIR183 Gene

Previous HGNC Symbols for MIR183 Gene

  • MIRN183

Previous GeneCards Identifiers for MIR183 Gene

  • GC07M129204
  • GC07M129415
  • GC07M129416
  • GC07M129420
  • GC07M129429
  • GC07M129775
  • GC07M129776
  • GC07M129777
  • GC07M129778
  • GC07M129779

Summaries for MIR183 Gene

Entrez Gene Summary for MIR183 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR183 Gene

MIR183 (MicroRNA 183) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer.

fRNAdb sequence ontologies for MIR183 Gene - the ORGUL cluster for this gene includes several descriptions:

  • miRNA: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene. Micro RNAs are produced from precursor molecules (SO:0000647) that can form local hairpin structures, which ordinarily are processed (via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors.

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

View fRNAdb secondary structures for MIR183

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR183 Gene

Genomics for MIR183 Gene

Regulatory Elements for MIR183 Gene

Enhancers for MIR183 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G129776 1.7 FANTOM5 Ensembl ENCODE 0.7 -4.5 -4472 6.5 HDGF CREB3L1 AGO1 ARID4B SIN3A ZNF2 ZBTB7B FOS KLF13 SP3 ENSG00000273329 ENSG00000270953 UBE2H SMKR1 FLNC STRIP2 MIR183 GC07M129784
GH07G129775 0.5 ENCODE 0.7 -0.8 -812 0.2 MAZ KLF17 CTBP2 MIR183 GC07M129784
GH07G129777 0.5 ENCODE 0.7 -1.2 -1162 0.2 BCOR MAZ HDAC2 CTBP2 ENSG00000273329 MIR183 GC07M129784
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR183 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR183 Gene

Chromosome:
7
Start:
129,774,905 bp from pter
End:
129,775,014 bp from pter
Size:
110 bases
Orientation:
Minus strand

Genomic View for MIR183 Gene

Genes around MIR183 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR183 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR183 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR183 Gene

ORGUL Member Location for MIR183 Gene

ORGUL Member Location for MIR183 gene

Proteins for MIR183 Gene

Post-translational modifications for MIR183 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR183 Gene

Domains & Families for MIR183 Gene

Gene Families for MIR183 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR183: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR183 Gene

Function for MIR183 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR183 Gene

Localization for MIR183 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR183 Gene

Pathways & Interactions for MIR183 Gene

SuperPathways for MIR183 Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR183: view

Pathways by source for MIR183 Gene

1 KEGG pathway for MIR183 Gene

Interacting Proteins for MIR183 Gene

Gene Ontology (GO) - Biological Process for MIR183 Gene

None

No data available for SIGNOR curated interactions for MIR183 Gene

Drugs & Compounds for MIR183 Gene

No Compound Related Data Available

Transcripts for MIR183 Gene

fRNAdb Secondary structures for MIR183 Gene

  • FR182760

mRNA/cDNA for MIR183 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR183 Gene

No ASD Table

Relevant External Links for MIR183 Gene

GeneLoc Exon Structure for
MIR183
ECgene alternative splicing isoforms for
MIR183

Expression for MIR183 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR183 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR183 Gene:

MIR183
genes like me logo Genes that share expression patterns with MIR183: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR183 Gene

Orthologs for MIR183 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR183 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Mir183 35
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-183 35
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-183 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-183 35
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-183 35
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-183 35
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-183 35
  • 87 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-183 35
  • 89 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea csa-mir-183 35
  • 50 (a)
OneToOne
Species where no ortholog for MIR183 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR183 Gene

ENSEMBL:
Gene Tree for MIR183 (if available)
TreeFam:
Gene Tree for MIR183 (if available)

Paralogs for MIR183 Gene

No data available for Paralogs for MIR183 Gene

Variants for MIR183 Gene

Sequence variations from dbSNP and Humsavar for MIR183 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs587776522 Pathogenic 129,774,757(+) TAGTG(C/T)CAAAA nc-transcript-variant, downstream-variant-500B
rs587776523 Pathogenic 129,774,756(+) CTAGT(G/T)CCAAA nc-transcript-variant, downstream-variant-500B
rs72631833 Likely benign 129,774,964(-) ACTGT(G/T)AACAG nc-transcript-variant, upstream-variant-2KB
rs73159662 Likely benign 129,774,728(+) AGAGC(A/G)GAGAG nc-transcript-variant, downstream-variant-500B
rs41274239 Benign 129,774,734(+) GAGAG(A/G)CACAA nc-transcript-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for MIR183 Gene

Variant ID Type Subtype PubMed ID
esv23078 CNV gain 19812545
nsv464721 CNV loss 19166990
nsv516024 CNV gain+loss 19592680
nsv608420 CNV loss 21841781
nsv949946 CNV deletion 24416366

Relevant External Links for MIR183 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR183

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR183 Gene

Disorders for MIR183 Gene

Relevant External Links for MIR183

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR183

No disorders were found for MIR183 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR183 Gene

Publications for MIR183 Gene

  1. Targeting of integrin beta1 and kinesin 2alpha by microRNA 183. (PMID: 19940135) Li G. … Gonzalez P. (J. Biol. Chem. 2010) 3 22 64
  2. Vertebrate microRNA genes. (PMID: 12624257) Lim L.P. … Bartel D.P. (Science 2003) 1 3 64
  3. Interaction between transcription factors PAX6/PAX6-5a and specific members of miR-183-96-182 cluster, may contribute to glioma progression in glioblastoma cell lines. (PMID: 28184912) Pavlakis E. … Stoykova A. (Oncol. Rep. 2017) 3 64
  4. MicroRNA-183 promotes cell proliferation via regulating programmed cell death 6 in pediatric acute myeloid leukemia. (PMID: 27738758) Wang X. … Zhang R. (J. Cancer Res. Clin. Oncol. 2017) 3 64
  5. miR-183 Modulates Cell Apoptosis and Proliferation in Tongue Squamous Cell Carcinoma SCC25 Cell Line. (PMID: 28281960) Yan D. … Feng Y. (Oncol. Res. 2016) 3 64

Products for MIR183 Gene

Sources for MIR183 Gene

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