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Aliases for MIR1825 Gene

Subcategory (RNA class) for MIR1825 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR1825 Gene

  • MicroRNA 1825 2 3
  • EC 2.4.1.221 4 61
  • POFUT1 4 5
  • Peptide-O-Fucosyltransferase 1 4
  • Protein O-Fucosyltransferase 1 5
  • Hsa-Mir-1825 3
  • MIRN1825 3
  • KIAA0180 4
  • O-FucT-1 4
  • FUT12 4

External Ids for MIR1825 Gene

Previous HGNC Symbols for MIR1825 Gene

  • MIRN1825

Previous GeneCards Identifiers for MIR1825 Gene

  • GC00U923067
  • GC20P030290
  • GC20P030825

Summaries for MIR1825 Gene

Entrez Gene Summary for MIR1825 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR1825 Gene

MIR1825 (MicroRNA 1825) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR1825 include Dowling-Degos Disease 2. Among its related pathways are Pre-NOTCH Expression and Processing and Signaling by GPCR.

UniProtKB/Swiss-Prot for MIR1825 Gene

  • Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue found in the consensus sequence C2-X(4,5)-[S/T]-C3 of EGF domains, where C2 and C3 are the second and third conserved cysteines. Specifically uses GDP-fucose as donor substrate and proper disulfide pairing of the substrate EGF domains is required for fucose transfer. Plays a crucial role in NOTCH signaling. Initial fucosylation of NOTCH by POFUT1 generates a substrate for FRINGE/RFNG, an acetylglucosaminyltransferase that can then extend the fucosylation on the NOTCH EGF repeats. This extended fucosylation is required for optimal ligand binding and canonical NOTCH signaling induced by DLL1 or JAGGED1. Fucosylates AGRN and determines its ability to cluster acetylcholine receptors (AChRs).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR1825 Gene

Genomics for MIR1825 Gene

Regulatory Elements for MIR1825 Gene

Enhancers for MIR1825 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20F032254 1.3 Ensembl ENCODE 12.3 +48.5 48490 2.8 PKNOX1 ARID4B DMAP1 ZNF48 FOS JUNB MIER2 TSHZ1 KAT8 ATF4 POFUT1 MIR1825 PLAGL2 TSPY26P NOL4L GC20P032252 KIF3B
GH20F032154 0.9 Ensembl ENCODE 11.6 -52.5 -52545 1.5 CTCF SAP130 TAF1 MAX EBF1 RAD21 RARA RELA EED HOMEZ MIR1825 PLAGL2 POFUT1 TM9SF4 MYLK2 RSL24D1P6 ENSG00000275576
GH20F032152 0.2 ENCODE 11.6 -55.0 -54964 1.2 ELF3 SOX13 ZNF792 SAP130 ZNF644 RARA TEAD3 MAFK THAP11 GATAD2A MIR1825 PLAGL2 POFUT1 TM9SF4 MYLK2 TSPY26P RSL24D1P6 ENSG00000275576
GH20F032270 0.6 Ensembl 11.4 +63.0 63022 0.2 ELF3 ZNF384 FEZF1 ZIC2 ZNF2 RAD21 ZNF324 ZBTB48 ZNF366 PATZ1 MIR1825 PLAGL2 POFUT1 KIF3B GC20P032252
GH20F032159 0.8 ENCODE 11.3 -48.7 -48653 0.1 ZNF664 TM9SF4 MIR1825 XKR7 TSPY26P RSL24D1P6 ENSG00000275576
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR1825 on UCSC Golden Path with GeneCards custom track

Promoters for MIR1825 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000399738 -280 2001 ARNT CREB3L1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9

Genomic Location for MIR1825 Gene

Chromosome:
20
Start:
32,207,880 bp from pter
End:
32,238,667 bp from pter
Size:
30,788 bases
Orientation:
Plus strand

Genomic View for MIR1825 Gene

Genes around MIR1825 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR1825 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR1825 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR1825 Gene

Proteins for MIR1825 Gene

  • Protein details for MIR1825 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H488-OFUT1_HUMAN
    Recommended name:
    GDP-fucose protein O-fucosyltransferase 1
    Protein Accession:
    Q9H488
    Secondary Accessions:
    • A8K4R8
    • E1P5M4
    • Q14685
    • Q5W185
    • Q9BW76

    Protein attributes for MIR1825 Gene

    Size:
    388 amino acids
    Molecular mass:
    43956 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MIR1825 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MIR1825 Gene

Selected DME Specific Peptides for MIR1825 Gene

Q9H488:
  • SLEDFME
  • CPCMGRFGNQ
  • GNPFGPFWD

Post-translational modifications for MIR1825 Gene

Other Protein References for MIR1825 Gene

ENSEMBL proteins:

Domains & Families for MIR1825 Gene

Gene Families for MIR1825 Gene

Protein Domains for MIR1825 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9H488

UniProtKB/Swiss-Prot:

OFUT1_HUMAN :
  • Belongs to the glycosyltransferase 68 family.
Family:
  • Belongs to the glycosyltransferase 68 family.
genes like me logo Genes that share domains with MIR1825: view

No data available for Suggested Antigen Peptide Sequences for MIR1825 Gene

Function for MIR1825 Gene

Molecular function for MIR1825 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=6 uM for F7 EGF domain {ECO:0000269 PubMed:11524432}; KM=4 uM for GDP-fucose {ECO:0000269 PubMed:11524432}; Vmax=3 umol/min/mg enzyme {ECO:0000269 PubMed:11524432};
UniProtKB/Swiss-Prot CatalyticActivity:
Transfers an alpha-L-fucosyl residue from GDP-beta-L-fucose to the serine hydroxy group of a protein acceptor.
UniProtKB/Swiss-Prot Function:
Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue found in the consensus sequence C2-X(4,5)-[S/T]-C3 of EGF domains, where C2 and C3 are the second and third conserved cysteines. Specifically uses GDP-fucose as donor substrate and proper disulfide pairing of the substrate EGF domains is required for fucose transfer. Plays a crucial role in NOTCH signaling. Initial fucosylation of NOTCH by POFUT1 generates a substrate for FRINGE/RFNG, an acetylglucosaminyltransferase that can then extend the fucosylation on the NOTCH EGF repeats. This extended fucosylation is required for optimal ligand binding and canonical NOTCH signaling induced by DLL1 or JAGGED1. Fucosylates AGRN and determines its ability to cluster acetylcholine receptors (AChRs).

Enzyme Numbers (IUBMB) for MIR1825 Gene

Gene Ontology (GO) - Molecular Function for MIR1825 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008417 fucosyltransferase activity IDA --
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
GO:0046922 peptide-O-fucosyltransferase activity TAS --
genes like me logo Genes that share ontologies with MIR1825: view

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR1825 Gene

Localization for MIR1825 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIR1825 Gene

Endoplasmic reticulum.

Gene Ontology (GO) - Cellular Components for MIR1825 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0016020 membrane IDA --
genes like me logo Genes that share ontologies with MIR1825: view

No data available for Subcellular locations from COMPARTMENTS for MIR1825 Gene

Pathways & Interactions for MIR1825 Gene

genes like me logo Genes that share pathways with MIR1825: view

UniProtKB/Swiss-Prot Q9H488-OFUT1_HUMAN

  • Pathway: Protein modification; protein glycosylation.

Gene Ontology (GO) - Biological Process for MIR1825 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001756 somitogenesis IEA --
GO:0005975 carbohydrate metabolic process IEA --
GO:0006004 fucose metabolic process IEA --
GO:0006355 regulation of transcription, DNA-templated NAS --
GO:0006486 protein glycosylation IEA --
genes like me logo Genes that share ontologies with MIR1825: view

No data available for SIGNOR curated interactions for MIR1825 Gene

Transcripts for MIR1825 Gene

mRNA/cDNA for MIR1825 Gene

(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR1825 Gene

No ASD Table

Relevant External Links for MIR1825 Gene

GeneLoc Exon Structure for
MIR1825
ECgene alternative splicing isoforms for
MIR1825

Expression for MIR1825 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR1825 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR1825 Gene:

MIR1825

mRNA Expression by UniProt/SwissProt for MIR1825 Gene:

Q9H488-OFUT1_HUMAN
Tissue specificity: Highly expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
genes like me logo Genes that share expression patterns with MIR1825: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for MIR1825 Gene

Orthologs for MIR1825 Gene

This gene was present in the common ancestor of animals.

Orthologs for MIR1825 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-1825 35
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia POFUT1 35
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia POFUT1 35
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pofut1 35
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia POFUT1 35
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia POFUT1 35
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves POFUT1 35
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia POFUT1 35
  • 69 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii pofut1 35
  • 67 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta O-fut1 35
  • 42 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C15C7.7 35
  • 38 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7678 35
  • 48 (a)
OneToOne
Species where no ortholog for MIR1825 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MIR1825 Gene

ENSEMBL:
Gene Tree for MIR1825 (if available)
TreeFam:
Gene Tree for MIR1825 (if available)

Paralogs for MIR1825 Gene

No data available for Paralogs for MIR1825 Gene

Variants for MIR1825 Gene

Sequence variations from dbSNP and Humsavar for MIR1825 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs117907228 -- 32,237,117(+) GGGAG(G/T)TTACC nc-transcript-variant, upstream-variant-2KB, utr-variant-3-prime
rs137998077 -- 32,237,020(+) TGTGT(A/G)CCATG nc-transcript-variant, upstream-variant-2KB, utr-variant-3-prime
rs138762395 -- 32,237,327(+) TGTAC(C/T)GTGGG nc-transcript-variant, upstream-variant-2KB, utr-variant-3-prime
rs140363751 -- 32,236,796(+) TGCTT(C/T)ATGGG nc-transcript-variant, upstream-variant-2KB, utr-variant-3-prime
rs141223071 -- 32,236,727(+) TGGCT(-/GGGG)GTTGA nc-transcript-variant, upstream-variant-2KB, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MIR1825 Gene

Variant ID Type Subtype PubMed ID
nsv833954 CNV loss 17160897

Relevant External Links for MIR1825 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR1825

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR1825 Gene

Disorders for MIR1825 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIR1825 Gene - From: GeneCards

Disorder Aliases PubMed IDs
dowling-degos disease 2
  • ddd2
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

OFUT1_HUMAN
  • Dowling-Degos disease 2 (DDD2) [MIM:615327]: An autosomal dominant genodermatosis. Affected individuals develop a postpubertal reticulate hyperpigmentation that is progressive and disfiguring, and small hyperkeratotic dark brown papules that affect mainly the flexures and great skin folds. Patients usually show no abnormalities of the hair or nails. {ECO:0000269 PubMed:23684010}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for MIR1825

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR1825
genes like me logo Genes that share disorders with MIR1825: view

No data available for Genatlas for MIR1825 Gene

Publications for MIR1825 Gene

  1. N-terminome analysis of the human mitochondrial proteome. (PMID: 25944712) Vaca Jacome A.S. … Carapito C. (Proteomics 2015) 4 64
  2. Mutations in POFUT1, encoding protein O-fucosyltransferase 1, cause generalized Dowling-Degos disease. (PMID: 23684010) Li M. … Yao Z. (Am. J. Hum. Genet. 2013) 4 64
  3. Initial characterization of the human central proteome. (PMID: 21269460) Burkard T.R. … Colinge J. (BMC Syst. Biol. 2011) 4 64
  4. Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. (PMID: 19159218) Chen R. … Zou H. (J. Proteome Res. 2009) 4 64
  5. Discovering microRNAs from deep sequencing data using miRDeep. (PMID: 18392026) FriedlAonder M.R. … Rajewsky N. (Nat. Biotechnol. 2008) 3 64

Products for MIR1825 Gene

Sources for MIR1825 Gene

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