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Aliases for MIR182 Gene

Subcategory (RNA class) for MIR182 Gene


Quality Score for this RNA gene is


Aliases for MIR182 Gene

  • MicroRNA 182 2 3
  • MIRN182 3 6
  • Hsa-Mir-182 3
  • MiRNA182 3

External Ids for MIR182 Gene

Previous HGNC Symbols for MIR182 Gene

  • MIRN182

Previous GeneCards Identifiers for MIR182 Gene

  • GC07M129199
  • GC07M129410

Summaries for MIR182 Gene

Entrez Gene Summary for MIR182 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. The microRNA encoded by this gene has been shown to down-regulate production of FOXO1, FOXO3, and microphthalmia-associated transcription factor-M, resulting in metastasis of certain tumors. [provided by RefSeq, Mar 2010]

GeneCards Summary for MIR182 Gene

MIR182 (MicroRNA 182) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR182 include posterior uveal melanoma and gastric adenocarcinoma.

fRNAdb sequence ontologies for MIR182 Gene - the ORGUL cluster for this gene includes several descriptions:

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR182

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR182 Gene

Genomics for MIR182 Gene

Genomic Location for MIR182 Gene

129,770,379 bp from pter
129,770,492 bp from pter
114 bases
Minus strand

Genomic View for MIR182 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR182 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR182 Gene

ORGUL Member Location for MIR182 Gene

ORGUL Member Location for MIR182 gene

No data available for Regulatory Elements for MIR182 Gene

Proteins for MIR182 Gene

Post-translational modifications for MIR182 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR182 Gene

Domains for MIR182 Gene

Gene Families for MIR182 Gene

  • MIR :ncRNAs / Micro RNAs

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR182: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR182 Gene

Function for MIR182 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MIR182 Gene

Localization for MIR182 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR182 Gene

Pathways for MIR182 Gene

SuperPathways for MIR182 Gene

No Data Available

Interacting Proteins for MIR182 Gene

Gene Ontology (GO) - Biological Process for MIR182 Gene


No data available for Pathways by source for MIR182 Gene

Transcripts for MIR182 Gene

fRNAdb Secondary structures for MIR182 Gene

  • FR212512
  • hsa-mir-182_MI0000272_Homo_sapiens_miR-182_stem-loop_hairpin

mRNA/cDNA for MIR182 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR182 Gene

No ASD Table

Relevant External Links for MIR182 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR182 Gene

mRNA expression in normal human tissues for MIR182 Gene

genes like me logo Genes that share expressions with MIR182: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for MIR182 Gene

Orthologs for MIR182 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR182 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia bta-mir-182 36
  • 86 (a)
(Canis familiaris)
Mammalia cfa-mir-182 36
  • 96 (a)
(Monodelphis domestica)
Mammalia mdo-mir-182 36
  • 90 (a)
(Mus musculus)
Mammalia Mir182 36
  • 89 (a)
(Ornithorhynchus anatinus)
Mammalia oan-mir-182 36
  • 90 (a)
(Pan troglodytes)
Mammalia ptr-mir-182 36
  • 99 (a)
(Gallus gallus)
Aves -- 36
  • 78 (a)
(Danio rerio)
Actinopterygii dre-mir-182 36
  • 93 (a)
Species with no ortholog for MIR182:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR182 Gene

Gene Tree for MIR182 (if available)
Gene Tree for MIR182 (if available)

Paralogs for MIR182 Gene

No data available for Paralogs for MIR182 Gene

Variants for MIR182 Gene

Sequence variations from dbSNP and Humsavar for MIR182 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs4467881 -- 129,770,304(+) AGTCC(A/G)GGACC downstream-variant-500B
rs4541843 -- 129,770,355(+) TGGCC(A/G)GCCCT downstream-variant-500B
rs7809195 -- 129,769,918(+) ACGGC(A/G)TGCCC downstream-variant-500B
rs11971745 -- 129,771,922(+) GGACA(A/T)CAGCA upstream-variant-2KB
rs11982509 -- 129,772,135(+) CAGAG(A/G)CTGGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR182 Gene

Variant ID Type Subtype PubMed ID
esv23078 CNV Gain 19812545
nsv516024 CNV Gain+Loss 19592680
nsv464721 CNV Loss 19166990

Relevant External Links for MIR182 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MIR182 Gene

Disorders for MIR182 Gene

Relevant External Links for MIR182

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with MIR182: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for MIR182 Gene

Publications for MIR182 Gene

  1. Genetic variants and abnormal processing of pre-miR-182, a circadian clock modulator, in major depression patients with late insomnia. (PMID: 20656788) Saus E. … Estivill X. (Hum. Mol. Genet. 2010) 3 48
  2. miR-182-mediated downregulation of BRCA1 impacts DNA repair and sensitivity to PARP inhibitors. (PMID: 21195000) Moskwa P. … Chowdhury D. (Mol. Cell 2011) 3
  3. microRNA-182 inhibits the proliferation and invasion of human lung adenocarcinoma cells through its effect on human cortical actin-associated protein. (PMID: 21503569) Zhang L. … Liu J. (Int. J. Mol. Med. 2011) 3
  4. miR-183-96-182 cluster is overexpressed in prostate tissue and regulates zinc homeostasis in prostate cells. (PMID: 22045813) Mihelich B.L. … Nonn L. (J. Biol. Chem. 2011) 3
  5. RNA helicase DDX5 regulates microRNA expression and contributes to cytoskeletal reorganization in basal breast cancer cells. (PMID: 22086602) Wang D. … Hu Z. (Mol. Cell Proteomics 2012) 3

Products for MIR182 Gene

Sources for MIR182 Gene

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