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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MIR182 Gene

RNA gene   GIFtS: 24
GCID: GC07M129410

MicroRNA 182


(Previous symbol: MIRN182)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Subcategory (RNA class): miRNA

Quality score for this RNA gene is 13.2

Aliases
MicroRNA 1821 2
MIRN1821 2 5
miRNA1822
mir-1829

External Ids:    HGNC: 315531   Entrez Gene: 4069582   Ensembl: ENSG000002079907   OMIM: 6116075   
ORGUL members:    fRNAdb10:FR212512 FR331452 FR212512      
H-InvDB12: HIT000462430    
miRBase:MI0000272 MIMAT0000259 MIMAT0000260    
RNAdb15:EVF22888    

Export aliases for MIR182 gene to outside databases

Previous GC identifer: GC07M129199


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MIR182 Gene:
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of
gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are
transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can
be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme
to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the
cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The
mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through
imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of
the target mRNA. The RefSeq represents the predicted microRNA stem-loop. The microRNA encoded by this gene has
been shown to down-regulate production of FOXO1, FOXO3, and microphthalmia-associated transcription factor-M,
resulting in metastasis of certain tumors. (provided by RefSeq, Mar 2010)

GeneCards Summary for MIR182 Gene: 
MIR182 (microRNA 182) is an RNA gene, and is affiliated with the miRNA class. Diseases associated with MIR182 include lung adenocarcinoma, and microphthalmia.



fRNAdb sequence ontologies for MIR182 - the ORGUL cluster for this gene includes several descriptions:
nc_conserved_region - Non-coding region of sequence similarity by descent from a common ancestor.
pre_miRNA - The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR182

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for MIR182
         Other transcription factors

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Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MIR182


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q32.2   Ensembl cytogenetic band:  7q32.2   HGNC cytogenetic band: 7q32.2

MIR182 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MIR182 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M129410:  view genomic region (via miRBase)     (about GC identifiers)

Start:
129,410,223 bp from pter      End:
129,410,332 bp from pter
Size:
110 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 128,794,499-128,794,608     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB: --


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
MIR: ncRNAs / Micro RNAs

  --

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Animal Models:
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MIR182

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
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Search CenterWatch for drugs/clinical trials and news about MIR182

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section
2 fRNAdb Secondary structures:


1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000385255(miRNA)
miRNA
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GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

Expression evidence for MIR182:H-invDB

MIR182 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
MIR182 Expression
About this image

    SABiosciences Custom PCR Arrays for MIR182
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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for MIR182 gene from 2/8 species (see all 8)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
chicken
(Gallus gallus)
Aves --
--
78(a)
1 ↔ 1
1(795091-795178) ENSGALG00000027474
zebrafish
(Danio rerio)
Actinopterygii mir1826
microRNA 182
93(a)
1 ↔ 1
4(14141057-14141124) ENSDARG00000081095
        Species with no ortholog for MIR182

ENSEMBL Gene Tree for MIR182 (if available)
TreeFam Gene Tree for MIR182 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/52 SNPs in MIR182 are shown (see all 52)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 7 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1476805621,2
C--132753932(+) TGTCC-/GTGGTGAT 1 -- ds50010--------
rs78091951,2
C,F,A--132753945(+) ACGGCG/ATGCCC 1 -- ds50018Minor allele frequency- A:0.27NA WA EA 368
rs1863410471,2
--132754032(+) CCCTCA/GGGGCC 1 -- ds50010--------
rs1909449331,2
--132754060(+) CAGGGC/TCTTTC 1 -- ds50010--------
rs1820303811,2
--132754095(+) CACCCA/GGAGGA 1 -- ds50010--------
rs1469196371,2
--132754160(+) AGACTA/CCAGGG 1 -- ds50010--------
rs754589721,2
C,F--132754179(+) TGGAGC/TAGAGC 1 -- ds50012Minor allele frequency- T:0.01EU 1258
rs1912016271,2
--132754234(+) GGCTTC/TCCAGC 1 -- ds50010--------
rs44678811,2
C,F,A--132754331(+) AGTCCG/AGGACC 1 -- ds500111Minor allele frequency- A:0.39NA WA CSA EA 374
rs1379092441,2
--132754355(+) TCCTCA/GCGGAG 1 -- ds50010--------

HapMap Linkage Disequilibrium report for MIR182 (129410223 - 129410332 bp)

Structural Variations
     Database of Genomic Variants (DGV) 3 variations for MIR182:    About this table     
Variant IDTypeSubtypePubMed ID
nsv464721CNV Loss19166990
esv23078CNV Gain19812545
nsv516024CNV Gain+Loss19592680


Human Gene Mutation Database (HGMD): MIR182
SABiosciences Cancer Mutation PCR Assays
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 611607    OMIM disorders: --

11 diseases for MIR182:    About MalaCards
lung adenocarcinoma    microphthalmia    cervical cancer    gastric adenocarcinoma
medulloblastoma    melanoma    cervicitis    adenocarcinoma
colon cancer    breast cancer    prostatitis


MIR182 for disorders           About GeneDecksing

Genetic Association Database (GAD): MIR182
Human Genome Epidemiology (HuGE) Navigator: MIR182 (1 document)

Export disorders for MIR182 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for MIR182 gene, integrated from 9 sources (see all 36):
(articles sorted by number of sources associating them with MIR182)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Genetic variants and abnormal processing of pre-miR-1 82, a circadian clock modulator, in major depression patients with late insomni a. (PubMed id 20656788)1, 4 Saus E....Estivill X. (2010)
  2. MiR-182 and miR-203 induce mesenchymal to epithelial t ransition and self-sufficiency of growth signals via repressing SNAI2 in prostat e cells. (PubMed id 23354685)1 Qu Y....Ke X.S. (2013)
  3. MicroRNA-182-5p promotes cell invasion and proliferati on by down regulating FOXF2, RECK and MTSS1 genes in human prostate cancer. (PubMed id 23383207)1 Hirata H....Dahiya R. (2013)
  4. Up-regulation of miR-182 by b-catenin in breast cancer increases tumorigenicity and invasiveness by targeting the matrix metalloprotei nase inhibitor RECK. (PubMed id 23333633)1 Chiang C.H....Hung W.C. (2013)
  5. microRNA expression profile in a large series of bladd er tumors: identification of a 3-miRNA signature associated with aggressiveness of muscle-invasive bladder cancer. (PubMed id 23169479)1 Pignot G....Bieche I. (2013)
  6. Down-regulation of NAMPT expression by miR-182 is invo lved in Tat-induced HIV-1 long terminal repeat (LTR) transactivation. (PubMed id 23153509)1 Chen X.Y....Ruan Z. (2013)
  7. Expression and regulatory function of miRNA-182 in tri ple-negative breast cancer cells through its targeting of profilin 1. (PubMed id 23430586)1 Liu H....Li X.R. (2013)
  8. The upregulation of signal transducer and activator of transcription 5-dependent microRNA-182 and microRNA-96 promotes ovarian cancer cell proliferation by targeting forkhead box O3 upon leptin stimulation. (PubMed id 23262295)1 Xu X....Kong B. (2013)
  9. MicroRNA-182 and microRNA-200a control G-protein subun it a-13 (GNA13) expression and cell invasion synergistically in prostate cancer cells. (PubMed id 23329838)1 Rasheed S.A....Casey P.J. (2013)
  10. MicroRNA-182 plays an onco-miRNA role in cervical canc er. (PubMed id 23313739)1 Tang T....Choy K.W. (2013)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 406958 HGNC: 31553 Ensembl:ENSG00000207990 miRBase: hsa-mir-182 euGenes: HUgn406958
ECgene: MIR182 H-InvDB: MIR182

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for MIR182 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for MIR182 gene:
Search GeneIP for patents involving MIR182

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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