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Aliases for MIR182 Gene

Subcategory (RNA class) for MIR182 Gene

miRNA

Quality Score for this RNA gene is

13.2

Aliases for MIR182 Gene

  • MicroRNA 182 2 3 5
  • Hsa-Mir-182 3
  • MiRNA182 3
  • Mir-182 3
  • MIRN182 3

External Ids for MIR182 Gene

Previous HGNC Symbols for MIR182 Gene

  • MIRN182

Previous GeneCards Identifiers for MIR182 Gene

  • GC07M129199
  • GC07M129410

Summaries for MIR182 Gene

Entrez Gene Summary for MIR182 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR182 Gene

MIR182 (MicroRNA 182) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins..

fRNAdb sequence ontologies for MIR182 Gene - the ORGUL cluster for this gene includes several descriptions:

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR182

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR182 Gene

Genomics for MIR182 Gene

Regulatory Elements for MIR182 Gene

Enhancers for MIR182 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G129772 0.5 ENCODE 0.7 -1.6 -1584 0.2 ZNF316 POLR2A SMARCA4 ENSG00000273329 MIR182 GC07P129777
GH07G129771 0.4 ENCODE 0.7 -1.2 -1201 0.3 ZNF10 ZBTB33 UBE2H MIR182 GC07P129777
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR182 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR182 Gene

Chromosome:
7
Start:
129,770,383 bp from pter
End:
129,770,492 bp from pter
Size:
110 bases
Orientation:
Minus strand

Genomic View for MIR182 Gene

Genes around MIR182 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR182 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR182 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR182 Gene

ORGUL Member Location for MIR182 Gene

ORGUL Member Location for MIR182 gene

Proteins for MIR182 Gene

Post-translational modifications for MIR182 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR182 Gene

Domains & Families for MIR182 Gene

Gene Families for MIR182 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR182: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR182 Gene

Function for MIR182 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR182 Gene

Localization for MIR182 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR182 Gene

Pathways & Interactions for MIR182 Gene

genes like me logo Genes that share pathways with MIR182: view

Pathways by source for MIR182 Gene

1 BioSystems pathway for MIR182 Gene

Interacting Proteins for MIR182 Gene

Gene Ontology (GO) - Biological Process for MIR182 Gene

None

No data available for SIGNOR curated interactions for MIR182 Gene

Drugs & Compounds for MIR182 Gene

No Compound Related Data Available

Transcripts for MIR182 Gene

fRNAdb Secondary structures for MIR182 Gene

  • FR212512
  • hsa-mir-182_MI0000272_Homo_sapiens_miR-182_stem-loop_hairpin

mRNA/cDNA for MIR182 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR182 Gene

No ASD Table

Relevant External Links for MIR182 Gene

GeneLoc Exon Structure for
MIR182
ECgene alternative splicing isoforms for
MIR182

Expression for MIR182 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR182 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR182 Gene:

MIR182
genes like me logo Genes that share expression patterns with MIR182: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR182 Gene

Orthologs for MIR182 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR182 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-182 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-182 35
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-182 35
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-182 35
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir182 35
  • 89 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-182 35
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 35
  • 78 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-182 35
  • 93 (a)
OneToOne
Species where no ortholog for MIR182 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR182 Gene

ENSEMBL:
Gene Tree for MIR182 (if available)
TreeFam:
Gene Tree for MIR182 (if available)

Paralogs for MIR182 Gene

No data available for Paralogs for MIR182 Gene

Variants for MIR182 Gene

Sequence variations from dbSNP and Humsavar for MIR182 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1001285352 -- 129,771,338(+) ATTCT(-/CGGAGTGGCATTTCC)CCAGA upstream-variant-2KB
rs1002065772 -- 129,772,066(+) TCCAT(C/T)GGCAG upstream-variant-2KB
rs1002929091 -- 129,770,411(+) TAGTT(A/G)GCAAG nc-transcript-variant, upstream-variant-2KB
rs1005432215 -- 129,770,428(+) ACCAC(C/T)GGATC nc-transcript-variant, upstream-variant-2KB
rs1006570666 -- 129,770,150(+) CCTGG(A/G)GCAGA downstream-variant-500B, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR182 Gene

Variant ID Type Subtype PubMed ID
esv23078 CNV gain 19812545
esv3615005 CNV gain 21293372
nsv464721 CNV loss 19166990
nsv516024 CNV gain+loss 19592680
nsv608420 CNV loss 21841781
nsv949946 CNV deletion 24416366

Relevant External Links for MIR182 Gene

Human Gene Mutation Database (HGMD)
MIR182
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR182

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR182 Gene

Disorders for MIR182 Gene

Relevant External Links for MIR182

Genetic Association Database (GAD)
MIR182
Human Genome Epidemiology (HuGE) Navigator
MIR182
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR182

No disorders were found for MIR182 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR182 Gene

Publications for MIR182 Gene

  1. Genetic variants and abnormal processing of pre-miR-182, a circadian clock modulator, in major depression patients with late insomnia. (PMID: 20656788) Saus E. … Estivill X. (Hum. Mol. Genet. 2010) 3 46 64
  2. Vertebrate microRNA genes. (PMID: 12624257) Lim L.P. … Bartel D.P. (Science 2003) 1 3 64
  3. The miR-200 family and the miR-183~96~182 cluster target Foxf2 to inhibit invasion and metastasis in lung cancers. (PMID: 25798833) Kundu S.T. … Gibbons D.L. (Oncogene 2016) 3 64
  4. Contradicting roles of miR-182 in both NK cells and their host target hepatocytes in HCV. (PMID: 26518141) El Sobky S.A. … Abdelaziz A.I. (Immunol. Lett. 2016) 3 64
  5. High expression of microRNA-183/182/96 cluster as a prognostic biomarker for breast cancer. (PMID: 27071841) Song C. … Xie X. (Sci Rep 2016) 3 64

Products for MIR182 Gene

Sources for MIR182 Gene

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