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Aliases for MIR181D Gene

Subcategory (RNA class) for MIR181D Gene


Quality Score for this RNA gene is


Aliases for MIR181D Gene

  • MicroRNA 181d 2 3
  • Hsa-Mir-181d 3
  • MIRN181D 3

External Ids for MIR181D Gene

ORGUL Members for MIR181D Gene

Previous HGNC Symbols for MIR181D Gene

  • MIRN181D

Previous GeneCards Identifiers for MIR181D Gene

  • GC19P013856
  • GC19P013859
  • GC19P013986
  • GC19P013993
  • GC19P013997
  • GC19P014006

Summaries for MIR181D Gene

Entrez Gene Summary for MIR181D Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR181D Gene

MIR181D (MicroRNA 181d) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR181D Gene

Genomics for MIR181D Gene

Genomic Location for MIR181D Gene

13,874,875 bp from pter
13,875,011 bp from pter
137 bases
Plus strand

Genomic View for MIR181D Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR181D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR181D Gene

No data available for Regulatory Elements for MIR181D Gene

Proteins for MIR181D Gene

Post-translational modifications for MIR181D Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR181D Gene

Domains for MIR181D Gene

Gene Families for MIR181D Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR181D: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR181D Gene

Function for MIR181D Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR181D Gene

Localization for MIR181D Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR181D Gene

Pathways for MIR181D Gene

SuperPathways for MIR181D Gene

Superpath Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR181D: view

Pathways by source for MIR181D Gene

1 KEGG pathway for MIR181D Gene

Interacting Proteins for MIR181D Gene

Gene Ontology (GO) - Biological Process for MIR181D Gene


Transcripts for MIR181D Gene

mRNA/cDNA for MIR181D Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR181D Gene

No ASD Table

Relevant External Links for MIR181D Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR181D Gene

mRNA expression in normal human tissues for MIR181D Gene

genes like me logo Genes that share expressions with MIR181D: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for MIR181D Gene

Orthologs for MIR181D Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR181D Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia bta-mir-181d 36
  • 83 (a)
(Canis familiaris)
Mammalia cfa-mir-181d 36
  • 88 (a)
(Monodelphis domestica)
Mammalia mdo-mir-181b-3 36
  • 76 (a)
(Mus musculus)
Mammalia Mir181d 36
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia oan-mir-181c 36
  • 66 (a)
(Pan troglodytes)
Mammalia ptr-mir-181d 36
  • 99 (a)
(Gallus gallus)
Aves gga-mir-181b-1 36
  • 67 (a)
(Anolis carolinensis)
Reptilia aca-mir-181b-2 36
  • 67 (a)
(Danio rerio)
Actinopterygii CABZ01039424.1 36
  • 63 (a)
Species with no ortholog for MIR181D:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR181D Gene

Gene Tree for MIR181D (if available)
Gene Tree for MIR181D (if available)

Paralogs for MIR181D Gene

No data available for Paralogs for MIR181D Gene

Variants for MIR181D Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR181D Gene

Variant ID Type Subtype PubMed ID
nsv833757 CNV Loss 17160897
nsv911097 CNV Loss 21882294
nsv911098 CNV Loss 21882294
dgv3738n71 CNV Loss 21882294
nsv911102 CNV Loss 21882294
dgv3739n71 CNV Loss 21882294
nsv833760 CNV Loss 17160897

Relevant External Links for MIR181D Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for MIR181D Gene

Disorders for MIR181D Gene

No disorders were found for MIR181D Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for MIR181D Gene

Publications for MIR181D Gene

  1. Identification of hundreds of conserved and nonconserved human microRNAs. (PMID: 15965474) Bentwich I. … Bentwich Z. (Nat. Genet. 2005) 3
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3
  3. A mammalian microRNA expression atlas based on small RNA library sequencing. (PMID: 17604727) Landgraf P. … Tuschl T. (Cell 2007) 3
  4. miR-181d: a predictive glioblastoma biomarker that downregulates MGMT expression. (PMID: 22570426) Zhang W. … Chen C.C. (Neuro-oncology 2012) 3
  5. Birth and expression evolution of mammalian microRNA genes. (PMID: 23034410) Meunier J. … Kaessmann H. (Genome Res. 2013) 3

Products for MIR181D Gene

Sources for MIR181D Gene

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