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Aliases for MIR181D Gene

Subcategory (RNA class) for MIR181D Gene


Quality Score for this RNA gene is


Aliases for MIR181D Gene

  • MicroRNA 181d 2 3 5
  • Hsa-Mir-181d 3
  • Mir-181d 3
  • MIRN181D 3

External Ids for MIR181D Gene

ORGUL Members for MIR181D Gene

Previous HGNC Symbols for MIR181D Gene

  • MIRN181D

Previous GeneCards Identifiers for MIR181D Gene

  • GC19P013856
  • GC19P013859
  • GC19P013986
  • GC19P013993
  • GC19P013997
  • GC19P014006

Summaries for MIR181D Gene

Entrez Gene Summary for MIR181D Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR181D Gene

MIR181D (MicroRNA 181d) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins..

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR181D Gene

Genomics for MIR181D Gene

Regulatory Elements for MIR181D Gene

Enhancers for MIR181D Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F014078 1.4 FANTOM5 Ensembl 12.5 +203.7 203726 1.2 ZNF146 NANOS3 PRKACA MIR181C MIR181D C19orf57 CC2D1A ZSWIM4 CCDC130 ADGRE5 RFX1
GH19F014076 0.7 Ensembl 12.5 +201.9 201926 0.4 SMARCE1 HDAC1 KLF1 ESRRA RFX1 PKNOX1 ZBTB7A KLF16 IKZF1 GLIS1 PRKACA MIR181C MIR181D NANOS3 C19orf57 CC2D1A GC19M014079 MIR1199 MISP3
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR181D on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR181D Gene

13,874,875 bp from pter
13,875,011 bp from pter
137 bases
Plus strand

Genomic View for MIR181D Gene

Genes around MIR181D on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR181D Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR181D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR181D Gene

Proteins for MIR181D Gene

Post-translational modifications for MIR181D Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR181D Gene

Domains & Families for MIR181D Gene

Gene Families for MIR181D Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR181D: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR181D Gene

Function for MIR181D Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR181D Gene

Localization for MIR181D Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR181D Gene

Pathways & Interactions for MIR181D Gene

genes like me logo Genes that share pathways with MIR181D: view

Pathways by source for MIR181D Gene

1 BioSystems pathway for MIR181D Gene
1 KEGG pathway for MIR181D Gene

Interacting Proteins for MIR181D Gene

Gene Ontology (GO) - Biological Process for MIR181D Gene


No data available for SIGNOR curated interactions for MIR181D Gene

Transcripts for MIR181D Gene

mRNA/cDNA for MIR181D Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR181D Gene

No ASD Table

Relevant External Links for MIR181D Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR181D Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR181D Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR181D Gene:

genes like me logo Genes that share expression patterns with MIR181D: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR181D Gene

Orthologs for MIR181D Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR181D Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ptr-mir-181d 35
  • 99 (a)
(Canis familiaris)
Mammalia cfa-mir-181d 35
  • 88 (a)
(Bos Taurus)
Mammalia bta-mir-181d 35
  • 83 (a)
(Mus musculus)
Mammalia Mir181d 35
  • 78 (a)
(Monodelphis domestica)
Mammalia mdo-mir-181b-3 35
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia oan-mir-181c 35
  • 66 (a)
(Gallus gallus)
Aves gga-mir-181b-1 35
  • 67 (a)
(Anolis carolinensis)
Reptilia aca-mir-181b-2 35
  • 67 (a)
(Danio rerio)
Actinopterygii CABZ01039424.1 35
  • 63 (a)
Species where no ortholog for MIR181D was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR181D Gene

Gene Tree for MIR181D (if available)
Gene Tree for MIR181D (if available)

Paralogs for MIR181D Gene

No data available for Paralogs for MIR181D Gene

Variants for MIR181D Gene

Sequence variations from dbSNP and Humsavar for MIR181D Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10409992 -- 13,872,970(+) ACGAA(A/G)TTCGG upstream-variant-2KB
rs10415733 -- 13,873,016(+) GGGGG(C/T)TGGGC upstream-variant-2KB
rs113491840 -- 13,874,321(+) GCCAG(G/T)ATCCT upstream-variant-2KB
rs113693526 -- 13,875,220(+) CTCAC(C/T)CTGTT downstream-variant-500B, upstream-variant-2KB
rs115892272 -- 13,873,314(+) GGGCT(C/G)GGCCG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR181D Gene

Variant ID Type Subtype PubMed ID
nsv833757 CNV loss 17160897
nsv833760 CNV loss 17160897
nsv953979 CNV deletion 24416366

Relevant External Links for MIR181D Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR181D Gene

Disorders for MIR181D Gene

Relevant External Links for MIR181D

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MIR181D Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR181D Gene

Publications for MIR181D Gene

  1. Modulation of TNF-I+ mRNA stability by human antigen R and miR181s in sepsis-induced immunoparalysis. (PMID: 25535255) Dan C. … Wu Y. (EMBO Mol Med 2015) 3 64
  2. miR-181 subunits enhance the chemosensitivity of temozolomide by Rap1B-mediated cytoskeleton remodeling in glioblastoma cells. (PMID: 24573637) She X. … Wu M. (Med. Oncol. 2014) 3 64
  3. Birth and expression evolution of mammalian microRNA genes. (PMID: 23034410) Meunier J. … Kaessmann H. (Genome Res. 2013) 3 64
  4. Thyroid hormone negatively regulates CDX2 and SOAT2 mRNA expression via induction of miRNA-181d in hepatic cells. (PMID: 24103759) Yap C.S. … Yen P.M. (Biochem. Biophys. Res. Commun. 2013) 3 64
  5. MiR-181d acts as a tumor suppressor in glioma by targeting K-ras and Bcl-2. (PMID: 22207524) Wang X.F. … You Y.P. (J. Cancer Res. Clin. Oncol. 2012) 3 64

Products for MIR181D Gene

Sources for MIR181D Gene

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