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Aliases for MIR181C Gene

Subcategory (RNA class) for MIR181C Gene

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Quality Score for this RNA gene is

3

Aliases for MIR181C Gene

  • MicroRNA 181c 2 3 5
  • Hsa-Mir-181c 3
  • Mir-181c 3
  • MIRN181C 3

External Ids for MIR181C Gene

ORGUL Members for MIR181C Gene

Previous HGNC Symbols for MIR181C Gene

  • MIRN181C

Previous GeneCards Identifiers for MIR181C Gene

  • GC19P013855
  • GC19P013985

Summaries for MIR181C Gene

Entrez Gene Summary for MIR181C Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR181C Gene

MIR181C (MicroRNA 181c) is an RNA Gene, and is affiliated with the undefined RNA class. Among its related pathways are MicroRNAs in cancer.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR181C Gene

Genomics for MIR181C Gene

Regulatory Elements for MIR181C Gene

Enhancers for MIR181C Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F012983 1.8 FANTOM5 Ensembl ENCODE 15.2 -890.0 -889957 3.5 HDGF PKNOX1 CREB3L1 ARNT MLX SIN3A ARID4B DMAP1 ZNF2 ZNF143 ZNF136 CCDC130 ZNF564 ZNF625 WDR83OS ZNF844 ZNF442 MRI1 ZNF799 ZNF44
GH19F013042 1.7 FANTOM5 Ensembl ENCODE 15.2 -830.7 -830727 3.0 HDGF PKNOX1 ARNT ARID4B SIN3A ZNF2 YY1 ZNF766 CBX5 ZNF143 SYCE2 ZNF791 ZNF564 CCDC130 MTCO1P27 ENSG00000267735 MIR181C ZNF136 LYL1 TRMT1
GH19F013833 1.6 FANTOM5 ENCODE 15.5 -30.1 -30127 23.1 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 CCDC130 MRI1 TRMT1 ENSG00000267735 DCAF15 MIR181C RFX1 MIR24-2 ZSWIM4 SYCE2
GH19F013148 1.6 FANTOM5 ENCODE 15.2 -721.0 -721005 10.2 CREB3L1 MLX YBX1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 TBX21 ZNF791 ZNF136 ZNF564 ZNF442 CCDC130 WDR83OS ZNF44 C19orf43 WDR83 MTCO1P27
GH19F013011 1.5 FANTOM5 ENCODE 15.2 -854.5 -854505 17.2 HDGF PKNOX1 ARNT MLX SIN3A ARID4B FEZF1 DMAP1 ZNF2 YY1 ZNF791 ZNF136 TRMT1 ZNF442 MRI1 ZNF844 MTCO1P27 NFIX ENSG00000267735 MIR181C
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR181C on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR181C Gene

Chromosome:
19
Start:
13,874,699 bp from pter
End:
13,874,808 bp from pter
Size:
110 bases
Orientation:
Plus strand

Genomic View for MIR181C Gene

Genes around MIR181C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR181C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR181C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR181C Gene

Proteins for MIR181C Gene

Post-translational modifications for MIR181C Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR181C Gene

Domains & Families for MIR181C Gene

Gene Families for MIR181C Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR181C: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR181C Gene

Function for MIR181C Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR181C Gene

Localization for MIR181C Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR181C Gene

Pathways & Interactions for MIR181C Gene

SuperPathways for MIR181C Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR181C: view

Pathways by source for MIR181C Gene

1 KEGG pathway for MIR181C Gene

Interacting Proteins for MIR181C Gene

Gene Ontology (GO) - Biological Process for MIR181C Gene

None

No data available for SIGNOR curated interactions for MIR181C Gene

Transcripts for MIR181C Gene

mRNA/cDNA for MIR181C Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR181C Gene

No ASD Table

Relevant External Links for MIR181C Gene

GeneLoc Exon Structure for
MIR181C
ECgene alternative splicing isoforms for
MIR181C

Expression for MIR181C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR181C Gene

mRNA differential expression in normal tissues according to GTEx for MIR181C Gene

This gene is overexpressed in Testis (x37.3), Brain - Frontal Cortex (BA9) (x4.2), and Brain - Cortex (x4.1).

NURSA nuclear receptor signaling pathways regulating expression of MIR181C Gene:

MIR181C
genes like me logo Genes that share expression patterns with MIR181C: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR181C Gene

Orthologs for MIR181C Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR181C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-181c 35
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-181c 35
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-181c 35
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir181c 35
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-181a-3 35
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-181a-3 35
  • 80 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii BX649502.1 35
  • 65 (a)
OneToOne
Species where no ortholog for MIR181C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR181C Gene

ENSEMBL:
Gene Tree for MIR181C (if available)
TreeFam:
Gene Tree for MIR181C (if available)

Paralogs for MIR181C Gene

No data available for Paralogs for MIR181C Gene

Variants for MIR181C Gene

Sequence variations from dbSNP and Humsavar for MIR181C Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10409992 -- 13,872,970(+) ACGAA(A/G)TTCGG upstream-variant-2KB
rs10415733 -- 13,873,016(+) GGGGG(C/T)TGGGC upstream-variant-2KB
rs113491840 -- 13,874,321(+) GCCAG(G/T)ATCCT upstream-variant-2KB
rs113693526 -- 13,875,220(+) CTCAC(C/T)CTGTT downstream-variant-500B, upstream-variant-2KB
rs115892272 -- 13,873,314(+) GGGCT(C/G)GGCCG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR181C Gene

Variant ID Type Subtype PubMed ID
nsv833757 CNV loss 17160897
nsv833760 CNV loss 17160897
nsv953979 CNV deletion 24416366

Relevant External Links for MIR181C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR181C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR181C Gene

Disorders for MIR181C Gene

Relevant External Links for MIR181C

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR181C

No disorders were found for MIR181C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR181C Gene

Publications for MIR181C Gene

  1. MicroRNA-181c inhibits glioblastoma cell invasion, migration and mesenchymal transition by targeting TGF-I^ pathway. (PMID: 26682928) He X. … Yu C. (Biochem. Biophys. Res. Commun. 2016) 3 64
  2. Epigenetic silencing of miR-181c by DNA methylation in glioblastoma cell lines. (PMID: 26983574) Ayala-Ortega E. … Recillas-Targa F. (BMC Cancer 2016) 3 64
  3. Modulation of TNF-I+ mRNA stability by human antigen R and miR181s in sepsis-induced immunoparalysis. (PMID: 25535255) Dan C. … Wu Y. (EMBO Mol Med 2015) 3 64
  4. Brain metastatic cancer cells release microRNA-181c-containing extracellular vesicles capable of destructing blood-brain barrier. (PMID: 25828099) Tominaga N. … Ochiya T. (Nat Commun 2015) 3 64
  5. Tumor suppressor miR-181c attenuates proliferation, invasion, and self-renewal abilities in glioblastoma. (PMID: 25494473) Ruan J. … Sun X. (Neuroreport 2015) 3 64

Products for MIR181C Gene

Sources for MIR181C Gene

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