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Aliases for MIR181C Gene

Subcategory (RNA class) for MIR181C Gene

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Quality Score for this RNA gene is

3

Aliases for MIR181C Gene

  • MicroRNA 181c 2 3 5
  • Hsa-Mir-181c 3
  • Mir-181c 3
  • MIRN181C 3

External Ids for MIR181C Gene

ORGUL Members for MIR181C Gene

Previous HGNC Symbols for MIR181C Gene

  • MIRN181C

Previous GeneCards Identifiers for MIR181C Gene

  • GC19P013855
  • GC19P013985

Summaries for MIR181C Gene

Entrez Gene Summary for MIR181C Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR181C Gene

MIR181C (MicroRNA 181c) is an RNA Gene, and is affiliated with the undefined RNA class. Among its related pathways are MicroRNAs in cancer and Cell Differentiation - Index.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR181C Gene

Genomics for MIR181C Gene

Regulatory Elements for MIR181C Gene

Enhancers for MIR181C Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G014078 0.7 FANTOM5 Ensembl 12.5 +204.0 204002 1.0 ZNF146 NANOS3 PRKACA MIR181C MIR181D C19orf57 CC2D1A ZSWIM4 CCDC130 ADGRE5 RFX1
GH19G013872 1.1 Ensembl ENCODE 0.7 -1.5 -1489 1.4 HDAC1 ATF1 RB1 RAD21 CREM SP1 RAD51 NFIC MTA1 SMARCA4 CC2D1A MIR181C NANOS3
GH19G013864 1.4 FANTOM5 ENCODE dbSUPER 0.4 -9.9 -9878 1.5 HDGF KLF17 ZNF2 THRB ZNF48 GLIS2 KLF7 EGR2 ZEB2 ZFP69B ADGRL1 CACNA1A C19orf57 CC2D1A NANOS3 MIR181C
GH19G013865 1.4 FANTOM5 ENCODE dbSUPER 0.4 -8.4 -8359 1.0 HDGF PKNOX1 ZSCAN4 GLIS2 BCLAF1 EGR2 ZNF398 GATAD2B ZFP69B ZNF341 SNRPGP15 CACNA1A ADGRL1 ZSWIM4 RFX1 C19orf57 NANOS3 MIR181C
GH19G013866 0.8 ENCODE dbSUPER 0.4 -9.0 -9008 0.2 MAZ DPF2 ZBTB7A ZBTB26 EZH2 NANOS3 MIR181C
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR181C on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR181C Gene

Chromosome:
19
Start:
13,874,699 bp from pter
End:
13,874,808 bp from pter
Size:
110 bases
Orientation:
Plus strand

Genomic View for MIR181C Gene

Genes around MIR181C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR181C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR181C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR181C Gene

Proteins for MIR181C Gene

Post-translational modifications for MIR181C Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR181C Gene

Domains & Families for MIR181C Gene

Gene Families for MIR181C Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR181C: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR181C Gene

Function for MIR181C Gene

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR181C Gene

Localization for MIR181C Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR181C Gene

Pathways & Interactions for MIR181C Gene

genes like me logo Genes that share pathways with MIR181C: view

Pathways by source for MIR181C Gene

1 BioSystems pathway for MIR181C Gene
1 KEGG pathway for MIR181C Gene

Interacting Proteins for MIR181C Gene

Gene Ontology (GO) - Biological Process for MIR181C Gene

None

No data available for SIGNOR curated interactions for MIR181C Gene

Drugs & Compounds for MIR181C Gene

No Compound Related Data Available

Transcripts for MIR181C Gene

mRNA/cDNA for MIR181C Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR181C Gene

No ASD Table

Relevant External Links for MIR181C Gene

GeneLoc Exon Structure for
MIR181C
ECgene alternative splicing isoforms for
MIR181C

Expression for MIR181C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR181C Gene

mRNA differential expression in normal tissues according to GTEx for MIR181C Gene

This gene is overexpressed in Testis (x37.3), Brain - Frontal Cortex (BA9) (x4.2), and Brain - Cortex (x4.1).

NURSA nuclear receptor signaling pathways regulating expression of MIR181C Gene:

MIR181C
genes like me logo Genes that share expression patterns with MIR181C: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR181C Gene

Orthologs for MIR181C Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR181C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-181c 35
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-181c 35
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-181c 35
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir181c 35
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-181a-3 35
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-181a-3 35
  • 80 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii BX649502.1 35
  • 65 (a)
OneToOne
Species where no ortholog for MIR181C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR181C Gene

ENSEMBL:
Gene Tree for MIR181C (if available)
TreeFam:
Gene Tree for MIR181C (if available)

Paralogs for MIR181C Gene

No data available for Paralogs for MIR181C Gene

Variants for MIR181C Gene

Sequence variations from dbSNP and Humsavar for MIR181C Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1001098416 -- 13,872,756(+) ACTCC(A/G)CAGCC upstream-variant-2KB
rs1002550292 -- 13,873,302(+) GCGCG(A/T)CCTCG upstream-variant-2KB
rs1002864031 -- 13,873,484(+) TTTTG(-/CGA)CGACG upstream-variant-2KB
rs1003104628 -- 13,874,893(+) GGCCA(C/T)AGCCG nc-transcript-variant, downstream-variant-500B, upstream-variant-2KB
rs1003460913 -- 13,874,657(+) ATGCT(C/G)TCTGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR181C Gene

Variant ID Type Subtype PubMed ID
nsv833757 CNV loss 17160897
nsv833760 CNV loss 17160897
nsv953979 CNV deletion 24416366

Relevant External Links for MIR181C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR181C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR181C Gene

Disorders for MIR181C Gene

Relevant External Links for MIR181C

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR181C

No disorders were found for MIR181C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR181C Gene

Publications for MIR181C Gene

  1. Epigenetic silencing of miR-181c by DNA methylation in glioblastoma cell lines. (PMID: 26983574) Ayala-Ortega E. … Recillas-Targa F. (BMC Cancer 2016) 3 64
  2. Decreased microRNA miR-181c expression in peripheral blood mononuclear cells correlates with elevated serum levels of IL-7 and IL-17 in patients with myasthenia gravis. (PMID: 25962782) Zhang Y. … Geng D. (Clin. Exp. Med. 2016) 3 64
  3. MicroRNA-181c inhibits glioblastoma cell invasion, migration and mesenchymal transition by targeting TGF-I^ pathway. (PMID: 26682928) He X. … Yu C. (Biochem. Biophys. Res. Commun. 2016) 3 64
  4. Exosome Derived From Human Umbilical Cord Mesenchymal Stem Cell Mediates MiR-181c Attenuating Burn-induced Excessive Inflammation. (PMID: 27428420) Li X. … Yin H. (EBioMedicine 2016) 3 64
  5. Modulation of TNF-I+ mRNA stability by human antigen R and miR181s in sepsis-induced immunoparalysis. (PMID: 25535255) Dan C. … Wu Y. (EMBO Mol Med 2015) 3 64

Products for MIR181C Gene

Sources for MIR181C Gene

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