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Aliases for MIR181B2 Gene

Subcategory (RNA class) for MIR181B2 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR181B2 Gene

  • MicroRNA 181b-2 2 3
  • MIRN181B2 3 6
  • Hsa-Mir-181b-2 3

External Ids for MIR181B2 Gene

ORGUL Members for MIR181B2 Gene

Previous Symbols for MIR181B2 Gene

  • MIRN181B2

Summaries for MIR181B2 Gene

Entrez Gene Summary for MIR181B2 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR181B2 Gene

MIR181B2 (MicroRNA 181b-2) is a RNA Gene, and belongs to miRNA RNA class. Among its related pathways are MicroRNAs in cancer.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR181B2 Gene

Genomics for MIR181B2 Gene

Genomic Location for MIR181B2 Gene

Start:
124,693,710 bp from pter
End:
124,693,798 bp from pter
Size:
89 bases
Orientation:
Plus strand

Genomic View for MIR181B2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR181B2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR181B2 Gene

No data available for Regulatory Elements for MIR181B2 Gene

Proteins for MIR181B2 Gene

Post-translational modifications for MIR181B2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR181B2 Gene

Domains for MIR181B2 Gene

Gene Families for MIR181B2 Gene

HGNC:
  • MIR :ncRNAs / Micro RNAs
genes like me logo Genes that share domains with MIR181B2: view

No data available for Protein Domains and UniProtKB/Swiss-Prot for MIR181B2 Gene

Function for MIR181B2 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MIR181B2 Gene

Localization for MIR181B2 Gene

No data available for Gene Ontology (GO) - Cellular Components for MIR181B2 Gene

Pathways for MIR181B2 Gene

SuperPathways for MIR181B2 Gene

Superpath Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR181B2: view

Pathways by source for MIR181B2 Gene

1 KEGG pathway for MIR181B2 Gene

Interacting Proteins for MIR181B2 Gene

Gene Ontology (GO) - Biological Process for MIR181B2 Gene

None

Transcripts for MIR181B2 Gene

mRNA/cDNA for MIR181B2 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR181B2 Gene

No ASD Table

Relevant External Links for MIR181B2 Gene

GeneLoc Exon Structure for
MIR181B2
ECgene alternative splicing isoforms for
MIR181B2

Expression for MIR181B2 Gene

mRNA expression in normal human tissues for MIR181B2 Gene

genes like me logo Genes that share expressions with MIR181B2: view

Orthologs for MIR181B2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR181B2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-181b-2 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-181b-2 37
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-181b-2 37
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir181b-2 37
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-181b-2 37
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-181b-2 37
  • 93 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-181b-2 37
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-181b-1 37
  • 86 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-181b-2 37
  • 84 (a)
OneToOne
Species with no ortholog for MIR181B2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR181B2 Gene

ENSEMBL:
Gene Tree for MIR181B2 (if available)
TreeFam:
Gene Tree for MIR181B2 (if available)

Paralogs for MIR181B2 Gene

No data available for Paralogs for MIR181B2 Gene

Variants for MIR181B2 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR181B2 Gene

Variant ID Type Subtype PubMed ID
nsv893837 CNV Gain 21882294
nsv831721 CNV Gain 17160897

Relevant External Links for MIR181B2 Gene

HapMap Linkage Disequilibrium report
MIR181B2

No data available for Sequence variations from dbSNP and Humsavar for MIR181B2 Gene

Disorders for MIR181B2 Gene

Relevant External Links for MIR181B2

Genetic Association Database (GAD)
MIR181B2
Human Genome Epidemiology (HuGE) Navigator
MIR181B2
genes like me logo Genes that share disorders with MIR181B2: view

No data available for UniProtKB/Swiss-Prot for MIR181B2 Gene

Publications for MIR181B2 Gene

  1. MicroRNAs and target site screening reveals a pre-microRNA-30e variant associated with schizophrenia. (PMID: 20347265) Xu Y. … Liu P. (Schizophr. Res. 2010) 3 49
  2. microRNA-181b targets MLK2 in HL-60 cells. (PMID: 20596961) Chen H. … Mi Y. (Sci China Life Sci 2010) 3
  3. Aberrant microRNA expression in Chinese patients with chronic lymphocytic leukemia. (PMID: 21130495) Zhu D.X. … Li J.Y. (Leuk. Res. 2011) 3
  4. The clinical characteristics and prognostic significance of MN1 gene and MN1-associated microRNA expression in adult patients with de novo acute myeloid leukemia. (PMID: 23515710) Xiang L. … Gu W. (Ann. Hematol. 2013) 3
  5. MicroRNA-181b expression in prostate cancer tissues and its influence on the biological behavior of the prostate cancer cell line PC-3. (PMID: 23613247) He L. … Hao C.Q. (Genet. Mol. Res. 2013) 3

Products for MIR181B2 Gene

Sources for MIR181B2 Gene

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