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Aliases for MIR181B1 Gene

Subcategory (RNA class) for MIR181B1 Gene

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Quality Score for this RNA gene is

3.2

Aliases for MIR181B1 Gene

  • MicroRNA 181b-1 2 3
  • MIRN181B1 3 6
  • Hsa-Mir-181b-1 3

External Ids for MIR181B1 Gene

Previous Symbols for MIR181B1 Gene

  • MIRN181B1

Summaries for MIR181B1 Gene

Entrez Gene Summary for MIR181B1 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR181B1 Gene

MIR181B1 (MicroRNA 181b-1) is a RNA Gene, and belongs to undefined RNA class. Diseases associated with MIR181B1 include pancreatic ductal adenocarcinoma and gastric adenocarcinoma. Among its related pathways are MicroRNAs in cancer and miRNAs involved in DDR.

fRNAdb sequence ontologies for MIR181B1 Gene

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR181B1 Gene

Genomics for MIR181B1 Gene

Genomic Location for MIR181B1 Gene

Start:
198,858,873 bp from pter
End:
198,858,982 bp from pter
Size:
110 bases
Orientation:
Minus strand

Genomic View for MIR181B1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR181B1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR181B1 Gene

ORGUL Member Location for MIR181B1 Gene

ORGUL Member Location for MIR181B1 gene

No data available for Regulatory Elements for MIR181B1 Gene

Proteins for MIR181B1 Gene

Post-translational modifications for MIR181B1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR181B1 Gene

Domains for MIR181B1 Gene

Gene Families for MIR181B1 Gene

HGNC:
  • MIR :ncRNAs / Micro RNAs
genes like me logo Genes that share domains with MIR181B1: view

No data available for Protein Domains and UniProtKB/Swiss-Prot for MIR181B1 Gene

Function for MIR181B1 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MIR181B1 Gene

Localization for MIR181B1 Gene

No data available for Gene Ontology (GO) - Cellular Components for MIR181B1 Gene

Pathways for MIR181B1 Gene

genes like me logo Genes that share pathways with MIR181B1: view

Pathways by source for MIR181B1 Gene

1 BioSystems pathway for MIR181B1 Gene
1 KEGG pathway for MIR181B1 Gene

Interacting Proteins for MIR181B1 Gene

Gene Ontology (GO) - Biological Process for MIR181B1 Gene

None

Transcripts for MIR181B1 Gene

mRNA/cDNA for MIR181B1 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR181B1 Gene

No ASD Table

Relevant External Links for MIR181B1 Gene

GeneLoc Exon Structure for
MIR181B1
ECgene alternative splicing isoforms for
MIR181B1

Expression for MIR181B1 Gene

mRNA expression in normal human tissues for MIR181B1 Gene

genes like me logo Genes that share expressions with MIR181B1: view

Orthologs for MIR181B1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR181B1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-181b-1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-181b-1 37
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-181b-1 37
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir181b-1 37
  • 98 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-181b-1 37
  • 97 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-181b-1 37
  • 76 (a)
ManyToMany
chicken
(Gallus gallus)
Aves gga-mir-181b-1 37
  • 96 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia aca-mir-181b-2 37
  • 97 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii dre-mir-181b-1 37
  • 72 (a)
ManyToMany
dre-mir-181c 37
  • 67 (a)
ManyToMany
Species with no ortholog for MIR181B1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR181B1 Gene

ENSEMBL:
Gene Tree for MIR181B1 (if available)
TreeFam:
Gene Tree for MIR181B1 (if available)

Paralogs for MIR181B1 Gene

No data available for Paralogs for MIR181B1 Gene

Variants for MIR181B1 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR181B1 Gene

Variant ID Type Subtype PubMed ID
nsv873081 CNV Loss 21882294
nsv873082 CNV Loss 21882294

Relevant External Links for MIR181B1 Gene

HapMap Linkage Disequilibrium report
MIR181B1

No data available for Sequence variations from dbSNP and Humsavar for MIR181B1 Gene

Disorders for MIR181B1 Gene

Relevant External Links for MIR181B1

Genetic Association Database (GAD)
MIR181B1
Human Genome Epidemiology (HuGE) Navigator
MIR181B1
genes like me logo Genes that share disorders with MIR181B1: view

No data available for UniProtKB/Swiss-Prot for MIR181B1 Gene

Publications for MIR181B1 Gene

  1. MicroRNAs and target site screening reveals a pre-microRNA-30e variant associated with schizophrenia. (PMID: 20347265) Xu Y. … Liu P. (Schizophr. Res. 2010) 3 49
  2. microRNA-181b targets MLK2 in HL-60 cells. (PMID: 20596961) Chen H. … Mi Y. (Sci China Life Sci 2010) 3
  3. STAT3 activation of miR-21 and miR-181b-1 via PTEN and CYLD are part of the epigenetic switch linking inflammation to cancer. (PMID: 20797623) Iliopoulos D. … Struhl K. (Mol. Cell 2010) 3
  4. Aberrant microRNA expression in Chinese patients with chronic lymphocytic leukemia. (PMID: 21130495) Zhu D.X. … Li J.Y. (Leuk. Res. 2011) 3
  5. miR-181b is a biomarker of disease progression in chronic lymphocytic leukemia. (PMID: 21636858) Visone R. … Croce C.M. (Blood 2011) 3

Products for MIR181B1 Gene

Sources for MIR181B1 Gene

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