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Aliases for MIR181B1 Gene

Subcategory (RNA class) for MIR181B1 Gene


Quality Score for this RNA gene is


Aliases for MIR181B1 Gene

  • MicroRNA 181b-1 2 3
  • MIRN181B1 3 6
  • Hsa-Mir-181b-1 3

External Ids for MIR181B1 Gene

Previous HGNC Symbols for MIR181B1 Gene

  • MIRN181B1

Previous GeneCards Identifiers for MIR181B1 Gene

  • GC01M197096
  • GC01M198828

Summaries for MIR181B1 Gene

Entrez Gene Summary for MIR181B1 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR181B1 Gene

MIR181B1 (MicroRNA 181b-1) is an RNA Gene, and is affiliated with the undefined RNA class. Diseases associated with MIR181B1 include pancreatic ductal adenocarcinoma and gastric adenocarcinoma. Among its related pathways are MicroRNAs in cancer and miRNAs involved in DDR.

fRNAdb sequence ontologies for MIR181B1 Gene

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR181B1 Gene

Genomics for MIR181B1 Gene

Genomic Location for MIR181B1 Gene

198,858,873 bp from pter
198,858,982 bp from pter
110 bases
Minus strand

Genomic View for MIR181B1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR181B1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR181B1 Gene

ORGUL Member Location for MIR181B1 Gene

ORGUL Member Location for MIR181B1 gene

No data available for Regulatory Elements for MIR181B1 Gene

Proteins for MIR181B1 Gene

Post-translational modifications for MIR181B1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR181B1 Gene

Domains for MIR181B1 Gene

Gene Families for MIR181B1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR181B1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR181B1 Gene

Function for MIR181B1 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MIR181B1 Gene

Localization for MIR181B1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR181B1 Gene

Pathways for MIR181B1 Gene

genes like me logo Genes that share pathways with MIR181B1: view

Pathways by source for MIR181B1 Gene

1 BioSystems pathway for MIR181B1 Gene
1 KEGG pathway for MIR181B1 Gene

Interacting Proteins for MIR181B1 Gene

Gene Ontology (GO) - Biological Process for MIR181B1 Gene


Transcripts for MIR181B1 Gene

mRNA/cDNA for MIR181B1 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR181B1 Gene

No ASD Table

Relevant External Links for MIR181B1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR181B1 Gene

mRNA expression in normal human tissues for MIR181B1 Gene

genes like me logo Genes that share expressions with MIR181B1: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for MIR181B1 Gene

Orthologs for MIR181B1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR181B1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia bta-mir-181b-1 36
  • 94 (a)
(Canis familiaris)
Mammalia cfa-mir-181b-1 36
  • 97 (a)
(Monodelphis domestica)
Mammalia mdo-mir-181b-1 36
  • 97 (a)
(Mus musculus)
Mammalia Mir181b-1 36
  • 98 (a)
(Ornithorhynchus anatinus)
Mammalia oan-mir-181b-1 36
  • 76 (a)
(Pan troglodytes)
Mammalia ptr-mir-181b-1 36
  • 100 (a)
(Gallus gallus)
Aves gga-mir-181b-1 36
  • 96 (a)
(Anolis carolinensis)
Reptilia aca-mir-181b-2 36
  • 97 (a)
(Danio rerio)
Actinopterygii dre-mir-181b-1 36
  • 72 (a)
dre-mir-181c 36
  • 67 (a)
Species with no ortholog for MIR181B1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR181B1 Gene

Gene Tree for MIR181B1 (if available)
Gene Tree for MIR181B1 (if available)

Paralogs for MIR181B1 Gene

No data available for Paralogs for MIR181B1 Gene

Variants for MIR181B1 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR181B1 Gene

Variant ID Type Subtype PubMed ID
nsv873081 CNV Loss 21882294
nsv873082 CNV Loss 21882294

Relevant External Links for MIR181B1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for MIR181B1 Gene

Disorders for MIR181B1 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for MIR181B1 Gene in MalaCards »

(2) Diseases for MIR181B1 Gene

Relevant External Links for MIR181B1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with MIR181B1: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for MIR181B1 Gene

Publications for MIR181B1 Gene

  1. MicroRNAs and target site screening reveals a pre-microRNA-30e variant associated with schizophrenia. (PMID: 20347265) Xu Y. … Liu P. (Schizophr. Res. 2010) 3 48
  2. microRNA-181b targets MLK2 in HL-60 cells. (PMID: 20596961) Chen H. … Mi Y. (Sci China Life Sci 2010) 3
  3. STAT3 activation of miR-21 and miR-181b-1 via PTEN and CYLD are part of the epigenetic switch linking inflammation to cancer. (PMID: 20797623) Iliopoulos D. … Struhl K. (Mol. Cell 2010) 3
  4. Aberrant microRNA expression in Chinese patients with chronic lymphocytic leukemia. (PMID: 21130495) Zhu D.X. … Li J.Y. (Leuk. Res. 2011) 3
  5. miR-181b is a biomarker of disease progression in chronic lymphocytic leukemia. (PMID: 21636858) Visone R. … Croce C.M. (Blood 2011) 3

Products for MIR181B1 Gene

Sources for MIR181B1 Gene

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