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Aliases for MIR181B1 Gene

Subcategory (RNA class) for MIR181B1 Gene

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Quality Score for this RNA gene is

3.2

Aliases for MIR181B1 Gene

  • MicroRNA 181b-1 2 3 5
  • Hsa-Mir-181b-1 3
  • Mir-181b-1 3
  • MIRN181B1 3

External Ids for MIR181B1 Gene

Previous HGNC Symbols for MIR181B1 Gene

  • MIRN181B1

Previous GeneCards Identifiers for MIR181B1 Gene

  • GC01M197096
  • GC01M198828

Summaries for MIR181B1 Gene

Entrez Gene Summary for MIR181B1 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR181B1 Gene

MIR181B1 (MicroRNA 181b-1) is an RNA Gene, and is affiliated with the undefined RNA class. Among its related pathways are miRNAs involved in DNA damage response and MicroRNAs in cancer.

fRNAdb sequence ontologies for MIR181B1 Gene

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR181B1 Gene

Genomics for MIR181B1 Gene

Regulatory Elements for MIR181B1 Gene

Enhancers for MIR181B1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G198879 1.9 FANTOM5 Ensembl ENCODE dbSUPER 11.6 -21.8 -21842 2.8 PKNOX1 ZNF493 ZFP64 BRCA1 ZNF302 GATA2 FOS DEK ZNF202 ZHX2 MIR181A1 MIR181B1 LOC105371679 PTPRC GC01P198890 GC01P198860
GH01G198918 1.5 FANTOM5 Ensembl ENCODE dbSUPER 10.6 -60.8 -60806 2.0 BHLHE40 JUN JUNB MAFG EP300 ZNF316 MAFF CREB1 RELB FOS MIR181A1 MIR181B1 PTPRC GC01P198915 MIR181A1HG
GH01G198890 1.3 Ensembl ENCODE dbSUPER 11.4 -33.2 -33223 4.1 FEZF1 BMI1 RAD21 ZBTB40 GATA2 FOS CEBPB ZEB2 ZNF843 MAFF LOC105371679 MIR181A1 MIR181B1 GC01P198890 GC01P198909
GH01G198921 1.3 Ensembl ENCODE dbSUPER 10.6 -63.6 -63620 1.6 PKNOX1 ZNF792 BACH1 FEZF1 BMI1 EBF1 CTBP1 GATA2 FOS RELB MIR181A1 MIR181B1 GC01P198915 MIR181A1HG
GH01G198775 1 Ensembl ENCODE 10.4 +82.0 82005 2.8 CTCF ZNF792 JUN FEZF1 RELA ZNF324 GATA2 POLR2A RELB FOS MIR181A1 MIR181B1 GC01M198840 GC01P198684 PIR61364
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR181B1 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR181B1 Gene

Chromosome:
1
Start:
198,858,873 bp from pter
End:
198,858,982 bp from pter
Size:
110 bases
Orientation:
Minus strand

Genomic View for MIR181B1 Gene

Genes around MIR181B1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR181B1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR181B1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR181B1 Gene

ORGUL Member Location for MIR181B1 Gene

ORGUL Member Location for MIR181B1 gene

Proteins for MIR181B1 Gene

Post-translational modifications for MIR181B1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR181B1 Gene

Domains & Families for MIR181B1 Gene

Gene Families for MIR181B1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR181B1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR181B1 Gene

Function for MIR181B1 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR181B1 Gene

Localization for MIR181B1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR181B1 Gene

Pathways & Interactions for MIR181B1 Gene

genes like me logo Genes that share pathways with MIR181B1: view

Pathways by source for MIR181B1 Gene

1 KEGG pathway for MIR181B1 Gene

Interacting Proteins for MIR181B1 Gene

Gene Ontology (GO) - Biological Process for MIR181B1 Gene

None

No data available for SIGNOR curated interactions for MIR181B1 Gene

Transcripts for MIR181B1 Gene

mRNA/cDNA for MIR181B1 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR181B1 Gene

No ASD Table

Relevant External Links for MIR181B1 Gene

GeneLoc Exon Structure for
MIR181B1
ECgene alternative splicing isoforms for
MIR181B1

Expression for MIR181B1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR181B1 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR181B1 Gene:

MIR181B1
genes like me logo Genes that share expression patterns with MIR181B1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR181B1 Gene

Orthologs for MIR181B1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR181B1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-181b-1 35
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir181b-1 35
  • 98 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia cfa-mir-181b-1 35
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-181b-1 35
  • 97 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia bta-mir-181b-1 35
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-181b-1 35
  • 76 (a)
ManyToMany
chicken
(Gallus gallus)
Aves gga-mir-181b-1 35
  • 96 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia aca-mir-181b-2 35
  • 97 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii dre-mir-181b-1 35
  • 72 (a)
ManyToMany
dre-mir-181c 35
  • 67 (a)
ManyToMany
Species where no ortholog for MIR181B1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR181B1 Gene

ENSEMBL:
Gene Tree for MIR181B1 (if available)
TreeFam:
Gene Tree for MIR181B1 (if available)

Paralogs for MIR181B1 Gene

No data available for Paralogs for MIR181B1 Gene

Variants for MIR181B1 Gene

Sequence variations from dbSNP and Humsavar for MIR181B1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000285651 -- 198,860,897(+) TATAA(C/T)GATTC intron-variant, upstream-variant-2KB
rs1000647972 -- 198,859,678(+) ATGCT(A/G)AACAA intron-variant, upstream-variant-2KB
rs1001018666 -- 198,859,400(+) ATGGA(A/G)TTATC intron-variant, upstream-variant-2KB
rs1001509062 -- 198,858,525(+) CATAT(G/T)TGTAA intron-variant, downstream-variant-500B
rs1002441028 -- 198,860,154(+) CGAAA(C/T)GTTAG intron-variant, upstream-variant-2KB

Relevant External Links for MIR181B1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR181B1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR181B1 Gene

Disorders for MIR181B1 Gene

Relevant External Links for MIR181B1

Genetic Association Database (GAD)
MIR181B1
Human Genome Epidemiology (HuGE) Navigator
MIR181B1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR181B1

No disorders were found for MIR181B1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR181B1 Gene

Publications for MIR181B1 Gene

  1. MicroRNAs and target site screening reveals a pre-microRNA-30e variant associated with schizophrenia. (PMID: 20347265) Xu Y. … Liu P. (Schizophr. Res. 2010) 3 46 64
  2. MicroRNA-181b Controls Atherosclerosis and Aneurysms Through Regulation of TIMP-3 and Elastin. (PMID: 27756793) Di Gregoli K. … Johnson J.L. (Circ. Res. 2017) 3 64
  3. miRNA-181a/b Regulates Phenotypes of Vessel Smooth Muscle Cells Through Serum Response Factor. (PMID: 27911586) Wei X. … Liu Y. (DNA Cell Biol. 2017) 3 64
  4. MiR-181b-5p, ETS1 and c-Met pathway exacerbates the prognosis of pancreatic ductal adenocarcinoma after radiation therapy. (PMID: 28064436) Tomihara H. … Doki Y. (Cancer Sci. 2017) 3 64
  5. Epigenetic silencing of miR-181b contributes to tumorigenicity in colorectal cancer by targeting RASSF1A. (PMID: 26935905) Zhao L.D. … Hao S. (Int. J. Oncol. 2016) 3 64

Products for MIR181B1 Gene

Sources for MIR181B1 Gene

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