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MIR181B1 Gene

RNA gene   GIFtS: 25
GCID: GC01M198828

MicroRNA 181b-1


(Previous symbol: MIRN181B1)
  See MIR181B1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Subcategory (RNA class): miRNA

Quality score for this RNA gene is 9.2

Aliases
MicroRNA 181b-11 2
MIRN181B11 2 5
mir-181b-19

External Ids:    HGNC: 315501   Entrez Gene: 4069552   Ensembl: ENSG000002079757   OMIM: 6127445   
ORGUL members:    fRNAdb10:FR297567 FR402608 FR297567      
miRBase: MI0000270 MIMAT0000257 MIMAT0022692    
NCBI13:AJ550410    
NONCODE14:u3200    
RNAdb15:EVF4453    

Export aliases for MIR181B1 gene to outside databases

Previous GC identifer: GC01M197096


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MIR181B1 Gene:
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of
gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are
transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can
be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme
to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the
cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The
mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through
imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of
the target mRNA. The RefSeq represents the predicted microRNA stem-loop. (provided by RefSeq, Sep 2009)

GeneCards Summary for MIR181B1 Gene:
MIR181B1 (microRNA 181b-1) is an RNA gene, and is affiliated with the miRNA class. Diseases associated with MIR181B1 include pancreatic ductal adenocarcinoma, and gastric adenocarcinoma.



fRNAdb sequence ontologies for MIR181B1 - the ORGUL cluster for this gene includes several descriptions:
miRNA - Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene. Micro RNAs are produced from precursor molecules (SO:0000647) that can form local hairpin structures, which ordinarily are processed (via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors.
nc_conserved_region - Non-coding region of sequence similarity by descent from a common ancestor.

View fRNAdb secondary structures for MIR181B1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for MIR181B1
         Other transcription factors

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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MIR181B1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32.1   Ensembl cytogenetic band:  1q32.1   HGNC cytogenetic band: 1q32.1

MIR181B1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MIR181B1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M198828:  view genomic region (via miRBase)     (about GC identifiers)

Start:
198,828,002 bp from pter      End:
198,828,111 bp from pter
Size:
110 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB: --


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
MIR: ncRNAs / Micro RNAs

  --

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Animal Models:
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for MIR181B1 About    
See pathways by source

SuperPathContained pathways About
1miRNAs involved in DDR
miRNAs involved in DDR
2MicroRNAs in cancer
MicroRNAs in cancer


Find genes that share SuperPaths with MIR181B1           About GenesLikeMe

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


1 BioSystems Pathway for MIR181B1
    miRNAs involved in DDR


1 Kegg Pathway  (Kegg details for MIR181B1):
    MicroRNAs in cancer

    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MIR181B1
Interactions:

    Search GeneGlobe Interaction Network for MIR181B1

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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2 fRNAdb Secondary structures:


1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000385240(miRNA)
miRNA
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GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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Expression evidence for MIR181B1:miRBase

See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --

MIR181B1 Protein expression data from MOPED1, PaxDb2 and MaxQB3 --
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In Situ
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MIR181B1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for MIR181B1 gene from Selected species (see all 9)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
chicken
(Gallus gallus)
Aves gga-mir-181b-16
gga-mir-181b-1
96(a)
1 → many
8(1986876-1986964) ENSGALG00000021726
lizard
(Anolis carolinensis)
Reptilia aca-mir-181b-26
aca-mir-181b-2
97(a)
1 → many
GL343211.1(716889-716977)
zebrafish
(Danio rerio)
Actinopterygii dre-mir-181b-16
dre-mir-181c6
dre-mir-181c
72(a)
67(a)
many ↔ many
many ↔ many
2(45252630-45252738) ENSDARG00000081145
3(34282990-34283067)
        Species with no ortholog for MIR181B1

ENSEMBL Gene Tree for MIR181B1 (if available)
TreeFam Gene Tree for MIR181B1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Structural Variations
     Database of Genomic Variants (DGV) 2 variations for MIR181B1:    About this table    
Variant IDTypeSubtypePubMed ID
nsv873082CNV Loss21882294
nsv873081CNV Loss21882294

Site Specific Mutation Identification with PCR Assays
Search QIAGEN SeqTarget long-range PCR primers for resequencing MIR181B1
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 612744OMIM information: 602778    
3 diseases for MIR181B1:    
About MalaCards
pancreatic ductal adenocarcinoma    gastric adenocarcinoma    acute myeloid leukemia


Find genes that share disorders with MIR181B1           About GenesLikeMe

Genetic Association Database (GAD): MIR181B1
Human Genome Epidemiology (HuGE) Navigator: MIR181B1 (1 document)

Export disorders for MIR181B1 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for MIR181B1 gene, integrated from 10 sources (see all 34):
(articles sorted by number of sources associating them with MIR181B1)
    Utopia: connect your pdf to the dynamic
world of online information

  1. MicroRNAs and target site screening reveals a pre-microRNA-30e variant associated with schizophrenia. (PubMed id 20347265)1, 4 Xu Y....Liu P. (Schizophr. Res. 2010)
  2. miR-181b promotes cell proliferation and reduces apoptosis by repressing the expression of adenylyl cyclase 9 (AC9) in cervical cancer cells. (PubMed id 24269684)1 Yang L....Tang H. (FEBS Lett. 2014)
  3. Systemic Delivery of MicroRNA-181b Inhibits Nuclear Factor-I_B Activation, Vascular Inflammation, and Atherosclerosis in Apolipoprotein E-Deficient Mice. (PubMed id 24084690)1 Sun X....Feinberg M.W. (Circ. Res. 2014)
  4. Involvement of FOS-mediated miR-181b/miR-21 signalling in the progression of malignant gliomas. (PubMed id 23810250)1 Tao T....You Y. (Eur. J. Cancer 2013)
  5. Identification of circulating microRNAs as potential biomarkers for detecting acute myeloid leukemia. (PubMed id 23437222)1 Zhi F....Liu Y. (PLoS ONE 2013)
  6. MicroRNAs distinguish cytogenetic subgroups in pediatric AML and contribute to complex regulatory networks in AML-relevant pathways. (PubMed id 23418555)1 Daschkey S....Landgraf P. (PLoS ONE 2013)
  7. MicroRNA-181b regulates articular chondrocytes differentiation and cartilage integrity. (PubMed id 23313477)1 Song J....Jin E.J. (Biochem. Biophys. Res. Commun. 2013)
  8. Down-regulation of microRNA-181b is a potential prognostic marker of non-small cell lung cancer. (PubMed id 23827213)1 Yang J....Sun Y. (Pathol. Res. Pract. 2013)
  9. MiRNA-181b suppresses IGF-1R and functions as a tumor suppressor gene in gliomas. (PubMed id 23431408)1 Shi Z.M....You Y.P. (RNA 2013)
  10. The clinical characteristics and prognostic significance of MN1 gene and MN1-associated microRNA expression in adult patients with de novo acute myeloid leukemia. (PubMed id 23515710)1 Xiang L....Gu W. (Ann. Hematol. 2013)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 406955 HGNC: 31550 Ensembl:ENSG00000207975 miRBase: hsa-mir-181b-1 euGenes: HUgn406955
ECgene: MIR181B1 Kegg: 406955 H-InvDB: MIR181B1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for MIR181B1 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for MIR181B1 gene:
Search GeneIP for patents involving MIR181B1

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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