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Aliases for MIR181A2 Gene

Subcategory (RNA class) for MIR181A2 Gene


Quality Score for this RNA gene is


Aliases for MIR181A2 Gene

  • MicroRNA 181a-2 2 3 5
  • Hsa-Mir-181a-2 3
  • MicroRNA 181a 2
  • Hsa-Mir-181a 3
  • Mir-181a-2 3
  • MIRN181A2 3
  • MIRN181A 3

External Ids for MIR181A2 Gene

ORGUL Members for MIR181A2 Gene

Previous HGNC Symbols for MIR181A2 Gene

  • MIRN181A
  • MIRN181A2

Previous GeneCards Identifiers for MIR181A2 Gene

  • GC09P126496
  • GC09P127455
  • GC09P127460
  • GC09P127466
  • GC09P127471

Summaries for MIR181A2 Gene

Entrez Gene Summary for MIR181A2 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR181A2 Gene

MIR181A2 (MicroRNA 181a-2) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins..

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR181A2 Gene

Genomics for MIR181A2 Gene

Regulatory Elements for MIR181A2 Gene

Enhancers for MIR181A2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09F124720 1.2 Ensembl ENCODE 12.2 +28.8 28797 2.0 HDAC1 MLX ARID4B FEZF1 ZSCAN9 RARA GATA4 GATA2 CREM MIXL1 MIR181A2 MIR181B2 ENSG00000236643 NR6A1 WDR38 ARPC5L RPL35 ENSG00000231149 NR5A1 GC09P124694
GH09F124617 1.2 Ensembl ENCODE 11 -74.4 -74363 1.9 HDGF PKNOX1 CBX3 BRCA1 ZNF2 RAD21 RFX5 ZNF766 ZNF143 RCOR1 MIR181A2 MIR181B2 WDR38 ARPC5L RPL35 ENSG00000231149 NR5A1 RN7SL302P MIR181A2HG
GH09F124592 1.2 Ensembl ENCODE 10.9 -97.7 -97707 5.4 ATF1 PKNOX1 MLX ARID4B DMAP1 ETS1 REST PPARG KAT8 CREB3 MIR181A2HG MIR181A2 MIR181B2 ENSG00000231149 NR5A1 LOC100419284 PIR56415
GH09F124656 1.1 ENCODE 11.5 -33.1 -33051 5.0 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 FEZF1 YY1 MIR181A2 MIR181B2 MIR181A2HG PIR50063
GH09F124651 1.1 Ensembl ENCODE 10.9 -39.8 -39822 2.2 TBP ZNF133 SIN3A KLF17 RAD21 RFX5 ZNF366 RCOR1 FOS DEK MIR181A2 MIR181B2 MIR181A2HG RN7SL302P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR181A2 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR181A2 Gene

124,692,442 bp from pter
124,692,551 bp from pter
110 bases
Plus strand

Genomic View for MIR181A2 Gene

Genes around MIR181A2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR181A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR181A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR181A2 Gene

Proteins for MIR181A2 Gene

Post-translational modifications for MIR181A2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR181A2 Gene

Domains & Families for MIR181A2 Gene

Gene Families for MIR181A2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR181A2: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR181A2 Gene

Function for MIR181A2 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR181A2 Gene

Localization for MIR181A2 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR181A2 Gene

Pathways & Interactions for MIR181A2 Gene

genes like me logo Genes that share pathways with MIR181A2: view

Pathways by source for MIR181A2 Gene

1 BioSystems pathway for MIR181A2 Gene
1 KEGG pathway for MIR181A2 Gene

Interacting Proteins for MIR181A2 Gene

Gene Ontology (GO) - Biological Process for MIR181A2 Gene


No data available for SIGNOR curated interactions for MIR181A2 Gene

Transcripts for MIR181A2 Gene

mRNA/cDNA for MIR181A2 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR181A2 Gene

No ASD Table

Relevant External Links for MIR181A2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR181A2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR181A2 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR181A2 Gene:

genes like me logo Genes that share expression patterns with MIR181A2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR181A2 Gene

Orthologs for MIR181A2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR181A2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ptr-mir-181a-2 35
  • 100 (a)
(Canis familiaris)
Mammalia cfa-mir-181a-2 35
  • 95 (a)
(Bos Taurus)
Mammalia bta-mir-181a-2 35
  • 86 (a)
(Mus musculus)
Mammalia Mir181a-2 35
  • 86 (a)
(Ornithorhynchus anatinus)
Mammalia oan-mir-181a-2 35
  • 81 (a)
(Monodelphis domestica)
Mammalia mdo-mir-181a-2 35
  • 76 (a)
(Gallus gallus)
Aves gga-mir-181a-2 35
  • 78 (a)
(Anolis carolinensis)
Reptilia aca-mir-181a-2 35
  • 78 (a)
(Danio rerio)
Actinopterygii dre-mir-181a-2 35
  • 72 (a)
CABZ01086560.1 35
  • 66 (a)
Species where no ortholog for MIR181A2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR181A2 Gene

Gene Tree for MIR181A2 (if available)
Gene Tree for MIR181A2 (if available)

Paralogs for MIR181A2 Gene

No data available for Paralogs for MIR181A2 Gene

Variants for MIR181A2 Gene

Sequence variations from dbSNP and Humsavar for MIR181A2 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs10760371 -- 124,690,698(+) GTCAC(G/T)CTTAG intron-variant, upstream-variant-2KB
rs116294401 -- 124,691,985(+) GAGCA(C/T)TGGAA intron-variant, upstream-variant-2KB
rs117185554 -- 124,690,815(+) TGCTT(G/T)ATGAT intron-variant, upstream-variant-2KB
rs138500643 -- 124,690,553(+) TTTTT(-/A)AGAGA intron-variant, upstream-variant-2KB
rs138832222 -- 124,692,260(+) CATTC(-/ATTT)GAGTC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR181A2 Gene

Variant ID Type Subtype PubMed ID
nsv831721 CNV gain 17160897

Relevant External Links for MIR181A2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR181A2 Gene

Disorders for MIR181A2 Gene

Relevant External Links for MIR181A2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MIR181A2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR181A2 Gene

Publications for MIR181A2 Gene

  1. Induction of miRNA-181a by genotoxic treatments promotes chemotherapeutic resistance and metastasis in breast cancer. (PMID: 26028030) Niu J. … Wu Z.H. (Oncogene 2016) 3 64
  2. TGF-I^ regulates TGFBIp expression in corneal fibroblasts via miR-21, miR-181a, and Smad signaling. (PMID: 26915797) Choi S.I. … Kim E.K. (Biochem. Biophys. Res. Commun. 2016) 3 64
  3. Quantitative and integrated proteome and microRNA analysis of endothelial replicative senescence. (PMID: 26013412) Yentrapalli R. … Tapio S. (J Proteomics 2015) 3 64
  4. MicroRNA-181a regulates epithelial-mesenchymal transition by targeting PTEN in drug-resistant lung adenocarcinoma cells. (PMID: 26323677) Li H. … Liu X. (Int. J. Oncol. 2015) 3 64
  5. Evaluation of miR-27a, miR-181a, and miR-570 genetic variants with gallbladder cancer susceptibility and treatment outcome in a North Indian population. (PMID: 26288960) Gupta A. … Mittal B. (Mol Diagn Ther 2015) 3 64

Products for MIR181A2 Gene

Sources for MIR181A2 Gene

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