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Aliases for MIR181A2 Gene

Subcategory (RNA class) for MIR181A2 Gene


Quality Score for this RNA gene is


Aliases for MIR181A2 Gene

  • MicroRNA 181a-2 2 3
  • Hsa-Mir-181a-2 3
  • MicroRNA 181a 2
  • Hsa-Mir-181a 3
  • Mir-181a-2 3
  • MIRN181A2 3
  • MIRN181A 3

External Ids for MIR181A2 Gene

ORGUL Members for MIR181A2 Gene

Previous HGNC Symbols for MIR181A2 Gene

  • MIRN181A
  • MIRN181A2

Previous GeneCards Identifiers for MIR181A2 Gene

  • GC09P126496
  • GC09P127455
  • GC09P127460
  • GC09P127466
  • GC09P127471

Summaries for MIR181A2 Gene

Entrez Gene Summary for MIR181A2 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR181A2 Gene

MIR181A2 (MicroRNA 181a-2) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR181A2 Gene

Genomics for MIR181A2 Gene

Genomic Location for MIR181A2 Gene

124,692,442 bp from pter
124,692,551 bp from pter
110 bases
Plus strand

Genomic View for MIR181A2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR181A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR181A2 Gene

No data available for Regulatory Elements for MIR181A2 Gene

Proteins for MIR181A2 Gene

Post-translational modifications for MIR181A2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR181A2 Gene

Domains & Families for MIR181A2 Gene

Gene Families for MIR181A2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR181A2: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR181A2 Gene

Function for MIR181A2 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR181A2 Gene

Localization for MIR181A2 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR181A2 Gene

Pathways & Interactions for MIR181A2 Gene

SuperPathways for MIR181A2 Gene

Superpath Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR181A2: view

Pathways by source for MIR181A2 Gene

1 KEGG pathway for MIR181A2 Gene

Interacting Proteins for MIR181A2 Gene

Gene Ontology (GO) - Biological Process for MIR181A2 Gene


No data available for SIGNOR curated interactions for MIR181A2 Gene

Drugs & Compounds for MIR181A2 Gene

No Compound Related Data Available

Transcripts for MIR181A2 Gene

mRNA/cDNA for MIR181A2 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR181A2 Gene

No ASD Table

Relevant External Links for MIR181A2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR181A2 Gene

mRNA expression in normal human tissues for MIR181A2 Gene

genes like me logo Genes that share expression patterns with MIR181A2: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MIR181A2 Gene

Orthologs for MIR181A2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR181A2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia bta-mir-181a-2 36
  • 86 (a)
(Canis familiaris)
Mammalia cfa-mir-181a-2 36
  • 95 (a)
(Monodelphis domestica)
Mammalia mdo-mir-181a-2 36
  • 76 (a)
(Mus musculus)
Mammalia Mir181a-2 36
  • 86 (a)
(Ornithorhynchus anatinus)
Mammalia oan-mir-181a-2 36
  • 81 (a)
(Pan troglodytes)
Mammalia ptr-mir-181a-2 36
  • 100 (a)
(Gallus gallus)
Aves gga-mir-181a-2 36
  • 78 (a)
(Anolis carolinensis)
Reptilia aca-mir-181a-2 36
  • 78 (a)
(Danio rerio)
Actinopterygii CABZ01086560.1 36
  • 66 (a)
dre-mir-181a-2 36
  • 72 (a)
Species with no ortholog for MIR181A2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR181A2 Gene

Gene Tree for MIR181A2 (if available)
Gene Tree for MIR181A2 (if available)

Paralogs for MIR181A2 Gene

No data available for Paralogs for MIR181A2 Gene

Variants for MIR181A2 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR181A2 Gene

Variant ID Type Subtype PubMed ID
nsv893837 CNV Gain 21882294
nsv831721 CNV Gain 17160897

Relevant External Links for MIR181A2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Variation tolerance for MIR181A2 Gene

Disorders for MIR181A2 Gene

Relevant External Links for MIR181A2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with MIR181A2: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR181A2 Gene

Publications for MIR181A2 Gene

  1. Human natural killer cell microRNA: differential expression of MIR181A1B1 and MIR181A2B2 genes encoding identical mature microRNAs. (PMID: 25410655) Presnell S.R. … Lutz C.T. (Genes Immun. 2015) 67
  2. Functional analysis of miR-181a and Fas involved in hepatitis B virus-related hepatocellular carcinoma pathogenesis. (PMID: 25449696) Zou C. … Tang H. (Exp. Cell Res. 2015) 67
  3. MiR-181a-5p is downregulated in hepatocellular carcinoma and suppresses motility, invasion and branching-morphogenesis by directly targeting c-Met. (PMID: 25058462) Korhan P. … Atabey N. (Biochem. Biophys. Res. Commun. 2014) 67
  4. Analysis of TP53 gene expression and p53 level of human hypopharyngeal FaDu (HTB-43) head and neck cancer cell line after microRNA-181a inhibition. (PMID: 24535903) Cheah Y.K. … See H.S. (Genet. Mol. Res. 2014) 67
  5. MitomiRs in human inflamm-aging: a hypothesis involving miR-181a, miR-34a and miR-146a. (PMID: 24607549) Rippo M.R. … Procopio A.D. (Exp. Gerontol. 2014) 67

Products for MIR181A2 Gene

Sources for MIR181A2 Gene

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