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Aliases for MIR181A2 Gene

Subcategory (RNA class) for MIR181A2 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR181A2 Gene

  • MicroRNA 181a-2 2 3 5
  • Hsa-Mir-181a-2 3
  • MicroRNA 181a 2
  • Hsa-Mir-181a 3
  • Mir-181a-2 3
  • MIRN181A2 3
  • MIRN181A 3

External Ids for MIR181A2 Gene

ORGUL Members for MIR181A2 Gene

Previous HGNC Symbols for MIR181A2 Gene

  • MIRN181A
  • MIRN181A2

Previous GeneCards Identifiers for MIR181A2 Gene

  • GC09P126496
  • GC09P127455
  • GC09P127460
  • GC09P127466
  • GC09P127471

Summaries for MIR181A2 Gene

Entrez Gene Summary for MIR181A2 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR181A2 Gene

MIR181A2 (MicroRNA 181a-2) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins..

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR181A2 Gene

Genomics for MIR181A2 Gene

Regulatory Elements for MIR181A2 Gene

Enhancers for MIR181A2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09G124592 1.5 Ensembl ENCODE dbSUPER 10.9 -97.7 -97707 5.4 HDGF PKNOX1 ATF1 FOXA2 MLX ARID4B DMAP1 YY1 ETS1 REST MIR181A2HG MIR181A2 MIR181B2 ENSG00000231149 NR5A1 LOC100419284 PIR56415
GH09G124656 1.4 ENCODE dbSUPER 11.5 -33.1 -33051 5.0 HDGF FOXA2 PKNOX1 CREB3L1 ARNT WRNIP1 ARID4B SIN3A DMAP1 FEZF1 MIR181A2 MIR181B2 MIR181A2HG PIR50063
GH09G124651 1.4 Ensembl ENCODE dbSUPER 10.9 -39.8 -39822 2.2 TBP ZNF133 SIN3A KLF17 RAD21 RFX5 ZNF366 ZSCAN5C RCOR1 FOS MIR181A2 MIR181B2 MIR181A2HG RN7SL302P
GH09G124720 1.2 Ensembl ENCODE 12.2 +28.8 28797 2.0 FOXA2 MLX ARID4B FEZF1 ZNF766 GATA2 ZNF263 SP5 PPARG GLIS1 MIR181A2 MIR181B2 ENSG00000236643 NR6A1 WDR38 ARPC5L RPL35 ENSG00000231149 NR5A1 GC09P124694
GH09G124664 1.2 ENCODE dbSUPER 12 -27.0 -27045 1.9 ELF3 FOXA2 ATF1 ZNF366 FOS CREM MIXL1 KLF11 ZNF362 OVOL3 MIR181A2 MIR181B2 MIR181A2HG PIR50063
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR181A2 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR181A2 Gene

Chromosome:
9
Start:
124,692,442 bp from pter
End:
124,692,551 bp from pter
Size:
110 bases
Orientation:
Plus strand

Genomic View for MIR181A2 Gene

Genes around MIR181A2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR181A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR181A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR181A2 Gene

Proteins for MIR181A2 Gene

Post-translational modifications for MIR181A2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR181A2 Gene

Domains & Families for MIR181A2 Gene

Gene Families for MIR181A2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR181A2: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR181A2 Gene

Function for MIR181A2 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR181A2 Gene

Localization for MIR181A2 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR181A2 Gene

Pathways & Interactions for MIR181A2 Gene

genes like me logo Genes that share pathways with MIR181A2: view

Pathways by source for MIR181A2 Gene

2 BioSystems pathways for MIR181A2 Gene
1 KEGG pathway for MIR181A2 Gene

Interacting Proteins for MIR181A2 Gene

Gene Ontology (GO) - Biological Process for MIR181A2 Gene

None

No data available for SIGNOR curated interactions for MIR181A2 Gene

Drugs & Compounds for MIR181A2 Gene

No Compound Related Data Available

Transcripts for MIR181A2 Gene

mRNA/cDNA for MIR181A2 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR181A2 Gene

No ASD Table

Relevant External Links for MIR181A2 Gene

GeneLoc Exon Structure for
MIR181A2
ECgene alternative splicing isoforms for
MIR181A2

Expression for MIR181A2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR181A2 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR181A2 Gene:

MIR181A2
genes like me logo Genes that share expression patterns with MIR181A2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR181A2 Gene

Orthologs for MIR181A2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR181A2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-181a-2 35
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-181a-2 35
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-181a-2 35
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir181a-2 35
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-181a-2 35
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-181a-2 35
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-181a-2 35
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-181a-2 35
  • 78 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-181a-2 35
  • 72 (a)
ManyToMany
CABZ01086560.1 35
  • 66 (a)
ManyToMany
Species where no ortholog for MIR181A2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR181A2 Gene

ENSEMBL:
Gene Tree for MIR181A2 (if available)
TreeFam:
Gene Tree for MIR181A2 (if available)

Paralogs for MIR181A2 Gene

No data available for Paralogs for MIR181A2 Gene

Variants for MIR181A2 Gene

Sequence variations from dbSNP and Humsavar for MIR181A2 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1000058003 -- 124,692,233(+) AATAC(-/CATT)CAAAG intron-variant, upstream-variant-2KB
rs1000152779 -- 124,690,516(+) TTGGA(C/G/T)TGGCT intron-variant, upstream-variant-2KB
rs1001774490 -- 124,691,669(+) GAAAT(A/G)CAAGC intron-variant, upstream-variant-2KB
rs1002120456 -- 124,690,643(+) ATCCT(-/C)CCCTC intron-variant, upstream-variant-2KB
rs1005651127 -- 124,690,844(+) AGGAA(A/T)GAGGA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR181A2 Gene

Variant ID Type Subtype PubMed ID
nsv831721 CNV gain 17160897

Relevant External Links for MIR181A2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR181A2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR181A2 Gene

Disorders for MIR181A2 Gene

Relevant External Links for MIR181A2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR181A2

No disorders were found for MIR181A2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR181A2 Gene

Publications for MIR181A2 Gene

  1. Induction of miRNA-181a by genotoxic treatments promotes chemotherapeutic resistance and metastasis in breast cancer. (PMID: 26028030) Niu J. … Wu Z.H. (Oncogene 2016) 3 64
  2. TGF-I^ regulates TGFBIp expression in corneal fibroblasts via miR-21, miR-181a, and Smad signaling. (PMID: 26915797) Choi S.I. … Kim E.K. (Biochem. Biophys. Res. Commun. 2016) 3 64
  3. IL-1I^/NF-kb signaling promotes colorectal cancer cell growth through miR-181a/PTEN axis. (PMID: 27264420) Hai Ping P. … Hong Z. (Arch. Biochem. Biophys. 2016) 3 64
  4. Human natural killer cell microRNA: differential expression of MIR181A1B1 and MIR181A2B2 genes encoding identical mature microRNAs. (PMID: 25410655) Presnell S.R. … Lutz C.T. (Genes Immun. 2015) 3 64
  5. Quantitative and integrated proteome and microRNA analysis of endothelial replicative senescence. (PMID: 26013412) Yentrapalli R. … Tapio S. (J Proteomics 2015) 3 64

Products for MIR181A2 Gene

Sources for MIR181A2 Gene

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