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Aliases for MIR181A1 Gene

Subcategory (RNA class) for MIR181A1 Gene

miRNA

Quality Score for this RNA gene is

9.2

Aliases for MIR181A1 Gene

  • MicroRNA 181a-1 2 3 5
  • MicroRNA 213 2 3
  • Hsa-Mir-181a-1 3
  • Hsa-Mir-213 3
  • Mir-181a-1 3
  • MIRN181A1 3
  • Mir-213 3
  • MIRN213 3
  • MIR213 3

External Ids for MIR181A1 Gene

Previous HGNC Symbols for MIR181A1 Gene

  • MIRN213
  • MIRN181A1

Previous GeneCards Identifiers for MIR181A1 Gene

  • GC01M197097
  • GC01M198829
  • GC01M198830
  • GC01M198831
  • GC01M198836

Summaries for MIR181A1 Gene

Entrez Gene Summary for MIR181A1 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR181A1 Gene

MIR181A1 (MicroRNA 181a-1) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and MicroRNAs in cancer.

fRNAdb sequence ontologies for MIR181A1 Gene - the ORGUL cluster for this gene includes several descriptions:

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR181A1

Additional gene information for MIR181A1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR181A1 Gene

Genomics for MIR181A1 Gene

Regulatory Elements for MIR181A1 Gene

Enhancers for MIR181A1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H198879 1.8 FANTOM5 Ensembl ENCODE dbSUPER 11.5 -21.7 -21671 2 ZNF493 ZFP64 BRCA1 ZNF302 FOS DEK ZNF202 ZC3H11A REST TSHZ1 MIR181B1 MIR181A1 LOC105371679 PTPRC GC01P198890 GC01P198860
GH01H198918 1.4 FANTOM5 Ensembl ENCODE dbSUPER 10.6 -60.6 -60635 2 ZNF217 POLR2A JUN CREB1 JUNB RUNX3 MIR181A1 MIR181B1 PTPRC GC01P198915 MIR181A1HG
GH01H198890 1.3 Ensembl ENCODE dbSUPER 11.4 -33.1 -33052 4 ZNF792 JUN FEZF1 BMI1 ZNF316 GATA3 POLR2A FOSL2 FOS MAFK LOC105371679 MIR181A1 MIR181B1 GC01P198890 GC01P198909
GH01H198921 1.2 Ensembl ENCODE dbSUPER 10.6 -63.4 -63449 1 PKNOX1 BACH1 JUNB EBF1 DPF2 BATF ZNF592 ZNF217 IKZF1 ATF7 MIR181B1 MIR181A1 GC01P198915 MIR181A1HG
GH01H198775 1 Ensembl ENCODE 10.4 +82.2 82176 2 CTCF ZNF792 JUN FEZF1 RELA ZNF324 POLR2A FOS RUNX3 L3MBTL2 MIR181B1 MIR181A1 GC01M198840 GC01P198684 PIR61364
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR181A1 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR181A1 Gene

Chromosome:
1
Start:
198,859,044 bp from pter
End:
198,859,153 bp from pter
Size:
110 bases
Orientation:
Minus strand

Genomic View for MIR181A1 Gene

Genes around MIR181A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR181A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR181A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR181A1 Gene

ORGUL Member Location for MIR181A1 Gene

ORGUL Member Location for MIR181A1 gene

Proteins for MIR181A1 Gene

Post-translational modifications for MIR181A1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR181A1 Gene

Domains & Families for MIR181A1 Gene

Gene Families for MIR181A1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR181A1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR181A1 Gene

Function for MIR181A1 Gene

Phenotypes From GWAS Catalog for MIR181A1 Gene

Gene Ontology (GO) - Molecular Function for MIR181A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IMP 23993976
genes like me logo Genes that share ontologies with MIR181A1: view

Animal Model Products

CRISPR Products

miRNA Products

Clone Products

  • Applied Biological Materials Clones for MIR181A1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR181A1 Gene

Localization for MIR181A1 Gene

Gene Ontology (GO) - Cellular Components for MIR181A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 18766170
GO:0045177 apical part of cell IDA 26322847
genes like me logo Genes that share ontologies with MIR181A1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR181A1 Gene

Pathways & Interactions for MIR181A1 Gene

genes like me logo Genes that share pathways with MIR181A1: view

Interacting Proteins for MIR181A1 Gene

Gene Ontology (GO) - Biological Process for MIR181A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010629 negative regulation of gene expression IGI 18728182
GO:0030335 positive regulation of cell migration IMP 23993976
GO:0035195 gene silencing by miRNA IMP 23993976
GO:0035278 miRNA mediated inhibition of translation IMP 23993976
GO:1900745 positive regulation of p38MAPK cascade IMP 23993976
genes like me logo Genes that share ontologies with MIR181A1: view

No data available for SIGNOR curated interactions for MIR181A1 Gene

Drugs & Compounds for MIR181A1 Gene

No Compound Related Data Available

Transcripts for MIR181A1 Gene

fRNAdb Secondary structures for MIR181A1 Gene

  • hsa-miR-181a-5p_MIMAT0000256_Homo_sapiens_miR-181a-5p_mature
  • FR284577

mRNA/cDNA for MIR181A1 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Clone Products

  • Applied Biological Materials Clones for MIR181A1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for MIR181A1 Gene

No ASD Table

Relevant External Links for MIR181A1 Gene

GeneLoc Exon Structure for
MIR181A1
ECgene alternative splicing isoforms for
MIR181A1

Expression for MIR181A1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR181A1 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR181A1 Gene:

MIR181A1
genes like me logo Genes that share expression patterns with MIR181A1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR181A1 Gene

Orthologs for MIR181A1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR181A1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-181a-1 34
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-181a-1 34
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-181a-1 34
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir181a-1 34
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-181a-1 34
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-181a-1 34
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-181a-1 34
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-181a-1 34
  • 73 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-181a-1 34
  • 82 (a)
OneToMany
CU571393.1 34
  • 81 (a)
OneToMany
Species where no ortholog for MIR181A1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR181A1 Gene

ENSEMBL:
Gene Tree for MIR181A1 (if available)
TreeFam:
Gene Tree for MIR181A1 (if available)

Paralogs for MIR181A1 Gene

No data available for Paralogs for MIR181A1 Gene

Variants for MIR181A1 Gene

Sequence variations from dbSNP and Humsavar for MIR181A1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000285651 -- 198,860,897(+) TATAA(C/T)GATTC intron-variant, upstream-variant-2KB
rs1000647972 -- 198,859,678(+) ATGCT(A/G)AACAA intron-variant, upstream-variant-2KB
rs1001018666 -- 198,859,400(+) ATGGA(A/G)TTATC intron-variant, upstream-variant-2KB
rs1002441028 -- 198,860,154(+) CGAAA(C/T)GTTAG intron-variant, upstream-variant-2KB
rs1003141961 -- 198,861,150(+) TATTT(C/T)GAGCA intron-variant, upstream-variant-2KB

Relevant External Links for MIR181A1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR181A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR181A1 Gene

Disorders for MIR181A1 Gene

Relevant External Links for MIR181A1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR181A1

No disorders were found for MIR181A1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR181A1 Gene

Publications for MIR181A1 Gene

  1. New human and mouse microRNA genes found by homology search. (PMID: 15634332) Weber MJ (The FEBS journal 2005) 1 3 60
  2. Numerous microRNPs in neuronal cells containing novel microRNAs. (PMID: 12554860) Dostie J … Dreyfuss G (RNA (New York, N.Y.) 2003) 1 3 60
  3. Vertebrate microRNA genes. (PMID: 12624257) Lim LP … Bartel DP (Science (New York, N.Y.) 2003) 1 3 60
  4. MicroRNA-181a-5p Impedes IL-17-Induced Nonsmall Cell Lung Cancer Proliferation and Migration through Targeting VCAM-1. (PMID: 28535543) Cao Y … Wang Y (Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017) 3 60
  5. Upregulation of miR-181a suppresses the formation of glioblastoma stem cells by targeting the Notch2 oncogene and correlates with good prognosis in patients with glioblastoma multiforme. (PMID: 28389242) Huang SX … Liu T (Biochemical and biophysical research communications 2017) 3 60

Products for MIR181A1 Gene

Sources for MIR181A1 Gene

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