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Aliases for MIR17HG Gene

Subcategory (RNA class) for MIR17HG Gene

miRNA

Quality Score for this RNA gene is

13

Aliases for MIR17HG Gene

  • MiR-17-92a-1 Cluster Host Gene 2 3 5
  • Long Intergenic Non-Protein Coding RNA 48 2 3
  • MicroRNA Host Gene 1 (Non-Protein Coding) 2 3
  • MIR17 Host Gene (Non-Protein Coding) 2 3
  • C13orf25 3 4
  • MIRHG1 3 4
  • MIRH1 3 4
  • MiR-17-92 Cluster Host Gene (Non-Protein Coding) 3
  • MicroRNA Host Gene (Non-Protein Coding) 1 3
  • Putative MicroRNA Host Gene 1 Protein 4
  • Chromosome 13 Open Reading Frame 25 2
  • MiR-17-92 Cluster Host Gene 2
  • Mir-17-92 MicroRNA Cluster 3
  • Non-Protein Coding RNA 48 2
  • NCRNA00048 3
  • LINC00048 3
  • MiR-17-92 3
  • FGLDS2 3
  • MIHG1 3

External Ids for MIR17HG Gene

Previous HGNC Symbols for MIR17HG Gene

  • C13orf25
  • MIRHG1

Previous GeneCards Identifiers for MIR17HG Gene

  • GC13P090885
  • GC13P092000
  • GC13P072595

Summaries for MIR17HG Gene

Entrez Gene Summary for MIR17HG Gene

  • This gene is the host gene for the MIR17-92 cluster, a group of at least six microRNAs (miRNAs) that may be involved in cell survival, proliferation, differentiation, and angiogenesis. Amplification of this gene has been found in several lymphomas and solid tumors. Two non-protein coding transcript variants have been found for this host gene, but only the longest is a polycistronic transcript containing the MIR17-92 cluster. [provided by RefSeq, May 2012]

GeneCards Summary for MIR17HG Gene

MIR17HG (MiR-17-92a-1 Cluster Host Gene) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR17HG include Feingold Syndrome 2 and Feingold Syndrome. Among its related pathways are Parkinsons Disease Pathway and DNA damage response.

Gene Wiki entry for MIR17HG Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR17HG Gene

Genomics for MIR17HG Gene

Regulatory Elements for MIR17HG Gene

Enhancers for MIR17HG Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH13F091346 1 ENCODE 0.8 +1.2 1213 4.8 PKNOX1 ATF1 ARID4B SIN3A FEZF1 DMAP1 YY1 GLIS2 ELK1 CBX5 GPC5 GC13P091376 MIR17 MIR17HG MIR18A MIR19A MIR19B1 MIR20A MIR92A1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR17HG on UCSC Golden Path with GeneCards custom track

Promoters for MIR17HG Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000667089 780 3601 PKNOX1 MLX ARID4B SIN3A FEZF1 DMAP1 YY1 GLIS2 ELK1 CBX5

Genomic Location for MIR17HG Gene

Chromosome:
13
Start:
91,347,820 bp from pter
End:
91,354,579 bp from pter
Size:
6,760 bases
Orientation:
Plus strand

Genomic View for MIR17HG Gene

Genes around MIR17HG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR17HG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR17HG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR17HG Gene

Proteins for MIR17HG Gene

  • Protein details for MIR17HG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q75NE6-MIRH1_HUMAN
    Recommended name:
    Putative microRNA 17 host gene protein
    Protein Accession:
    Q75NE6
    Secondary Accessions:
    • A4QMU7
    • Q75NE7

    Protein attributes for MIR17HG Gene

    Size:
    70 amino acids
    Molecular mass:
    8163 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • The microRNAs that are encoded in a MIR17HG intron stimulate growth of cultured lung cancer cells.

    Alternative splice isoforms for MIR17HG Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MIR17HG Gene

Post-translational modifications for MIR17HG Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR17HG Gene

Domains & Families for MIR17HG Gene

Gene Families for MIR17HG Gene

Protein Domains for MIR17HG Gene

ProtoNet:

Suggested Antigen Peptide Sequences for MIR17HG Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR17HG: view

No data available for UniProtKB/Swiss-Prot for MIR17HG Gene

Function for MIR17HG Gene

Phenotypes for MIR17HG Gene

genes like me logo Genes that share phenotypes with MIR17HG: view

Human Phenotype Ontology for MIR17HG Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

miRNA for MIR17HG Gene

miRTarBase miRNAs that target MIR17HG

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for MIR17HG Gene

Localization for MIR17HG Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIR17HG Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR17HG gene
Compartment Confidence
extracellular 2
nucleus 1

No data available for Gene Ontology (GO) - Cellular Components for MIR17HG Gene

Pathways & Interactions for MIR17HG Gene

genes like me logo Genes that share pathways with MIR17HG: view

Pathways by source for MIR17HG Gene

Interacting Proteins for MIR17HG Gene

Gene Ontology (GO) - Biological Process for MIR17HG Gene

None

No data available for SIGNOR curated interactions for MIR17HG Gene

Transcripts for MIR17HG Gene

mRNA/cDNA for MIR17HG Gene

(3) Selected AceView cDNA sequences:
(9) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR17HG Gene

No ASD Table

Relevant External Links for MIR17HG Gene

GeneLoc Exon Structure for
MIR17HG
ECgene alternative splicing isoforms for
MIR17HG

Expression for MIR17HG Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR17HG Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR17HG Gene:

MIR17HG

SOURCE GeneReport for Unigene cluster for MIR17HG Gene:

Hs.24115

mRNA Expression by UniProt/SwissProt for MIR17HG Gene:

Q75NE6-MIRH1_HUMAN
Tissue specificity: Highly expressed in B-cell lymphoma and lung cancer.
genes like me logo Genes that share expression patterns with MIR17HG: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for MIR17HG Gene

Orthologs for MIR17HG Gene

Evolution for MIR17HG Gene

ENSEMBL:
Gene Tree for MIR17HG (if available)
TreeFam:
Gene Tree for MIR17HG (if available)

No data available for Orthologs for MIR17HG Gene

Paralogs for MIR17HG Gene

No data available for Paralogs for MIR17HG Gene

Variants for MIR17HG Gene

Sequence variations from dbSNP and Humsavar for MIR17HG Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs1046057 -- 91,354,383(+) AAGTT(G/T)AAGAA nc-transcript-variant
rs10630963 -- 91,348,166(+) GAGGG(-/CA/GCA)GGGCA intron-variant
rs111371822 -- 91,352,880(+) GAGGC(A/G)GACGG intron-variant, nc-transcript-variant
rs111988997 -- 91,353,933(+) TACAG(C/G)CAGAC nc-transcript-variant
rs112107109 -- 91,350,002(+) GTTTA(C/T)GAAAT intron-variant, nc-transcript-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR17HG Gene

Variant ID Type Subtype PubMed ID
nsv832679 CNV gain 17160897
nsv562697 CNV loss 21841781
nsv562696 CNV loss 21841781
esv28603 CNV loss 19812545
dgv3317n54 CNV loss 21841781
dgv3316n54 CNV gain 21841781
dgv3315n54 CNV gain+loss 21841781
dgv3314n54 CNV gain+loss 21841781
dgv3313n54 CNV loss 21841781

Relevant External Links for MIR17HG Gene

Human Gene Mutation Database (HGMD)
MIR17HG
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR17HG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR17HG Gene

Disorders for MIR17HG Gene

MalaCards: The human disease database

(3) MalaCards diseases for MIR17HG Gene - From: OMIM, GeneTests, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
feingold syndrome 2
  • fglds2
feingold syndrome
  • feingold syndrome 1
mantle cell lymphoma
  • lymphoma, mantle cell
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

MIRH1_HUMAN
  • Feingold syndrome 2 (FGLDS2) [MIM:614326]: A syndrome characterized by microcephaly, short stature, and digital abnormalities including brachydactyly, brachymesophalangy of the second and fifth fingers, hypoplastic thumbs of variable severity, and cutaneous syndactyly of the toes. {ECO:0000269 PubMed:21892160}. Note=The disease is caused by mutations affecting the gene represented in this entry. Microdeletions encompassing the MIR17HG locus can be responsible of FGLDS2.

Relevant External Links for MIR17HG

Genetic Association Database (GAD)
MIR17HG
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR17HG
genes like me logo Genes that share disorders with MIR17HG: view

No data available for Genatlas for MIR17HG Gene

Publications for MIR17HG Gene

  1. A polycistronic microRNA cluster, miR-17-92, is overexpressed in human lung cancers and enhances cell proliferation. (PMID: 16266980) Hayashita Y. … Takahashi T. (Cancer Res. 2005) 2 3 4 22 64
  2. Identification and characterization of a novel gene, C13orf25, as a target for 13q31-q32 amplification in malignant lymphoma. (PMID: 15126345) Ota A. … Seto M. (Cancer Res. 2004) 2 3 4 64
  3. Role of microRNA in the pathogenesis of malignant lymphoma. (PMID: 23551855) Tagawa H. … Sawada K. (Cancer Sci. 2013) 2 3 64
  4. Germline deletion of the miR-17 approximately 92 cluster causes skeletal and growth defects in humans. (PMID: 21892160) de Pontual L. … Amiel J. (Nat. Genet. 2011) 3 4 64
  5. Role for amplification and expression of glypican-5 in rhabdomyosarcoma. (PMID: 17210683) Williamson D. … Shipley J. (Cancer Res. 2007) 2 3 64

Products for MIR17HG Gene

Sources for MIR17HG Gene

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