Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MIR16-2 Gene

Subcategory (RNA class) for MIR16-2 Gene


Quality Score for this RNA gene is


Aliases for MIR16-2 Gene

  • MicroRNA 16-2 2 3 5
  • Hsa-Mir-16-2 3
  • Mir-16-3 3
  • Mir-16-2 3
  • MIRN16-2 3

External Ids for MIR16-2 Gene

Previous HGNC Symbols for MIR16-2 Gene

  • MIRN16-2

Previous GeneCards Identifiers for MIR16-2 Gene

  • GC03P161613
  • GC03P160123
  • GC03P160124
  • GC03P160130
  • GC03P160136
  • GC03P160405
  • GC03P160407
  • GC03P160408
  • GC03P160409

Summaries for MIR16-2 Gene

Entrez Gene Summary for MIR16-2 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR16-2 Gene

MIR16-2 (MicroRNA 16-2) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Parkinsons Disease Pathway and MicroRNAs in cancer.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR16-2 Gene

Genomics for MIR16-2 Gene

Genomic Location for MIR16-2 Gene

160,404,745 bp from pter
160,404,825 bp from pter
81 bases
Plus strand

Genomic View for MIR16-2 Gene

Genes around MIR16-2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR16-2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR16-2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR16-2 Gene

No data available for Regulatory Elements for MIR16-2 Gene

Proteins for MIR16-2 Gene

Post-translational modifications for MIR16-2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR16-2 Gene

Domains & Families for MIR16-2 Gene

Gene Families for MIR16-2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR16-2: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR16-2 Gene

Function for MIR16-2 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR16-2 Gene

Localization for MIR16-2 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR16-2 Gene

Pathways & Interactions for MIR16-2 Gene

genes like me logo Genes that share pathways with MIR16-2: view

Pathways by source for MIR16-2 Gene

1 BioSystems pathway for MIR16-2 Gene
1 KEGG pathway for MIR16-2 Gene

Interacting Proteins for MIR16-2 Gene

Gene Ontology (GO) - Biological Process for MIR16-2 Gene


No data available for SIGNOR curated interactions for MIR16-2 Gene

Transcripts for MIR16-2 Gene

mRNA/cDNA for MIR16-2 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR16-2 Gene

No ASD Table

Relevant External Links for MIR16-2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR16-2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR16-2 Gene

genes like me logo Genes that share expression patterns with MIR16-2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR16-2 Gene

Orthologs for MIR16-2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR16-2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ptr-mir-16-2 35
  • 94 (a)
(Canis familiaris)
Mammalia cfa-mir-16-2 35
  • 91 (a)
(Mus musculus)
Mammalia Mir16-2 35
  • 80 (a)
(Monodelphis domestica)
Mammalia mdo-mir-16-2 35
  • 78 (a)
(Bos Taurus)
Mammalia bta-mir-16b 35
  • 77 (a)
(Ornithorhynchus anatinus)
Mammalia oan-mir-16b 35
  • 63 (a)
(Gallus gallus)
Aves gga-mir-16-2 35
  • 70 (a)
(Anolis carolinensis)
Reptilia aca-mir-16a 35
  • 67 (a)
(Danio rerio)
Actinopterygii dre-mir-16a 35
  • 63 (a)
dre-mir-457b 35
  • 59 (a)
Species where no ortholog for MIR16-2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR16-2 Gene

Gene Tree for MIR16-2 (if available)
Gene Tree for MIR16-2 (if available)

Paralogs for MIR16-2 Gene

No data available for Paralogs for MIR16-2 Gene

Variants for MIR16-2 Gene

Sequence variations from dbSNP and Humsavar for MIR16-2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs10936201 -- 160,404,051(+) ATAAA(A/C)GTTTT intron-variant, upstream-variant-2KB
rs112178044 -- 160,404,850(+) TATCA(A/G)TTGTT intron-variant, downstream-variant-500B
rs114501490 -- 160,405,277(+) AAATC(A/C)CCTAT intron-variant, downstream-variant-500B
rs114686976 -- 160,403,631(+) CTTTC(C/T)ATTGT intron-variant, upstream-variant-2KB
rs116669990 -- 160,402,911(+) GAAAA(C/T)GGACT intron-variant, upstream-variant-2KB

Relevant External Links for MIR16-2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR16-2 Gene

Disorders for MIR16-2 Gene

Relevant External Links for MIR16-2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MIR16-2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR16-2 Gene

Publications for MIR16-2 Gene

  1. miR-16-5p Is a Stably-Expressed Housekeeping MicroRNA in Breast Cancer Tissues from Primary Tumors and from Metastatic Sites. (PMID: 26821018) Rinnerthaler G. … Greil R. (Int J Mol Sci 2016) 3 64
  2. MiR-16 targets Bcl-2 in paclitaxel-resistant lung cancer cells and overexpression of miR-16 along with miR-17 causes unprecedented sensitivity by simultaneously modulating autophagy and apoptosis. (PMID: 25435430) Chatterjee A. … Chakrabarti G. (Cell. Signal. 2015) 3 64
  3. MicroRNA-16 modulates HuR regulation of cyclin E1 in breast cancer cells. (PMID: 25830480) Guo X. … Hartley R.S. (Int J Mol Sci 2015) 3 64
  4. miR-15b/16-2 deletion promotes B-cell malignancies. (PMID: 26324892) Lovat F. … Croce C.M. (Proc. Natl. Acad. Sci. U.S.A. 2015) 3 64
  5. MicroRNA-16-5p Controls Development of Osteoarthritis by Targeting SMAD3 in Chondrocytes. (PMID: 26350536) Li L. … Zhang Y. (Curr. Pharm. Des. 2015) 3 64

Products for MIR16-2 Gene

Sources for MIR16-2 Gene

Loading form....