Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MIR16-2 Gene

Subcategory (RNA class) for MIR16-2 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR16-2 Gene

  • MicroRNA 16-2 2 3 5
  • Hsa-Mir-16-2 3
  • Mir-16-3 3
  • Mir-16-2 3
  • MIRN16-2 3

External Ids for MIR16-2 Gene

Previous HGNC Symbols for MIR16-2 Gene

  • MIRN16-2

Previous GeneCards Identifiers for MIR16-2 Gene

  • GC03P161613
  • GC03P160123
  • GC03P160124
  • GC03P160130
  • GC03P160136
  • GC03P160405
  • GC03P160407

Summaries for MIR16-2 Gene

Entrez Gene Summary for MIR16-2 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR16-2 Gene

MIR16-2 (MicroRNA 16-2) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR16-2 Gene

Genomics for MIR16-2 Gene

Regulatory Elements for MIR16-2 Gene

Enhancers for MIR16-2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MIR16-2 on UCSC Golden Path with GeneCards custom track

Promoters for MIR16-2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MIR16-2 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR16-2 Gene

Chromosome:
3
Start:
160,404,745 bp from pter
End:
160,404,825 bp from pter
Size:
81 bases
Orientation:
Plus strand

Genomic View for MIR16-2 Gene

Genes around MIR16-2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR16-2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR16-2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR16-2 Gene

Proteins for MIR16-2 Gene

Post-translational modifications for MIR16-2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR16-2 Gene

Domains & Families for MIR16-2 Gene

Gene Families for MIR16-2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR16-2: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR16-2 Gene

Function for MIR16-2 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR16-2 Gene

Localization for MIR16-2 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR16-2 Gene

Pathways & Interactions for MIR16-2 Gene

SuperPathways for MIR16-2 Gene

Superpath Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR16-2: view

Pathways by source for MIR16-2 Gene

1 KEGG pathway for MIR16-2 Gene

Interacting Proteins for MIR16-2 Gene

Gene Ontology (GO) - Biological Process for MIR16-2 Gene

None

No data available for SIGNOR curated interactions for MIR16-2 Gene

Drugs & Compounds for MIR16-2 Gene

No Compound Related Data Available

Transcripts for MIR16-2 Gene

mRNA/cDNA for MIR16-2 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR16-2 Gene

No ASD Table

Relevant External Links for MIR16-2 Gene

GeneLoc Exon Structure for
MIR16-2
ECgene alternative splicing isoforms for
MIR16-2

Expression for MIR16-2 Gene

mRNA expression in normal human tissues for MIR16-2 Gene

genes like me logo Genes that share expression patterns with MIR16-2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MIR16-2 Gene

Orthologs for MIR16-2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR16-2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia bta-mir-16b 36
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-16-2 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-16-2 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir16-2 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-16b 36
  • 63 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-16-2 36
  • 94 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-16-2 36
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-16a 36
  • 67 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-16a 36
  • 63 (a)
ManyToMany
dre-mir-457b 36
  • 59 (a)
ManyToMany
Species with no ortholog for MIR16-2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR16-2 Gene

ENSEMBL:
Gene Tree for MIR16-2 (if available)
TreeFam:
Gene Tree for MIR16-2 (if available)

Paralogs for MIR16-2 Gene

No data available for Paralogs for MIR16-2 Gene

Variants for MIR16-2 Gene

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) , Variation tolerance and Relevant External Links for MIR16-2 Gene

Disorders for MIR16-2 Gene

Relevant External Links for MIR16-2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR16-2

No disorders were found for MIR16-2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR16-2 Gene

Publications for MIR16-2 Gene

  1. MiR-16 targets Bcl-2 in paclitaxel-resistant lung cancer cells and overexpression of miR-16 along with miR-17 causes unprecedented sensitivity by simultaneously modulating autophagy and apoptosis. (PMID: 25435430) Chatterjee A. … Chakrabarti G. (Cell. Signal. 2015) 3 67
  2. MicroRNA-16 modulates HuR regulation of cyclin E1 in breast cancer cells. (PMID: 25830480) Guo X. … Hartley R.S. (Int J Mol Sci 2015) 3
  3. miR-15b/16-2 deletion promotes B-cell malignancies. (PMID: 26324892) Lovat F. … Croce C.M. (Proc. Natl. Acad. Sci. U.S.A. 2015) 3
  4. MicroRNA-16 inhibits glioma cell growth and invasion through suppression of BCL2 and the nuclear factor-I_B1/MMP9 signaling pathway. (PMID: 24418124) Yang T.Q. … Du Z.W. (Cancer Sci. 2014) 3
  5. miR-15b/16-2 regulates factors that promote p53 phosphorylation and augments the DNA damage response following radiation in the lung. (PMID: 25092292) Rahman M. … Nana-Sinkam P. (J. Biol. Chem. 2014) 3

Products for MIR16-2 Gene

Sources for MIR16-2 Gene

Content