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Aliases for MIR16-1 Gene

Subcategory (RNA class) for MIR16-1 Gene


Quality Score for this RNA gene is


Aliases for MIR16-1 Gene

  • MicroRNA 16-1 2 3
  • MIRN16-1 3 6
  • Hsa-Mir-16-1 3
  • MiRNA16-1 3

External Ids for MIR16-1 Gene

Previous HGNC Symbols for MIR16-1 Gene

  • MIRN16-1

Previous GeneCards Identifiers for MIR16-1 Gene

  • GC13M049527
  • GC13M050623

Summaries for MIR16-1 Gene

Entrez Gene Summary for MIR16-1 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR16-1 Gene

MIR16-1 (MicroRNA 16-1) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR16-1 include critical limb ischemia and limb ischemia. Among its related pathways are MicroRNAs in cancer and SIDS Susceptibility Pathways.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR16-1 Gene

Genomics for MIR16-1 Gene

Genomic Location for MIR16-1 Gene

50,048,973 bp from pter
50,049,061 bp from pter
89 bases
Minus strand

Genomic View for MIR16-1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR16-1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR16-1 Gene

No data available for Regulatory Elements for MIR16-1 Gene

Proteins for MIR16-1 Gene

Post-translational modifications for MIR16-1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR16-1 Gene

Domains for MIR16-1 Gene

Gene Families for MIR16-1 Gene

  • MIR :ncRNAs / Micro RNAs

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR16-1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR16-1 Gene

Function for MIR16-1 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MIR16-1 Gene

Localization for MIR16-1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR16-1 Gene

Pathways for MIR16-1 Gene

genes like me logo Genes that share pathways with MIR16-1: view

Pathways by source for MIR16-1 Gene

2 BioSystems pathways for MIR16-1 Gene
1 KEGG pathway for MIR16-1 Gene

Interacting Proteins for MIR16-1 Gene

Gene Ontology (GO) - Biological Process for MIR16-1 Gene


Transcripts for MIR16-1 Gene

mRNA/cDNA for MIR16-1 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR16-1 Gene

No ASD Table

Relevant External Links for MIR16-1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR16-1 Gene

mRNA expression in normal human tissues for MIR16-1 Gene

genes like me logo Genes that share expressions with MIR16-1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for MIR16-1 Gene

Orthologs for MIR16-1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR16-1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia bta-mir-16a 36
  • 98 (a)
(Canis familiaris)
Mammalia cfa-mir-16-1 36
  • 100 (a)
(Monodelphis domestica)
Mammalia mdo-mir-16-1 36
  • 87 (a)
(Mus musculus)
Mammalia Mir16-1 36
  • 77 (a)
(Ornithorhynchus anatinus)
Mammalia oan-mir-16a 36
  • 58 (a)
(Pan troglodytes)
Mammalia ptr-mir-16-1 36
  • 100 (a)
(Gallus gallus)
Aves gga-mir-16-1 36
  • 83 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 57 (a)
(Danio rerio)
Actinopterygii dre-mir-16b 36
  • 43 (a)
dre-mir-16c 36
  • 39 (a)
Species with no ortholog for MIR16-1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR16-1 Gene

Gene Tree for MIR16-1 (if available)
Gene Tree for MIR16-1 (if available)

Paralogs for MIR16-1 Gene

No data available for Paralogs for MIR16-1 Gene

Variants for MIR16-1 Gene

Relevant External Links for MIR16-1 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Structural Variations from Database of Genomic Variants (DGV) for MIR16-1 Gene

Disorders for MIR16-1 Gene

Relevant External Links for MIR16-1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with MIR16-1: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for MIR16-1 Gene

Publications for MIR16-1 Gene

  1. Investigation of the miR16-1 (C > T) + 7 Substitution in Seven Different Types of Cancer from Three Ethnic Groups. (PMID: 19865490) Yazici H. … Santella R.M. (J Oncol 2009) 3 48
  2. Hematopoiesis-related microRNA expression in myelodysplastic syndromes. (PMID: 19883312) Pons A. … Monzo M. (Leuk. Lymphoma 2009) 3
  3. The DLEU2/miR-15a/16-1 cluster controls B cell proliferation and its deletion leads to chronic lymphocytic leukemia. (PMID: 20060366) Klein U. … Dalla-Favera R. (Cancer Cell 2010) 3
  4. MicroRNA profiling of benign and malignant pheochromocytomas identifies novel diagnostic and therapeutic targets. (PMID: 20621999) Meyer-Rochow G.Y. … Sidhu S.B. (Endocr. Relat. Cancer 2010) 3
  5. Loss of repression of HuR translation by miR-16 may be responsible for the elevation of HuR in human breast carcinoma. (PMID: 20626035) Xu F. … Wang W. (J. Cell. Biochem. 2010) 3

Products for MIR16-1 Gene

Sources for MIR16-1 Gene

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