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microRNA 16-1
(Previous symbol: MIRN16-1)
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Aliases
for MIR16-1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
Subcategory (RNA class): miRNA
Quality score for this RNA gene is 13
| Aliases |
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| MicroRNA 16-11 2 | | MIRN16-11 2 5 | | Hsa-Mir-16-11 | | MiRNA16-11 | | Mir-16-11 |
| External Ids: | HGNC: 315451 | Entrez Gene: 4069502 | Ensembl: ENSG000002080067 | OMIM: 6097045 |
Export aliases for MIR16-1 gene to outside databasesPrevious GC identifer: GC13M049527
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Summaries
for MIR16-1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MIR16-1:
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of geneexpression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribedby RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be eitherprotein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce anapproximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicerribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporatedinto a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with themiRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeqrepresents the predicted microRNA stem-loop. (provided by RefSeq, Sep 2009)
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Genomic Views
for MIR16-1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for MIR16-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for MIR16-1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MIR16-1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 13q14.2 Ensembl cytogenetic band: 13q14.2 HGNC cytogenetic band: 13q14.2MIR16-1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 13 GeneLoc Exon Structure GeneLoc location for GC13M050623: view genomic region (via miRBase)
(about GC identifiers)
Start:
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50,623,109 bp from pter |
End:
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50,623,197 bp from pter |
Size:
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89 bases |
Orientation:
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minus strand |
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Proteins
for MIR16-1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
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UniProtKB: --
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Protein
Domains /
Families
for MIR16-1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| -- |
Function
for MIR16-1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
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Pathways & Interactions
for MIR16-1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Unified GeneCards pathways About this table 
See pathways by source
| Super-pathway | contained gene-specific pathways |
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| 1 | SIDS Susceptibility Pathways | |
1  BioSystems Pathway for MIR16-1
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MIR16-1
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Drugs & Compounds
for MIR16-1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MIR16-1
Search CenterWatch for drugs/clinical trials and news about MIR16-1
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Transcripts
for MIR16-1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
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1 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000385271(miRNA)
GeneLoc Exon Structure
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Expression
for MIR16-1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| Expression evidence for MIR16-1:none
MIR16-1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image SABiosciences Custom PCR Arrays for MIR16-1
Primer
Products: |  | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat MIR16-1 | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MIR16-1 | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MIR16-1 |
Orthologs
for MIR16-1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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ENSEMBL Gene Tree for MIR16-1 (if available)
TreeFam Gene Tree for MIR16-1 (if available) |
Paralogs
for MIR16-1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MIR16-1 gene
- MIR1952 MIR15B2 MIR16-22 MIR15A2
MIR16-1 for paralogs About GeneDecksing
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Genomic Variants
for MIR16-1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
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Human Gene Mutation Database (HGMD): MIR16-1
| SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for MIR16-1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
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MIR16-1 for disorders About GeneDecksing
OMIM gene information: 609704
OMIM disorders: --
20  diseases for MIR16-1: About MalaCardsmantle cell lymphoma acute lymphoblastic leukemia chronic lymphocytic leukemia lymphoblastic leukemia
lymphocytic leukemia multiple myeloma rheumatoid arthritis leukemia
myeloma hematopoiesis cervical cancer cervicitis
arthritis gastric cancer breast carcinoma lung cancer
prostate cancer hypoxia prostatitis carcinoma
Human Genome Epidemiology (HuGE) Navigator: MIR16-1 (1 document)
Export disorders for MIR16-1 gene to outside databases
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Publications
for MIR16-1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
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PubMed articles for MIR16-1 gene, integrated from 9 sources (see all 57):
(articles sorted by number of sources associating them with MIR16-1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- MiR-15a, miR-16-1 and miR-17-92 cluster expression are linked to poor prognosis in multiple myeloma. (PubMed id 22959509)1 Gao X....Chen L. (2012)
- The mRNA stability factor HuR inhibits microRNA-16 tar geting of COX-2. (PubMed id 22049153)1 Young L.E....Dixon D.A. (2012)
- Myc represses miR-15a/miR-16-1 expression through recr uitment of HDAC3 in mantle cell and other non-Hodgkin B-cell lymphomas. (PubMed id 22002311)1 Zhang X....Tao J. (2012)
- miR-16 targets transcriptional corepressor SMRT and mo dulates NF-kappaB-regulated transactivation of interleukin-8 gene. (PubMed id 22292036)1 Zhou R....Chen X.M. (2012)
- miR-15a/16-1 influences BCL2 expression in keratocysti c odontogenic tumors. (PubMed id 22684875)1 Diniz M.G....Gomez R.S. (2012)
- Vector-based miR-15a/16-1 plasmid inhibits colon cance r growth in vivo. (PubMed id 22574716)1 Dai L....Deng H.X. (2012)
- Downregulation of HMGA-targeting microRNAs has a criti cal role in human pituitary tumorigenesis. (PubMed id 22139073)1 Palmieri D....Fusco A. (2012)
- MicroRNA 16 modulates epithelial sodium channel in hum an alveolar epithelial cells. (PubMed id 22940131)1 Tamarapu Parthasarathy P....Kolliputi N. (2012)
- Adenosine A2A receptor upregulation in human PMNs is c ontrolled by miRNA-214, miRNA-15, and miRNA-16. (PubMed id 22249219)1 Heyn J....Kreth S. (2012)
- MicroRNA 16 enhances differentiation of human bone mar row mesenchymal stem cells in a cardiac niche toward myogenic phenotypes in vitr o. (PubMed id 22677435)1 Liu J.L....Shan Z.X. (2012)
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External Searches for MIR16-1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing MIR16-1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing MIR16-1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MIR16-1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MIR16-1 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for MIR16-1 gene:
Search GeneIP for patents involving MIR16-1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for MIR16-1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MIR16-1 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MIR16-1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MIR16-1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MIR16-1 | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MIR16-1 | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MIR16-1 |
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| | | | Search Tocris compounds for MIR16-1 |
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 | | | | |  |  |  | | | | Search ThermoFisher Antibodies for MIR16-1 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MIR16-1 |
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Last full update: 19 Mar 2013 -
Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013
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