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Aliases for MIR16-1 Gene

Subcategory (RNA class) for MIR16-1 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR16-1 Gene

  • MicroRNA 16-1 2 3 5
  • Hsa-Mir-16-1 3
  • MiRNA16-1 3
  • Mir-16-1 3
  • MIRN16-1 3

External Ids for MIR16-1 Gene

Previous HGNC Symbols for MIR16-1 Gene

  • MIRN16-1

Previous GeneCards Identifiers for MIR16-1 Gene

  • GC13M049527
  • GC13M050623

Summaries for MIR16-1 Gene

Entrez Gene Summary for MIR16-1 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR16-1 Gene

MIR16-1 (MicroRNA 16-1) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are miRNAs involved in DNA damage response and Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR16-1 Gene

Genomics for MIR16-1 Gene

Regulatory Elements for MIR16-1 Gene

Enhancers for MIR16-1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH13G050015 1 Ensembl ENCODE 11.6 +33.4 33363 0.8 PKNOX1 SIN3A FOSL1 PRDM6 JUND GLIS1 ZSCAN5C ZNF629 HMBOX1 ZNF600 MIR16-1 KCNRG GC13M050020
GH13G050026 0.8 ENCODE 12 +21.9 21873 0.8 TBL1XR1 BMI1 CBX5 RELB ETV6 IKZF2 CREM JUNB TBX21 MAFF MIR16-1 CAB39L GC13M050020 KCNRG
GH13G050016 0.5 ENCODE 11.6 +32.5 32512 0.0 OSR2 ZNF664 PRDM6 WT1 MIR16-1 KCNRG GC13M050020
GH13G050023 0.4 FANTOM5 12 +25.6 25554 0.3 MIR16-1 TRIM13 RCBTB1 KCNRG GC13M050020
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR16-1 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR16-1 Gene

Chromosome:
13
Start:
50,048,973 bp from pter
End:
50,049,061 bp from pter
Size:
89 bases
Orientation:
Minus strand

Genomic View for MIR16-1 Gene

Genes around MIR16-1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR16-1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR16-1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR16-1 Gene

Proteins for MIR16-1 Gene

Post-translational modifications for MIR16-1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR16-1 Gene

Domains & Families for MIR16-1 Gene

Gene Families for MIR16-1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR16-1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR16-1 Gene

Function for MIR16-1 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR16-1 Gene

Localization for MIR16-1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR16-1 Gene

Pathways & Interactions for MIR16-1 Gene

genes like me logo Genes that share pathways with MIR16-1: view

Interacting Proteins for MIR16-1 Gene

Gene Ontology (GO) - Biological Process for MIR16-1 Gene

None

No data available for SIGNOR curated interactions for MIR16-1 Gene

Drugs & Compounds for MIR16-1 Gene

No Compound Related Data Available

Transcripts for MIR16-1 Gene

mRNA/cDNA for MIR16-1 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR16-1 Gene

No ASD Table

Relevant External Links for MIR16-1 Gene

GeneLoc Exon Structure for
MIR16-1
ECgene alternative splicing isoforms for
MIR16-1

Expression for MIR16-1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR16-1 Gene

genes like me logo Genes that share expression patterns with MIR16-1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR16-1 Gene

Orthologs for MIR16-1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR16-1 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia cfa-mir-16-1 35
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-16-1 35
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-16a 35
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-16-1 35
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir16-1 35
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-16a 35
  • 58 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-16-1 35
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 57 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-16b 35
  • 43 (a)
OneToMany
dre-mir-16c 35
  • 39 (a)
OneToMany
Species where no ortholog for MIR16-1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR16-1 Gene

ENSEMBL:
Gene Tree for MIR16-1 (if available)
TreeFam:
Gene Tree for MIR16-1 (if available)

Paralogs for MIR16-1 Gene

No data available for Paralogs for MIR16-1 Gene

Variants for MIR16-1 Gene

Sequence variations from dbSNP and Humsavar for MIR16-1 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs1001996172 -- 50,049,917(+) TAGAA(A/G)TTCTC intron-variant, upstream-variant-2KB
rs1003576601 -- 50,050,378(+) TGAGT(A/G)TTTTT intron-variant, upstream-variant-2KB
rs1003739787 -- 50,048,595(+) TCTGT(C/T)CAAAA intron-variant, downstream-variant-500B
rs1005123286 -- 50,048,629(+) CTGTA(A/T)AGACA intron-variant, downstream-variant-500B
rs1005480841 -- 50,049,132(+) TTTTG(A/G)GGCAG intron-variant, nc-transcript-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR16-1 Gene

Variant ID Type Subtype PubMed ID
esv3580637 CNV loss 25503493
nsv1035151 CNV loss 25217958
nsv1054415 CNV loss 25217958
nsv561618 CNV loss 21841781

Relevant External Links for MIR16-1 Gene

Human Gene Mutation Database (HGMD)
MIR16-1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR16-1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR16-1 Gene

Disorders for MIR16-1 Gene

Relevant External Links for MIR16-1

Genetic Association Database (GAD)
MIR16-1
Human Genome Epidemiology (HuGE) Navigator
MIR16-1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR16-1

No disorders were found for MIR16-1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR16-1 Gene

Publications for MIR16-1 Gene

  1. Investigation of the miR16-1 (C > T) + 7 Substitution in Seven Different Types of Cancer from Three Ethnic Groups. (PMID: 19865490) Yazici H. … Santella R.M. (J Oncol 2009) 3 46 64
  2. Cytoplasmic Localization of WT1 and Decrease of miRNA-16-1 in Nephrotic Syndrome. (PMID: 28299339) Zapata-Benavides P. … RodrA-guez-Padilla C. (Biomed Res Int 2017) 3 64
  3. A microRNA code for prostate cancer metastasis. (PMID: 26073083) Bonci D. … De Maria R. (Oncogene 2016) 3 64
  4. Mono-(2-ethylhexyl) phthalate induces apoptosis through miR-16 in human first trimester placental cell line HTR-8/SVneo. (PMID: 26597031) Meruvu S. … Choudhury M. (Toxicol In Vitro 2016) 3 64
  5. miR-16-5p Is a Stably-Expressed Housekeeping MicroRNA in Breast Cancer Tissues from Primary Tumors and from Metastatic Sites. (PMID: 26821018) Rinnerthaler G. … Greil R. (Int J Mol Sci 2016) 3 64

Products for MIR16-1 Gene

Sources for MIR16-1 Gene

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