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Aliases for MIR15B Gene

Subcategory (RNA class) for MIR15B Gene


Quality Score for this RNA gene is


Aliases for MIR15B Gene

  • MicroRNA 15b 2 3 5
  • Hsa-Mir-15b 3
  • MiR-15b 3
  • MIRN15B 3

External Ids for MIR15B Gene

ORGUL Members for MIR15B Gene

Previous HGNC Symbols for MIR15B Gene

  • MIRN15B

Previous GeneCards Identifiers for MIR15B Gene

  • GC03P161612
  • GC03P160122

Summaries for MIR15B Gene

Entrez Gene Summary for MIR15B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR15B Gene

MIR15B (MicroRNA 15b) is an RNA Gene, and is affiliated with the undefined RNA class. Among its related pathways are Ectoderm Differentiation and miRNA targets in ECM and membrane receptors.

Additional gene information for MIR15B Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR15B Gene

Genomics for MIR15B Gene

GeneHancer (GH) Regulatory Elements for MIR15B Gene

Promoters and enhancers for MIR15B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I160398 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 0.8 -2.7 -2697 7.5 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF213 E2F8 SMC4 IFT80 B3GAT3P1 GC03P160406 GC03P160416 GC03P160417 GC03P160418 MIR15B MIR16-2 ENSG00000248710
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR15B on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR15B Gene

Genomic Locations for MIR15B Gene
98 bases
Plus strand

Genomic View for MIR15B Gene

Genes around MIR15B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR15B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR15B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR15B Gene

Proteins for MIR15B Gene

Post-translational modifications for MIR15B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR15B Gene

Domains & Families for MIR15B Gene

Gene Families for MIR15B Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR15B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR15B Gene

Function for MIR15B Gene

Gene Ontology (GO) - Molecular Function for MIR15B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 18449891
genes like me logo Genes that share ontologies with MIR15B: view

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR15B Gene

Localization for MIR15B Gene

Gene Ontology (GO) - Cellular Components for MIR15B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 26646931
genes like me logo Genes that share ontologies with MIR15B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR15B Gene

Pathways & Interactions for MIR15B Gene

genes like me logo Genes that share pathways with MIR15B: view

Pathways by source for MIR15B Gene

Interacting Proteins for MIR15B Gene

Gene Ontology (GO) - Biological Process for MIR15B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003300 cardiac muscle hypertrophy ISS --
GO:0008285 negative regulation of cell proliferation IGI 22139073
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway ISS --
GO:0035195 gene silencing by miRNA IDA 18449891
GO:0035278 miRNA mediated inhibition of translation IGI 25403480
genes like me logo Genes that share ontologies with MIR15B: view

No data available for SIGNOR curated interactions for MIR15B Gene

Drugs & Compounds for MIR15B Gene

No Compound Related Data Available

Transcripts for MIR15B Gene

mRNA/cDNA for MIR15B Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR15B Gene

No ASD Table

Relevant External Links for MIR15B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR15B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR15B Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR15B Gene:

genes like me logo Genes that share expression patterns with MIR15B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR15B Gene

Orthologs for MIR15B Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR15B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ptr-mir-15b 34
  • 100 (a)
(Bos Taurus)
Mammalia bta-mir-15b 34
  • 98 (a)
(Canis familiaris)
Mammalia cfa-mir-15b 34
  • 98 (a)
(Mus musculus)
Mammalia Mir15b 34
  • 96 (a)
(Monodelphis domestica)
Mammalia mdo-mir-15a 34
  • 65 (a)
(Ornithorhynchus anatinus)
Mammalia oan-mir-15b 34
  • 64 (a)
(Gallus gallus)
Aves gga-mir-15b 34
  • 93 (a)
(Anolis carolinensis)
Reptilia aca-mir-15a 34
  • 82 (a)
(Danio rerio)
Actinopterygii dre-mir-15c 34
  • 72 (a)
Species where no ortholog for MIR15B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR15B Gene

Gene Tree for MIR15B (if available)
Gene Tree for MIR15B (if available)

Paralogs for MIR15B Gene

No data available for Paralogs for MIR15B Gene

Variants for MIR15B Gene

Sequence variations from dbSNP and Humsavar for MIR15B Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1003289383 -- 160,405,065(+) TTGTT/TT downstream_transcript_variant
rs1004952413 -- 160,403,772(+) A/T upstream_transcript_variant
rs1005248609 -- 160,405,142(+) A/G downstream_transcript_variant
rs1006512358 -- 160,403,801(+) A/G upstream_transcript_variant
rs1007214283 -- 160,403,860(+) TTAAATTAA/TTAA upstream_transcript_variant

Additional Variant Information for MIR15B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR15B Gene

Disorders for MIR15B Gene

Additional Disease Information for MIR15B

No disorders were found for MIR15B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR15B Gene

Publications for MIR15B Gene

  1. SIRT1 suppresses colorectal cancer metastasis by transcriptional repression of miR-15b-5p. (PMID: 28923398) Sun LN … Li JM (Cancer letters 2017) 3 58
  2. Role of G3BP1 in glucocorticoid receptor-mediated microRNA-15b and microRNA-23a biogenesis in endothelial cells. (PMID: 28523344) Kwok HH … Wong RN (Cellular and molecular life sciences : CMLS 2017) 3 58
  3. miR-15b inhibits cancer-initiating cell phenotypes and chemoresistance of cisplatin by targeting TRIM14 in oral tongue squamous cell cancer. (PMID: 28350138) Wang X … Helms J (Oncology reports 2017) 3 58
  4. Down-regulation of miR-15a/b accelerates fibrotic remodelling in the Type 2 diabetic human and mouse heart. (PMID: 28289072) Rawal S … Katare R (Clinical science (London, England : 1979) 2017) 3 58
  5. MiR-15b-5p Regulates Collateral Artery Formation by Targeting AKT3 (Protein Kinase B-3). (PMID: 28254819) Zhu LP … Zhang GG (Arteriosclerosis, thrombosis, and vascular biology 2017) 3 58

Products for MIR15B Gene

Sources for MIR15B Gene

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