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Aliases for MIR15B Gene

Subcategory (RNA class) for MIR15B Gene

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Quality Score for this RNA gene is

3

Aliases for MIR15B Gene

  • MicroRNA 15b 2 3 5
  • Hsa-Mir-15b 3
  • MiR-15b 3
  • MIRN15B 3

External Ids for MIR15B Gene

ORGUL Members for MIR15B Gene

Previous HGNC Symbols for MIR15B Gene

  • MIRN15B

Previous GeneCards Identifiers for MIR15B Gene

  • GC03P161612
  • GC03P160122

Summaries for MIR15B Gene

Entrez Gene Summary for MIR15B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR15B Gene

MIR15B (MicroRNA 15b) is an RNA Gene, and is affiliated with the undefined RNA class. Among its related pathways are miRNA targets in ECM and membrane receptors and Ectoderm Differentiation.

Additional gene information for MIR15B Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR15B Gene

Genomics for MIR15B Gene

Regulatory Elements for MIR15B Gene

Enhancers for MIR15B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03H160398 1.3 ENCODE dbSUPER 0.7 -2.7 -2697 7 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 DEK SP3 SP5 B3GAT3P1 IFT80 SMC4 MIR15B
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR15B on UCSC Golden Path with GeneCards custom track

Promoters for MIR15B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000161220 -688 201 MLLT1 PRDM1

Genomic Location for MIR15B Gene

Chromosome:
3
Start:
160,404,588 bp from pter
End:
160,404,685 bp from pter
Size:
98 bases
Orientation:
Plus strand

Genomic View for MIR15B Gene

Genes around MIR15B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR15B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR15B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR15B Gene

Proteins for MIR15B Gene

Post-translational modifications for MIR15B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR15B Gene

Domains & Families for MIR15B Gene

Gene Families for MIR15B Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR15B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR15B Gene

Function for MIR15B Gene

Gene Ontology (GO) - Molecular Function for MIR15B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 18449891
genes like me logo Genes that share ontologies with MIR15B: view

Animal Model Products

CRISPR Products

miRNA Products

Clone Products

  • Applied Biological Materials Clones for MIR15B
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR15B Gene

Localization for MIR15B Gene

Gene Ontology (GO) - Cellular Components for MIR15B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 26646931
genes like me logo Genes that share ontologies with MIR15B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR15B Gene

Pathways & Interactions for MIR15B Gene

genes like me logo Genes that share pathways with MIR15B: view

Pathways by source for MIR15B Gene

Interacting Proteins for MIR15B Gene

Gene Ontology (GO) - Biological Process for MIR15B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003300 cardiac muscle hypertrophy ISS --
GO:0008285 negative regulation of cell proliferation IGI 22139073
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway ISS --
GO:0035195 gene silencing by miRNA IDA 18449891
GO:0035278 miRNA mediated inhibition of translation IGI 25403480
genes like me logo Genes that share ontologies with MIR15B: view

No data available for SIGNOR curated interactions for MIR15B Gene

Drugs & Compounds for MIR15B Gene

No Compound Related Data Available

Transcripts for MIR15B Gene

mRNA/cDNA for MIR15B Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Clone Products

  • Applied Biological Materials Clones for MIR15B
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for MIR15B Gene

No ASD Table

Relevant External Links for MIR15B Gene

GeneLoc Exon Structure for
MIR15B
ECgene alternative splicing isoforms for
MIR15B

Expression for MIR15B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR15B Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR15B Gene:

MIR15B
genes like me logo Genes that share expression patterns with MIR15B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR15B Gene

Orthologs for MIR15B Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR15B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-15b 34
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-15b 34
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-15b 34
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir15b 34
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-15a 34
  • 65 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-15b 34
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-15b 34
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-15a 34
  • 82 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-15c 34
  • 72 (a)
OneToOne
Species where no ortholog for MIR15B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR15B Gene

ENSEMBL:
Gene Tree for MIR15B (if available)
TreeFam:
Gene Tree for MIR15B (if available)

Paralogs for MIR15B Gene

No data available for Paralogs for MIR15B Gene

Variants for MIR15B Gene

Sequence variations from dbSNP and Humsavar for MIR15B Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1003289383 -- 160,405,065(+) GGTTT(-/TTG)TTTTG intron-variant, downstream-variant-500B
rs1004952413 -- 160,403,772(+) TGTTA(A/T)AGTAG intron-variant, upstream-variant-2KB
rs1005248609 -- 160,405,142(+) TAAGT(A/G)TCAGA intron-variant, downstream-variant-500B
rs1006512358 -- 160,403,801(+) TAAAA(A/G)TCTGT intron-variant, upstream-variant-2KB
rs1007214283 -- 160,403,860(+) TTACT(-/TTAAA)TTAAC intron-variant, upstream-variant-2KB

Relevant External Links for MIR15B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR15B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR15B Gene

Disorders for MIR15B Gene

Relevant External Links for MIR15B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR15B

No disorders were found for MIR15B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR15B Gene

Publications for MIR15B Gene

  1. miR-15b inhibits cancer-initiating cell phenotypes and chemoresistance of cisplatin by targeting TRIM14 in oral tongue squamous cell cancer. (PMID: 28350138) Wang X … Helms J (Oncology reports 2017) 3 60
  2. Downregulation of miR-15a/b accelerates fibrotic remodelling in the type-2 diabetic human and mouse heart. (PMID: 28289072) Rawal S … Katare RG (Clinical science (London, England : 1979) 2017) 3 60
  3. MiR-15b-5p Regulates Collateral Artery Formation by Targeting AKT3 (Protein Kinase B-3). (PMID: 28254819) Zhu LP … Zhang GG (Arteriosclerosis, thrombosis, and vascular biology 2017) 3 60
  4. O (PMID: 28228555) Liu R … Hao J (Journal of immunology (Baltimore, Md. : 1950) 2017) 3 60
  5. miR-15b Inhibits the Progression of Glioblastoma Cells Through Targeting Insulin-like Growth Factor Receptor 1. (PMID: 27896672) Wang J … Bai YA (Hormones & cancer 2017) 3 60

Products for MIR15B Gene

Sources for MIR15B Gene

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