Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MIR15B Gene

Subcategory (RNA class) for MIR15B Gene


Quality Score for this RNA gene is


Aliases for MIR15B Gene

  • MicroRNA 15b 2 3 5
  • Hsa-Mir-15b 3
  • MiR-15b 3
  • MIRN15B 3

External Ids for MIR15B Gene

ORGUL Members for MIR15B Gene

Previous HGNC Symbols for MIR15B Gene

  • MIRN15B

Previous GeneCards Identifiers for MIR15B Gene

  • GC03P161612
  • GC03P160122

Summaries for MIR15B Gene

Entrez Gene Summary for MIR15B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR15B Gene

MIR15B (MicroRNA 15b) is an RNA Gene, and is affiliated with the undefined RNA class. Among its related pathways are miRNAs involved in DNA damage response and Ectoderm Differentiation.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR15B Gene

Genomics for MIR15B Gene

Regulatory Elements for MIR15B Gene

Enhancers for MIR15B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G160398 1.3 ENCODE dbSUPER 0.7 -2.7 -2697 7.5 CREB3L1 ARNT WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 DEK B3GAT3P1 IFT80 SMC4 MIR15B
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR15B on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR15B Gene

160,404,588 bp from pter
160,404,685 bp from pter
98 bases
Plus strand

Genomic View for MIR15B Gene

Genes around MIR15B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR15B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR15B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR15B Gene

Proteins for MIR15B Gene

Post-translational modifications for MIR15B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR15B Gene

Domains & Families for MIR15B Gene

Gene Families for MIR15B Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR15B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR15B Gene

Function for MIR15B Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR15B Gene

Localization for MIR15B Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR15B Gene

Pathways & Interactions for MIR15B Gene

genes like me logo Genes that share pathways with MIR15B: view

Pathways by source for MIR15B Gene

Interacting Proteins for MIR15B Gene

Gene Ontology (GO) - Biological Process for MIR15B Gene


No data available for SIGNOR curated interactions for MIR15B Gene

Drugs & Compounds for MIR15B Gene

No Compound Related Data Available

Transcripts for MIR15B Gene

mRNA/cDNA for MIR15B Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR15B Gene

No ASD Table

Relevant External Links for MIR15B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR15B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR15B Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR15B Gene:

genes like me logo Genes that share expression patterns with MIR15B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR15B Gene

Orthologs for MIR15B Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR15B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ptr-mir-15b 35
  • 100 (a)
(Bos Taurus)
Mammalia bta-mir-15b 35
  • 98 (a)
(Canis familiaris)
Mammalia cfa-mir-15b 35
  • 98 (a)
(Mus musculus)
Mammalia Mir15b 35
  • 96 (a)
(Monodelphis domestica)
Mammalia mdo-mir-15a 35
  • 65 (a)
(Ornithorhynchus anatinus)
Mammalia oan-mir-15b 35
  • 64 (a)
(Gallus gallus)
Aves gga-mir-15b 35
  • 93 (a)
(Anolis carolinensis)
Reptilia aca-mir-15a 35
  • 82 (a)
(Danio rerio)
Actinopterygii dre-mir-15c 35
  • 72 (a)
Species where no ortholog for MIR15B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR15B Gene

Gene Tree for MIR15B (if available)
Gene Tree for MIR15B (if available)

Paralogs for MIR15B Gene

No data available for Paralogs for MIR15B Gene

Variants for MIR15B Gene

Sequence variations from dbSNP and Humsavar for MIR15B Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1003289383 -- 160,405,065(+) GGTTT(-/TTG)TTTTG intron-variant, downstream-variant-500B
rs1004952413 -- 160,403,772(+) TGTTA(A/T)AGTAG intron-variant, upstream-variant-2KB
rs1005248609 -- 160,405,142(+) TAAGT(A/G)TCAGA intron-variant, downstream-variant-500B
rs1006512358 -- 160,403,801(+) TAAAA(A/G)TCTGT intron-variant, upstream-variant-2KB
rs1007214283 -- 160,403,860(+) TTACT(-/TTAAA)TTAAC intron-variant, upstream-variant-2KB

Relevant External Links for MIR15B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR15B Gene

Disorders for MIR15B Gene

Relevant External Links for MIR15B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MIR15B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR15B Gene

Publications for MIR15B Gene

  1. Identification of miR-15b as a transformation-related factor in mantle cell lymphoma. (PMID: 26676972) Arakawa F. … Ohshima K. (Int. J. Oncol. 2016) 3 64
  2. High expression of miR-15b predicts poor prognosis for hepatocellular carcinoma after curative hepatectomy. (PMID: 27499071) Ji W.B. … Zhang W.Z. (Oncol. Rep. 2016) 3 64
  3. MicroRNA-15b regulates reversion-inducing cysteine-rich protein with Kazal motifs (RECK) expression in human uterine leiomyoma. (PMID: 27530410) Guan Y. … Styer A.K. (Reprod. Biol. Endocrinol. 2016) 3 64
  4. MicroRNA-15b suppresses the growth and invasion of glioma cells through targeted inhibition of cripto-1 expression. (PMID: 27082313) Sun G. … Guo J. (Mol Med Rep 2016) 3 64
  5. The WEE1 regulators CPEB1 and miR-15b switch from inhibitor to activators at G2/M. (PMID: 27027998) Kratassiouk G. … Groisman I. (Cell Cycle 2016) 3 64

Products for MIR15B Gene

Sources for MIR15B Gene

Loading form....