Aliases for MIR15A Gene
Subcategory (RNA class) for MIR15A Gene
miRNA
Quality Score for this RNA gene is
8.2
External Ids for MIR15A Gene
- HGNC: 31543
- Entrez Gene: 406948
- Ensembl: ENSG00000283785
- OMIM: 609703
- miRBase: hsa-mir-15a
ORGUL Members for MIR15A Gene
Previous HGNC Symbols for MIR15A Gene
- MIRN15A
Previous GeneCards Identifiers for MIR15A Gene
- GC13M049528
- GC13M050624
- GC13M050625
- GC13M050601
- GC13M049983
Summaries for MIR15A Gene
-
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
GeneCards Summary for MIR15A Gene
MIR15A (MicroRNA 15a) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer.
fRNAdb sequence ontologies for MIR15A Gene
-
nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR15A Gene
Genomics for MIR15A Gene
Regulatory Element Products
Genomic Location for MIR15A Gene
- Chromosome:
- 13
- Start:
- 50,049,119 bp from pter
- End:
- 50,049,201 bp from pter
- Size:
- 83 bases
- Orientation:
- Minus strand
Genomic View for MIR15A Gene
Genes around MIR15A on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 13q14.2 by Ensembl
- 13q14.2 by Entrez Gene
- 13q14.2 by HGNC
MIR15A Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MIR15A Gene
ORGUL Member Location for MIR15A Gene
No data available for Regulatory Elements for MIR15A Gene
Proteins for MIR15A Gene
Post-translational modifications for MIR15A Gene
No Post-translational modifications
Antibody Products
- Search GeneTex for Antibodies for MIR15A
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MIR15A
- Origene Custom Protein Services for MIR15A
- Search GeneTex for Proteins for MIR15A
Assay Products
No data available for DME Specific Peptides for MIR15A Gene
Domains & Families for MIR15A Gene
Gene Families for MIR15A Gene
- HGNC:
Graphical View of Domain Structure for InterPro Entry
No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR15A Gene
Function for MIR15A Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for MIR15A
-
- Search ViGene Biosciences for MIR15A
CRISPR Products
- Browse CRISPR knockouts for MIR15A
miRNA Products
- Search ViGene Biosciences for MIR15A
Inhibitory RNA Products
- Search ViGene Biosciences for MIR15A
Clone Products
- GenScript: Custom all cDNA clones Services for MIR15A
- VectorBuilder custom plasmid, inducible vectors for MIR15A
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MIR15A
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
- Search ViGene Biosciences for MIR15A
Flow Cytometry Products
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR15A Gene
Localization for MIR15A Gene
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR15A Gene
Pathways & Interactions for MIR15A Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | MicroRNAs in cancer | ||
Pathways by source for MIR15A Gene
1 KEGG pathway for MIR15A Gene
Interacting Proteins for MIR15A Gene
No data available for SIGNOR curated interactions for MIR15A Gene
Transcripts for MIR15A Gene
fRNAdb Secondary structures for MIR15A Gene
mRNA/cDNA for MIR15A Gene
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
- Browse CRISPR knockouts for MIR15A
miRNA Products
- Search ViGene Biosciences for MIR15A
Inhibitory RNA Products
- Search ViGene Biosciences for MIR15A
Clone Products
- GenScript: Custom all cDNA clones Services for MIR15A
- VectorBuilder custom plasmid, inducible vectors for MIR15A
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MIR15A
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
Expression for MIR15A Gene
NURSA nuclear receptor signaling pathways regulating expression of MIR15A Gene:
MIR15A
No Expression Related Data Available
Primer Products
No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR15A Gene
Orthologs for MIR15A Gene
No data available for Orthologs for MIR15A Gene
Paralogs for MIR15A Gene
No data available for Paralogs for MIR15A Gene
Variants for MIR15A Gene
| SNP ID | Clin | Chr 13 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1001996172 | -- | 50,049,917(+) | TAGAA(A/G)TTCTC | intron-variant, upstream-variant-2KB | |
| rs1003576601 | -- | 50,050,378(+) | TGAGT(A/G)TTTTT | intron-variant, upstream-variant-2KB | |
| rs1005123286 | -- | 50,048,629(+) | CTGTA(A/T)AGACA | intron-variant, downstream-variant-500B | |
| rs1005480841 | -- | 50,049,132(+) | TTTTG(A/G)GGCAG | intron-variant, nc-transcript-variant, upstream-variant-2KB | |
| rs1006341372 | -- | 50,051,128(+) | AAATC(C/T)GTTTG | intron-variant, upstream-variant-2KB |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3580637 | CNV | loss | 25503493 |
| nsv1035151 | CNV | loss | 25217958 |
| nsv1054415 | CNV | loss | 25217958 |
| nsv561618 | CNV | loss | 21841781 |
Relevant External Links for MIR15A Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MIR15A
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR15A Gene
Disorders for MIR15A Gene
Relevant External Links for MIR15A
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- MIR15A
No disorders were found for MIR15A Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR15A Gene
Publications for MIR15A Gene
- miR-15 and miR-16 induce apoptosis by targeting BCL2. (PMID: 16166262) Cimmino A. … Croce C.M. (Proc. Natl. Acad. Sci. U.S.A. 2005) 3 22 64
- Role of miR-15a in intervertebral disc degeneration through targeting MAP3K9. (PMID: 28081468) Cai P. … Xia J. (Biomed. Pharmacother. 2017) 3 64
- Downregulation of miR-15a and miR-16-1 at 13q14 in Chronic Lymphocytic Leukemia. (PMID: 26908869) Acunzo M. … Croce C.M. (Clin. Chem. 2016) 3 64
- miR-15a induces cell apoptosis by targeting BCL2L2 and BCL2 in HPV-positive hypopharyngeal squamous cell carcinoma. (PMID: 27573302) Lu W. … Lou W. (Oncol. Rep. 2016) 3 64
- MicroRNA-15a inhibits the growth and invasiveness of malignant melanoma and directly targets on CDCA4 gene. (PMID: 27492455) Alderman C. … Yang Y. (Tumour Biol. 2016) 3 64
Products for MIR15A Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
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- Browse OriGene Antibodies
- Custom Antibody Services
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- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MIR15A
- Origene Custom Protein Services for MIR15A
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- Browse OriGene qPCR primer pairs and template standards
- Browse CRISPR knockouts for MIR15A
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For MIR15A
- GenScript: Custom all cDNA clones Services for MIR15A
- GenScript Custom Purified and Recombinant Proteins Services for MIR15A
- GenScript Custom Assay Services for MIR15A
- GenScript Custom overexpressing Cell Line Services for MIR15A
- Browse GenScript CRISPR for MIR15A
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for MIR15A
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Proteins
- Sino Biological Antibodies
- Sino Biological ELISA Kits and Pair Sets
- Sino Biological Cell Lysates
- Sino Biological qPCR Primers
- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Cyagen custom Knockout/knockin (KOKI) mouse models for MIR15A
- VectorBuilder custom plasmid, inducible vectors for MIR15A
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MIR15A
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for MIR15A Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer