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Aliases for MIR15A Gene

Subcategory (RNA class) for MIR15A Gene

miRNA

Quality Score for this RNA gene is

8.2

Aliases for MIR15A Gene

  • MicroRNA 15a 2 3 5
  • Hsa-Mir-15a 3
  • MiRNA15A 3
  • Mir-15a 3
  • MIRN15A 3

External Ids for MIR15A Gene

Previous HGNC Symbols for MIR15A Gene

  • MIRN15A

Previous GeneCards Identifiers for MIR15A Gene

  • GC13M049528
  • GC13M050624
  • GC13M050625
  • GC13M050601
  • GC13M049983

Summaries for MIR15A Gene

Entrez Gene Summary for MIR15A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR15A Gene

MIR15A (MicroRNA 15a) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer.

fRNAdb sequence ontologies for MIR15A Gene

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

View fRNAdb secondary structures for MIR15A

Additional gene information for MIR15A Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR15A Gene

Genomics for MIR15A Gene

Genomic Location for MIR15A Gene

Chromosome:
13
Start:
50,049,119 bp from pter
End:
50,049,201 bp from pter
Size:
83 bases
Orientation:
Minus strand

Genomic View for MIR15A Gene

Genes around MIR15A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR15A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR15A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR15A Gene

ORGUL Member Location for MIR15A Gene

ORGUL Member Location for MIR15A gene

No data available for Regulatory Elements for MIR15A Gene

Proteins for MIR15A Gene

Post-translational modifications for MIR15A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR15A Gene

Domains & Families for MIR15A Gene

Gene Families for MIR15A Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR15A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR15A Gene

Function for MIR15A Gene

Gene Ontology (GO) - Molecular Function for MIR15A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 15131085
genes like me logo Genes that share ontologies with MIR15A: view

Animal Model Products

CRISPR Products

Clone Products

  • Applied Biological Materials Clones for MIR15A
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR15A Gene

Localization for MIR15A Gene

Gene Ontology (GO) - Cellular Components for MIR15A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 26646931
GO:0070062 extracellular exosome IDA 23233752
genes like me logo Genes that share ontologies with MIR15A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR15A Gene

Pathways & Interactions for MIR15A Gene

SuperPathways for MIR15A Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR15A: view

Pathways by source for MIR15A Gene

1 KEGG pathway for MIR15A Gene

Interacting Proteins for MIR15A Gene

Gene Ontology (GO) - Biological Process for MIR15A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IDA 23353574
GO:0008285 negative regulation of cell proliferation IGI 22139073
GO:0016525 negative regulation of angiogenesis IDA 23233752
GO:0035195 gene silencing by miRNA IDA 15131085
GO:0035278 miRNA mediated inhibition of translation IDA 23233752
genes like me logo Genes that share ontologies with MIR15A: view

No data available for SIGNOR curated interactions for MIR15A Gene

Drugs & Compounds for MIR15A Gene

No Compound Related Data Available

Transcripts for MIR15A Gene

fRNAdb Secondary structures for MIR15A Gene

  • FR269952

mRNA/cDNA for MIR15A Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Clone Products

  • Applied Biological Materials Clones for MIR15A
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for MIR15A Gene

No ASD Table

Relevant External Links for MIR15A Gene

GeneLoc Exon Structure for
MIR15A
ECgene alternative splicing isoforms for
MIR15A

Expression for MIR15A Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR15A Gene:

MIR15A
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR15A Gene

Orthologs for MIR15A Gene

Evolution for MIR15A Gene

ENSEMBL:
Gene Tree for MIR15A (if available)
TreeFam:
Gene Tree for MIR15A (if available)

No data available for Orthologs for MIR15A Gene

Paralogs for MIR15A Gene

No data available for Paralogs for MIR15A Gene

Variants for MIR15A Gene

Sequence variations from dbSNP and Humsavar for MIR15A Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs1001996172 -- 50,049,917(+) TAGAA(A/G)TTCTC intron-variant, upstream-variant-2KB
rs1003576601 -- 50,050,378(+) TGAGT(A/G)TTTTT intron-variant, upstream-variant-2KB
rs1005123286 -- 50,048,629(+) CTGTA(A/T)AGACA intron-variant, downstream-variant-500B
rs1005480841 -- 50,049,132(+) TTTTG(A/G)GGCAG intron-variant, nc-transcript-variant, upstream-variant-2KB
rs1006341372 -- 50,051,128(+) AAATC(C/T)GTTTG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR15A Gene

Variant ID Type Subtype PubMed ID
esv3580637 CNV loss 25503493
nsv1035151 CNV loss 25217958
nsv1054415 CNV loss 25217958
nsv561618 CNV loss 21841781

Relevant External Links for MIR15A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR15A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR15A Gene

Disorders for MIR15A Gene

Relevant External Links for MIR15A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR15A

No disorders were found for MIR15A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR15A Gene

Publications for MIR15A Gene

  1. miR-15 and miR-16 induce apoptosis by targeting BCL2. (PMID: 16166262) Cimmino A … Croce CM (Proceedings of the National Academy of Sciences of the United States of America 2005) 3 22 60
  2. Downregulation of miR-15a/b accelerates fibrotic remodelling in the type-2 diabetic human and mouse heart. (PMID: 28289072) Rawal S … Katare RG (Clinical science (London, England : 1979) 2017) 3 60
  3. Upregulation of MicroRNA-15a Contributes to Pathogenesis of Abdominal Aortic Aneurysm (AAA) by Modulating the Expression of Cyclin-Dependent Kinase Inhibitor 2B (CDKN2B). (PMID: 28214350) Gao P … Yu J (Medical science monitor : international medical journal of experimental and clinical research 2017) 3 60
  4. Role of miR-15a in intervertebral disc degeneration through targeting MAP3K9. (PMID: 28081468) Cai P … Xia J (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017) 3 60
  5. Association of MicroRNAs and YRNAs With Platelet Function. (PMID: 26646931) Kaudewitz D … Mayr M (Circulation research 2016) 3 60

Products for MIR15A Gene

Sources for MIR15A Gene

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