Aliases for MIR15A Gene
Subcategory (RNA class) for MIR15A Gene
miRNA
Quality Score for this RNA gene is
8.2
External Ids for MIR15A Gene
- HGNC: 31543
- Entrez Gene: 406948
- Ensembl: ENSG00000283785
- OMIM: 609703
- miRBase: hsa-mir-15a
ORGUL Members for MIR15A Gene
Previous HGNC Symbols for MIR15A Gene
- MIRN15A
Previous GeneCards Identifiers for MIR15A Gene
- GC13M049528
- GC13M050624
- GC13M050625
- GC13M050601
- GC13M049983
Summaries for MIR15A Gene
-
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
GeneCards Summary for MIR15A Gene
MIR15A (MicroRNA 15a) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer.
fRNAdb sequence ontologies for MIR15A Gene
-
nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.
Additional gene information for MIR15A Gene
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR15A Gene
Genomics for MIR15A Gene
Regulatory Element Products
Genomic Locations for MIR15A Gene
Genomic Locations for MIR15A Gene
- chr13:50,049,119-50,049,201
- (GRCh38/hg38)
- Size:
- 83 bases
- Orientation:
- Minus strand
- chr13:50,601,269-50,699,856
- (GRCh37/hg19)
Genomic View for MIR15A Gene
Genes around MIR15A on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 13q14.2 by Ensembl
- 13q14.2 by Entrez Gene
- 13q14.2 by HGNC
MIR15A Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MIR15A Gene
ORGUL Member Location for MIR15A Gene
No data available for GeneHancer (GH) Regulatory Elements for MIR15A Gene
Proteins for MIR15A Gene
Post-translational modifications for MIR15A Gene
No Post-translational modifications
Antibody Products
- Search GeneTex for Antibodies for MIR15A
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MIR15A
- Origene Custom Protein Services for MIR15A
- Search GeneTex for Proteins for MIR15A
No data available for DME Specific Peptides for MIR15A Gene
Domains & Families for MIR15A Gene
Gene Families for MIR15A Gene
- HGNC:
Graphical View of Domain Structure for InterPro Entry
No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR15A Gene
Function for MIR15A Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:1903231 | mRNA binding involved in posttranscriptional gene silencing | IDA | 15131085 |
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Search ViGene Biosciences for MIR15A
CRISPR Products
- Browse CRISPR knockouts for MIR15A
- Applied Biological Materials CRISPR for MIR15A
-
Vectors and viruses for KO, Activation, Repression, and more
miRNA Products
- Search ViGene Biosciences for MIR15A
Inhibitory RNA Products
- Search ViGene Biosciences for MIR15A
Clone Products
- GenScript: Custom all cDNA clones Services for MIR15A
- Applied Biological Materials Clones for MIR15A
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR15A Gene
Localization for MIR15A Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005615 | extracellular space | IDA | 26646931 |
| GO:0070062 | extracellular exosome | IDA | 23233752 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR15A Gene
Pathways & Interactions for MIR15A Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | MicroRNAs in cancer | ||
Pathways by source for MIR15A Gene
1 KEGG pathway for MIR15A Gene
Interacting Proteins for MIR15A Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006919 | activation of cysteine-type endopeptidase activity involved in apoptotic process | IDA | 23353574 |
| GO:0008285 | negative regulation of cell proliferation | IGI | 22139073 |
| GO:0016525 | negative regulation of angiogenesis | IMP,IDA | 23867820 |
| GO:0035195 | gene silencing by miRNA | IDA | 15131085 |
| GO:0035278 | miRNA mediated inhibition of translation | IDA | 23233752 |
No data available for SIGNOR curated interactions for MIR15A Gene
Transcripts for MIR15A Gene
fRNAdb Secondary structures for MIR15A Gene
mRNA/cDNA for MIR15A Gene
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
- Browse CRISPR knockouts for MIR15A
- Applied Biological Materials CRISPR for MIR15A
-
Vectors and viruses for KO, Activation, Repression, and more
miRNA Products
- Search ViGene Biosciences for MIR15A
Inhibitory RNA Products
- Search ViGene Biosciences for MIR15A
Clone Products
- GenScript: Custom all cDNA clones Services for MIR15A
- Applied Biological Materials Clones for MIR15A
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for MIR15A Gene
NURSA nuclear receptor signaling pathways regulating expression of MIR15A Gene:
MIR15A
No Expression Related Data Available
Primer Products
No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR15A Gene
Orthologs for MIR15A Gene
No data available for Orthologs for MIR15A Gene
Paralogs for MIR15A Gene
No data available for Paralogs for MIR15A Gene
Variants for MIR15A Gene
| SNP ID | Clin | Chr 13 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1001996172 | -- | 50,049,917(-) | G/A | upstream_transcript_variant | |
| rs1003576601 | -- | 50,050,378(-) | A/G | upstream_transcript_variant | |
| rs1005123286 | -- | 50,048,629(-) | A/T | downstream_transcript_variant | |
| rs1005480841 | -- | 50,049,132(-) | A/G | non_coding_transcript_variant | |
| rs1006341372 | -- | 50,051,128(-) | C/T | upstream_transcript_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3580637 | CNV | loss | 25503493 |
| nsv1035151 | CNV | loss | 25217958 |
| nsv1054415 | CNV | loss | 25217958 |
| nsv561618 | CNV | loss | 21841781 |
Additional Variant Information for MIR15A Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MIR15A
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR15A Gene
Disorders for MIR15A Gene
Additional Disease Information for MIR15A
No disorders were found for MIR15A Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR15A Gene
Publications for MIR15A Gene
- miR-15 and miR-16 induce apoptosis by targeting BCL2. (PMID: 16166262) Cimmino A … Croce CM (Proceedings of the National Academy of Sciences of the United States of America 2005) 3 22 58
- Altered Expression of MicroRNA-15a and Kruppel-Like Factor 4 in Cerebrospinal Fluid and Plasma After Aneurysmal Subarachnoid Hemorrhage. (PMID: 28893694) Kikkawa Y … Kurita H (World neurosurgery 2017) 3 58
- Interplay of mitochondria apoptosis regulatory factors and microRNAs in valvular heart disease. (PMID: 28888871) Jan MI … Murtaza I (Archives of biochemistry and biophysics 2017) 3 58
- MicroRNAs in the miR-17 and miR-15 families are downregulated in chronic kidney disease with hypertension. (PMID: 28771472) Nandakumar P … Chakravarti A (PloS one 2017) 3 58
- Down-regulation of miR-15a/b accelerates fibrotic remodelling in the Type 2 diabetic human and mouse heart. (PMID: 28289072) Rawal S … Katare R (Clinical science (London, England : 1979) 2017) 3 58
Products for MIR15A Gene
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- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
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Sources for MIR15A Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew