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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MIR15A Gene

RNA gene   GIFtS: 22
GCID: GC13M050601

MicroRNA 15a


(Previous symbol: MIRN15A)
  15 related diseases
at
MalaCards
 

Aliases
for MIR15A gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section
Subcategory (RNA class): lncRNA

Quality score for this RNA gene is 20.2

Aliases
MicroRNA 15a1 2
MIRN15A1 2 5
hsa-mir-15a2
miRNA15A2
mir-15a9

External Ids:    HGNC: 315431   Entrez Gene: 4069482   Ensembl: ENSG000002316077   OMIM: 6097035   
ORGUL members:    fRNAdb10:FR269952 FR143866 FR247099 FR063331 FR144295      
H-InvDB12:HIT000066122 HIT000422024 HIT000066122    
NCBI13:AY455757 AF279660 AF075100    
NONCODE14:n345701 n382032 n377912 n382036 n382033 see all 19      
RNAdb15:EVF35869 EVF35868 LIT3420 LIT3419 HIV1262    

Export aliases for MIR15A gene to outside databases

Previous GC identifers: GC13M049528 GC13M050624 GC13M050625


Summaries
for MIR15A gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for MIR15A Gene:
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene
expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed
by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either
protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an
approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer
ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated
into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the
miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq
represents the predicted microRNA stem-loop. (provided by RefSeq, Sep 2009)

GeneCards Summary for MIR15A Gene: 
MIR15A (microRNA 15a) is an RNA gene, and is affiliated with the lncRNA class. Diseases associated with MIR15A include multiple myeloma, and chronic lymphocytic leukemia.



fRNAdb sequence ontologies for MIR15A - the ORGUL cluster for this gene includes several descriptions:
nc_conserved_region - Non-coding region of sequence similarity by descent from a common ancestor.
antisense_RNA - Antisense RNA is RNA that is transcribed from the coding, rather than the template, strand of DNA. It is therefore complementary to mRNA.
ncRNA - An RNA transcript that does not encode for a protein rather the RNA molecule is the gene product.

View fRNAdb secondary structures for MIR15A

Genomic Views
for MIR15A gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
 Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for MIR15A
         Other transcription factors

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Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MIR15A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q14.2   Ensembl cytogenetic band:  13q14.2   HGNC cytogenetic band: 13q14.2

MIR15A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MIR15A gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M050601:  view genomic region (via miRBase)     (about GC identifiers)

Start:
 50,601,269 bp from pter      End:
 50,699,856 bp from pter
Size:
 98,588 bases      Orientation:
 minus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for MIR15A

Proteins
for MIR15A gene

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section
UniProtKB: --

Protein Domains /
Families
for MIR15A gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
 HGNC Gene Families: 
MIR: ncRNAs / Micro RNAs

  --

Function
for MIR15A gene

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section
Animal Models:
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miRNA
Products:    		miRTarBase genes targeted by MIR15A:
NFKB1(MIRT004829), TSPYL2(MIRT004680), TMEM184B(MIRT003891), BRCA1(MIRT003333), APP(MIRT003899), BACE1(MIRT001802), CCNE1(MIRT001228), MYB(MIRT000283), BCL2(MIRT000815), CCND1(MIRT001227), DMTF1(MIRT002946), CDC25A(MIRT000284), TP53(MIRT005763), VEGFA(MIRT004275), BMI1(MIRT000280), WNT3A(MIRT000282), CHUK(MIRT005552), UCP2(MIRT004046), CCND2(MIRT000285)

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In Situ Assay
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Pathways & Interactions
for MIR15A gene

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for MIR15A About                                                                                                See pathways by source

SuperPathContained pathways About
1MicroRNAs in cancer
MicroRNAs in cancer
2miRNAs involved in DDR
miRNAs involved in DDR

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


1 BioSystems Pathway for MIR15A
    miRNAs involved in DDR


1         Kegg Pathway  (Kegg details for MIR15A):
    MicroRNAs in cancer


MIR15A for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MIR15A

Drugs & Compounds
for MIR15A gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, IUPHAR, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for MIR15A

Search CenterWatch for drugs/clinical trials and news about MIR15A

Transcripts
for MIR15A gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section
 3 fRNAdb Secondary structures:


8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000425586(uc001vdn.1 uc001vdo.1) ENST00000458725 ENST00000433070
ENST00000443587 ENST00000421758 ENST00000449579(uc001veb.2) ENST00000607334
ENST00000235290(uc001vdw.3 uc001vdy.3 uc001vdz.3)
miRNA
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GeneLoc Exon Structure


Expression
for MIR15A gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

Expression evidence for MIR15A:RNAdb

MIR15A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
MIR15A Expression
About this image

    SABiosciences Custom PCR Arrays for MIR15A
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In Situ
Assay Products: 
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Orthologs
for MIR15A gene

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section
   --

ENSEMBL Gene Tree for MIR15A (if available)
TreeFam Gene Tree for MIR15A (if available)

Paralogs
for MIR15A gene

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
  --

Genomic Variants
for MIR15A gene

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
SABiosciences Cancer Mutation PCR Assays
Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MIR15A
DNA2.0 Custom Variant and Variant Library Synthesis for MIR15A

Disorders / Diseases
for MIR15A gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
MIR15A for disorders           About GeneDecksing

OMIM gene information: 609703OMIM information: 605766 605661 607947    
15 diseases for MIR15A:    About MalaCards
multiple myeloma    chronic lymphocytic leukemia    acute lymphoblastic leukemia    cervical cancer
myeloma    lymphoblastic leukemia    lung cancer    cervicitis
gastric cancer    b-cell lymphomas    leukemia    multiple sclerosis
prostate cancer    prostatitis    neuronitis


Export disorders for MIR15A gene to outside databases

Publications
for MIR15A gene

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for MIR15A gene, integrated from 9 sources (see all 56):
(articles sorted by number of sources associating them with MIR15A)		    Utopia: connect your pdf to the dynamic
world of online information

  1. miR-15 and miR-16 induce apoptosis by targeting BCL2. (PubMed id 16166262)1, 9 Cimmino A....Croce C.M. (2005)
  2. MicroRNA-15a and microRNA-16 impair human circulating proangiogenic cell functions and are increased in the proangiogenic cells and se rum of patients with critical limb ischemia. (PubMed id 23233752)1 Spinetti G....Emanueli C. (2013)
  3. Hepatitis B viral RNA directly mediates down-regulatio n of the tumor suppressor microRNA miR-15a/miR-16-1 in hepatocytes. (PubMed id 23649629)1 Wang Y....Fu X.D. (2013)
  4. miR-15a and miR-16 affect the angiogenesis of multiple myeloma by targeting VEGF. (PubMed id 23104180)1 Sun C.Y....Hu Y. (2013)
  5. MicroRNA-15a promotes neuroblastoma migration by targe ting reversion-inducing cysteine-rich protein with Kazal motifs (RECK) and regul ating matrix metalloproteinase-9 expression. (PubMed id 23176145)1 Xin C....Renjie W. (2013)
  6. MiR-15a, miR-16-1 and miR-17-92 cluster expression are linked to poor prognosis in multiple myeloma. (PubMed id 22959509)1 Gao X....Chen L. (2012)
  7. Myc represses miR-15a/miR-16-1 expression through recr uitment of HDAC3 in mantle cell and other non-Hodgkin B-cell lymphomas. (PubMed id 22002311)1 Zhang X....Tao J. (2012)
  8. miR-15a and 16-1 are downregulated in CD4+ T cells of multiple sclerosis relapsing patients. (PubMed id 22463747)1 Lorenzi J.C....da Silva W.A. (2012)
  9. miR-15a/16-1 influences BCL2 expression in keratocysti c odontogenic tumors. (PubMed id 22684875)1 Diniz M.G....Gomez R.S. (2012)
  10. Vector-based miR-15a/16-1 plasmid inhibits colon cance r growth in vivo. (PubMed id 22574716)1 Dai L....Deng H.X. (2012)

External Searches for MIR15A gene

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing MIR15A gene

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 406948 HGNC: 31543 Ensembl:ENSG00000231607 miRBase: hsa-mir-15a euGenes: HUgn406948
ECgene: MIR15A Kegg: 406948 H-InvDB: MIR15A

Other Databases showing MIR15A gene

(According to HUGE)
About This Section
   --

Specialized Databases showing MIR15A gene

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for MIR15A Pharmacogenomics, SNPs, Pathways

Intellectual Property
for MIR15A gene

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for MIR15A gene:
Search GeneIP for patents involving MIR15A

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



Products
for MIR15A gene

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About This Section

 
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