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Aliases for MIR15A Gene

Subcategory (RNA class) for MIR15A Gene

miRNA

Quality Score for this RNA gene is

8.2

Aliases for MIR15A Gene

  • MicroRNA 15a 2 3
  • MIRN15A 3 6
  • Hsa-Mir-15a 3
  • MiRNA15A 3

External Ids for MIR15A Gene

Previous Symbols for MIR15A Gene

  • MIRN15A

Summaries for MIR15A Gene

Entrez Gene Summary for MIR15A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR15A Gene

MIR15A (MicroRNA 15a) is an RNA Gene, and belongs to the miRNA class. Diseases associated with MIR15A include b-cell lymphomas and multiple myeloma. Among its related pathways are MicroRNAs in cancer and miRNAs involved in DDR.

fRNAdb sequence ontologies for MIR15A Gene

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

View fRNAdb secondary structures for MIR15A

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR15A Gene

Genomics for MIR15A Gene

Genomic Location for MIR15A Gene

Start:
50,049,119 bp from pter
End:
50,049,201 bp from pter
Size:
83 bases
Orientation:
Minus strand

Genomic View for MIR15A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR15A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR15A Gene

ORGUL Member Location for MIR15A Gene

ORGUL Member Location for MIR15A gene

No data available for Regulatory Elements for MIR15A Gene

Proteins for MIR15A Gene

Post-translational modifications for MIR15A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR15A Gene

Domains for MIR15A Gene

Gene Families for MIR15A Gene

HGNC:
  • MIR :ncRNAs / Micro RNAs

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR15A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR15A Gene

Function for MIR15A Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MIR15A Gene

Localization for MIR15A Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR15A Gene

Pathways for MIR15A Gene

genes like me logo Genes that share pathways with MIR15A: view

Pathways by source for MIR15A Gene

1 BioSystems pathway for MIR15A Gene
1 KEGG pathway for MIR15A Gene

Interacting Proteins for MIR15A Gene

Gene Ontology (GO) - Biological Process for MIR15A Gene

None

Transcripts for MIR15A Gene

fRNAdb Secondary structures for MIR15A Gene

  • FR269952

mRNA/cDNA for MIR15A Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR15A Gene

No ASD Table

Relevant External Links for MIR15A Gene

GeneLoc Exon Structure for
MIR15A
ECgene alternative splicing isoforms for
MIR15A

Expression for MIR15A Gene

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for MIR15A Gene

Orthologs for MIR15A Gene

Evolution for MIR15A Gene

ENSEMBL:
Gene Tree for MIR15A (if available)
TreeFam:
Gene Tree for MIR15A (if available)

No data available for Orthologs for MIR15A Gene

Paralogs for MIR15A Gene

No data available for Paralogs for MIR15A Gene

Variants for MIR15A Gene

Relevant External Links for MIR15A Gene

HapMap Linkage Disequilibrium report
MIR15A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Structural Variations from Database of Genomic Variants (DGV) for MIR15A Gene

Disorders for MIR15A Gene

genes like me logo Genes that share disorders with MIR15A: view

No data available for UniProtKB/Swiss-Prot for MIR15A Gene

Publications for MIR15A Gene

  1. miR-15 and miR-16 induce apoptosis by targeting BCL2. (PMID: 16166262) Cimmino A. … Croce C.M. (Proc. Natl. Acad. Sci. U.S.A. 2005) 3 23
  2. Identification of novel genes coding for small expressed RNAs. (PMID: 11679670) Lagos-Quintana M. … Tuschl T. (Science 2001) 3
  3. Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia. (PMID: 12434020) Calin G.A. … Croce C.M. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  4. Numerous microRNPs in neuronal cells containing novel microRNAs. (PMID: 12554860) Dostie J. … Dreyfuss G. (RNA 2003) 3
  5. Altered expression profiles of microRNAs during TPA-induced differentiation of HL-60 cells. (PMID: 15325244) Kasashima K. … Kozu T. (Biochem. Biophys. Res. Commun. 2004) 3

Products for MIR15A Gene

Sources for MIR15A Gene

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