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MIR15A Gene(RNA Gene)

MicroRNA 15a

GCID:
GC13M049983
GIFtS:
15
Genes Participants
UDN Logo

Aliases for MIR15A Gene

Subcategory (RNA class) for MIR15A Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR15A Gene

  • MicroRNA 15a 2 3
  • Deleted In Lymphocytic Leukemia 2 (Non-Protein Coding) 5
  • Hsa-Mir-15a 3
  • MiRNA15A 3
  • Mir-15a 3
  • MIRN15A 3
  • DLEU2 5

External Ids for MIR15A Gene

Previous HGNC Symbols for MIR15A Gene

  • MIRN15A

Previous GeneCards Identifiers for MIR15A Gene

  • GC13M049528
  • GC13M050624
  • GC13M050625
  • GC13M050601
  • GC13M050049

Summaries for MIR15A Gene

Entrez Gene Summary for MIR15A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR15A Gene

MIR15A (MicroRNA 15a) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR15A Gene

Genomics for MIR15A Gene

Products:

  1. Regulatory Element

Regulatory Elements for MIR15A Gene

Enhancers for MIR15A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH13F050104 0.6 Ensembl 12.6 +20.5 20520 0.8 FOSL1 GATA3 ATF1 ZFHX2 BACH1 CEBPG GABPA DLEU1 DLEU2 MIR15A KCNRG DLEU7-AS1 DLEU7 ENSG00000273541
GH13F050106 0.4 Ensembl 12.8 +21.6 21620 0.2 ZNF121 GABPA DLEU1 DLEU2 MIR15A ENSG00000273541 RPL18P10
GH13F050115 1 Ensembl ENCODE 0.4 +9.3 9319 2.4 ZNF202 ZFP37 MAFG OVOL3 FEZF1 ZNF623 ZNF316 GATA3 JUND ATF3 KCNRG TRIM13 DLEU1 RNASEH2B RNASEH2B-AS1 KPNA3 CTAGE10P DLEU2 MIR15A ENSG00000273541
GH13F050105 0.8 Ensembl ENCODE 0.3 +18.8 18825 2.2 ZFP64 MYNN JUNB FOXP2 DLEU1 KCNRG DLEU7-AS1 DLEU7 PHF11 ENSG00000273541 MIR15A DLEU2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR15A on UCSC Golden Path with GeneCards custom track

Promoters for MIR15A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001509772 620 3401 PKNOX1 CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 FOS ZNF263 SP3

Genomic Location for MIR15A Gene

Chromosome:
13
Start:
49,982,552 bp from pter
End:
50,125,720 bp from pter
Size:
143,169 bases
Orientation:
Minus strand

Genomic View for MIR15A Gene

Genes around MIR15A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR15A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR15A Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MIR15A Gene

Proteins for MIR15A Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

Post-translational modifications for MIR15A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR15A Gene

Domains & Families for MIR15A Gene

Gene Families for MIR15A Gene

HGNC:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR15A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR15A Gene

Function for MIR15A Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR15A Gene

Localization for MIR15A Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR15A Gene

Pathways & Interactions for MIR15A Gene

SuperPathways for MIR15A Gene

PathCards logo More details on SuperPathways for MIR15A
SuperPathway Contained pathways
1 MicroRNAs in cancer
MicroRNAs in cancer
-
genes like me logo Genes that share pathways with MIR15A: view

Pathways by source for MIR15A Gene

1 KEGG pathway for MIR15A Gene

Interacting Proteins for MIR15A Gene

Gene Ontology (GO) - Biological Process for MIR15A Gene

None

No data available for SIGNOR curated interactions for MIR15A Gene

Drugs & Compounds for MIR15A Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for MIR15A Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for MIR15A Gene

(9) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR15A Gene

No ASD Table

Relevant External Links for MIR15A Gene

GeneLoc Exon Structure for
MIR15A
ECgene alternative splicing isoforms for
MIR15A

Expression for MIR15A Gene

Products:

  1. Primer

NURSA nuclear receptor signaling pathways regulating expression of MIR15A Gene:

MIR15A
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR15A Gene

Orthologs for MIR15A Gene

Evolution for MIR15A Gene

ENSEMBL:
Gene Tree for MIR15A (if available)
TreeFam:
Gene Tree for MIR15A (if available)

No data available for Orthologs for MIR15A Gene

Paralogs for MIR15A Gene

No data available for Paralogs for MIR15A Gene

Variants for MIR15A Gene

Sequence variations from dbSNP and Humsavar for MIR15A Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs112304471 -- 50,049,101(+) ATATT(C/T)TCTTC intron-variant, downstream-variant-500B, upstream-variant-2KB
rs115069827 -- 50,049,312(+) ATTGA(C/T)GTAAT intron-variant, upstream-variant-2KB
rs115680605 -- 50,049,617(+) TTGTT(C/T)CTTGC nc-transcript-variant, upstream-variant-2KB
rs138168786 -- 50,050,549(+) AAATT(A/C)ATTTC intron-variant, upstream-variant-2KB
rs141096501 -- 50,050,448(+) TAACT(A/C)TGCTC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR15A Gene

Variant ID Type Subtype PubMed ID
esv3580637 CNV loss 25503493
nsv1035151 CNV loss 25217958
nsv1054415 CNV loss 25217958
nsv561618 CNV loss 21841781

Relevant External Links for MIR15A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR15A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR15A Gene

Disorders for MIR15A Gene

Relevant External Links for MIR15A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR15A

No disorders were found for MIR15A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR15A Gene

Publications for MIR15A Gene

  1. miR-15 and miR-16 induce apoptosis by targeting BCL2. (PMID: 16166262) Cimmino A. … Croce C.M. (Proc. Natl. Acad. Sci. U.S.A. 2005) 3 22 64
  2. A microRNA code for prostate cancer metastasis. (PMID: 26073083) Bonci D. … De Maria R. (Oncogene 2016) 3 64
  3. Downregulation of miR-15a and miR-16-1 at 13q14 in Chronic Lymphocytic Leukemia. (PMID: 26908869) Acunzo M. … Croce C.M. (Clin. Chem. 2016) 3 64
  4. hsa-miR-15a exerts protective effects against osteoarthritis by targeting aggrecanase-2 (ADAMTS5) in human chondrocytes. (PMID: 26707794) Lu X. … Weng X. (Int. J. Mol. Med. 2016) 3 64
  5. CDK4 and miR-15a comprise an abnormal automodulatory feedback loop stimulating the pathogenesis and inducing chemotherapy resistance in nasopharyngeal carcinoma. (PMID: 26993269) Liu Z. … Fang W. (BMC Cancer 2016) 3 64

Products for MIR15A Gene

Sources for MIR15A Gene

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