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Aliases for MIR15A Gene

Subcategory (RNA class) for MIR15A Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR15A Gene

  • MicroRNA 15a 2 3
  • Deleted In Lymphocytic Leukemia 2 (Non-Protein Coding) 5
  • Hsa-Mir-15a 3
  • MiRNA15A 3
  • Mir-15a 3
  • MIRN15A 3
  • DLEU2 5

External Ids for MIR15A Gene

Previous HGNC Symbols for MIR15A Gene

  • MIRN15A

Previous GeneCards Identifiers for MIR15A Gene

  • GC13M049528
  • GC13M050624
  • GC13M050625
  • GC13M050601
  • GC13M050049

Summaries for MIR15A Gene

Entrez Gene Summary for MIR15A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR15A Gene

MIR15A (MicroRNA 15a) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer and miRNAs involved in DDR.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR15A Gene

Genomics for MIR15A Gene

Regulatory Elements for MIR15A Gene

Enhancers for MIR15A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around MIR15A on UCSC Golden Path with GeneCards custom track

Promoters for MIR15A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for MIR15A Gene

Chromosome:
13
Start:
49,982,552 bp from pter
End:
50,125,720 bp from pter
Size:
143,169 bases
Orientation:
Minus strand

Genomic View for MIR15A Gene

Genes around MIR15A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR15A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR15A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR15A Gene

ORGUL Member Location for MIR15A Gene

ORGUL Member Location for MIR15A gene

Proteins for MIR15A Gene

Post-translational modifications for MIR15A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR15A Gene

Domains & Families for MIR15A Gene

Gene Families for MIR15A Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR15A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR15A Gene

Function for MIR15A Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR15A Gene

Localization for MIR15A Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR15A Gene

Pathways & Interactions for MIR15A Gene

genes like me logo Genes that share pathways with MIR15A: view

Pathways by source for MIR15A Gene

1 BioSystems pathway for MIR15A Gene
1 KEGG pathway for MIR15A Gene

Interacting Proteins for MIR15A Gene

Gene Ontology (GO) - Biological Process for MIR15A Gene

None

No data available for SIGNOR curated interactions for MIR15A Gene

Drugs & Compounds for MIR15A Gene

No Compound Related Data Available

Transcripts for MIR15A Gene

mRNA/cDNA for MIR15A Gene

(9) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR15A Gene

No ASD Table

Relevant External Links for MIR15A Gene

GeneLoc Exon Structure for
MIR15A
ECgene alternative splicing isoforms for
MIR15A

Expression for MIR15A Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR15A Gene:

MIR15A
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR15A Gene

Orthologs for MIR15A Gene

Evolution for MIR15A Gene

ENSEMBL:
Gene Tree for MIR15A (if available)
TreeFam:
Gene Tree for MIR15A (if available)

No data available for Orthologs for MIR15A Gene

Paralogs for MIR15A Gene

No data available for Paralogs for MIR15A Gene

Variants for MIR15A Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR15A Gene

Variant ID Type Subtype PubMed ID
esv3580637 CNV loss 25503493
nsv1035151 CNV loss 25217958
nsv1054415 CNV loss 25217958
nsv561618 CNV loss 21841781

Relevant External Links for MIR15A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR15A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Variation tolerance for MIR15A Gene

Disorders for MIR15A Gene

Relevant External Links for MIR15A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR15A

No disorders were found for MIR15A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR15A Gene

Publications for MIR15A Gene

  1. miR-15 and miR-16 induce apoptosis by targeting BCL2. (PMID: 16166262) Cimmino A. … Croce C.M. (Proc. Natl. Acad. Sci. U.S.A. 2005) 3 22 65
  2. A microRNA code for prostate cancer metastasis. (PMID: 26073083) Bonci D. … De Maria R. (Oncogene 2016) 3 65
  3. Downregulation of miR-15a and miR-16-1 at 13q14 in Chronic Lymphocytic Leukemia. (PMID: 26908869) Acunzo M. … Croce C.M. (Clin. Chem. 2016) 3 65
  4. Allele-specific loss and transcription of the miR-15a/16-1 cluster in chronic lymphocytic leukemia. (PMID: 24732594) Veronese A. … Visone R. (Leukemia 2015) 3 65
  5. Role of miR-15/16 in CLL. (PMID: 24971479) Pekarsky Y. … Croce C.M. (Cell Death Differ. 2015) 3 65

Products for MIR15A Gene

Sources for MIR15A Gene

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