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MIR155HG Gene

RNA gene   GIFtS: 23
GCID: GC21P026934

MIR155 Host Gene (Non-Protein Coding)

(Previous name: microRNA host gene 2 (non-protein coding))
(Previous symbol: MIRHG2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Subcategory (RNA class): lncRNA

Quality score for this RNA gene is 5.2

Aliases
MIR155 Host Gene (Non-Protein Coding)1 2     MicroRNA Host Gene 2 (Non-Protein Coding)1
MIRHG21 2     Non-Protein Coding RNA 1721
B-Cell Receptor Inducible1     BIC2
BIC Transcript1     NCRNA001722

External Ids:    HGNC: 354601   Entrez Gene: 1146142   Ensembl: ENSG000002348837   
ORGUL members:    fRNAdb10:FR020024 FR190578      
H-InvDB12:HIT000079124    
NCBI13:AF402776    
NONCODE14:u1757 n1851 n344571 n379054 n332444    
RNAdb15:EVF47792 LIT1586    

Export aliases for MIR155HG gene to outside databases

Previous GC identifers: GC21P025873 GC21P012337


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MIR155HG Gene:
MicroRNAs (miRNAs), such as miRNA155, are endogenous noncoding RNAs of about 22 nucleotides that regulate mRNAs by
targeting them for cleavage or translational repression. The primary miRNA transcript containing the mature
miRNA155 sequence, pri-miRNA155, is also referred to as BIC (Kluiver et al., 2005 (PubMed 16041695)).(supplied by
OMIM, Mar 2008)

GeneCards Summary for MIR155HG Gene:
MIR155HG (MIR155 host gene (non-protein coding)) is an RNA gene, and is affiliated with the lncRNA class. Diseases associated with MIR155HG include diffuse large b-cell lymphoma, and mediastinitis.



fRNAdb sequence ontologies for MIR155HG - the ORGUL cluster for this gene includes several descriptions:
nc_conserved_region - Non-coding region of sequence similarity by descent from a common ancestor.
ncRNA - An RNA transcript that does not encode for a protein rather the RNA molecule is the gene product.

View fRNAdb secondary structures for MIR155HG

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for MIR155HG
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for MIR155HG

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MIR155HG


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Ensembl cytogenetic band:  21q21.3   HGNC cytogenetic band: 21q21.3

MIR155HG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MIR155HG gene location

GeneLoc information about chromosome 21         GeneLoc Exon Structure

GeneLoc location for GC21P026934:  view genomic region     (about GC identifiers)

Start:
26,934,221 bp from pter      End:
26,947,480 bp from pter
Size:
13,260 bases      Orientation:
plus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for MIR155HG

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB: --


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
LNCRNA: Long non-coding RNAs

  --

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Animal Models:
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MIR155HG
Interactions:

    Search GeneGlobe Interaction Network for MIR155HG

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Tocris compounds for MIR155HG



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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1 fRNAdb Secondary structure:


2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000456917(lincRNA)(uc002ylm.4) ENST00000385060(lincRNA)(uc021why.1)
miRNA
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Selected AceView cDNA sequences (see all 48):

CD676643 CB528893 AV713470 AA382132 AW079379 BX109321 NR_001458 AA810953 
AI281442 AA283087 BG058739 CD638682 BG570624 AF402776 AV716500 AV717582 
AV715299 BG058661 CD641410 BU198987 CD641131 BU939960 AI766963 BG231557 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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Expression evidence for MIR155HG:RNAdb

MIR155HG expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: AGTCTTTAGT
MIR155HG Expression
About this image

MIR155HG Protein expression data from MOPED1, PaxDb2 and MaxQB3 --
    Custom PCR Arrays for MIR155HG
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for MIR155HG gene from Selected species (see all 10)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
chicken
(Gallus gallus)
Aves gga-mir-1556
gga-mir-155
92(a)
1 ↔ 1
1(101820932-101820994) ENSGALG00000018245
lizard
(Anolis carolinensis)
Reptilia aca-mir-1556
aca-mir-155
85(a)
1 ↔ 1
3(148357602-148357668) ENSACAG00000019987
zebrafish
(Danio rerio)
Actinopterygii dre-mir-1556
dre-mir-155
56(a)
1 ↔ 1
1(451141-451218) ENSDARG00000081781
        Species with no ortholog for MIR155HG

ENSEMBL Gene Tree for MIR155HG (if available)
TreeFam Gene Tree for MIR155HG (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for MIR155HG (see all 226)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 21 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1898430091,2
--26932773(+) CCTAGA/TATGAG 1 -- us2k10--------
rs1381504971,2
--26932830(+) GGGACA/GTGCCC 1 -- us2k10--------
rs1826274891,2
--26933076(+) TATGAA/TCATAG 1 -- us2k10--------
rs1414050951,2
--26933125(+) GACAGA/GATCTG 1 -- us2k10--------
rs1877518991,2
--26933209(+) GCATGA/TATCTT 1 -- us2k10--------
rs349002691,2
F--26933332(+) TCAGTT/CTAATA 1 -- us2k15Minor allele frequency- C:0.01MN 408
rs751634791,2
C,F--26933369(+) CTTGAC/AAGGGA 1 -- us2k11Minor allele frequency- A:0.04WA 118
rs1174261981,2
C,F--26933387(+) GTACTG/AGATAC 1 -- us2k11Minor allele frequency- A:0.02NA 120
rs1508346881,2
--26933418(+) GGCCCC/TGTCTT 1 -- us2k10--------
rs794023431,2
C,F--26933462(+) GGCTAG/AATCTA 1 -- us2k11Minor allele frequency- A:0.04WA 118

HapMap Linkage Disequilibrium report for MIR155HG (26934221 - 26947480 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for MIR155HG: --
Site Specific Mutation Identification with PCR Assays
Search QIAGEN SeqTarget long-range PCR primers for resequencing MIR155HG
DNA2.0 Custom Variant and Variant Library Synthesis for MIR155HG

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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13 diseases for MIR155HG:    
About MalaCards
diffuse large b-cell lymphoma    mediastinitis    lung cancer susceptibility    b-cell lymphomas
kaposi's sarcoma    burkitt's lymphoma    chronic lymphocytic leukemia    lung cancer
sarcoma    hodgkin's lymphoma    rheumatoid arthritis    arthritis
leukemia


MIR155HG for disorders           About GeneDecksing

Genetic Association Database (GAD): MIR155HG
Human Genome Epidemiology (HuGE) Navigator: MIR155HG (0 documents)

Export disorders for MIR155HG gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for MIR155HG gene, integrated from 10 sources (see all 25):
(articles sorted by number of sources associating them with MIR155HG)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Regulation of the MIR155 host gene in physiological and pathological processes. (PubMed id 23246696)1, 3 Elton T.S....Parinandi N.L. (Gene 2013)
  2. MYB transcriptionally regulates the miR-155 host gene in chronic lymphocytic leukemia. (PubMed id 21296997)1, 3 Vargova K....Stopka T. (Blood 2011)
  3. Genetic susceptibility to distinct bladder cancer subphenotypes. (PubMed id 19692168)1, 4 Guey L.T....Malats N. (Eur. Urol. 2010)
  4. PTEN identified as important risk factor of chronic obstructive pulmonary disease. (PubMed id 19625176)1, 4 Hosgood H.D....Lan Q. (Respir Med 2009)
  5. Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. (PubMed id 19170196)1 Shen M....Lan Q. (Environ. Mol. Mutagen. 2009)
  6. BIC is processed efficiently to microRNA-155 in Burkitt lymphoma cells. (PubMed id 18354490)1 Zhang T....Tam W. (Leukemia 2008)
  7. B-cell receptor activation induces BIC/miR-155 expression through a conserved AP-1 element. (PubMed id 18048365)1 Yin Q....Flemington E. (J. Biol. Chem. 2008)
  8. Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway. (PubMed id 18676680)1 Hosgood H.D....Lan Q. (Carcinogenesis 2008)
  9. Altered expression of MicroRNA in synovial fibroblasts and synovial tissue in rheumatoid arthritis. (PubMed id 18383392)1 Stanczyk J....Kyburz D. (Arthritis Rheum. 2008)
  10. Kaposi's sarcoma herpes virus taps into a host microRNA regulatory network. (PubMed id 18191785)1 McClure L.V. and Sullivan C.S. (amp 2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 114614 HGNC: 35460 AceView: BIC Ensembl:ENSG00000234883 euGenes: HUgn114614
ECgene: MIR155HG H-InvDB: MIR155HG

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for MIR155HG Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for MIR155HG gene:
Search GeneIP for patents involving MIR155HG

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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