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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MIR155 Gene

RNA gene   GIFtS: 21
GCID: GC21P026946

microRNA 155


(Previous symbol: MIRN155)
 Explore 31 diseases affiliated with
MIR155 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for MIR155    

Aliases
for MIR155 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Subcategory (RNA class): miRNA

Quality score for this RNA gene is 13

Aliases
MicroRNA 1551 2
MIRN1551 2 5
Hsa-Mir-1551
MiRNA1551
BIC5
Mir-1551

External Ids:    HGNC: 315421   Entrez Gene: 4069472   Ensembl: ENSG000002077957   OMIM: 6093375   
ORGUL members:    fRNAdb10:FR069419      
miRBase: MI0000681    

Export aliases for MIR155 gene to outside databases

Previous GC identifer: GC21P025871


Summaries
for MIR155 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for MIR155:
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene
expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed
by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either
protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an
approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer
ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated
into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the
miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq
represents the predicted microRNA stem-loop. (provided by RefSeq, Sep 2009)




Genomic Views
for MIR155 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
 Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for MIR155
         Other transcription factors

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Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MIR155


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q21.3   Ensembl cytogenetic band:  21q21.3   HGNC cytogenetic band: 21q21.3

MIR155 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MIR155 gene location

GeneLoc information about chromosome 21         GeneLoc Exon Structure

GeneLoc location for GC21P026946:  view genomic region (via miRBase)     (about GC identifiers)

Start:
 26,946,292 bp from pter      End:
 26,946,356 bp from pter
Size:
 65 bases      Orientation:
 plus strand

Proteins
for MIR155 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB: --

Protein Domains /
Families
for MIR155 gene

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
   --

Function
for MIR155 gene

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section
Animal Models:
   inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for MIR155 

miRNA
Products:    		miRTarBase genes targeted by MIR155:
CLDN1(MIRT001558), ERMP1(MIRT005256), HIVEP2(MIRT000974), PODXL(MIRT001522), SERTAD2(MIRT005095), CYR61(MIRT005484), C3orf58(MIRT005247), ICAM1(MIRT005709), MAFB(MIRT004507), LOC150786(MIRT005250), CHAF1A(MIRT001559), PPP5C(MIRT001518), CAMTA1(MIRT005101), ARID2(MIRT001569), FGF7(MIRT003482), DPP7(MIRT001551), METTL7A(MIRT001538), PRAF2(MIRT001516), PHF17(MIRT001806), BRPF3(MIRT001563), SKI(MIRT005885), MSH2(MIRT000460), PSMG1(MIRT005249), KBTBD2(MIRT005097), ARL5B(MIRT001567), CYP51A1(MIRT001555), JARID2(MIRT001075), ATP6V1C1(MIRT001565), MECP2(MIRT000442), FOXO3(MIRT004495), RAB6A(MIRT001509), WDFY1(MIRT001486), CDK5RAP3(MIRT001561), LY6K(MIRT001541), PICALM(MIRT001525), RAI14(MIRT001508), KIAA0776(MIRT001543), TXNDC12(MIRT001490), ARFIP1(MIRT001571), TBCA(MIRT001495), MOSPD2(MIRT001535), DHX40(MIRT001554), NFATC2IP(MIRT004056), CTLA4(MIRT004436), EHD1(MIRT005094), MSI2(MIRT001533), MSH6(MIRT000459), DCAF7(MIRT005255), MEIS1(MIRT000287), SCAMP1(MIRT001504), FMNL2(MIRT001547), BCAT1(MIRT004088), UBE2J1(MIRT001488), RCOR1(MIRT001506), LDOC1(MIRT001805), TLE4(MIRT005105), ETS1(MIRT005104), BET1(MIRT001564), EDEM3(MIRT005245), PPL(MIRT001519), FADS1(MIRT001549), TNFRSF10A(MIRT001494), PDLIM5(MIRT001527), RAB27B(MIRT001512), CUL4B(MIRT001556), SMAD1(MIRT001500), NAMPT(MIRT005102), IRAK3(MIRT005808), DSG2(MIRT001550), TAB2(MIRT000289), SH3BP4(MIRT001502), ZNF236(MIRT005091), ZNF652(MIRT000975), SLC30A1(MIRT001501), SYPL1(MIRT001497), MYO1E(MIRT001531), IKBIP(MIRT005251), PTPRJ(MIRT001514), FLI1(MIRT005349), TSHZ3(MIRT004604), POLE3(MIRT001521), APC(MIRT001207), MLH1(MIRT000461), AGTR1(MIRT002006), HNRNPA3P1(MIRT005098), ATG3(MIRT001566), PELI1(MIRT005096), DOCK4(MIRT005411), PHC2(MIRT001526), ANKFY1(MIRT001572), TP53INP1(MIRT003007), TRIM32(MIRT001492), MPZL1(MIRT001534), SNAP29(MIRT001499), PRKCI(MIRT001515), KRAS(MIRT005100), LPL(MIRT001542), IKBKE(MIRT003484), CTNNB1(MIRT001557), CBFB(MIRT001562), MYB(MIRT005884), KRT80(MIRT005257), ARFIP2(MIRT001570), RHOA(MIRT001961), DNAJB1(MIRT001553), VEZF1(MIRT005253), PAPOLA(MIRT005093), PKN2(MIRT001524), NT5E(MIRT001529), SMAD2(MIRT005872), DNAJC19(MIRT001552), DET1(MIRT000972), ARL10(MIRT001568), MATR3(MIRT001804), VAMP3(MIRT001487), HSDL1(MIRT001544), BACH1(MIRT001043), RAB5C(MIRT001510), AMIGO2(MIRT001573), FAR1(MIRT005244), LAT2(MIRT005092), SLC39A10(MIRT005099), TRIP13(MIRT001491), PLXND1(MIRT001523), IFNGR1(MIRT005032), POLE4(MIRT001520), HSD17B12(MIRT001545), TACSTD2(MIRT001496), SMAD5(MIRT000973), RHEB(MIRT001505), INPP5D(MIRT000631), SOCS1(MIRT000456), GNA13(MIRT001546), RCN2(MIRT001507), MYO10(MIRT001532), ZIC3(MIRT000976), MOSC1(MIRT001536), C5orf41(MIRT005103), NARS(MIRT001530), SDCBP(MIRT001503), SACM1L(MIRT005254), TXNRD1(MIRT001489), SYNE2(MIRT001498), RAB34(MIRT001511), SPI1(MIRT004282), RUNX2(MIRT004707), TM6SF1(MIRT001803), RAB23(MIRT001513), EDN1(MIRT004455), SLC25A40(MIRT005248), PDE3A(MIRT001528), LCLAT1(MIRT005252), TWF1(MIRT005246), CEBPB(MIRT001560), SELE(MIRT005713), TRAM1(MIRT001493), CUX1(MIRT004087)

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In Situ Assay
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Pathways & Interactions
for MIR155 gene

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MIR155

Drugs & Compounds
for MIR155 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
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Browse Tocris compounds for MIR155
Search CenterWatch for drugs/clinical trials and news about MIR155 

Transcripts
for MIR155 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000385060(miRNA)

miRNA
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Inhib. RNA
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Primer
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GeneLoc Exon Structure


Expression
for MIR155 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

Expression evidence for MIR155:none

MIR155 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
MIR155 Expression
About this image

MIR155 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell 
Tissue Anatomical Compartment CellCategory (developmental path)
PancreasPancreatic DuctsDuct CellsPancreas
Expression: Positive    Negative     Selective marker
Experimental details: Curated     Microarrays     In-situ hybridization
    SABiosciences Custom PCR Arrays for MIR155
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In Situ
Assay Products: 
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Orthologs
for MIR155 gene

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section
   --

ENSEMBL Gene Tree for MIR155 (if available)
TreeFam Gene Tree for MIR155 (if available) 

Paralogs
for MIR155 gene

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
  --

Genomic Variants
for MIR155 gene

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
SABiosciences Cancer Mutation PCR Assays
Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MIR155
DNA2.0 Custom Variant and Variant Library Synthesis for MIR155

Disorders / Diseases
for MIR155 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
MIR155 for disorders           About GeneDecksing

OMIM gene information: 609337    OMIM disorders: --

20/31 diseases for MIR155 (see all 31):    About MalaCards
diffuse large b-cell lymphoma    b-cell lymphomas    systemic lupus erythematosus    lupus erythematosus
chronic lymphocytic leukemia    burkitt's lymphoma    lymphocytic leukemia    kaposi's sarcoma
hodgkin's lymphoma    mediastinitis    rheumatoid arthritis    down syndrome
hepatitis c    endometrial cancer    sarcoma    cervical cancer
cervicitis    arthritis    nasopharyngitis    colorectal cancer

Human Genome Epidemiology (HuGE) Navigator: MIR155 (5 documents)

Export disorders for MIR155 gene to outside databases

Publications
for MIR155 gene

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for MIR155 gene, integrated from 9 sources (see all 126):
(articles sorted by number of sources associating them with MIR155)		    Utopia: connect your pdf to the dynamic
world of online information

  1. [Expressions of miR-21, miR-155 and miR-210 in plasma of patients with lymphoma and its clinical significance]. (PubMed id 22541087)1 Ge T.T....Shao Z.H. (2012)
  2. MiR-424 and miR-155 deregulated expression in cytogene tically normal acute myeloid leukaemia: correlation with NPM1 and FLT3 mutation status. (PubMed id 22681934)1 Faraoni I....Lo-Coco F. (2012)
  3. Quantitative proteomics reveals that miR-155 regulates the PI3K-AKT pathway in diffuse large B-cell lymphoma. (PubMed id 22609116)1 Huang X....Fu K. (2012)
  4. MiR-155 negatively regulates c-Jun expression at the p ost-transcriptional level in human dermal fibroblasts in vitro: implications in UVA irradiation-induced photoaging. (PubMed id 22508041)1 Song J....Peng Z. (2012)
  5. An autoimmune phenotype in vulvar lichen sclerosus and lichen planus: a Th1 response and high levels of microRNA-155. (PubMed id 22113482)1 Terlou A....Blok L.J. (2012)
  6. Adipocyte differentiation of human bone marrow-derived stromal cells is modulated by microRNA-155, microRNA-221, and microRNA-222. (PubMed id 21756067)1 Skarn M....Myklebost O. (2012)
  7. [Expression and clinical significance of miR-155 in pe ripheral blood CD4(+);T cells of patients with allergic asthma]. (PubMed id 22558995)1 Zhang Y.Y....Lv K. (2012)
  8. Changes in microRNA expression in peripheral mononucle ar cells according to the progression of osteoarthritis. (PubMed id 22006119)1 Okuhara A....Ochi M. (2012)
  9. MicroRNA expression profile helps to distinguish benig n nodules from papillary thyroid carcinomas starting from cells of fine-needle a spiration. (PubMed id 22728346)1 Agretti P....Tonacchera M. (2012)
  10. Post-transcriptional down-regulation of Toll-like rece ptor signaling pathway in umbilical cord blood plasmacytoid dendritic cells. (PubMed id 22578600)1 Charrier E....Duval M. (2012)

External Searches for MIR155 gene

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing MIR155 gene

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 406947 HGNC: 31542 Ensembl:ENSG00000207795 miRBase: hsa-mir-155 euGenes: HUgn406947
ECgene: MIR155 H-InvDB: MIR155

Other Databases showing MIR155 gene

(According to HUGE)
About This Section
   --

Specialized Databases showing MIR155 gene

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for MIR155 Pharmacogenomics, SNPs, Pathways

Intellectual Property
for MIR155 gene

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for MIR155 gene:
Search GeneIP for patents involving MIR155

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



Products
for MIR155 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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About This Section

 
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 inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for MIR155
Sirion Biotech Customized:
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