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Aliases for MIR154 Gene

Subcategory (RNA class) for MIR154 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR154 Gene

  • MicroRNA 154 2 3 5
  • Hsa-Mir-154 3
  • Mir-154 3
  • MIRN154 3

External Ids for MIR154 Gene

Previous HGNC Symbols for MIR154 Gene

  • MIRN154

Previous GeneCards Identifiers for MIR154 Gene

  • GC14P100836
  • GC14P100926
  • GC14P101527
  • GC14P101556
  • GC14P101590
  • GC14P101629
  • GC14P101657
  • GC14P101691
  • GC14P101729
  • GC14P101769
  • GC14P101827
  • GC14P101967
  • GC14P102164
  • GC14P101269
  • GC14P101885

Summaries for MIR154 Gene

Entrez Gene Summary for MIR154 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR154 Gene

MIR154 (MicroRNA 154) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR154 Gene

Genomics for MIR154 Gene

Genomic Location for MIR154 Gene

Chromosome:
14
Start:
101,059,755 bp from pter
End:
101,059,838 bp from pter
Size:
84 bases
Orientation:
Plus strand

Genomic View for MIR154 Gene

Genes around MIR154 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR154 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR154 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR154 Gene

No data available for Regulatory Elements for MIR154 Gene

Proteins for MIR154 Gene

Post-translational modifications for MIR154 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR154 Gene

Domains & Families for MIR154 Gene

Gene Families for MIR154 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR154: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR154 Gene

Function for MIR154 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR154 Gene

Localization for MIR154 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR154 Gene

Pathways & Interactions for MIR154 Gene

SuperPathways for MIR154 Gene

No Data Available

Interacting Proteins for MIR154 Gene

Gene Ontology (GO) - Biological Process for MIR154 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR154 Gene

Drugs & Compounds for MIR154 Gene

No Compound Related Data Available

Transcripts for MIR154 Gene

mRNA/cDNA for MIR154 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR154 Gene

No ASD Table

Relevant External Links for MIR154 Gene

GeneLoc Exon Structure for
MIR154
ECgene alternative splicing isoforms for
MIR154

Expression for MIR154 Gene

mRNA expression in normal human tissues for MIR154 Gene

genes like me logo Genes that share expression patterns with MIR154: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MIR154 Gene

Orthologs for MIR154 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR154 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia bta-mir-154a 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 52 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Mir154 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-154 36
  • 100 (a)
OneToOne
Species with no ortholog for MIR154:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR154 Gene

ENSEMBL:
Gene Tree for MIR154 (if available)
TreeFam:
Gene Tree for MIR154 (if available)

Paralogs for MIR154 Gene

No data available for Paralogs for MIR154 Gene

Variants for MIR154 Gene

Sequence variations from dbSNP and Humsavar for MIR154 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs77420123 -- 101,058,131(+) CCAGA(C/T)ATATG upstream-variant-2KB
rs144803045 -- 101,057,797(+) TGTCC(A/G)TTTTT upstream-variant-2KB
rs113463193 -- 101,058,510(+) TTTGT(A/G)GAGGA upstream-variant-2KB
rs186414016 -- 101,058,028(+) TCAAT(A/C)CCTAT upstream-variant-2KB
rs138192660 -- 101,058,398(+) TTGCA(-/AACATGTTGCTC)TGAAC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR154 Gene

Variant ID Type Subtype PubMed ID
nsv509551 CNV Insertion 20534489

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Variation tolerance and Relevant External Links for MIR154 Gene

Disorders for MIR154 Gene

Relevant External Links for MIR154

Genetic Association Database (GAD)
MIR154
Human Genome Epidemiology (HuGE) Navigator
MIR154
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR154

No disorders were found for MIR154 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR154 Gene

Publications for MIR154 Gene

  1. Novel genetic variants in miR-191 gene and familial ovarian cancer. (PMID: 20167074) Shen J. … Zhao H. (BMC Cancer 2010) 3 48 67
  2. miR-154 suppresses non-small cell lung cancer growth in vitro and in vivo. (PMID: 25846246) Lin X. … Shao G. (Oncol. Rep. 2015) 3
  3. Decreased miR-154 expression and its clinical significance in human colorectal cancer. (PMID: 26048406) Kai Y. … Kuailu L. (World J Surg Oncol 2015) 3
  4. miR-154 inhibits prostate cancer cell proliferation by targeting CCND2. (PMID: 23428540) Zhu C. … Yin C. (Urol. Oncol. 2014) 3
  5. MicroRNAs, miR-154, miR-299-5p, miR-376a, miR-376c, miR-377, miR-381, miR-487b, miR-485-3p, miR-495 and miR-654-3p, mapped to the 14q32.31 locus, regulate proliferation, apoptosis, migration and invasion in metastatic prostate cancer cells. (PMID: 24166498) Formosa A. … Candi E. (Oncogene 2014) 3

Products for MIR154 Gene

Sources for MIR154 Gene

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