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Aliases for MIR154 Gene

Subcategory (RNA class) for MIR154 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR154 Gene

  • MicroRNA 154 2 3
  • Hsa-Mir-154 3
  • MIRN154 3

External Ids for MIR154 Gene

Previous Symbols for MIR154 Gene

  • MIRN154

Summaries for MIR154 Gene

Entrez Gene Summary for MIR154 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR154 Gene

MIR154 (MicroRNA 154) is a RNA Gene, and belongs to miRNA RNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR154 Gene

Genomics for MIR154 Gene

Genomic Location for MIR154 Gene

Start:
101,059,755 bp from pter
End:
101,059,838 bp from pter
Size:
84 bases
Orientation:
Plus strand

Genomic View for MIR154 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR154 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR154 Gene

No data available for Regulatory Elements for MIR154 Gene

Proteins for MIR154 Gene

Post-translational modifications for MIR154 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR154 Gene

Domains for MIR154 Gene

Gene Families for MIR154 Gene

HGNC:
  • MIR :ncRNAs / Micro RNAs
genes like me logo Genes that share domains with MIR154: view

No data available for Protein Domains and UniProtKB/Swiss-Prot for MIR154 Gene

Function for MIR154 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MIR154 Gene

Localization for MIR154 Gene

No data available for Gene Ontology (GO) - Cellular Components for MIR154 Gene

Pathways for MIR154 Gene

SuperPathways for MIR154 Gene

No Data Available

Interacting Proteins for MIR154 Gene

Gene Ontology (GO) - Biological Process for MIR154 Gene

None

No data available for Pathways by source for MIR154 Gene

Transcripts for MIR154 Gene

mRNA/cDNA for MIR154 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR154 Gene

No ASD Table

Relevant External Links for MIR154 Gene

GeneLoc Exon Structure for
MIR154
ECgene alternative splicing isoforms for
MIR154

Expression for MIR154 Gene

mRNA expression in normal human tissues for MIR154 Gene

genes like me logo Genes that share expressions with MIR154: view

Orthologs for MIR154 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR154 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-154 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-154a 37
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 37
  • 52 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Mir154 37
  • 96 (a)
OneToOne
Species with no ortholog for MIR154:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR154 Gene

ENSEMBL:
Gene Tree for MIR154 (if available)
TreeFam:
Gene Tree for MIR154 (if available)

Paralogs for MIR154 Gene

No data available for Paralogs for MIR154 Gene

Variants for MIR154 Gene

Sequence variations from dbSNP and Humsavar for MIR154 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs77420123 -- 101,058,131(+) CCAGA(C/T)ATATG upstream-variant-2KB
rs113463193 -- 101,058,510(+) TTTGT(A/G)GAGGA upstream-variant-2KB
rs138192660 -- 101,058,398(+) TTGCA(-/AACATGTTGCTC)TGAAC upstream-variant-2KB
rs144803045 -- 101,057,797(+) TGTCC(A/G)TTTTT upstream-variant-2KB
rs182617632 -- 101,058,351(+) TTGGA(A/G)CCTCT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR154 Gene

Variant ID Type Subtype PubMed ID
nsv509551 CNV Insertion 20534489

Relevant External Links for MIR154 Gene

HapMap Linkage Disequilibrium report
MIR154

Disorders for MIR154 Gene

Relevant External Links for MIR154

Genetic Association Database (GAD)
MIR154
Human Genome Epidemiology (HuGE) Navigator
MIR154
genes like me logo Genes that share disorders with MIR154: view

No data available for UniProtKB/Swiss-Prot for MIR154 Gene

Publications for MIR154 Gene

  1. Novel genetic variants in miR-191 gene and familial ovarian cancer. (PMID: 20167074) Shen J. … Zhao H. (BMC Cancer 2010) 3 49
  2. Genetic polymorphisms in the precursor MicroRNA flanking region and non-small cell lung cancer survival. (PMID: 20889907) Hu Z. … Shen H. (Am. J. Respir. Crit. Care Med. 2011) 3
  3. Differential microRNA expression in peripheral blood mononuclear cells from Graves' disease patients. (PMID: 22456620) Liu R. … Wang S. (J. Clin. Endocrinol. Metab. 2012) 3
  4. Profibrotic role of miR-154 in pulmonary fibrosis. (PMID: 23043088) Milosevic J. … Kaminski N. (Am. J. Respir. Cell Mol. Biol. 2012) 3
  5. miR-154 inhibits prostate cancer cell proliferation by targeting CCND2. (PMID: 23428540) Zhu C. … Yin C. (Urol. Oncol. 2014) 3

Products for MIR154 Gene

Sources for MIR154 Gene

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