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Aliases for MIR1539 Gene

Subcategory (RNA class) for MIR1539 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR1539 Gene

  • MicroRNA 1539 2 3 5
  • Hsa-Mir-1539 3
  • MIRN1539 3

External Ids for MIR1539 Gene

Previous HGNC Symbols for MIR1539 Gene

  • MIRN1539

Previous GeneCards Identifiers for MIR1539 Gene

  • GC00U922935
  • GC18P045268
  • GC18P047013

Summaries for MIR1539 Gene

Entrez Gene Summary for MIR1539 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR1539 Gene

MIR1539 (MicroRNA 1539) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR1539 Gene

Genomics for MIR1539 Gene

Regulatory Elements for MIR1539 Gene

Enhancers for MIR1539 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH18F049485 0.5 ENCODE 6.3 +2.5 2527 8.4 HDGF PKNOX1 CREB3L1 MLX WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 C18orf32 RPL17 DYM ACAA2 ENSG00000252139 SCARNA17 LIPG MIR1539 GC18M049490 GC18M049507
GH18F048958 0.8 Ensembl ENCODE 4.6 -526.9 -526902 3.1 KLF17 ZNF2 ZEB1 GLIS2 ZNF366 FOS EGR2 ZNF263 ZNF362 ZNF280D ENSG00000265128 LOC105372107 ENSG00000263895 LOC101928144 SRP72P1 LOC105372111 MIR1539 LOC105372108 SMAD7
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR1539 on UCSC Golden Path with GeneCards custom track

Promoters for MIR1539 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000525768 -639 2201 HDGF PKNOX1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF302

Genomic Location for MIR1539 Gene

Chromosome:
18
Start:
49,487,339 bp from pter
End:
49,491,878 bp from pter
Size:
4,540 bases
Orientation:
Plus strand

Genomic View for MIR1539 Gene

Genes around MIR1539 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR1539 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR1539 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR1539 Gene

Proteins for MIR1539 Gene

Post-translational modifications for MIR1539 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR1539 Gene

Domains & Families for MIR1539 Gene

Gene Families for MIR1539 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR1539: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR1539 Gene

Function for MIR1539 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR1539 Gene

Localization for MIR1539 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR1539 Gene

Pathways & Interactions for MIR1539 Gene

SuperPathways for MIR1539 Gene

No Data Available

Interacting Proteins for MIR1539 Gene

Gene Ontology (GO) - Biological Process for MIR1539 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR1539 Gene

Transcripts for MIR1539 Gene

mRNA/cDNA for MIR1539 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR1539 Gene

No ASD Table

Relevant External Links for MIR1539 Gene

GeneLoc Exon Structure for
MIR1539
ECgene alternative splicing isoforms for
MIR1539

Expression for MIR1539 Gene

mRNA expression in normal human tissues for MIR1539 Gene

mRNA differential expression in normal tissues according to GTEx for MIR1539 Gene

This gene is overexpressed in Testis (x11.3).

NURSA nuclear receptor signaling pathways regulating expression of MIR1539 Gene:

MIR1539
genes like me logo Genes that share expression patterns with MIR1539: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR1539 Gene

Orthologs for MIR1539 Gene

Evolution for MIR1539 Gene

ENSEMBL:
Gene Tree for MIR1539 (if available)
TreeFam:
Gene Tree for MIR1539 (if available)

No data available for Orthologs for MIR1539 Gene

Paralogs for MIR1539 Gene

No data available for Paralogs for MIR1539 Gene

Variants for MIR1539 Gene

Sequence variations from dbSNP and Humsavar for MIR1539 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs111328497 -- 49,485,515(+) CGCCA(C/T)TGCAC intron-variant, upstream-variant-2KB
rs111560325 -- 49,486,085(+) CAAGA(C/T)TAAAA intron-variant, upstream-variant-2KB
rs111624227 -- 49,485,414(+) CTGGG(C/T)GTGGT intron-variant, upstream-variant-2KB
rs111715115 -- 49,487,420(+) AGATG(C/T)CCAAC intron-variant, nc-transcript-variant, upstream-variant-2KB
rs113823866 -- 49,486,907(+) CGGAA(A/T)AGAAC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR1539 Gene

Variant ID Type Subtype PubMed ID
nsv1065279 CNV gain 25217958
nsv2294 CNV deletion 18451855
nsv978629 CNV duplication 23825009

Relevant External Links for MIR1539 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR1539

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR1539 Gene

Disorders for MIR1539 Gene

Relevant External Links for MIR1539

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR1539

No disorders were found for MIR1539 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR1539 Gene

Publications for MIR1539 Gene

  1. Characterization of endogenous human Argonautes and their miRNA partners in RNA silencing. (PMID: 18524951) Azuma-Mukai A. … Siomi M.C. (Proc. Natl. Acad. Sci. U.S.A. 2008) 3 64
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64

Products for MIR1539 Gene

Sources for MIR1539 Gene

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