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Aliases for MIR1539 Gene

Subcategory (RNA class) for MIR1539 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR1539 Gene

  • MicroRNA 1539 2 3 5
  • Hsa-Mir-1539 3
  • MIRN1539 3

External Ids for MIR1539 Gene

Previous HGNC Symbols for MIR1539 Gene

  • MIRN1539

Previous GeneCards Identifiers for MIR1539 Gene

  • GC00U922935
  • GC18P045268
  • GC18P047013

Summaries for MIR1539 Gene

Entrez Gene Summary for MIR1539 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR1539 Gene

MIR1539 (MicroRNA 1539) is an RNA Gene, and is affiliated with the miRNA class.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR1539 Gene

Genomics for MIR1539 Gene

Regulatory Elements for MIR1539 Gene

Enhancers for MIR1539 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH18G049485 1.2 ENCODE 6.3 +2.5 2493 8.4 MLX CREB3L1 AGO1 FEZF1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC DYM C18orf32 RPL17 ACAA2 ENSG00000252139 SCARNA17 LIPG MIR1539 SNORD58C SNORD58A
GH18G048958 1.4 Ensembl ENCODE dbSUPER 4.6 -527.0 -527044 2.9 KLF17 ZNF2 ZEB1 ETS1 GLIS2 ZNF366 ZSCAN5C FOS EGR2 ZNF263 MIR1539 LOC105372108 SMAD7
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR1539 on UCSC Golden Path with GeneCards custom track

Promoters for MIR1539 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000103215 -473 1401 HDGF PKNOX1 AGO1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF302

Genomic Location for MIR1539 Gene

Chromosome:
18
Start:
49,487,373 bp from pter
End:
49,487,422 bp from pter
Size:
50 bases
Orientation:
Plus strand

Genomic View for MIR1539 Gene

Genes around MIR1539 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR1539 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR1539 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR1539 Gene

Proteins for MIR1539 Gene

Post-translational modifications for MIR1539 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR1539 Gene

Domains & Families for MIR1539 Gene

Gene Families for MIR1539 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR1539: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR1539 Gene

Function for MIR1539 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR1539 Gene

Localization for MIR1539 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR1539 Gene

Pathways & Interactions for MIR1539 Gene

SuperPathways for MIR1539 Gene

No Data Available

Interacting Proteins for MIR1539 Gene

Gene Ontology (GO) - Biological Process for MIR1539 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR1539 Gene

Drugs & Compounds for MIR1539 Gene

No Compound Related Data Available

Transcripts for MIR1539 Gene

mRNA/cDNA for MIR1539 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR1539 Gene

No ASD Table

Relevant External Links for MIR1539 Gene

GeneLoc Exon Structure for
MIR1539
ECgene alternative splicing isoforms for
MIR1539

Expression for MIR1539 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR1539 Gene

mRNA differential expression in normal tissues according to GTEx for MIR1539 Gene

This gene is overexpressed in Testis (x11.3).

NURSA nuclear receptor signaling pathways regulating expression of MIR1539 Gene:

MIR1539
genes like me logo Genes that share expression patterns with MIR1539: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR1539 Gene

Orthologs for MIR1539 Gene

Evolution for MIR1539 Gene

ENSEMBL:
Gene Tree for MIR1539 (if available)
TreeFam:
Gene Tree for MIR1539 (if available)

No data available for Orthologs for MIR1539 Gene

Paralogs for MIR1539 Gene

No data available for Paralogs for MIR1539 Gene

Variants for MIR1539 Gene

Sequence variations from dbSNP and Humsavar for MIR1539 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs1000460489 -- 49,486,700(+) GACAG(C/T)TAAAG intron-variant, upstream-variant-2KB
rs1000599285 -- 49,487,575(+) GCTAT(C/T)AGTTT intron-variant, downstream-variant-500B, upstream-variant-2KB
rs1000651768 -- 49,487,383(+) TGCGG(C/T)CTGCA intron-variant, nc-transcript-variant, upstream-variant-2KB
rs1000712280 -- 49,487,322(+) AACCC(A/G)GGGTC intron-variant, upstream-variant-2KB
rs1000747061 -- 49,487,426(+) CCAAC(C/T)AAAAG intron-variant, downstream-variant-500B, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR1539 Gene

Variant ID Type Subtype PubMed ID
nsv1065279 CNV gain 25217958
nsv2294 CNV deletion 18451855
nsv978629 CNV duplication 23825009

Relevant External Links for MIR1539 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR1539

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR1539 Gene

Disorders for MIR1539 Gene

Relevant External Links for MIR1539

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR1539

No disorders were found for MIR1539 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR1539 Gene

Publications for MIR1539 Gene

  1. Characterization of endogenous human Argonautes and their miRNA partners in RNA silencing. (PMID: 18524951) Azuma-Mukai A. … Siomi M.C. (Proc. Natl. Acad. Sci. U.S.A. 2008) 3 64
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64

Products for MIR1539 Gene

Sources for MIR1539 Gene

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