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Aliases for MIR153-2 Gene

Subcategory (RNA class) for MIR153-2 Gene

miRNA

Quality Score for this RNA gene is

3.2

Aliases for MIR153-2 Gene

  • MicroRNA 153-2 2 3 5
  • Hsa-Mir-153-2 3
  • Mir-153-2 3
  • MIRN153-2 3

External Ids for MIR153-2 Gene

Previous HGNC Symbols for MIR153-2 Gene

  • MIRN153-2

Previous GeneCards Identifiers for MIR153-2 Gene

  • GC07M157060
  • GC07M157367

Summaries for MIR153-2 Gene

Entrez Gene Summary for MIR153-2 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR153-2 Gene

MIR153-2 (MicroRNA 153-2) is an RNA Gene, and is affiliated with the miRNA class.

fRNAdb sequence ontologies for MIR153-2 Gene

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR153-2 Gene

Genomics for MIR153-2 Gene

Regulatory Elements for MIR153-2 Gene

Enhancers for MIR153-2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G157490 1.2 Ensembl ENCODE 10.9 +83.7 83722 0.6 PKNOX1 ATF1 FOXA2 ARNT SIN3A GATA2 FOS ZHX2 NCOA1 ZNF579 ENSG00000233191 MIR153-2 GC07P157483 LOC105375610
GH07G157659 0.7 dbSUPER 11.5 -88.2 -88237 6.3 CTCF ZNF146 MAX ZIC2 ZNF507 ZFHX2 ZBTB48 FOS ZSCAN29 TCF7L2 LOC105375614 MIR153-2 PTPRN2 PIR42294 ENSG00000231515
GH07G157839 0.5 ENCODE 10.6 -266.9 -266946 2.8 CTCF CREB1 MNT ZNF488 NR2C2 ENSG00000233191 MIR153-2 LOC100506585 PIR37994
GH07G157701 0.2 dbSUPER 10.9 -127.2 -127195 0.4 LOC100506585 MIR153-2 ENSG00000231515 PIR42294
GH07G157576 0.6 ENCODE 0.7 -2.2 -2212 0.2 HDAC6 L3MBTL2 ZBTB11 ELF1 ZBTB40 GABPA MLLT1 CREM LOC105375614 MIR153-2 LOC105375615
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR153-2 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR153-2 Gene

Chromosome:
7
Start:
157,574,336 bp from pter
End:
157,574,422 bp from pter
Size:
87 bases
Orientation:
Minus strand

Genomic View for MIR153-2 Gene

Genes around MIR153-2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR153-2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR153-2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR153-2 Gene

ORGUL Member Location for MIR153-2 Gene

ORGUL Member Location for MIR153-2 gene

Proteins for MIR153-2 Gene

Post-translational modifications for MIR153-2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR153-2 Gene

Domains & Families for MIR153-2 Gene

Gene Families for MIR153-2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR153-2: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR153-2 Gene

Function for MIR153-2 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR153-2 Gene

Localization for MIR153-2 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR153-2 Gene

Pathways & Interactions for MIR153-2 Gene

SuperPathways for MIR153-2 Gene

No Data Available

Interacting Proteins for MIR153-2 Gene

Gene Ontology (GO) - Biological Process for MIR153-2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR153-2 Gene

Drugs & Compounds for MIR153-2 Gene

No Compound Related Data Available

Transcripts for MIR153-2 Gene

mRNA/cDNA for MIR153-2 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR153-2 Gene

No ASD Table

Relevant External Links for MIR153-2 Gene

GeneLoc Exon Structure for
MIR153-2
ECgene alternative splicing isoforms for
MIR153-2

Expression for MIR153-2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR153-2 Gene

genes like me logo Genes that share expression patterns with MIR153-2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR153-2 Gene

Orthologs for MIR153-2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR153-2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia bta-mir-153-2 35
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-153-2 35
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-153-2 35
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir153 35
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-153 35
  • 91 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-153 35
  • 99 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-153-1 35
  • 97 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-153a 35
  • 98 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea csa-mir-153 35
  • 52 (a)
OneToMany
Species where no ortholog for MIR153-2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR153-2 Gene

ENSEMBL:
Gene Tree for MIR153-2 (if available)
TreeFam:
Gene Tree for MIR153-2 (if available)

Paralogs for MIR153-2 Gene

No data available for Paralogs for MIR153-2 Gene

Variants for MIR153-2 Gene

Sequence variations from dbSNP and Humsavar for MIR153-2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000444994 -- 157,575,171(+) ATGAA(C/T)GCAAA intron-variant, upstream-variant-2KB
rs1000795371 -- 157,575,938(+) CCACC(C/T)AGCCA intron-variant, upstream-variant-2KB
rs1003385174 -- 157,574,061(+) CAAGA(C/T)GTAGA intron-variant, downstream-variant-500B
rs1004472621 -- 157,575,319(+) AGAAT(A/G)TACAT intron-variant, upstream-variant-2KB
rs1006606556 -- 157,575,717(+) TAACT(A/G)TTAAG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR153-2 Gene

Variant ID Type Subtype PubMed ID
esv2759580 CNV gain 17122850
esv3377143 OTHER inversion 20981092
nsv428191 CNV gain 18775914

Relevant External Links for MIR153-2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR153-2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR153-2 Gene

Disorders for MIR153-2 Gene

Relevant External Links for MIR153-2

Human Genome Epidemiology (HuGE) Navigator
MIR153-2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR153-2

No disorders were found for MIR153-2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR153-2 Gene

Publications for MIR153-2 Gene

  1. MicroRNA-153 Regulates NRF2 Expression and is Associated with Breast Carcinogenesis. (PMID: 27012032) Wang B. … Liu Q. (Clin. Lab. 2016) 3 64
  2. MiR-153 as a Tumor Suppressor in Glioblastoma Multiforme is Downregulated by DNA Methylation. (PMID: 27215075) Ghasemi A. … Ansari M. (Clin. Lab. 2016) 3 64
  3. MiR-153 inhibits migration and invasion of human non-small-cell lung cancer by targeting ADAM19. (PMID: 25475731) Shan N. … Duan C. (Biochem. Biophys. Res. Commun. 2015) 3 64
  4. miR-153 inhibits epithelial-to-mesenchymal transition in hepatocellular carcinoma by targeting Snail. (PMID: 26035427) Xia W. … Yang Z. (Oncol. Rep. 2015) 3 64
  5. MicroRNA-153 is a prognostic marker and inhibits cell migration and invasion by targeting SNAI1 in human pancreatic ductal adenocarcinoma. (PMID: 26062664) Bai Z. … Zhang Z. (Oncol. Rep. 2015) 3 64

Products for MIR153-2 Gene

Sources for MIR153-2 Gene

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