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Aliases for MIR153-1 Gene

Subcategory (RNA class) for MIR153-1 Gene

miRNA

Quality Score for this RNA gene is

3.2

Aliases for MIR153-1 Gene

  • MicroRNA 153-1 2 3 5
  • Hsa-Mir-153-1 3
  • Mir-153-1 3
  • MIRN153-1 3

External Ids for MIR153-1 Gene

Previous HGNC Symbols for MIR153-1 Gene

  • MIRN153-1

Previous GeneCards Identifiers for MIR153-1 Gene

  • GC02M219868
  • GC02M220158

Summaries for MIR153-1 Gene

Entrez Gene Summary for MIR153-1 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR153-1 Gene

MIR153-1 (MicroRNA 153-1) is an RNA Gene, and is affiliated with the miRNA class.

fRNAdb sequence ontologies for MIR153-1 Gene - the ORGUL cluster for this gene includes several descriptions:

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

Additional gene information for MIR153-1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR153-1 Gene

Genomics for MIR153-1 Gene

Regulatory Elements for MIR153-1 Gene

Enhancers for MIR153-1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02H219244 1.4 ENCODE dbSUPER 12.5 +44.1 44083 11.2 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 GLB1L ZFAND2B DES LINC00608 LINC01803 ENSG00000234638 ANKZF1 ATG9A DNAJB2 TUBA4A
GH02H219121 1.5 Ensembl ENCODE dbSUPER 10.1 +169.1 169132 7.2 FOXA2 ATF1 ARID4B YBX1 TCF12 FOS ATF7 RUNX3 SP5 REST SLC23A3 NHEJ1 IHH LOC100129175 MIR375 FEV CRYBA2 LINC00608 RETREG2 CNPPD1
GH02H219080 1.1 ENCODE dbSUPER 10.6 +212.2 212242 2.4 FOXA2 DNMT3B ZSCAN9 RARA CREM IKZF2 THAP11 HMG20B SP5 KAT8 IHH NHEJ1 SLC23A3 LOC100129175 MIR375 PTPRN MIR153-1 RESP18 ENSG00000272644 RN7SL764P
GH02H219362 0.8 ENCODE 10.6 -68.5 -68459 1 PAX8 BATF ZIC2 ZFHX2 GLIS2 ZNF366 POLR2A EED FOS ZNF600 PTPRN RESP18 MIR153-1 TUBA4A DNAJB2 TUBA4B SPEG ENSG00000232789 LOC105373883
GH02H219181 0.4 dbSUPER 12.5 +111.0 110950 3.1 POLR2A SLC23A3 MIR153-1 PTPRN TUBA4B TUBA4A DNAJB2 ATG9A ANKZF1 GC02M219186 CNPPD1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR153-1 on UCSC Golden Path with GeneCards custom track

Promoters for MIR153-1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000130527 -800 801 HDGF PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B SLC30A9

Genomic Locations for MIR153-1 Gene

Genomic Locations for MIR153-1 Gene
chr2:219,294,111-219,294,200
(GRCh38/hg38)
Size:
90 bases
Orientation:
Minus strand
chr2:220,158,833-220,158,922
(GRCh37/hg19)

Genomic View for MIR153-1 Gene

Genes around MIR153-1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR153-1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR153-1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR153-1 Gene

ORGUL Member Location for MIR153-1 Gene

ORGUL Member Location for MIR153-1 gene

Proteins for MIR153-1 Gene

Post-translational modifications for MIR153-1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR153-1 Gene

Domains & Families for MIR153-1 Gene

Gene Families for MIR153-1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR153-1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR153-1 Gene

Function for MIR153-1 Gene

Phenotypes From GWAS Catalog for MIR153-1 Gene

Gene Ontology (GO) - Molecular Function for MIR153-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 20829195
genes like me logo Genes that share ontologies with MIR153-1: view

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR153-1 Gene

Localization for MIR153-1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR153-1 Gene

Pathways & Interactions for MIR153-1 Gene

SuperPathways for MIR153-1 Gene

No Data Available

Interacting Proteins for MIR153-1 Gene

Gene Ontology (GO) - Biological Process for MIR153-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IDA 20829195
GO:0060087 relaxation of vascular smooth muscle ISS --
GO:1903817 negative regulation of voltage-gated potassium channel activity ISS --
GO:1905651 regulation of artery morphogenesis ISS --
genes like me logo Genes that share ontologies with MIR153-1: view

No data available for Pathways by source and SIGNOR curated interactions for MIR153-1 Gene

Drugs & Compounds for MIR153-1 Gene

No Compound Related Data Available

Transcripts for MIR153-1 Gene

mRNA/cDNA for MIR153-1 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR153-1 Gene

No ASD Table

Relevant External Links for MIR153-1 Gene

GeneLoc Exon Structure for
MIR153-1
ECgene alternative splicing isoforms for
MIR153-1

Expression for MIR153-1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR153-1 Gene

genes like me logo Genes that share expression patterns with MIR153-1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR153-1 Gene

Orthologs for MIR153-1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR153-1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia bta-mir-153-1 34
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-153-1 34
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 34
  • 62 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 59 (a)
OneToMany
oan-mir-153-1 34
  • 59 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia aca-mir-153-2 34
  • 59 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-153c 34
  • 51 (a)
OneToMany
dre-mir-153b 34
  • 49 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea csa-mir-153 34
  • 50 (a)
OneToMany
Species where no ortholog for MIR153-1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR153-1 Gene

ENSEMBL:
Gene Tree for MIR153-1 (if available)
TreeFam:
Gene Tree for MIR153-1 (if available)

Paralogs for MIR153-1 Gene

No data available for Paralogs for MIR153-1 Gene

Variants for MIR153-1 Gene

Sequence variations from dbSNP and Humsavar for MIR153-1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1001043528 -- 219,295,620(+) GGACT(C/T)ACGTT intron-variant, upstream-variant-2KB
rs1001931698 -- 219,294,717(+) AGTCC(C/T)GGGAG intron-variant, upstream-variant-2KB
rs1002385811 -- 219,294,878(+) CGAGG(C/G)TCCAG intron-variant, upstream-variant-2KB
rs1003483728 -- 219,293,792(+) ATCAG(A/G)CCAGC intron-variant, downstream-variant-500B
rs1004024354 -- 219,295,884(+) TAGCT(A/G)TTAGC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR153-1 Gene

Variant ID Type Subtype PubMed ID
nsv834543 CNV loss 17160897
nsv584501 CNV loss 21841781
nsv527936 CNV loss 19592680
nsv508885 CNV insertion 20534489

Relevant External Links for MIR153-1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR153-1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR153-1 Gene

Disorders for MIR153-1 Gene

Relevant External Links for MIR153-1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR153-1

No disorders were found for MIR153-1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR153-1 Gene

Publications for MIR153-1 Gene

  1. Identification of tissue-specific microRNAs from mouse. (PMID: 12007417) Lagos-Quintana M … Tuschl T (Current biology : CB 2002) 1 3 60
  2. MicroRNA-153-3p suppress cell proliferation and invasion by targeting SNAI1 in melanoma. (PMID: 28400282) Zeng HF … Wu SF (Biochemical and biophysical research communications 2017) 3 60
  3. MicroRNA-153 targeting of KCNQ4 contributes to vascular dysfunction in hypertension. (PMID: 27389411) Carr G … Greenwood IA (Cardiovascular research 2016) 3 60
  4. microRNA-153 Targets mTORC2 Component Rictor to Inhibit Glioma Cells. (PMID: 27295037) Cui Y … Jiang Y (PloS one 2016) 3 60
  5. MiR-153 as a Tumor Suppressor in Glioblastoma Multiforme is Downregulated by DNA Methylation. (PMID: 27215075) Ghasemi A … Ansari M (Clinical laboratory 2016) 3 60

Products for MIR153-1 Gene

Sources for MIR153-1 Gene

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