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Aliases for MIR153-1 Gene

Subcategory (RNA class) for MIR153-1 Gene


Quality Score for this RNA gene is


Aliases for MIR153-1 Gene

  • MicroRNA 153-1 2 3
  • Hsa-Mir-153-1 3
  • Mir-153-1 3
  • MIRN153-1 3

External Ids for MIR153-1 Gene

Previous HGNC Symbols for MIR153-1 Gene

  • MIRN153-1

Previous GeneCards Identifiers for MIR153-1 Gene

  • GC02M219868
  • GC02M220158

Summaries for MIR153-1 Gene

Entrez Gene Summary for MIR153-1 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR153-1 Gene

MIR153-1 (MicroRNA 153-1) is an RNA Gene, and is affiliated with the miRNA class.

fRNAdb sequence ontologies for MIR153-1 Gene - the ORGUL cluster for this gene includes several descriptions:

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR153-1 Gene

Genomics for MIR153-1 Gene

Genomic Location for MIR153-1 Gene

219,294,111 bp from pter
219,294,200 bp from pter
90 bases
Minus strand

Genomic View for MIR153-1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR153-1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR153-1 Gene

ORGUL Member Location for MIR153-1 Gene

ORGUL Member Location for MIR153-1 gene

No data available for Regulatory Elements for MIR153-1 Gene

Proteins for MIR153-1 Gene

Post-translational modifications for MIR153-1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR153-1 Gene

Domains & Families for MIR153-1 Gene

Gene Families for MIR153-1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR153-1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR153-1 Gene

Function for MIR153-1 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR153-1 Gene

Localization for MIR153-1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR153-1 Gene

Pathways & Interactions for MIR153-1 Gene

SuperPathways for MIR153-1 Gene

No Data Available

Interacting Proteins for MIR153-1 Gene

Gene Ontology (GO) - Biological Process for MIR153-1 Gene


No data available for Pathways by source and SIGNOR curated interactions for MIR153-1 Gene

Drugs & Compounds for MIR153-1 Gene

No Compound Related Data Available

Transcripts for MIR153-1 Gene

mRNA/cDNA for MIR153-1 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR153-1 Gene

No ASD Table

Relevant External Links for MIR153-1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR153-1 Gene

mRNA expression in normal human tissues for MIR153-1 Gene

genes like me logo Genes that share expression patterns with MIR153-1: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MIR153-1 Gene

Orthologs for MIR153-1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR153-1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia bta-mir-153-1 36
  • 97 (a)
(Canis familiaris)
Mammalia -- 36
  • 62 (a)
(Monodelphis domestica)
Mammalia mdo-mir-153-1 36
  • 97 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 59 (a)
oan-mir-153-1 36
  • 59 (a)
(Anolis carolinensis)
Reptilia aca-mir-153-2 36
  • 59 (a)
(Danio rerio)
Actinopterygii dre-mir-153b 36
  • 49 (a)
dre-mir-153c 36
  • 51 (a)
sea squirt
(Ciona savignyi)
Ascidiacea csa-mir-153 36
  • 50 (a)
Species with no ortholog for MIR153-1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR153-1 Gene

Gene Tree for MIR153-1 (if available)
Gene Tree for MIR153-1 (if available)

Paralogs for MIR153-1 Gene

No data available for Paralogs for MIR153-1 Gene

Variants for MIR153-1 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR153-1 Gene

Variant ID Type Subtype PubMed ID
nsv834543 CNV Loss 17160897
nsv508885 CNV Insertion 20534489
nsv527936 CNV Loss 19592680

Relevant External Links for MIR153-1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Variation tolerance for MIR153-1 Gene

Disorders for MIR153-1 Gene

Relevant External Links for MIR153-1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with MIR153-1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR153-1 Gene

Publications for MIR153-1 Gene

  1. Identification of tissue-specific microRNAs from mouse. (PMID: 12007417) Lagos-Quintana M. … Tuschl T. (Curr. Biol. 2002) 1 67
  2. MiR-153 inhibits migration and invasion of human non-small-cell lung cancer by targeting ADAM19. (PMID: 25475731) Shan N. … Duan C. (Biochem. Biophys. Res. Commun. 2015) 67
  3. Suppression of AKT expression by miR-153 produced anti-tumor activity in lung cancer. (PMID: 25066607) Yuan Y. … Pan Z. (Int. J. Cancer 2015) 67
  4. miR-153 silencing induces apoptosis in the MDA-MB-231 breast cancer cell line. (PMID: 23803066) Anaya-Ruiz M. … PAcrez-Santos J.L. (Asian Pac. J. Cancer Prev. 2013) 67
  5. miR-153 supports colorectal cancer progression via pleiotropic effects that enhance invasion and chemotherapeutic resistance. (PMID: 23950211) Zhang L. … Mirnezami A.H. (Cancer Res. 2013) 67

Products for MIR153-1 Gene

Sources for MIR153-1 Gene

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