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Aliases for MIR153-1 Gene

Subcategory (RNA class) for MIR153-1 Gene

miRNA

Quality Score for this RNA gene is

3.2

Aliases for MIR153-1 Gene

  • MicroRNA 153-1 2 3 5
  • Hsa-Mir-153-1 3
  • Mir-153-1 3
  • MIRN153-1 3

External Ids for MIR153-1 Gene

Previous HGNC Symbols for MIR153-1 Gene

  • MIRN153-1

Previous GeneCards Identifiers for MIR153-1 Gene

  • GC02M219868
  • GC02M220158

Summaries for MIR153-1 Gene

Entrez Gene Summary for MIR153-1 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR153-1 Gene

MIR153-1 (MicroRNA 153-1) is an RNA Gene, and is affiliated with the miRNA class.

fRNAdb sequence ontologies for MIR153-1 Gene - the ORGUL cluster for this gene includes several descriptions:

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR153-1 Gene

Genomics for MIR153-1 Gene

Regulatory Elements for MIR153-1 Gene

Enhancers for MIR153-1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F219244 0.2 ENCODE 12.5 +44.1 44083 11.3 HDGF PKNOX1 CREB3L1 MLX WRNIP1 ARID4B SIN3A FEZF1 DMAP1 YBX1 GLB1L LINC00608 LINC01803 ZFAND2B ANKZF1 ATG9A TUBA4A DNAJB2 MIR153-1 PTPRN
GH02F219080 0.5 Ensembl ENCODE 10.6 +212.2 212242 2.4 ZSCAN9 DNMT3B RARA CREM THAP11 HMG20B SP5 TBX21 KAT8 TGIF2 IHH NHEJ1 SLC23A3 LOC100129175 MIR375 MIR153-1 PTPRN RESP18 ENSG00000272644 RN7SL764P
GH02F219362 1 Ensembl ENCODE 10.5 -68.6 -68580 1.2 SIN3A ZIC2 ZFHX2 GLIS2 POLR2A ZNF366 EED ZNF600 FOS CREM RESP18 PTPRN MIR153-1 DNAJB2 TUBA4A TUBA4B SPEG ENSG00000232789 LOC105373883
GH02F219121 1.1 Ensembl ENCODE 10 +169.1 169062 7.3 ATF1 ARID4B YBX1 FOS SP5 KAT8 SREBF1 MIER3 ETV4 RCOR2 SLC23A3 NHEJ1 IHH LOC100129175 MIR375 FEV CRYBA2 LINC00608 CNPPD1 FAM134A
GH02F219289 1.2 Ensembl ENCODE 0.8 +4.2 4172 1.8 BCOR CTCF KLF1 PKNOX1 ZMYM3 ZNF384 ZNF48 ZBTB40 ZFHX2 ADNP PTPRN GLB1L USP37 GC02M219287 MIR153-1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR153-1 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR153-1 Gene

Chromosome:
2
Start:
219,294,111 bp from pter
End:
219,294,200 bp from pter
Size:
90 bases
Orientation:
Minus strand

Genomic View for MIR153-1 Gene

Genes around MIR153-1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR153-1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR153-1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR153-1 Gene

ORGUL Member Location for MIR153-1 Gene

ORGUL Member Location for MIR153-1 gene

Proteins for MIR153-1 Gene

Post-translational modifications for MIR153-1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR153-1 Gene

Domains & Families for MIR153-1 Gene

Gene Families for MIR153-1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR153-1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR153-1 Gene

Function for MIR153-1 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR153-1 Gene

Localization for MIR153-1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR153-1 Gene

Pathways & Interactions for MIR153-1 Gene

SuperPathways for MIR153-1 Gene

No Data Available

Interacting Proteins for MIR153-1 Gene

Gene Ontology (GO) - Biological Process for MIR153-1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR153-1 Gene

Transcripts for MIR153-1 Gene

mRNA/cDNA for MIR153-1 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR153-1 Gene

No ASD Table

Relevant External Links for MIR153-1 Gene

GeneLoc Exon Structure for
MIR153-1
ECgene alternative splicing isoforms for
MIR153-1

Expression for MIR153-1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR153-1 Gene

genes like me logo Genes that share expression patterns with MIR153-1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR153-1 Gene

Orthologs for MIR153-1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR153-1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia bta-mir-153-1 35
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-153-1 35
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 35
  • 62 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 59 (a)
OneToMany
oan-mir-153-1 35
  • 59 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia aca-mir-153-2 35
  • 59 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-153c 35
  • 51 (a)
OneToMany
dre-mir-153b 35
  • 49 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea csa-mir-153 35
  • 50 (a)
OneToMany
Species where no ortholog for MIR153-1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR153-1 Gene

ENSEMBL:
Gene Tree for MIR153-1 (if available)
TreeFam:
Gene Tree for MIR153-1 (if available)

Paralogs for MIR153-1 Gene

No data available for Paralogs for MIR153-1 Gene

Variants for MIR153-1 Gene

Sequence variations from dbSNP and Humsavar for MIR153-1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs111853777 -- 219,294,873(+) GAGGC(A/C)GAGGC intron-variant, upstream-variant-2KB
rs112728964 -- 219,295,633(+) CCCAT(C/T)TGTCT intron-variant, upstream-variant-2KB
rs112910848 -- 219,295,975(+) ACAGG(-/AC)ACACA intron-variant, upstream-variant-2KB
rs11887718 -- 219,295,355(+) GCTAT(C/T)GTGAG intron-variant, upstream-variant-2KB
rs12621717 -- 219,293,828(+) AAGGG(C/T)GCAGT intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for MIR153-1 Gene

Variant ID Type Subtype PubMed ID
nsv508885 CNV insertion 20534489
nsv527936 CNV loss 19592680
nsv584501 CNV loss 21841781
nsv834543 CNV loss 17160897

Relevant External Links for MIR153-1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR153-1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR153-1 Gene

Disorders for MIR153-1 Gene

Relevant External Links for MIR153-1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR153-1

No disorders were found for MIR153-1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR153-1 Gene

Publications for MIR153-1 Gene

  1. Identification of tissue-specific microRNAs from mouse. (PMID: 12007417) Lagos-Quintana M. … Tuschl T. (Curr. Biol. 2002) 1 3 64
  2. MicroRNA-153 Regulates NRF2 Expression and is Associated with Breast Carcinogenesis. (PMID: 27012032) Wang B. … Liu Q. (Clin. Lab. 2016) 3 64
  3. MiR-153 as a Tumor Suppressor in Glioblastoma Multiforme is Downregulated by DNA Methylation. (PMID: 27215075) Ghasemi A. … Ansari M. (Clin. Lab. 2016) 3 64
  4. Suppression of AKT expression by miR-153 produced anti-tumor activity in lung cancer. (PMID: 25066607) Yuan Y. … Pan Z. (Int. J. Cancer 2015) 3 64
  5. MiR-153 inhibits migration and invasion of human non-small-cell lung cancer by targeting ADAM19. (PMID: 25475731) Shan N. … Duan C. (Biochem. Biophys. Res. Commun. 2015) 3 64

Products for MIR153-1 Gene

Sources for MIR153-1 Gene

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