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Aliases for MIR152 Gene

Subcategory (RNA class) for MIR152 Gene

miRNA

Quality Score for this RNA gene is

10

Aliases for MIR152 Gene

  • MicroRNA 152 2 3 5
  • Hsa-Mir-152 3
  • Mir-152 3
  • MIRN152 3

External Ids for MIR152 Gene

Previous HGNC Symbols for MIR152 Gene

  • MIRN152

Previous GeneCards Identifiers for MIR152 Gene

  • GC17U901085
  • GC17M043473
  • GC17M046114

Summaries for MIR152 Gene

Entrez Gene Summary for MIR152 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR152 Gene

MIR152 (MicroRNA 152) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer.

fRNAdb sequence ontologies for MIR152 Gene - the ORGUL cluster for this gene includes several descriptions:

  • miRNA: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene. Micro RNAs are produced from precursor molecules (SO:0000647) that can form local hairpin structures, which ordinarily are processed (via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors.

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR152

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR152 Gene

Genomics for MIR152 Gene

Regulatory Elements for MIR152 Gene

Enhancers for MIR152 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G048011 1.9 FANTOM5 Ensembl ENCODE dbSUPER 11.3 +23.8 23816 4.3 HDGF PKNOX1 ARNT SIN3A ZNF2 ZBTB7B ZNF121 GLIS2 ZNF143 ZNF207 PRR15L SCRN2 COPZ2 CDK5RAP3 SKAP1 MRPL45P2 CBX1 SUMO2P17 MIR152 RPS2P47
GH17G047964 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10 +70.2 70218 4.6 MLX ARNT SIN3A ARID4B FEZF1 YY1 ZNF121 SLC30A9 GATA2 FOS SCRN2 CDK5RAP3 PNPO PRR15L SKAP1 SP2-AS1 SP2 MIR152 COPZ2 CBX1
GH17G047970 1.4 ENCODE dbSUPER 10.1 +65.9 65925 2.1 CREB3L1 AGO1 ZFP64 YBX1 DMAP1 YY1 ZNF143 SP3 NFYC SSRP1 SCRN2 PNPO PRR15L CDK5RAP3 SP2-AS1 KPNB1 MRPL45P2 SP2 NFE2L1 ENSG00000266601
GH17G047982 1.1 ENCODE dbSUPER 10.8 +54.8 54758 0.2 HDAC1 PKNOX1 ATF1 TCF12 ZNF766 GATA2 ELK1 EGR1 CREM KDM4B PRR15L MIR152 COPZ2 SP2 ENSG00000264701 CDK5RAP3
GH17G048106 1.1 ENCODE 10.8 -70.7 -70706 2.6 HDGF PKNOX1 CREB3L1 ARID4B SIN3A YBX1 ZBTB7B YY1 ZNF207 ZNF143 SNX11 COPZ2 NFE2L1 MIR152 SCRN2 GC17P048126
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR152 on UCSC Golden Path with GeneCards custom track

Promoters for MIR152 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000095266 -353 801 HDGF PKNOX1 ZNF133 ARID4B SIN3A BMI1 ZNF2 THRB ZNF48 ZBTB40

Genomic Location for MIR152 Gene

Chromosome:
17
Start:
48,037,161 bp from pter
End:
48,037,247 bp from pter
Size:
87 bases
Orientation:
Minus strand

Genomic View for MIR152 Gene

Genes around MIR152 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR152 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR152 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR152 Gene

ORGUL Member Location for MIR152 Gene

ORGUL Member Location for MIR152 gene

Proteins for MIR152 Gene

Post-translational modifications for MIR152 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR152 Gene

Domains & Families for MIR152 Gene

Gene Families for MIR152 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR152: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR152 Gene

Function for MIR152 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR152 Gene

Localization for MIR152 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR152 Gene

Pathways & Interactions for MIR152 Gene

SuperPathways for MIR152 Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR152: view

Pathways by source for MIR152 Gene

1 KEGG pathway for MIR152 Gene

Interacting Proteins for MIR152 Gene

Gene Ontology (GO) - Biological Process for MIR152 Gene

None

No data available for SIGNOR curated interactions for MIR152 Gene

Drugs & Compounds for MIR152 Gene

No Compound Related Data Available

Transcripts for MIR152 Gene

fRNAdb Secondary structures for MIR152 Gene

  • hsa-miR-152-5p_MIMAT0026479_Homo_sapiens_miR-152-5p_mature

mRNA/cDNA for MIR152 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR152 Gene

No ASD Table

Relevant External Links for MIR152 Gene

GeneLoc Exon Structure for
MIR152
ECgene alternative splicing isoforms for
MIR152

Expression for MIR152 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR152 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR152 Gene:

MIR152
genes like me logo Genes that share expression patterns with MIR152: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR152 Gene

Orthologs for MIR152 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR152 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-152 35
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-152 35
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir152 35
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-152 35
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-152 35
  • 90 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-152 35
  • 79 (a)
OneToOne
Species where no ortholog for MIR152 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR152 Gene

ENSEMBL:
Gene Tree for MIR152 (if available)
TreeFam:
Gene Tree for MIR152 (if available)

Paralogs for MIR152 Gene

No data available for Paralogs for MIR152 Gene

Variants for MIR152 Gene

Sequence variations from dbSNP and Humsavar for MIR152 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1003604651 -- 48,037,395(+) GCCAC(G/T)CCTTA intron-variant, upstream-variant-2KB
rs1004065050 -- 48,038,097(+) AGTGT(C/G)TATAG intron-variant, nc-transcript-variant, upstream-variant-2KB
rs1007796613 -- 48,038,185(+) ATACG(C/T)CAGGT intron-variant, nc-transcript-variant, upstream-variant-2KB
rs1008151725 -- 48,037,932(+) CGCCC(C/T)CACCC intron-variant, upstream-variant-2KB
rs1008343103 -- 48,037,592(+) AGTTG(G/T)CTGCT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR152 Gene

Variant ID Type Subtype PubMed ID
nsv469808 CNV loss 16826518

Relevant External Links for MIR152 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR152

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR152 Gene

Disorders for MIR152 Gene

Relevant External Links for MIR152

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR152

No disorders were found for MIR152 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR152 Gene

Publications for MIR152 Gene

  1. Identification of tissue-specific microRNAs from mouse. (PMID: 12007417) Lagos-Quintana M. … Tuschl T. (Curr. Biol. 2002) 1 3 64
  2. MicroRNA-152 inhibits tumor cell growth by directly targeting RTKN in hepatocellular carcinoma. (PMID: 27922690) Zhou J. … Liang J. (Oncol. Rep. 2017) 3 64
  3. miR-152 down-regulation is associated with MET up-regulation in leiomyosarcoma and undifferentiated pleomorphic sarcoma. (PMID: 27900663) Pazzaglia L. … Benassi M.S. (Cell Oncol (Dordr) 2017) 3 64
  4. Down-expression of miR-152 lead to impaired anti-tumor effect of NK via upregulation of HLA-G. (PMID: 26468017) Bian X. … Zhang Y. (Tumour Biol. 2016) 3 64
  5. Circulating miR-148/152 family as potential biomarkers in hepatocellular carcinoma. (PMID: 26531720) Wang F. … Wang S. (Tumour Biol. 2016) 3 64

Products for MIR152 Gene

Sources for MIR152 Gene

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