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Aliases for MIR151A Gene

Subcategory (RNA class) for MIR151A Gene

miRNA

Quality Score for this RNA gene is

8.2

Aliases for MIR151A Gene

  • MicroRNA 151a 2 3 5
  • MicroRNA 151 2 3
  • Hsa-Mir-151a 3
  • Hsa-Mir-151 3
  • MIRN151 3
  • MIR151 3

External Ids for MIR151A Gene

Previous HGNC Symbols for MIR151A Gene

  • MIRN151
  • MIR151

Previous GeneCards Identifiers for MIR151A Gene

  • GC08M141744
  • GC08M141748

Summaries for MIR151A Gene

Entrez Gene Summary for MIR151A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR151A Gene

MIR151A (MicroRNA 151a) is an RNA Gene, and is affiliated with the miRNA class.

fRNAdb sequence ontologies for MIR151A Gene - the ORGUL cluster for this gene includes several descriptions:

  • miRNA: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene. Micro RNAs are produced from precursor molecules (SO:0000647) that can form local hairpin structures, which ordinarily are processed (via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors.

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

View fRNAdb secondary structures for MIR151A

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR151A Gene

Genomics for MIR151A Gene

Regulatory Elements for MIR151A Gene

Enhancers for MIR151A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08G140789 1.9 FANTOM5 Ensembl ENCODE dbSUPER 11.7 -58.5 -58492 3.7 PKNOX1 ATF1 ARNT FEZF1 BRCA1 YY1 GATA2 FOS DEK ZHX2 AGO2 MIR151A PTK2 TRAPPC9 CHRAC1 ENSG00000279786 GC08M140734
GH08G140693 1.2 ENCODE dbSUPER 11.6 +38.9 38917 0.2 HDAC1 PKNOX1 ATF1 CBX3 TBL1XR1 ZBTB40 CHAMP1 TCF12 ZNF766 ELK1 MIR151A PTK2 GC08M140724 AGO2
GH08G140794 1.1 FANTOM5 ENCODE dbSUPER 11.6 -62.0 -61978 1.2 ZNF316 SCRT2 MAFG NFE2 NFE2L2 MIR151A PTK2 ENSG00000279786 GC08M140734
GH08G140797 1.1 ENCODE dbSUPER 11.6 -64.5 -64454 0.2 PKNOX1 SIN3A FEZF1 RAD21 ZNF2 RFX5 GATA2 ZNF366 RCOR1 ZNF391 MIR151A PTK2 AGO2 ENSG00000279786 GC08M140734
GH08G140834 1.1 Ensembl ENCODE 10.6 -102.4 -102443 2.1 SIN3A RAD21 ZNF366 SCRT2 FOS DEK EGR2 ZNF263 SP3 ZNF280D MIR151A PTK2 ENSG00000279786 RNA5SP278
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR151A on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR151A Gene

Chromosome:
8
Start:
140,732,564 bp from pter
End:
140,732,653 bp from pter
Size:
90 bases
Orientation:
Minus strand

Genomic View for MIR151A Gene

Genes around MIR151A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR151A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR151A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR151A Gene

ORGUL Member Location for MIR151A Gene

ORGUL Member Location for MIR151A gene

Proteins for MIR151A Gene

Post-translational modifications for MIR151A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR151A Gene

Domains & Families for MIR151A Gene

Gene Families for MIR151A Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR151A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR151A Gene

Function for MIR151A Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR151A Gene

Localization for MIR151A Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR151A Gene

Pathways & Interactions for MIR151A Gene

SuperPathways for MIR151A Gene

No Data Available

Interacting Proteins for MIR151A Gene

Gene Ontology (GO) - Biological Process for MIR151A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR151A Gene

Transcripts for MIR151A Gene

fRNAdb Secondary structures for MIR151A Gene

  • FR049012

mRNA/cDNA for MIR151A Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR151A Gene

No ASD Table

Relevant External Links for MIR151A Gene

GeneLoc Exon Structure for
MIR151A
ECgene alternative splicing isoforms for
MIR151A

Expression for MIR151A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR151A Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR151A Gene:

MIR151A
genes like me logo Genes that share expression patterns with MIR151A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR151A Gene

Orthologs for MIR151A Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR151A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-151 35
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-151 35
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir151 35
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-151 35
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 72 (a)
ManyToMany
-- 35
  • 71 (a)
ManyToMany
-- 35
  • 70 (a)
ManyToMany
-- 35
  • 60 (a)
ManyToMany
-- 35
  • 58 (a)
ManyToMany
-- 35
  • 49 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 55 (a)
OneToOne
Species where no ortholog for MIR151A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR151A Gene

ENSEMBL:
Gene Tree for MIR151A (if available)
TreeFam:
Gene Tree for MIR151A (if available)

Paralogs for MIR151A Gene

No data available for Paralogs for MIR151A Gene

Variants for MIR151A Gene

Sequence variations from dbSNP and Humsavar for MIR151A Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1001545720 -- 140,733,133(+) AAGAG(C/T)GTGGG intron-variant, upstream-variant-2KB
rs1002564133 -- 140,732,921(+) GACAG(A/G)AGGGT intron-variant, upstream-variant-2KB
rs1004571059 -- 140,734,394(+) TCAAC(A/T)AATGT intron-variant, upstream-variant-2KB
rs1005918609 -- 140,734,053(+) TATAG(A/G/T)TCTTA intron-variant, upstream-variant-2KB
rs1006277510 -- 140,733,832(+) AGAGT(C/T)ATGGG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR151A Gene

Variant ID Type Subtype PubMed ID
esv2737756 CNV deletion 23290073
nsv1025478 CNV gain 25217958
nsv1126125 CNV deletion 24896259
nsv526444 CNV gain 19592680
nsv612568 CNV gain 21841781

Relevant External Links for MIR151A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR151A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR151A Gene

Disorders for MIR151A Gene

Relevant External Links for MIR151A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR151A

No disorders were found for MIR151A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR151A Gene

Publications for MIR151A Gene

  1. New human and mouse microRNA genes found by homology search. (PMID: 15634332) Weber M.J. (FEBS J. 2005) 1 3 64
  2. Identification of human fetal liver miRNAs by a novel method. (PMID: 15978578) Fu H. … Zheng X. (FEBS Lett. 2005) 1 3 64
  3. Identification of many microRNAs that copurify with polyribosomes in mammalian neurons. (PMID: 14691248) Kim J. … Ruvkun G. (Proc. Natl. Acad. Sci. U.S.A. 2004) 1 3 64
  4. Identification of valid reference genes for microRNA expression studies in a hepatitis B virus replicating liver cell line. (PMID: 26801621) Jacobsen K.S. … Hogh B. (BMC Res Notes 2016) 3 64
  5. Disease specific enrichment of circulating let-7 family microRNA in MuSK+ myasthenia gravis. (PMID: 26943954) Punga T. … Punga A.R. (J. Neuroimmunol. 2016) 3 64

Products for MIR151A Gene

Sources for MIR151A Gene

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