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Aliases for MIR150 Gene

Subcategory (RNA class) for MIR150 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR150 Gene

  • MicroRNA 150 2 3 5
  • Hsa-Mir-150 3
  • MiRNA150 3
  • Mir-150 3
  • MIRN150 3

External Ids for MIR150 Gene

Previous HGNC Symbols for MIR150 Gene

  • MIRN150

Previous GeneCards Identifiers for MIR150 Gene

  • GC19M054698
  • GC19M050004

Summaries for MIR150 Gene

Entrez Gene Summary for MIR150 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR150 Gene

MIR150 (MicroRNA 150) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Hematopoietic Stem Cell Differentiation and MicroRNAs in cancer.

fRNAdb sequence ontologies for MIR150 Gene

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR150 Gene

Genomics for MIR150 Gene

Regulatory Elements for MIR150 Gene

Enhancers for MIR150 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G049567 1.5 Ensembl ENCODE dbSUPER 12.4 -68.7 -68698 4.6 PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 ZNF2 YY1 ZNF121 ZNF143 PRR12 NOSIP PRRG2 FCGRT MIR150 RPS11 SNORD35B RCN3 FLT3LG BCL2L12
GH19G049552 1.4 Ensembl ENCODE dbSUPER 12.1 -54.5 -54482 5.7 PKNOX1 CBX3 NFRKB ARID4B ZBTB40 GATA2 CBX5 FOS MIXL1 EGR2 NOSIP PRR12 FCGRT RCN3 PRRG2 MIR150 SNORD35B RPS11 SNORD33 SNORD34
GH19G049558 1.2 Ensembl ENCODE dbSUPER 12.2 -59.9 -59857 4.3 BCOR TFAP4 ZMYM3 ZNF664 ZFHX2 FOXK2 EGR1 ADNP ZSCAN29 NFE2 PRR12 NOSIP RCN3 FCGRT MIR150 RPS11 SNORD35B SNORD35A SNORD34 RPL13A
GH19G049564 0.8 ENCODE dbSUPER 12.4 -64.6 -64635 2.2 BCOR ZNF121 NFIC NFIB ADNP CEBPB KDM1A PRR12 NOSIP FCGRT MIR150 RPS11 SNORD35B RCN3 SLC17A7 GC19P049568 PIR42034
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR150 on UCSC Golden Path with GeneCards custom track

Promoters for MIR150 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000110907 168 601 HDGF AGO1 SIN3A GLIS2 ZNF766 FOS DEK PAF1 JUNB REST

Genomic Location for MIR150 Gene

Chromosome:
19
Start:
49,500,785 bp from pter
End:
49,500,868 bp from pter
Size:
84 bases
Orientation:
Minus strand

Genomic View for MIR150 Gene

Genes around MIR150 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR150 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR150 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR150 Gene

ORGUL Member Location for MIR150 Gene

ORGUL Member Location for MIR150 gene

Proteins for MIR150 Gene

Post-translational modifications for MIR150 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR150 Gene

Domains & Families for MIR150 Gene

Gene Families for MIR150 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR150: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR150 Gene

Function for MIR150 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR150 Gene

Localization for MIR150 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR150 Gene

Pathways & Interactions for MIR150 Gene

genes like me logo Genes that share pathways with MIR150: view

Pathways by source for MIR150 Gene

Interacting Proteins for MIR150 Gene

Gene Ontology (GO) - Biological Process for MIR150 Gene

None

No data available for SIGNOR curated interactions for MIR150 Gene

Drugs & Compounds for MIR150 Gene

No Compound Related Data Available

Transcripts for MIR150 Gene

mRNA/cDNA for MIR150 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR150 Gene

No ASD Table

Relevant External Links for MIR150 Gene

GeneLoc Exon Structure for
MIR150
ECgene alternative splicing isoforms for
MIR150

Expression for MIR150 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR150 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR150 Gene:

MIR150
genes like me logo Genes that share expression patterns with MIR150: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR150 Gene

Orthologs for MIR150 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR150 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-150 35
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir150 35
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-150 35
  • 86 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-150 35
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-150 35
  • 65 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-150 35
  • 43 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-150 35
  • 72 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-150 35
  • 66 (a)
OneToOne
Species where no ortholog for MIR150 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR150 Gene

ENSEMBL:
Gene Tree for MIR150 (if available)
TreeFam:
Gene Tree for MIR150 (if available)

Paralogs for MIR150 Gene

No data available for Paralogs for MIR150 Gene

Variants for MIR150 Gene

Sequence variations from dbSNP and Humsavar for MIR150 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000196537 -- 49,501,994(+) TTAAT(G/T)GTTTA upstream-variant-2KB
rs1000963591 -- 49,501,078(+) GGCAG(G/T)AGAGA upstream-variant-2KB
rs1001416581 -- 49,500,981(+) GGGGC(C/T)GCATC upstream-variant-2KB
rs1001701454 -- 49,502,051(+) AGGAA(C/T)AAGTC upstream-variant-2KB
rs1002208133 -- 49,500,420(+) AAGGA(A/G)GTGGG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for MIR150 Gene

Variant ID Type Subtype PubMed ID
nsv1160655 CNV deletion 26073780
nsv833862 CNV loss 17160897
nsv833863 CNV loss 17160897
nsv953599 CNV deletion 24416366
nsv9739 CNV gain+loss 18304495

Variation tolerance for MIR150 Gene

Gene Damage Index Score: 10.58; 91.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MIR150 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR150

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MIR150 Gene

Disorders for MIR150 Gene

Relevant External Links for MIR150

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR150

No disorders were found for MIR150 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR150 Gene

Publications for MIR150 Gene

  1. Identification of tissue-specific microRNAs from mouse. (PMID: 12007417) Lagos-Quintana M. … Tuschl T. (Curr. Biol. 2002) 1 3 64
  2. MicroRNA-150 targets ELK1 and modulates the apoptosis induced by ox-LDL in endothelial cells. (PMID: 28110404) Qin B. … Lu Z. (Mol. Cell. Biochem. 2017) 3 64
  3. miR-150-5p and miR-133a suppress glioma cell proliferation and migration through targeting membrane-type-1 matrix metalloproteinase. (PMID: 27154818) Sakr M. … Sato H. (Gene 2016) 3 64
  4. Association of miR-34a, miR-130a, miR-150 and miR-155 polymorphisms with the risk of ischemic stroke. (PMID: 27246008) Choi G.H. … Kim N.K. (Int. J. Mol. Med. 2016) 3 64
  5. TNF-I+-induced NF-I_B activation upregulates microRNA-150-3p and inhibits osteogenesis of mesenchymal stem cells by targeting I^-catenin. (PMID: 26935950) Wang N. … Yu X. (Open Biol 2016) 3 64

Products for MIR150 Gene

Sources for MIR150 Gene

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