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Aliases for MIR149 Gene

Subcategory (RNA class) for MIR149 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR149 Gene

  • MicroRNA 149 2 3
  • Hsa-Mir-149 3
  • MIRN149 3

External Ids for MIR149 Gene

ORGUL Members for MIR149 Gene

Previous Symbols for MIR149 Gene

  • MIRN149

Summaries for MIR149 Gene

Entrez Gene Summary for MIR149 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR149 Gene

MIR149 (MicroRNA 149) is a RNA Gene, and belongs to miRNA RNA class. Diseases associated with MIR149 include pneumoconiosis and lung cancer.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR149 Gene

Genomics for MIR149 Gene

Genomic Location for MIR149 Gene

Start:
240,456,001 bp from pter
End:
240,456,089 bp from pter
Size:
89 bases
Orientation:
Plus strand

Genomic View for MIR149 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR149 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR149 Gene

No data available for Regulatory Elements for MIR149 Gene

Proteins for MIR149 Gene

Post-translational modifications for MIR149 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR149 Gene

Domains for MIR149 Gene

Gene Families for MIR149 Gene

HGNC:
  • MIR :ncRNAs / Micro RNAs
genes like me logo Genes that share domains with MIR149: view

No data available for Protein Domains and UniProtKB/Swiss-Prot for MIR149 Gene

Function for MIR149 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MIR149 Gene

Localization for MIR149 Gene

No data available for Gene Ontology (GO) - Cellular Components for MIR149 Gene

Pathways for MIR149 Gene

SuperPathways for MIR149 Gene

No Data Available

Interacting Proteins for MIR149 Gene

Gene Ontology (GO) - Biological Process for MIR149 Gene

None

No data available for Pathways by source for MIR149 Gene

Transcripts for MIR149 Gene

mRNA/cDNA for MIR149 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR149 Gene

No ASD Table

Relevant External Links for MIR149 Gene

GeneLoc Exon Structure for
MIR149
ECgene alternative splicing isoforms for
MIR149

Expression for MIR149 Gene

mRNA expression in normal human tissues for MIR149 Gene

genes like me logo Genes that share expressions with MIR149: view

Orthologs for MIR149 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR149 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-149 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-149 37
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-149 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir149 37
  • 95 (a)
OneToOne
Species with no ortholog for MIR149:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR149 Gene

ENSEMBL:
Gene Tree for MIR149 (if available)
TreeFam:
Gene Tree for MIR149 (if available)

Paralogs for MIR149 Gene

No data available for Paralogs for MIR149 Gene

Variants for MIR149 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR149 Gene

Variant ID Type Subtype PubMed ID
nsv876116 CNV Loss 21882294
nsv834585 CNV Loss 17160897
dgv4468n71 CNV Loss 21882294
nsv876125 CNV Loss 21882294
nsv508899 CNV Insertion 20534489
nsv876127 CNV Loss 21882294
dgv4469n71 CNV Loss 21882294
nsv460157 CNV Loss 19166990
dgv1295e1 CNV Complex 17122850
nsv876132 CNV Loss 21882294
nsv516179 CNV Loss 19592680
nsv876133 CNV Loss 21882294
nsv460158 CNV Loss 19166990
nsv819854 CNV Gain 19587683
dgv4470n71 CNV Loss 21882294
essv1993 CNV CNV 17122850
nsv876136 CNV Loss 21882294

Relevant External Links for MIR149 Gene

HapMap Linkage Disequilibrium report
MIR149
Human Gene Mutation Database (HGMD)
MIR149

No data available for Sequence variations from dbSNP and Humsavar for MIR149 Gene

Disorders for MIR149 Gene

(2) MalaCards Diseases for MIR149 Gene

Search for MIR149 Gene in MalaCards »

Relevant External Links for MIR149

Genetic Association Database (GAD)
MIR149
Human Genome Epidemiology (HuGE) Navigator
MIR149
genes like me logo Genes that share disorders with MIR149: view

No data available for UniProtKB/Swiss-Prot for MIR149 Gene

Publications for MIR149 Gene

  1. Functional variant in microRNA-196a2 contributes to the susceptibility of congenital heart disease in a Chinese population. (PMID: 19514064) Xu J. … Chen Y. (Hum. Mutat. 2009) 3 49
  2. Common genetic variants in pre-microRNAs are associated with risk of coal workers' pneumoconiosis. (PMID: 19881472) Wang M. … Ni C. (J. Hum. Genet. 2010) 3 49
  3. Single nucleotide polymorphisms in miRNA binding sites and miRNA genes as breast/ovarian cancer risk modifiers in Jewish high-risk women. (PMID: 19950226) Kontorovich T. … Friedman E. (Int. J. Cancer 2010) 3 49
  4. Genetic variants in selected pre-microRNA genes and the risk of squamous cell carcinoma of the head and neck. (PMID: 20549817) Liu Z. … Wei Q. (Cancer 2010) 3 49
  5. miR-149* induces apoptosis by inhibiting Akt1 and E2F1 in human cancer cells. (PMID: 20623644) Lin R.J. … Yu A.L. (Mol. Carcinog. 2010) 3

Products for MIR149 Gene

Sources for MIR149 Gene

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