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Aliases for MIR148B Gene

Subcategory (RNA class) for MIR148B Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR148B Gene

  • MicroRNA 148b 2 3 5
  • Hsa-Mir-148b 3
  • Mir-148b 3
  • MIRN148B 3

External Ids for MIR148B Gene

ORGUL Members for MIR148B Gene

Previous HGNC Symbols for MIR148B Gene

  • MIRN148B

Previous GeneCards Identifiers for MIR148B Gene

  • GC12P053019
  • GC12P054731

Summaries for MIR148B Gene

Entrez Gene Summary for MIR148B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR148B Gene

MIR148B (MicroRNA 148b) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are miRNA targets in ECM and membrane receptors and Metastatic brain tumor.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR148B Gene

Genomics for MIR148B Gene

Regulatory Elements for MIR148B Gene

Enhancers for MIR148B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G054354 2.1 FANTOM5 Ensembl ENCODE dbSUPER 12.4 +20.8 20786 6.6 FEZF1 YBX1 YY1 ZNF143 ZNF263 SP3 MCM3 NFYC TBX21 MEF2D MAP3K12 CBX5 GPR84 ZNF385A HOXC8 HOXC9 SP1 ENSG00000258086 ENSG00000258344 MIR148B
GH12G054291 1.9 FANTOM5 Ensembl ENCODE dbSUPER 12.7 -40.1 -40105 11.8 HDGF PKNOX1 CREB3L1 ARNT ARID4B SIN3A YBX1 DMAP1 ZNF2 YY1 HNRNPA1 MAP3K12 ITGA5 RNU6-950P MIR148B GPR84 ZNF385A FLJ12825 GTSF1 AAAS
GH12G054306 1.6 FANTOM5 Ensembl ENCODE 12.6 -30.0 -30011 2.1 HDGF PKNOX1 ATF1 CREB3L1 ZNF121 ZNF766 DEK SP3 SP5 YY2 NFE2 MIR148B GPR84 SMUG1 NCKAP1L ZNF385A COPZ1 GC12M054318 RNU6-950P
GH12G054285 1.6 Ensembl ENCODE dbSUPER 12.3 -49.0 -49046 6.0 HNRNPUL1 PKNOX1 FOXA2 AGO1 SIN3A FEZF1 ZNF2 YY1 ZNF766 KLF13 RNU6-950P GPR84 ENSG00000270175 MIR148B GTSF1 FLJ12825 HNRNPA1 NFE2
GH12G054367 1.6 Ensembl ENCODE dbSUPER 12 +33.1 33124 4.9 PKNOX1 ARNT AGO1 SIN3A ZNF2 ZNF143 DEK REST SMARCB1 ZNF592 MIR148B MAP3K12 CBX5 ENSG00000260470 ITGA5 GPR84 FLJ12825 ZNF385A HNRNPA1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR148B on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR148B Gene

Chromosome:
12
Start:
54,337,216 bp from pter
End:
54,337,314 bp from pter
Size:
99 bases
Orientation:
Plus strand

Genomic View for MIR148B Gene

Genes around MIR148B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR148B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR148B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR148B Gene

Proteins for MIR148B Gene

Post-translational modifications for MIR148B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR148B Gene

Domains & Families for MIR148B Gene

Gene Families for MIR148B Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR148B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR148B Gene

Function for MIR148B Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR148B Gene

Localization for MIR148B Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR148B Gene

Pathways & Interactions for MIR148B Gene

genes like me logo Genes that share pathways with MIR148B: view

Pathways by source for MIR148B Gene

Interacting Proteins for MIR148B Gene

Gene Ontology (GO) - Biological Process for MIR148B Gene

None

No data available for SIGNOR curated interactions for MIR148B Gene

Drugs & Compounds for MIR148B Gene

No Compound Related Data Available

Transcripts for MIR148B Gene

mRNA/cDNA for MIR148B Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR148B Gene

No ASD Table

Relevant External Links for MIR148B Gene

GeneLoc Exon Structure for
MIR148B
ECgene alternative splicing isoforms for
MIR148B

Expression for MIR148B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR148B Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR148B Gene:

MIR148B
genes like me logo Genes that share expression patterns with MIR148B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR148B Gene

Orthologs for MIR148B Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR148B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia bta-mir-148b 35
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-148b 35
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-148b 35
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir148b 35
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-148b 35
  • 89 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-148 35
  • 72 (a)
ManyToMany
Species where no ortholog for MIR148B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR148B Gene

ENSEMBL:
Gene Tree for MIR148B (if available)
TreeFam:
Gene Tree for MIR148B (if available)

Paralogs for MIR148B Gene

No data available for Paralogs for MIR148B Gene

Variants for MIR148B Gene

Sequence variations from dbSNP and Humsavar for MIR148B Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1001690106 -- 54,336,082(+) TCATT(A/G)TAGTT intron-variant, upstream-variant-2KB
rs1002118569 -- 54,335,472(+) GGTGC(C/G)ATCTC intron-variant, upstream-variant-2KB
rs1003367317 -- 54,337,655(+) AAGCT(C/G)CTGGC intron-variant, downstream-variant-500B
rs1004088790 -- 54,336,806(+) ATCAT(A/G)AGGTC intron-variant, upstream-variant-2KB
rs1004668571 -- 54,337,064(+) CAAAG(A/T)TTCAT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR148B Gene

Variant ID Type Subtype PubMed ID
nsv1049160 CNV gain 25217958

Relevant External Links for MIR148B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR148B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR148B Gene

Disorders for MIR148B Gene

Relevant External Links for MIR148B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR148B

No disorders were found for MIR148B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR148B Gene

Publications for MIR148B Gene

  1. MicroRNA-148b targets Rho-associated protein kinase 1 to inhibit cell proliferation, migration and invasion in hepatocellular carcinoma. (PMID: 26530325) Chen X. … Chen Q. (Mol Med Rep 2016) 3 64
  2. MicroRNA-148b enhances proliferation and apoptosis in human renal cancer cells via directly targeting MAP3K9. (PMID: 26573018) Nie F. … Chen T. (Mol Med Rep 2016) 3 64
  3. In a retrospective international study, circulating miR-148b and let-7b were found to be serum markers for detecting primary IgA nephropathy. (PMID: 26581012) Serino G. … Schena F.P. (Kidney Int. 2016) 3 64
  4. MicroRNA-148b is a potential prognostic biomarker and predictor of response to radiotherapy in non-small-cell lung cancer. (PMID: 27083571) Wang R. … Liu J. (J. Physiol. Biochem. 2016) 3 64
  5. MicroRNA-148b Acts as a Tumor Suppressor in Cervical Cancer by Inducing G1/S-Phase Cell Cycle Arrest and Apoptosis in a Caspase-3-Dependent Manner. (PMID: 27505047) Mou Z. … Xu J. (Med. Sci. Monit. 2016) 3 64

Products for MIR148B Gene

Sources for MIR148B Gene

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