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Aliases for MIR148B Gene

Subcategory (RNA class) for MIR148B Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR148B Gene

  • MicroRNA 148b 2 3 5
  • Hsa-Mir-148b 3
  • Mir-148b 3
  • MIRN148B 3

External Ids for MIR148B Gene

ORGUL Members for MIR148B Gene

Previous HGNC Symbols for MIR148B Gene

  • MIRN148B

Previous GeneCards Identifiers for MIR148B Gene

  • GC12P053019
  • GC12P054731

Summaries for MIR148B Gene

Entrez Gene Summary for MIR148B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR148B Gene

MIR148B (MicroRNA 148b) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are miRNA targets in ECM and membrane receptors and Metastatic brain tumor.

Additional gene information for MIR148B Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR148B Gene

Genomics for MIR148B Gene

GeneHancer (GH) Regulatory Elements for MIR148B Gene

Promoters and enhancers for MIR148B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I054336 Enhancer 1.3 Ensembl ENCODE dbSUPER 550.8 +1.0 1021 2.6 ARNT TCF12 GATA2 ARID2 FOS NCOA1 REST MEF2D MAFF SMARCA4 MIR148B GC12P054339 GC12P054338 GPR84 RNU6-950P COPZ1 CBX5 RN7SL744P ENSG00000258344
GH12I054337 Enhancer 0.7 ENCODE 550.8 -0.6 -574 0.2 BCOR HDAC1 CTCF ZBTB6 NFATC3 ARNT ZNF384 E4F1 RAD21 FOXK2 GC12P054338 GC12P054339 MIR148B GC12P054329 COPZ1 ENSG00000258344
GH12I054291 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 12.7 -40.1 -40104 11.8 HDGF PKNOX1 SMAD1 ARNT ARID4B YBX1 DMAP1 ZNF2 POLR2B ZNF766 NFE2 HNRNPA1 RNU6-950P MIR148B GPR84 ZNF385A FLJ12825 GTSF1 AAAS COPZ1
GH12I054381 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 12 +49.5 49525 10.5 HDGF PKNOX1 CLOCK IRF4 FOS SP3 ZNF592 SMARCA4 GLIS1 ZNF624 ZNF385A GPR84 MAP3K12 MIR148B ITGA5 RNU6-950P COPZ1 GTSF1 FLJ12825 ENSG00000258086
GH12I054354 Enhancer 1.9 FANTOM5 Ensembl ENCODE dbSUPER 12.4 +20.8 20786 6.6 FEZF1 YBX1 IRF4 YY1 ZNF213 E2F8 ZNF143 MCM3 SP3 NFYC SP1 PCBP2 ENSG00000258344 CBX5 GPR84 ZNF385A MAP3K12 ATF7 LOC100652999 HNRNPA1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR148B on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR148B Gene

Genomic Locations for MIR148B Gene
chr12:54,337,216-54,337,314
(GRCh38/hg38)
Size:
99 bases
Orientation:
Plus strand
chr12:54,731,000-54,731,098
(GRCh37/hg19)

Genomic View for MIR148B Gene

Genes around MIR148B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR148B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR148B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR148B Gene

Proteins for MIR148B Gene

Post-translational modifications for MIR148B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR148B Gene

Domains & Families for MIR148B Gene

Gene Families for MIR148B Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR148B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR148B Gene

Function for MIR148B Gene

Phenotypes From GWAS Catalog for MIR148B Gene

Gene Ontology (GO) - Molecular Function for MIR148B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 20829195
genes like me logo Genes that share ontologies with MIR148B: view

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR148B Gene

Localization for MIR148B Gene

Gene Ontology (GO) - Cellular Components for MIR148B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 26646931
genes like me logo Genes that share ontologies with MIR148B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR148B Gene

Pathways & Interactions for MIR148B Gene

genes like me logo Genes that share pathways with MIR148B: view

Pathways by source for MIR148B Gene

Interacting Proteins for MIR148B Gene

Gene Ontology (GO) - Biological Process for MIR148B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IDA 20829195
genes like me logo Genes that share ontologies with MIR148B: view

No data available for SIGNOR curated interactions for MIR148B Gene

Drugs & Compounds for MIR148B Gene

No Compound Related Data Available

Transcripts for MIR148B Gene

mRNA/cDNA for MIR148B Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR148B Gene

No ASD Table

Relevant External Links for MIR148B Gene

GeneLoc Exon Structure for
MIR148B
ECgene alternative splicing isoforms for
MIR148B

Expression for MIR148B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR148B Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR148B Gene:

MIR148B
genes like me logo Genes that share expression patterns with MIR148B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR148B Gene

Orthologs for MIR148B Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR148B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia bta-mir-148b 34
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-148b 34
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-148b 34
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir148b 34
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-148b 34
  • 89 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-148 34
  • 72 (a)
ManyToMany
Species where no ortholog for MIR148B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR148B Gene

ENSEMBL:
Gene Tree for MIR148B (if available)
TreeFam:
Gene Tree for MIR148B (if available)

Paralogs for MIR148B Gene

No data available for Paralogs for MIR148B Gene

Variants for MIR148B Gene

Sequence variations from dbSNP and Humsavar for MIR148B Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1001690106 -- 54,336,082(+) A/G upstream_transcript_variant
rs1002118569 -- 54,335,472(+) G/A/C/T upstream_transcript_variant
rs1003367317 -- 54,337,655(+) G/C downstream_transcript_variant
rs1004088790 -- 54,336,806(+) G/A upstream_transcript_variant
rs1004668571 -- 54,337,064(+) A/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR148B Gene

Variant ID Type Subtype PubMed ID
nsv1049160 CNV gain 25217958

Additional Variant Information for MIR148B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR148B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR148B Gene

Disorders for MIR148B Gene

Additional Disease Information for MIR148B

No disorders were found for MIR148B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR148B Gene

Publications for MIR148B Gene

  1. The role of the miR-148/-152 family in physiology and disease. (PMID: 28880997) Friedrich M … Seliger B (European journal of immunology 2017) 3 58
  2. MicroRNA-148b regulates megalin expression and is associated with receptor downregulation in mice with unilateral ureteral obstruction. (PMID: 28331063) Wen L … Birn H (American journal of physiology. Renal physiology 2017) 3 58
  3. Proteasome beta-4 subunit contributes to the development of melanoma and is regulated by miR-148b. (PMID: 28656878) Zhang X … Han S (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2017) 3 58
  4. Association of MicroRNAs and YRNAs With Platelet Function. (PMID: 26646931) Kaudewitz D … Mayr M (Circulation research 2016) 3 58
  5. MicroRNA-148b targets Rho-associated protein kinase 1 to inhibit cell proliferation, migration and invasion in hepatocellular carcinoma. (PMID: 26530325) Chen X … Chen Q (Molecular medicine reports 2016) 3 58

Products for MIR148B Gene

Sources for MIR148B Gene

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