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Aliases for MIR148B Gene

Subcategory (RNA class) for MIR148B Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR148B Gene

  • MicroRNA 148b 2 3 5
  • Hsa-Mir-148b 3
  • Mir-148b 3
  • MIRN148B 3

External Ids for MIR148B Gene

ORGUL Members for MIR148B Gene

Previous HGNC Symbols for MIR148B Gene

  • MIRN148B

Previous GeneCards Identifiers for MIR148B Gene

  • GC12P053019
  • GC12P054731

Summaries for MIR148B Gene

Entrez Gene Summary for MIR148B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR148B Gene

MIR148B (MicroRNA 148b) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR148B Gene

Genomics for MIR148B Gene

Regulatory Elements for MIR148B Gene

Enhancers for MIR148B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F054291 0.8 FANTOM5 ENCODE 12.7 -40.1 -40105 11.8 HDGF PKNOX1 ARNT CREB3L1 SIN3A ARID4B DMAP1 ZNF2 YY1 ZNF143 HNRNPA1 AAAS MAP3K12 ITGA5 RNU6-950P MIR148B GPR84 NFE2 ZNF385A FLJ12825
GH12F054303 1 FANTOM5 Ensembl ENCODE 12.6 -31.5 -31480 5.1 HDGF PKNOX1 ARNT CREB3L1 ARID4B DMAP1 KLF13 DEK SP3 SP5 NFE2 MAP3K12 AAAS OR6C74 OR10A7 LOC105378250 MIR148B GPR84 GTSF1 SMUG1
GH12F054354 1.4 FANTOM5 Ensembl ENCODE 12.4 +20.8 20841 6.7 FEZF1 YBX1 YY1 ZNF143 ZNF263 MCM3 SP3 NFYC TBX21 MEF2D SP1 ENSG00000258344 GPR84 ZNF385A LOC100652999 OR10A7 OR6C74 LOC105378250 MAP3K12 ENSG00000258086
GH12F054285 0.8 Ensembl ENCODE 12.3 -49.1 -49079 6.0 PKNOX1 SIN3A FEZF1 ZNF2 YY1 ZNF121 GLIS2 GATA2 KLF7 ZNF263 SP1 RNU6-950P GPR84 ENSG00000270175 MIR148B NFE2 GTSF1 FLJ12825 HNRNPA1
GH12F054373 0.9 FANTOM5 ENCODE 12 +38.2 38207 4.6 KLF1 ZNF146 PKNOX1 KLF17 ZIC2 ZFHX2 ZNF316 GLIS2 PRDM10 MAFK MIR148B RNU6-950P COPZ1 ITGA5 ZNF385A HOXC12 HNRNPA1 GPR84
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR148B on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR148B Gene

Chromosome:
12
Start:
54,337,216 bp from pter
End:
54,337,314 bp from pter
Size:
99 bases
Orientation:
Plus strand

Genomic View for MIR148B Gene

Genes around MIR148B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR148B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR148B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR148B Gene

Proteins for MIR148B Gene

Post-translational modifications for MIR148B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR148B Gene

Domains & Families for MIR148B Gene

Gene Families for MIR148B Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR148B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR148B Gene

Function for MIR148B Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR148B Gene

Localization for MIR148B Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR148B Gene

Pathways & Interactions for MIR148B Gene

SuperPathways for MIR148B Gene

No Data Available

Interacting Proteins for MIR148B Gene

Gene Ontology (GO) - Biological Process for MIR148B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR148B Gene

Transcripts for MIR148B Gene

mRNA/cDNA for MIR148B Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR148B Gene

No ASD Table

Relevant External Links for MIR148B Gene

GeneLoc Exon Structure for
MIR148B
ECgene alternative splicing isoforms for
MIR148B

Expression for MIR148B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR148B Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR148B Gene:

MIR148B
genes like me logo Genes that share expression patterns with MIR148B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR148B Gene

Orthologs for MIR148B Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR148B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia bta-mir-148b 35
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-148b 35
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-148b 35
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir148b 35
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-148b 35
  • 89 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-148 35
  • 72 (a)
ManyToMany
Species where no ortholog for MIR148B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR148B Gene

ENSEMBL:
Gene Tree for MIR148B (if available)
TreeFam:
Gene Tree for MIR148B (if available)

Paralogs for MIR148B Gene

No data available for Paralogs for MIR148B Gene

Variants for MIR148B Gene

Sequence variations from dbSNP and Humsavar for MIR148B Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs11170876 -- 54,336,354(+) cctgg(C/T)tacag intron-variant, upstream-variant-2KB
rs112169849 -- 54,336,416(+) GGTGC(A/G)TGTAG intron-variant, upstream-variant-2KB
rs113484236 -- 54,337,525(+) TTATC(A/C)GTAAT intron-variant, downstream-variant-500B
rs116206655 -- 54,335,402(+) ATGGC(C/T)TTAGG intron-variant, upstream-variant-2KB
rs117083250 -- 54,337,743(+) CTCCT(C/T)TGGAA intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for MIR148B Gene

Variant ID Type Subtype PubMed ID
nsv1049160 CNV gain 25217958

Relevant External Links for MIR148B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR148B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR148B Gene

Disorders for MIR148B Gene

Relevant External Links for MIR148B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR148B

No disorders were found for MIR148B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR148B Gene

Publications for MIR148B Gene

  1. MicroRNA-148b targets Rho-associated protein kinase 1 to inhibit cell proliferation, migration and invasion in hepatocellular carcinoma. (PMID: 26530325) Chen X. … Chen Q. (Mol Med Rep 2016) 3 64
  2. MicroRNA-148b enhances proliferation and apoptosis in human renal cancer cells via directly targeting MAP3K9. (PMID: 26573018) Nie F. … Chen T. (Mol Med Rep 2016) 3 64
  3. In a retrospective international study, circulating miR-148b and let-7b were found to be serum markers for detecting primary IgA nephropathy. (PMID: 26581012) Serino G. … Schena F.P. (Kidney Int. 2016) 3 64
  4. Altered p53 regulation of miR-148b and p55PIK contributes to tumor progression in colorectal cancer. (PMID: 24632606) Wang G. … Hu J. (Oncogene 2015) 3 64
  5. Serum miR-152, miR-148a, miR-148b, and miR-21 as novel biomarkers in non-small cell lung cancer screening. (PMID: 25501703) Yang J.S. … Song C.H. (Tumour Biol. 2015) 3 64

Products for MIR148B Gene

Sources for MIR148B Gene

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