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microRNA 148a(Previous name: microRNA 148 )
(Previous symbols: MIRN148, MIRN148A)
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Aliases
for MIR148A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
Subcategory (RNA class): miRNA
Quality score for this RNA gene is 3
| Aliases |
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| MicroRNA 148a1 2 | | Hsa-Mir-148a1 | | MIRN1481 2 | | MicroRNA 1481 | | MIRN148A1 2 | | Mir-148a1 | | Hsa-Mir-1481 | | |
Export aliases for MIR148A gene to outside databasesPrevious GC identifer: GC07M025957 |
Summaries
for MIR148A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MIR148A:
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of geneexpression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribedby RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be eitherprotein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce anapproximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicerribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporatedinto a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with themiRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeqrepresents the predicted microRNA stem-loop. (provided by RefSeq, Sep 2009)
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Genomic Views
for MIR148A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for MIR148A
Other transcription factors
Search SABiosciences Chromatin IP Primers for MIR148A
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MIR148A |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7p15.2 Ensembl cytogenetic band: 7p15.2 HGNC cytogenetic band: 7p15.2MIR148A Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07M025990: view genomic region (via miRBase)
(about GC identifiers)
Start:
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25,989,539 bp from pter |
End:
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25,989,606 bp from pter |
Size:
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68 bases |
Orientation:
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minus strand |
1 alternative location:
| Chr7-,CRA_TCAG 26,040,542-26,040,609 |
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Proteins
for MIR148A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
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UniProtKB: --
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Protein
Domains /
Families
for MIR148A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
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Function
for MIR148A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
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Pathways & Interactions
for MIR148A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MIR148A
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Drugs & Compounds
for MIR148A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
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 Browse Tocris compounds for MIR148A
Search CenterWatch for drugs/clinical trials and news about MIR148A 
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Transcripts
for MIR148A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
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1 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000362215(miRNA)
GeneLoc Exon Structure
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Expression
for MIR148A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| Expression evidence for MIR148A:none
MIR148A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image SABiosciences Custom PCR Arrays for MIR148A
Primer
Products: |  | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat MIR148A | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MIR148A | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MIR148A |
Orthologs
for MIR148A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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ENSEMBL Gene Tree for MIR148A (if available)
TreeFam Gene Tree for MIR148A (if available) |
Paralogs
for MIR148A gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MIR148A gene
- MIR1522 MIR148B2
MIR148A for paralogs About GeneDecksing
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Genomic Variants
for MIR148A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
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| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 7 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
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HapMap Linkage Disequilibrium report for MIR148A (25989539 - 25989606 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MIR148A: -- | SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for MIR148A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
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MIR148A for disorders About GeneDecksing
OMIM gene information: 613786
OMIM disorders: --
9  diseases for MIR148A: About MalaCardspanic disorder esophageal carcinoma esophagitis gastric cancer
prostate cancer prostatitis melanoma carcinoma
neuronitis
Export disorders for MIR148A gene to outside databases
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Publications
for MIR148A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
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PubMed articles for MIR148A gene, integrated from 9 sources (see all 18):
(articles sorted by number of sources associating them with MIR148A) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- MiRNA-mediated control of HLA-G expression and functio n. (PubMed id 22438923)1 Manaster I....Mandelboim O. (2012)
- Role of miR-148a in hepatitis B associated hepatocellu lar carcinoma. (PubMed id 22496917)1 Yuan K....Feitelson M.A. (2012)
- Altered expression of miR-152 and miR-148a in ovarian cancer is related to cell proliferation. (PubMed id 21971665)1 Zhou X....Xu H.M. (2012)
- MicroRNA-148a suppresses tumor cell invasion and metas tasis by downregulating ROCK1 in gastric cancer. (PubMed id 21994419)1 Zheng B....Shi Y. (2011)
- Human microRNAs miR-22, miR-138-2, miR-148a, and miR- 488 are associated with panic disorder and regulate several anxiety candidate g enes and related pathways. (PubMed id 21168126)1 MuiA+os-Gimeno M....Estivill X. (2011)
- MiRNAs and their association with locoregional stagin g and survival following surgery for esophageal carcinoma. (PubMed id 20628822)1 Hummel R....Watson D.I. (2011)
- MiR-148a promotes apoptosis by targeting Bcl-2 in col orectal cancer. (PubMed id 21455217)1 Zhang H....Lai M. (2011)
- Combined mRNA and microRNA profiling reveals that miR -148a and miR-20b control human mesenchymal stem cell phenotype via EPAS1. (PubMed id 21081659)1 Giraud-Triboult K....PiActu G. (2011)
- Altered methylation at microRNA-associated CpG island s in hereditary and sporadic carcinomas: a methylation-specific multiplex ligat ion-dependent probe amplification (MS-MLPA)-based approach. (PubMed id 21327300)1 Pavicic W....PeltomAoki P. (2011)
- miR-148a promoted cell proliferation by targeting p27 in gastric cancer cells. (PubMed id 21552422)1 Guo S.L....Yang X. (2011)
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External Searches for MIR148A gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing MIR148A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
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Other Databases showing MIR148A gene
(According to HUGE)
About This Section
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Specialized Databases showing MIR148A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
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| Name | Description |
| PharmGKB entry for MIR148A | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for MIR148A gene:
Search GeneIP for patents involving MIR148A
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for MIR148A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MIR148A | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MIR148A | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MIR148A | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MIR148A | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MIR148A | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MIR148A |
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| | | | Search Tocris compounds for MIR148A |
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 | | | | |  |  |  | | | | Search ThermoFisher Antibodies for MIR148A |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MIR148A |
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