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Aliases for MIR148A Gene

Subcategory (RNA class) for MIR148A Gene

miRNA

Quality Score for this RNA gene is

10.2

Aliases for MIR148A Gene

  • MicroRNA 148a 2 3 5
  • MicroRNA 148 2 3
  • Hsa-Mir-148a 3
  • Hsa-Mir-148 3
  • Mir-148a 3
  • MIRN148A 3
  • MIRN148 3

External Ids for MIR148A Gene

Previous HGNC Symbols for MIR148A Gene

  • MIRN148
  • MIRN148A

Previous GeneCards Identifiers for MIR148A Gene

  • GC07M025957
  • GC07M025990

Summaries for MIR148A Gene

Entrez Gene Summary for MIR148A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR148A Gene

MIR148A (MicroRNA 148a) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are miR-148a/miR-31/FIH1/HIF1andalpha;-Notch signaling in glioblastoma and Metastatic brain tumor.

fRNAdb sequence ontologies for MIR148A Gene

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR148A

Additional gene information for MIR148A Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR148A Gene

Genomics for MIR148A Gene

Regulatory Elements for MIR148A Gene

Enhancers for MIR148A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07H025892 1.3 Ensembl ENCODE 12 +55.7 55741 3.6 PKNOX1 YY1 ETS1 ELK1 ZNF143 ATF7 RUNX3 DEK SP3 YY2 MIR148A NFE2L3 LOC100506236 LOC105375200
GH07H026001 0.8 ENCODE 11.1 -52.0 -51952 1.1 FOXA2 RARA CREM MIXL1 HMG20B PPARG NFIL3 CEBPA KDM1A SOX13 MIR148A PIR39133 GC07P025973
GH07H026005 0.7 ENCODE 11.8 -56.9 -56858 3.2 ATF1 ZNF10 CEBPB ZNF398 ZNF2 ATF2 RARA CREB1 ZNF24 ATF7 MIR148A HNRNPA2B1 CBX3 NFE2L3 PIR39133 GC07P025973
GH07H025922 0.4 ENCODE 11.8 +27.4 27399 0.9 FOSL1 MIR148A LOC105375200 LOC100506236
GH07H025947 2 FANTOM5 Ensembl ENCODE dbSUPER 0.7 -0.5 -486 5.9 FOXA2 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF766 HNRNPA2B1 MIR148A GC07P025973
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR148A on UCSC Golden Path with GeneCards custom track

Promoters for MIR148A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000209725 -1014 2001 ATF1 MLX SIN3A FEZF1 DMAP1 YY1 ZNF766 GLIS2 ATF7 SP5

Genomic Locations for MIR148A Gene

Genomic Locations for MIR148A Gene
chr7:25,949,919-25,949,986
(GRCh38/hg38)
Size:
68 bases
Orientation:
Minus strand
chr7:25,989,539-25,989,606
(GRCh37/hg19)

Genomic View for MIR148A Gene

Genes around MIR148A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR148A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR148A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR148A Gene

ORGUL Member Location for MIR148A Gene

ORGUL Member Location for MIR148A gene

Proteins for MIR148A Gene

Post-translational modifications for MIR148A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR148A Gene

Domains & Families for MIR148A Gene

Gene Families for MIR148A Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR148A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR148A Gene

Function for MIR148A Gene

Phenotypes From GWAS Catalog for MIR148A Gene

Gene Ontology (GO) - Molecular Function for MIR148A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 20483747
genes like me logo Genes that share ontologies with MIR148A: view

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR148A Gene

Localization for MIR148A Gene

Gene Ontology (GO) - Cellular Components for MIR148A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 26646931
genes like me logo Genes that share ontologies with MIR148A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR148A Gene

Pathways & Interactions for MIR148A Gene

genes like me logo Genes that share pathways with MIR148A: view

Pathways by source for MIR148A Gene

Interacting Proteins for MIR148A Gene

Gene Ontology (GO) - Biological Process for MIR148A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010985 negative regulation of lipoprotein particle clearance ISS --
GO:0035195 gene silencing by miRNA IDA 20483747
GO:0042632 cholesterol homeostasis ISS --
GO:0055088 lipid homeostasis ISS --
GO:0090370 negative regulation of cholesterol efflux IDA 26501192
genes like me logo Genes that share ontologies with MIR148A: view

No data available for SIGNOR curated interactions for MIR148A Gene

Drugs & Compounds for MIR148A Gene

No Compound Related Data Available

Transcripts for MIR148A Gene

fRNAdb Secondary structures for MIR148A Gene

  • hsa-miR-148a-5p_MIMAT0004549_Homo_sapiens_miR-148a-5p_mature
  • hsa-mir-148a_MI0000253_Homo_sapiens_miR-148a_stem-loop_hairpin

mRNA/cDNA for MIR148A Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR148A Gene

No ASD Table

Relevant External Links for MIR148A Gene

GeneLoc Exon Structure for
MIR148A
ECgene alternative splicing isoforms for
MIR148A

Expression for MIR148A Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR148A Gene:

MIR148A
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR148A Gene

Orthologs for MIR148A Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR148A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-148a 34
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-148a 34
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-148a 34
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-148 34
  • 74 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir148a 34
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-148a 34
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-148a 34
  • 63 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii BX546447.1 34
  • 67 (a)
ManyToMany
Species where no ortholog for MIR148A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR148A Gene

ENSEMBL:
Gene Tree for MIR148A (if available)
TreeFam:
Gene Tree for MIR148A (if available)

Paralogs for MIR148A Gene

No data available for Paralogs for MIR148A Gene

Variants for MIR148A Gene

Sequence variations from dbSNP and Humsavar for MIR148A Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1002719409 -- 25,949,659(+) AAAGC(-/TTTATT)TTTAT intron-variant, downstream-variant-500B
rs1002903768 -- 25,951,675(+) TGTCT(-/CCTGGC)CCTGG intron-variant, upstream-variant-2KB
rs1003284882 -- 25,951,119(+) CTCCC(A/C/G)CCTCG intron-variant, upstream-variant-2KB
rs1003315917 -- 25,950,893(+) CCATC(C/T)CCCGC intron-variant, upstream-variant-2KB
rs1005643732 -- 25,950,808(+) CATAC(C/T)GCACC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR148A Gene

Variant ID Type Subtype PubMed ID
nsv7393 OTHER inversion 18451855
nsv606432 CNV gain 21841781
nsv1126776 CNV deletion 24896259

Relevant External Links for MIR148A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR148A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR148A Gene

Disorders for MIR148A Gene

Relevant External Links for MIR148A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR148A

No disorders were found for MIR148A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR148A Gene

Publications for MIR148A Gene

  1. Identification of human fetal liver miRNAs by a novel method. (PMID: 15978578) Fu H … Zheng X (FEBS letters 2005) 1 3 60
  2. Identification of tissue-specific microRNAs from mouse. (PMID: 12007417) Lagos-Quintana M … Tuschl T (Current biology : CB 2002) 1 3 60
  3. miR-148a suppresses human renal cell carcinoma malignancy by targeting AKT2. (PMID: 27878305) Cao H … Zhu M (Oncology reports 2017) 3 60
  4. MiR-148a and miR-152 reduce tamoxifen resistance in ER+ breast cancer via downregulating ALCAM. (PMID: 28063929) Chen MJ … Shen CJ (Biochemical and biophysical research communications 2017) 3 60
  5. miR-148a increases the sensitivity to cisplatin by targeting Rab14 in renal cancer cells. (PMID: 28098870) Kim EA … Lee TJ (International journal of oncology 2017) 3 60

Products for MIR148A Gene

Sources for MIR148A Gene

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