Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MIR147B Gene

Subcategory (RNA class) for MIR147B Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR147B Gene

  • MicroRNA 147b 2 3
  • C15orf48 4 5
  • Chromosome 15 Open Reading Frame 48 5
  • Protein FOAP-11 4
  • Hsa-Mir-147b 3
  • Mir-147b 3
  • MIRN147B 3
  • NMES1 4

External Ids for MIR147B Gene

Previous HGNC Symbols for MIR147B Gene

  • MIRN147B

Previous GeneCards Identifiers for MIR147B Gene

  • GC15P043514
  • GC15P045725

Summaries for MIR147B Gene

Entrez Gene Summary for MIR147B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR147B Gene

MIR147B (MicroRNA 147b) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR147B Gene

Genomics for MIR147B Gene

Regulatory Elements for MIR147B Gene

Enhancers for MIR147B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15F045454 1.3 FANTOM5 ENCODE 12.4 +26.0 25960 4.4 ATF1 SIN3A FEZF1 GLI4 BRCA1 ZNF143 FOS SP3 ZHX2 JUNB C15orf48 LOC100533853 SPATA5L1 MIR147B SLC30A4 SQRDL BLOC1S6 GC15P045452 GC15M045480
GH15F045400 0.6 ENCODE 11.2 -27.8 -27826 3.4 PKNOX1 MLX WRNIP1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 YY1 SLC30A9 SPATA5L1 CTDSPL2 C15orf48 EIF3J-AS1 HNRNPMP1 BLOC1S6 MIR147B RNU7-5P SQRDL DUOX2
GH15F045399 0.2 ENCODE 10.8 -30.7 -30732 0.2 GATAD2A CTCF ZNF654 ZNF792 ARID4B PPARG RAD21 RFX5 IKZF1 ZNF143 MIR147B C15orf48 DUOX1 DUOXA1 SPATA5L1 PIR55932
GH15F045475 1.2 FANTOM5 10.8 +45.1 45132 0.1 C15orf48 SLC30A4 RNU7-5P MIR147B SQRDL BLOC1S6 GC15M045480 GC15P045452
GH15F045476 0.9 ENCODE 10.8 +46.1 46089 0.2 SLC30A4 RNU7-5P C15orf48 MIR147B GC15M045480 GC15P045452
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR147B on UCSC Golden Path with GeneCards custom track

Promoters for MIR147B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001794581 171 1000 ATF1 CBX3 ZNF48 RAD21 GLIS2 ZNF143 CREM THAP11 SMARCA5 ZNF654

Genomic Location for MIR147B Gene

Chromosome:
15
Start:
45,430,529 bp from pter
End:
45,448,761 bp from pter
Size:
18,233 bases
Orientation:
Plus strand

Genomic View for MIR147B Gene

Genes around MIR147B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR147B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR147B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR147B Gene

Proteins for MIR147B Gene

  • Protein details for MIR147B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9C002-NMES1_HUMAN
    Recommended name:
    Normal mucosa of esophagus-specific gene 1 protein
    Protein Accession:
    Q9C002

    Protein attributes for MIR147B Gene

    Size:
    83 amino acids
    Molecular mass:
    9617 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MIR147B Gene

Post-translational modifications for MIR147B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MIR147B Gene

No data available for DME Specific Peptides for MIR147B Gene

Domains & Families for MIR147B Gene

Gene Families for MIR147B Gene

Protein Domains for MIR147B Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9C002

UniProtKB/Swiss-Prot:

NMES1_HUMAN :
  • Belongs to the complex I NDUFA4 subunit family.
Family:
  • Belongs to the complex I NDUFA4 subunit family.
genes like me logo Genes that share domains with MIR147B: view

No data available for Suggested Antigen Peptide Sequences for MIR147B Gene

Function for MIR147B Gene

Gene Ontology (GO) - Molecular Function for MIR147B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008137 NADH dehydrogenase (ubiquinone) activity IBA --
genes like me logo Genes that share ontologies with MIR147B: view

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR147B Gene

Localization for MIR147B Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIR147B Gene

Gene Ontology (GO) - Cellular Components for MIR147B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005739 mitochondrion IEA --
GO:0005751 mitochondrial respiratory chain complex IV IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MIR147B: view

No data available for Subcellular locations from COMPARTMENTS for MIR147B Gene

Pathways & Interactions for MIR147B Gene

SuperPathways for MIR147B Gene

No Data Available

Interacting Proteins for MIR147B Gene

Gene Ontology (GO) - Biological Process for MIR147B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055114 oxidation-reduction process IEA --
GO:1902600 hydrogen ion transmembrane transport IEA --
genes like me logo Genes that share ontologies with MIR147B: view

No data available for Pathways by source and SIGNOR curated interactions for MIR147B Gene

Transcripts for MIR147B Gene

mRNA/cDNA for MIR147B Gene

(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR147B Gene

No ASD Table

Relevant External Links for MIR147B Gene

GeneLoc Exon Structure for
MIR147B
ECgene alternative splicing isoforms for
MIR147B

Expression for MIR147B Gene

mRNA expression in normal human tissues for MIR147B Gene

mRNA differential expression in normal tissues according to GTEx for MIR147B Gene

This gene is overexpressed in Colon - Transverse (x25.2), Esophagus - Mucosa (x5.4), and Small Intestine - Terminal Ileum (x5.0).

NURSA nuclear receptor signaling pathways regulating expression of MIR147B Gene:

MIR147B

mRNA Expression by UniProt/SwissProt for MIR147B Gene:

Q9C002-NMES1_HUMAN
Tissue specificity: Expressed mainly in stomach, placenta, small intestine and colon, as well as in normal mucosa of esophagus. Down-regulated in esophageal squamous cell carcinoma.
genes like me logo Genes that share expression patterns with MIR147B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for MIR147B Gene

Orthologs for MIR147B Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR147B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-147b 35
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-147 35
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-147 35
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia AA467197 35
  • 72 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 64 (a)
OneToMany
-- 35
  • 57 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-147 35
  • 18 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-147 35
  • 60 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii C18H15orf48 35
  • 56 (a)
OneToOne
Species where no ortholog for MIR147B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR147B Gene

ENSEMBL:
Gene Tree for MIR147B (if available)
TreeFam:
Gene Tree for MIR147B (if available)

Paralogs for MIR147B Gene

No data available for Paralogs for MIR147B Gene

Variants for MIR147B Gene

Sequence variations from dbSNP and Humsavar for MIR147B Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs111524632 -- 45,432,383(+) ATACC(A/G)GCCAG intron-variant, upstream-variant-2KB
rs112497341 -- 45,432,392(+) AGGCA(C/T)GGTGT intron-variant, upstream-variant-2KB
rs11376524 -- 45,433,451(+) TAAGC(-/T)TTTTT downstream-variant-500B
rs1153844 -- 45,432,617(+) ttgca(A/G)ttgtg intron-variant, upstream-variant-2KB
rs1153845 -- 45,432,531(+) GTAGT(A/G)GAACG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR147B Gene

Variant ID Type Subtype PubMed ID
esv3569553 CNV gain 25503493
esv3892684 CNV gain 25118596
nsv1160292 CNV duplication 26073780
nsv469721 CNV gain 16826518
nsv569315 CNV gain 21841781

Relevant External Links for MIR147B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR147B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR147B Gene

Disorders for MIR147B Gene

Relevant External Links for MIR147B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR147B

No disorders were found for MIR147B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR147B Gene

Publications for MIR147B Gene

  1. MicroRNAs 146a and 147b biomarkers for colorectal tumor's localization. (PMID: 24800242) Omrane I. … Benammar-Elgaaied A. (Biomed Res Int 2014) 3 64
  2. MicroRNA-147b regulates vascular endothelial barrier function by targeting ADAM15 expression. (PMID: 25333931) Chatterjee V. … Yuan S.Y. (PLoS ONE 2014) 3 64
  3. "Seed-Milarity" confers to hsa-miR-210 and hsa-miR-147b similar functional activity. (PMID: 23028679) Bertero T. … Mari B. (PLoS ONE 2012) 3 64
  4. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A. … Griffiths-Jones S. (Nucleic Acids Res. 2011) 3 64
  5. A mammalian microRNA expression atlas based on small RNA library sequencing. (PMID: 17604727) Landgraf P. … Tuschl T. (Cell 2007) 3 64

Products for MIR147B Gene

Sources for MIR147B Gene

Content
Loading form....