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Aliases for MIR147A Gene

Subcategory (RNA class) for MIR147A Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR147A Gene

  • MicroRNA 147a 2 3 5
  • MicroRNA 147 2 3
  • Hsa-Mir-147a 3
  • Hsa-Mir-147 3
  • MIRN147 3
  • MIR147 3

External Ids for MIR147A Gene

Previous HGNC Symbols for MIR147A Gene

  • MIRN147
  • MIR147

Previous GeneCards Identifiers for MIR147A Gene

  • GC09M123008
  • GC09M123010
  • GC09M123013

Summaries for MIR147A Gene

Entrez Gene Summary for MIR147A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR147A Gene

MIR147A (MicroRNA 147a) is an RNA Gene, and is affiliated with the miRNA class.

fRNAdb sequence ontologies for MIR147A Gene - the ORGUL cluster for this gene includes several descriptions:

  • miRNA: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene. Micro RNAs are produced from precursor molecules (SO:0000647) that can form local hairpin structures, which ordinarily are processed (via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors.

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR147A

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR147A Gene

Genomics for MIR147A Gene

Regulatory Elements for MIR147A Gene

Enhancers for MIR147A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09F120264 0.5 ENCODE 12.2 -20.5 -20496 1.5 GATA3 ZNF366 SCRT2 MIR147A LOC105376253
GH09F120091 0.3 FANTOM5 10.2 +153.8 153825 0.0 MIR147A GC09P120186 ENSG00000225960
GH09F120325 0.9 ENCODE 0.2 -80.2 -80168 0.2 ELF3 MLX ARID4B ZSCAN9 DNMT3B RAD21 RARA KAT2B SLC30A9 GATA4 LOC105376253 MIR147A
GH09F120284 0.5 ENCODE 0.3 -39.8 -39848 0.2 HLF ZBTB33 RAD21 MIR147A LOC105376253
GH09F120383 1.2 Ensembl ENCODE 0.1 -139.3 -139317 1.6 MLX ARID4B DMAP1 ZNF48 YY1 ZHX2 MIER2 PPARG ZNF623 KAT8 LOC105376253 MIR147A
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR147A on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR147A Gene

Chromosome:
9
Start:
120,244,979 bp from pter
End:
120,245,050 bp from pter
Size:
72 bases
Orientation:
Minus strand

Genomic View for MIR147A Gene

Genes around MIR147A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR147A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR147A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR147A Gene

ORGUL Member Location for MIR147A Gene

ORGUL Member Location for MIR147A gene

Proteins for MIR147A Gene

Post-translational modifications for MIR147A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR147A Gene

Domains & Families for MIR147A Gene

Gene Families for MIR147A Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR147A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR147A Gene

Function for MIR147A Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR147A Gene

Localization for MIR147A Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR147A Gene

Pathways & Interactions for MIR147A Gene

SuperPathways for MIR147A Gene

No Data Available

Interacting Proteins for MIR147A Gene

Gene Ontology (GO) - Biological Process for MIR147A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR147A Gene

Transcripts for MIR147A Gene

fRNAdb Secondary structures for MIR147A Gene

  • hsa-miR-147a_MIMAT0000251_Homo_sapiens_miR-147a_mature

mRNA/cDNA for MIR147A Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR147A Gene

No ASD Table

Relevant External Links for MIR147A Gene

GeneLoc Exon Structure for
MIR147A
ECgene alternative splicing isoforms for
MIR147A

Expression for MIR147A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR147A Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR147A Gene:

MIR147A
genes like me logo Genes that share expression patterns with MIR147A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR147A Gene

Orthologs for MIR147A Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR147A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-147a 35
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 35
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-147b 35
  • 68 (a)
ManyToMany
-- 35
  • 66 (a)
ManyToMany
-- 35
  • 66 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 65 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-147 35
  • 43 (a)
OneToMany
chicken
(Gallus gallus)
Aves gga-mir-147 35
  • 79 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia aca-mir-147 35
  • 64 (a)
OneToMany
Species where no ortholog for MIR147A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR147A Gene

ENSEMBL:
Gene Tree for MIR147A (if available)
TreeFam:
Gene Tree for MIR147A (if available)

Paralogs for MIR147A Gene

No data available for Paralogs for MIR147A Gene

Variants for MIR147A Gene

Sequence variations from dbSNP and Humsavar for MIR147A Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs10534115 -- 120,245,299(+) TTAAA(-/AC)ACACA intron-variant, upstream-variant-2KB
rs113173421 -- 120,245,298(+) TTAAA(-/AC)ACACA intron-variant, upstream-variant-2KB
rs116769530 -- 120,245,508(+) ATCCA(C/T)GTACA intron-variant, upstream-variant-2KB
rs117532342 -- 120,245,331(+) AAAAT(A/C)GTGAA intron-variant, upstream-variant-2KB
rs11790567 -- 120,245,574(+) catca(A/G)tggat intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR147A Gene

Variant ID Type Subtype PubMed ID
nsv1048345 CNV loss 25217958
nsv7434 OTHER inversion 18451855

Relevant External Links for MIR147A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR147A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR147A Gene

Disorders for MIR147A Gene

Relevant External Links for MIR147A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR147A

No disorders were found for MIR147A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR147A Gene

Publications for MIR147A Gene

  1. Identification of tissue-specific microRNAs from mouse. (PMID: 12007417) Lagos-Quintana M. … Tuschl T. (Curr. Biol. 2002) 1 3 64
  2. Genome-wide association studies and heritability estimates of body mass index related phenotypes in Bangladeshi adults. (PMID: 25133637) Scannell Bryan M. … Ahsan H. (PLoS ONE 2014) 3 64
  3. Global microRNA level regulation of EGFR-driven cell-cycle protein network in breast cancer. (PMID: 22333974) Uhlmann S. … Sahin O. (Mol. Syst. Biol. 2012) 3 64
  4. Genome-wide association of lipid-lowering response to statins in combined study populations. (PMID: 20339536) Barber M.J. … Krauss R.M. (PLoS ONE 2010) 3 64
  5. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64

Products for MIR147A Gene

Sources for MIR147A Gene

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