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Aliases for MIR146B Gene

Subcategory (RNA class) for MIR146B Gene


Quality Score for this RNA gene is


Aliases for MIR146B Gene

  • MicroRNA 146b 2 3
  • Hsa-Mir-146b 3
  • MiRNA146B 3
  • MIRN146B 3

External Ids for MIR146B Gene

ORGUL Members for MIR146B Gene

Previous HGNC Symbols for MIR146B Gene

  • MIRN146B

Previous GeneCards Identifiers for MIR146B Gene

  • GC10P104187
  • GC10P104196

Summaries for MIR146B Gene

Entrez Gene Summary for MIR146B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR146B Gene

MIR146B (MicroRNA 146b) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR146B include sporadic breast cancer.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR146B Gene

Genomics for MIR146B Gene

Genomic Location for MIR146B Gene

102,436,500 bp from pter
102,436,609 bp from pter
110 bases
Plus strand

Genomic View for MIR146B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR146B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR146B Gene

No data available for Regulatory Elements for MIR146B Gene

Proteins for MIR146B Gene

Post-translational modifications for MIR146B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR146B Gene

Domains for MIR146B Gene

Gene Families for MIR146B Gene

  • MIR :ncRNAs / Micro RNAs

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR146B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR146B Gene

Function for MIR146B Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MIR146B Gene

Localization for MIR146B Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR146B Gene

Pathways for MIR146B Gene

SuperPathways for MIR146B Gene

No Data Available

Interacting Proteins for MIR146B Gene

Gene Ontology (GO) - Biological Process for MIR146B Gene


No data available for Pathways by source for MIR146B Gene

Transcripts for MIR146B Gene

mRNA/cDNA for MIR146B Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MIR146B

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR146B Gene

No ASD Table

Relevant External Links for MIR146B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR146B Gene

mRNA expression in normal human tissues for MIR146B Gene

genes like me logo Genes that share expressions with MIR146B: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for MIR146B Gene

Orthologs for MIR146B Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR146B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia bta-mir-146b 36
  • 66 (a)
(Canis familiaris)
Mammalia cfa-mir-146b 36
  • 80 (a)
(Monodelphis domestica)
Mammalia mdo-mir-146b 36
  • 84 (a)
(Mus musculus)
Mammalia Mir146b 36
  • 62 (a)
(Ornithorhynchus anatinus)
Mammalia oan-mir-146b 36
  • 52 (a)
(Pan troglodytes)
Mammalia ptr-mir-146b 36
  • 100 (a)
(Gallus gallus)
Aves gga-mir-146b 36
  • 50 (a)
(Anolis carolinensis)
Reptilia aca-mir-146a 36
  • 55 (a)
(Danio rerio)
Actinopterygii dre-mir-146a 36
  • 39 (a)
Species with no ortholog for MIR146B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR146B Gene

Gene Tree for MIR146B (if available)
Gene Tree for MIR146B (if available)

Paralogs for MIR146B Gene

No data available for Paralogs for MIR146B Gene

Variants for MIR146B Gene

Sequence variations from dbSNP and Humsavar for MIR146B Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs1536309 -- 102,435,445(-) GATGA(C/T)GGGGA upstream-variant-2KB
rs1926122 -- 102,436,961(-) TCTGA(A/G)AGAGG downstream-variant-500B
rs2224374 -- 102,436,708(+) TTGAC(C/T)CGGGC downstream-variant-500B
rs35920988 -- 102,436,373(+) CTCCC(-/C)TGGAA upstream-variant-2KB
rs74637481 -- 102,436,350(+) CATTT(C/T)CAGCT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR146B Gene

Variant ID Type Subtype PubMed ID
nsv895970 CNV Loss 21882294

Relevant External Links for MIR146B Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MIR146B Gene

Disorders for MIR146B Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for MIR146B Gene in MalaCards »

(1) Diseases for MIR146B Gene including...

genes like me logo Genes that share disorders with MIR146B: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for MIR146B Gene

Publications for MIR146B Gene

  1. Identification of hundreds of conserved and nonconserved human microRNAs. (PMID: 15965474) Bentwich I. … Bentwich Z. (Nat. Genet. 2005) 3
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3
  3. NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses. (PMID: 16885212) Taganov K.D. … Baltimore D. (Proc. Natl. Acad. Sci. U.S.A. 2006) 3
  4. A mammalian microRNA expression atlas based on small RNA library sequencing. (PMID: 17604727) Landgraf P. … Tuschl T. (Cell 2007) 3
  5. Expression of microRNA-146 suppresses NF-kappaB activity with reduction of metastatic potential in breast cancer cells. (PMID: 18504431) Bhaumik D. … Benz C.C. (Oncogene 2008) 3

Products for MIR146B Gene

Sources for MIR146B Gene

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