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Aliases for MIR146B Gene

Subcategory (RNA class) for MIR146B Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR146B Gene

  • MicroRNA 146b 2 3 5
  • Hsa-Mir-146b 3
  • MiRNA146B 3
  • Mir-146b 3
  • MIRN146B 3

External Ids for MIR146B Gene

ORGUL Members for MIR146B Gene

Previous HGNC Symbols for MIR146B Gene

  • MIRN146B

Previous GeneCards Identifiers for MIR146B Gene

  • GC10P104187
  • GC10P104196

Summaries for MIR146B Gene

Entrez Gene Summary for MIR146B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR146B Gene

MIR146B (MicroRNA 146b) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR146B Gene

Genomics for MIR146B Gene

Regulatory Elements for MIR146B Gene

Enhancers for MIR146B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10F102467 0.6 Ensembl ENCODE 12 +32.4 32363 2.7 ARID1B KLF1 NR2F1 IKZF1 CEBPB ZNF600 ZBTB40 SPI1 GABPA MFSD13A MIR146B CUEDC2 SUFU NFKB2 RNU6-43P FBXL15 PSD ELOVL3 RPARP-AS1
GH10F102478 0.2 ENCODE 11.6 +42.7 42716 0.9 PKNOX1 CREB3L1 ARID4B SIN3A ZNF2 ZNF143 DEK ZNF263 MXD4 MIER2 MFSD13A SUFU MIR146B CUEDC2 RNU6-43P NFKB2 ELOVL3 ENSG00000273262 GC10P102474 PIR54211
GH10F102473 0.5 ENCODE 11.6 +37.1 37087 0.2 SUFU MIR146B CUEDC2 RNU6-43P NFKB2 ELOVL3 GC10P102474 PIR54211 GC10P102468
GH10F102462 0.2 ENCODE 11.5 +27.0 27040 1.6 TBP HDAC1 ARID4B ZNF48 RARA KAT2B YY1 SCRT2 SMARCA5 USF2 MFSD13A MIR146B CUEDC2 PSD FBXL15 SUFU RNU6-43P NFKB2 ELOVL3 GC10P102468
GH10F102484 0.2 ENCODE 11.2 +48.8 48793 2.0 SMARCA4 TEAD1 ZBTB33 CEBPG TEAD3 MFSD13A C10orf95 RNU6-43P NFKB2 MIR146B CUEDC2 PSD FBXL15 ELOVL3 ENSG00000273262
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR146B on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR146B Gene

Chromosome:
10
Start:
102,436,512 bp from pter
End:
102,436,584 bp from pter
Size:
73 bases
Orientation:
Plus strand

Genomic View for MIR146B Gene

Genes around MIR146B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR146B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR146B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR146B Gene

Proteins for MIR146B Gene

Post-translational modifications for MIR146B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR146B Gene

Domains & Families for MIR146B Gene

Gene Families for MIR146B Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR146B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR146B Gene

Function for MIR146B Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR146B Gene

Localization for MIR146B Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR146B Gene

Pathways & Interactions for MIR146B Gene

SuperPathways for MIR146B Gene

No Data Available

Interacting Proteins for MIR146B Gene

Gene Ontology (GO) - Biological Process for MIR146B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR146B Gene

Transcripts for MIR146B Gene

mRNA/cDNA for MIR146B Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR146B Gene

No ASD Table

Relevant External Links for MIR146B Gene

GeneLoc Exon Structure for
MIR146B
ECgene alternative splicing isoforms for
MIR146B

Expression for MIR146B Gene

mRNA expression in normal human tissues for MIR146B Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR146B Gene:

MIR146B
genes like me logo Genes that share expression patterns with MIR146B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR146B Gene

Orthologs for MIR146B Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR146B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-146b 35
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-146b 35
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-146b 35
  • 80 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-146b 35
  • 66 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir146b 35
  • 62 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-146b 35
  • 52 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-146b 35
  • 50 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-146a 35
  • 55 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-146a 35
  • 39 (a)
OneToOne
Species where no ortholog for MIR146B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR146B Gene

ENSEMBL:
Gene Tree for MIR146B (if available)
TreeFam:
Gene Tree for MIR146B (if available)

Paralogs for MIR146B Gene

No data available for Paralogs for MIR146B Gene

Variants for MIR146B Gene

Sequence variations from dbSNP and Humsavar for MIR146B Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs116120836 -- 102,434,735(+) ACCAG(A/C)CATCC upstream-variant-2KB
rs116977473 -- 102,436,589(+) GCAGT(A/G)CTACA downstream-variant-500B
rs141645536 -- 102,435,161(+) GGCTC(C/T)CGGGA upstream-variant-2KB
rs143021398 -- 102,436,805(+) TTCAC(A/G)CCTGA downstream-variant-500B
rs145939040 -- 102,436,275(+) CCCTC(C/T)CCTCT upstream-variant-2KB

Relevant External Links for MIR146B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR146B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR146B Gene

Disorders for MIR146B Gene

Relevant External Links for MIR146B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR146B

No disorders were found for MIR146B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR146B Gene

Publications for MIR146B Gene

  1. miR-135b- and miR-146b-dependent silencing of calcium-sensing receptor expression in colorectal tumors. (PMID: 26178670) Fetahu I.S. … KA!llay E. (Int. J. Cancer 2016) 3 64
  2. A panel of four decreased serum microRNAs as a novel biomarker for early Parkinson's disease. (PMID: 26631297) Dong H. … Zhang C.Y. (Biomarkers 2016) 3 64
  3. Family of microRNA-146 Regulates RARI^ in Papillary Thyroid Carcinoma. (PMID: 27011326) Czajka A.A. … JaA1dA1ewski K. (PLoS ONE 2016) 3 64
  4. MicroRNA-146b acts as a potential tumor suppressor in human prostate cancer. (PMID: 27273955) Ding H.Y. … Xu J. (J BUON 2016) 3 64
  5. miR-146b-5p promotes invasion and metastasis contributing to chemoresistance in osteosarcoma by targeting zinc and ring finger 3. (PMID: 26549292) Xu E. … Zhou X. (Oncol. Rep. 2016) 3 64

Products for MIR146B Gene

Sources for MIR146B Gene

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