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Aliases for MIR146B Gene

Subcategory (RNA class) for MIR146B Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR146B Gene

  • MicroRNA 146b 2 3 5
  • Hsa-Mir-146b 3
  • MiRNA146B 3
  • Mir-146b 3
  • MIRN146B 3

External Ids for MIR146B Gene

ORGUL Members for MIR146B Gene

Previous HGNC Symbols for MIR146B Gene

  • MIRN146B

Previous GeneCards Identifiers for MIR146B Gene

  • GC10P104187
  • GC10P104196

Summaries for MIR146B Gene

Entrez Gene Summary for MIR146B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR146B Gene

MIR146B (MicroRNA 146b) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Cell Differentiation - Index.

Additional gene information for MIR146B Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR146B Gene

Genomics for MIR146B Gene

Regulatory Elements for MIR146B Gene

Enhancers for MIR146B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10H102595 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.5 +164.2 164159 11.2 FOXA2 MLX ARID4B DMAP1 ZNF2 YY1 ZNF766 ZNF143 FOS SP5 MFSD13A SFXN2 ACTR1A SUFU C10orf95 PSD FBXL15 CUEDC2 MIR146B ARL3
GH10H102478 1 ENCODE 11.6 +42.7 42716 0.9 PKNOX1 ATF1 ARNT ARID4B SIN3A ZNF2 ZNF143 RUNX3 DEK MXD4 MFSD13A SUFU MIR146B CUEDC2 RNU6-43P NFKB2 ELOVL3 ENSG00000273262 GC10P102474 PIR54211
GH10H102467 0.9 Ensembl ENCODE 12 +32.4 32363 2.7 HDAC1 KLF1 CEBPB DPF2 ELF1 ZBTB40 GABPA NFIC MTA1 IKZF1 MFSD13A MIR146B CUEDC2 SUFU NFKB2 RNU6-43P PSD FBXL15 ELOVL3 RPARP-AS1
GH10H102462 0.9 ENCODE 11.5 +27.0 27040 1.6 HDAC1 HDGF TBP FOXA2 ARID4B RARA YY1 SCRT2 SMARCA5 USF2 MFSD13A MIR146B CUEDC2 FBXL15 PSD SUFU RNU6-43P NFKB2 ELOVL3 GC10P102468
GH10H102473 0.2 ENCODE 11.6 +37.1 37087 0.2 SUFU MIR146B CUEDC2 RNU6-43P NFKB2 ELOVL3 PIR54211 GC10P102474 GC10P102468
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR146B on UCSC Golden Path with GeneCards custom track

Promoters for MIR146B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000261173 -612 601 TBP SMAD5 NRF1 ZBED1 GTF2B MBD2 ZFHX2 CBX1 NCOR1 POLR2A

Genomic Locations for MIR146B Gene

Genomic Locations for MIR146B Gene
chr10:102,436,512-102,436,584
(GRCh38/hg38)
Size:
73 bases
Orientation:
Plus strand
chr10:104,196,269-104,196,341
(GRCh37/hg19)

Genomic View for MIR146B Gene

Genes around MIR146B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR146B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR146B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR146B Gene

Proteins for MIR146B Gene

Post-translational modifications for MIR146B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR146B Gene

Domains & Families for MIR146B Gene

Gene Families for MIR146B Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR146B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR146B Gene

Function for MIR146B Gene

Phenotypes From GWAS Catalog for MIR146B Gene

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR146B Gene

Localization for MIR146B Gene

Gene Ontology (GO) - Cellular Components for MIR146B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 26646931
genes like me logo Genes that share ontologies with MIR146B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR146B Gene

Pathways & Interactions for MIR146B Gene

SuperPathways for MIR146B Gene

SuperPathway Contained pathways
1 Cell Differentiation - Index
genes like me logo Genes that share pathways with MIR146B: view

Pathways by source for MIR146B Gene

1 BioSystems pathway for MIR146B Gene

Interacting Proteins for MIR146B Gene

Gene Ontology (GO) - Biological Process for MIR146B Gene

None

No data available for SIGNOR curated interactions for MIR146B Gene

Drugs & Compounds for MIR146B Gene

No Compound Related Data Available

Transcripts for MIR146B Gene

mRNA/cDNA for MIR146B Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR146B Gene

No ASD Table

Relevant External Links for MIR146B Gene

GeneLoc Exon Structure for
MIR146B
ECgene alternative splicing isoforms for
MIR146B

Expression for MIR146B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR146B Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR146B Gene:

MIR146B
genes like me logo Genes that share expression patterns with MIR146B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR146B Gene

Orthologs for MIR146B Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR146B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-146b 34
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-146b 34
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-146b 34
  • 80 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-146b 34
  • 66 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir146b 34
  • 62 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-146b 34
  • 52 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-146b 34
  • 50 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-146a 34
  • 55 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-146a 34
  • 39 (a)
OneToOne
Species where no ortholog for MIR146B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR146B Gene

ENSEMBL:
Gene Tree for MIR146B (if available)
TreeFam:
Gene Tree for MIR146B (if available)

Paralogs for MIR146B Gene

No data available for Paralogs for MIR146B Gene

Variants for MIR146B Gene

Sequence variations from dbSNP and Humsavar for MIR146B Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1001822691 -- 102,436,597(+) ACAAC(A/T)TCAAT downstream-variant-500B
rs1002127724 -- 102,435,125(+) CACAG(A/T)CACAA upstream-variant-2KB
rs1002829046 -- 102,434,916(+) CTCCC(C/T)TATCC upstream-variant-2KB
rs1007707159 -- 102,434,703(+) CACAG(C/T)CCCAG upstream-variant-2KB
rs1008621168 -- 102,435,437(+) ACCTC(C/T)ATTCC upstream-variant-2KB

Relevant External Links for MIR146B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR146B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR146B Gene

Disorders for MIR146B Gene

Relevant External Links for MIR146B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR146B

No disorders were found for MIR146B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR146B Gene

Publications for MIR146B Gene

  1. MicroRNA-146a induces immune suppression and drug-resistant colorectal cancer cells. (PMID: 28466779) Khorrami S … Malekzadeh R (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2017) 3 60
  2. Association of MicroRNAs and YRNAs With Platelet Function. (PMID: 26646931) Kaudewitz D … Mayr M (Circulation research 2016) 3 60
  3. Analysis of the Indicating Value of Cardiac Troponin I, Tumor Necrosis Factor-α, Interleukin-18, Mir-1 and Mir-146b for Viral Myocarditis among Children. (PMID: 27997912) Wang D … Zhang Y (Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2016) 3 60
  4. IRAK1, a Target of miR-146b, Reduces Cell Aggressiveness of Human Papillary Thyroid Carcinoma. (PMID: 27533309) Chou CK … Kang HY (The Journal of clinical endocrinology and metabolism 2016) 3 60
  5. Association of microRNA 146 with middle ear hyperplasia in pediatric otitis media. (PMID: 27497395) Samuels TL … Kerschner JE (International journal of pediatric otorhinolaryngology 2016) 3 60

Products for MIR146B Gene

Sources for MIR146B Gene

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