Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MIR146A Gene

Subcategory (RNA class) for MIR146A Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR146A Gene

  • MicroRNA 146a 2 3
  • MIR3142 Host Gene 5
  • MicroRNA 146 2
  • Hsa-Mir-146a 3
  • Hsa-Mir-146 3
  • MiRNA146A 3
  • MIR3142HG 5
  • MiR-146a 3
  • MIRN146A 3
  • MIRN146 3

External Ids for MIR146A Gene

Previous HGNC Symbols for MIR146A Gene

  • MIRN146
  • MIRN146A

Previous GeneCards Identifiers for MIR146A Gene

  • GC05P159848
  • GC05P159912
  • GC05P159896
  • GC05P160485

Summaries for MIR146A Gene

Entrez Gene Summary for MIR146A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. Some of the targets of the encoded miRNA are the transcripts for tumor necrosis factor, interleukin 1 receptor-associated kinase 1, interleukin 1-beta, TNF receptor-associated factor 6, and complement factor H. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2015]

GeneCards Summary for MIR146A Gene

MIR146A (MicroRNA 146a) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR146A include Postpartum Psychosis and Peripartum Cardiomyopathy. Among its related pathways are MicroRNAs in cancer.

Gene Wiki entry for MIR146A Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR146A Gene

Genomics for MIR146A Gene

Regulatory Elements for MIR146A Gene

Enhancers for MIR146A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F160500 0.8 FANTOM5 13.4 +32.8 32846 0.5 FOSL1 JUND IKZF1 KLF17 BMI1 ZNF600 FOS SPI1 MIR146A SLU7 PWWP2A GC05M160494 GC05P160522
GH05F160505 1 FANTOM5 Ensembl ENCODE 13.4 +39.0 39033 3.8 ELF3 PKNOX1 WRNIP1 BMI1 RAD21 ZNF121 ELK1 GATA2 ZNF143 CREM MIR146A SLU7 PWWP2A GC05M160494 GC05P160522
GH05F160433 0.9 FANTOM5 Ensembl ENCODE 11.4 -34.3 -34322 1.0 HDGF ZNF76 BMI1 FEZF1 ZNF2 EGR1 ZNF366 EGR2 TBX21 SP1 MIR146A PTTG1 SLU7 FABP6 PWWP2A GC05P160436 GC05M160425
GH05F160424 0.4 Ensembl 11.2 -43.8 -43768 0.2 ZMYM3 MIR146A GC05M160425 PTTG1
GH05F160425 0.4 Ensembl 11.1 -42.9 -42868 1.2 CBX5 ZMYM3 MIR146A SLU7 GC05M160425 PTTG1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR146A on UCSC Golden Path with GeneCards custom track

Promoters for MIR146A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001295504 1332 4001 HDGF MLX WRNIP1 ZFP64 ARID4B YBX1 DMAP1 ZNF48 YY1 SLC30A9

Genomic Location for MIR146A Gene

Chromosome:
5
Start:
160,468,268 bp from pter
End:
160,487,426 bp from pter
Size:
19,159 bases
Orientation:
Plus strand

Genomic View for MIR146A Gene

Genes around MIR146A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR146A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR146A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR146A Gene

Proteins for MIR146A Gene

Post-translational modifications for MIR146A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR146A Gene

Domains & Families for MIR146A Gene

Gene Families for MIR146A Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR146A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR146A Gene

Function for MIR146A Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR146A Gene

Localization for MIR146A Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR146A Gene

Pathways & Interactions for MIR146A Gene

SuperPathways for MIR146A Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR146A: view

Pathways by source for MIR146A Gene

1 KEGG pathway for MIR146A Gene

Interacting Proteins for MIR146A Gene

Gene Ontology (GO) - Biological Process for MIR146A Gene

None

No data available for SIGNOR curated interactions for MIR146A Gene

Transcripts for MIR146A Gene

mRNA/cDNA for MIR146A Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR146A Gene

No ASD Table

Relevant External Links for MIR146A Gene

GeneLoc Exon Structure for
MIR146A
ECgene alternative splicing isoforms for
MIR146A

Expression for MIR146A Gene

mRNA expression in normal human tissues for MIR146A Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR146A Gene:

MIR146A
genes like me logo Genes that share expression patterns with MIR146A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR146A Gene

Orthologs for MIR146A Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR146A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-146a 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-146a 35
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-146a 35
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir146 35
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-146a 35
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-146a 35
  • 58 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-146a 35
  • 79 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-146b 35
  • 65 (a)
OneToOne
Species where no ortholog for MIR146A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR146A Gene

ENSEMBL:
Gene Tree for MIR146A (if available)
TreeFam:
Gene Tree for MIR146A (if available)

Paralogs for MIR146A Gene

No data available for Paralogs for MIR146A Gene

Variants for MIR146A Gene

Sequence variations from dbSNP and Humsavar for MIR146A Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs10045629 -- 160,484,054(+) atgcc(C/T)ggcga intron-variant, upstream-variant-2KB
rs10069300 -- 160,483,464(+) aacaa(C/T)ccaaa intron-variant, upstream-variant-2KB
rs112134384 -- 160,484,260(+) AGAGA(C/T)AATTT intron-variant, upstream-variant-2KB
rs113096728 -- 160,485,800(+) TGCCA(C/T)GCAAT nc-transcript-variant, downstream-variant-500B
rs115006365 -- 160,485,749(+) TACGA(A/G)ACTCT nc-transcript-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for MIR146A Gene

Variant ID Type Subtype PubMed ID
esv3607372 CNV gain 21293372
nsv1015634 CNV gain 25217958
nsv1026980 CNV gain 25217958

Relevant External Links for MIR146A Gene

Human Gene Mutation Database (HGMD)
MIR146A
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR146A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR146A Gene

Disorders for MIR146A Gene

MalaCards: The human disease database

(3) MalaCards diseases for MIR146A Gene - From: GeneCards

Disorder Aliases PubMed IDs
postpartum psychosis
  • puerperal psychosis
peripartum cardiomyopathy
  • meadows' syndrome
familial breast cancer
  • breast cancer, familial
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for MIR146A

Genetic Association Database (GAD)
MIR146A
Human Genome Epidemiology (HuGE) Navigator
MIR146A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR146A
genes like me logo Genes that share disorders with MIR146A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR146A Gene

Publications for MIR146A Gene

  1. A functional polymorphism in Pre-miR-146a gene is associated with prostate cancer risk and mature miR-146a expression in vivo. (PMID: 19902466) Xu B. … Wu H.F. (Prostate 2010) 3 46 64
  2. Evaluation of SNPs in miR-146a, miR196a2 and miR-499 as low-penetrance alleles in German and Italian familial breast cancer cases. (PMID: 19847796) Catucci I. … Peterlongo P. (Hum. Mutat. 2010) 3 46 64
  3. Common genetic variants in pre-microRNAs are associated with risk of coal workers' pneumoconiosis. (PMID: 19881472) Wang M. … Ni C. (J. Hum. Genet. 2010) 3 46 64
  4. Novel genetic variants in microRNA genes and familial breast cancer. (PMID: 19048628) Shen J. … Zhao H. (Int. J. Cancer 2009) 3 46 64
  5. Functional variant in microRNA-196a2 contributes to the susceptibility of congenital heart disease in a Chinese population. (PMID: 19514064) Xu J. … Chen Y. (Hum. Mutat. 2009) 3 46 64

Products for MIR146A Gene

Sources for MIR146A Gene

Content
Loading form....