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Aliases for MIR146A Gene

Subcategory (RNA class) for MIR146A Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR146A Gene

  • MicroRNA 146a 2 3 5
  • MicroRNA 146 2
  • Hsa-Mir-146a 3
  • Hsa-Mir-146 3
  • MiRNA146A 3
  • MiR-146a 3
  • MIRN146A 3
  • MIRN146 3

External Ids for MIR146A Gene

ORGUL Members for MIR146A Gene

Previous HGNC Symbols for MIR146A Gene

  • MIRN146
  • MIRN146A

Previous GeneCards Identifiers for MIR146A Gene

  • GC05P159848
  • GC05P159912
  • GC05P159896
  • GC05P160470

Summaries for MIR146A Gene

Entrez Gene Summary for MIR146A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. Some of the targets of the encoded miRNA are the transcripts for tumor necrosis factor, interleukin 1 receptor-associated kinase 1, interleukin 1-beta, TNF receptor-associated factor 6, and complement factor H. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2015]

GeneCards Summary for MIR146A Gene

MIR146A (MicroRNA 146a) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR146A include Postpartum Psychosis and Coronary Restenosis. Among its related pathways are MicroRNAs in cancer and Melatonin metabolism and effects.

Gene Wiki entry for MIR146A Gene

Additional gene information for MIR146A Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR146A Gene

Genomics for MIR146A Gene

Regulatory Elements for MIR146A Gene

Enhancers for MIR146A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05H160458 1.5 FANTOM5 ENCODE dbSUPER 13.2 -26.2 -26200 1 HDGF PKNOX1 TBL1XR1 BATF RFX5 ATF7 ETV6 RUNX3 CREM IKZF2 MIR146A SLU7 GC05P160465 GC05M160421
GH05H160505 1.2 FANTOM5 Ensembl ENCODE 13.4 +21.4 21447 2 RFX1 POLR2A IKZF1 BMI1 RUNX3 PRDM1 MIR146A SLU7 PWWP2A GC05M160494 GC05P160522
GH05H160433 1.4 FANTOM5 Ensembl ENCODE 11.3 -51.4 -51418 0 HDGF ZNF76 BMI1 FEZF1 ZNF2 ZNF366 ZNF143 RUNX3 IKZF2 EGR2 MIR146A PTTG1 SLU7 FABP6 PWWP2A GC05P160436 GC05M160425
GH05H160460 0.4 Ensembl 13.3 -24.8 -24751 0 CTCF RAD21 MIR146A GC05P160465 GC05M160421
GH05H160424 0.2 Ensembl 11.1 -60.4 -60352 0 MIR146A GC05M160425 PTTG1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR146A on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR146A Gene

Chromosome:
5
Start:
160,485,352 bp from pter
End:
160,485,450 bp from pter
Size:
99 bases
Orientation:
Plus strand

Genomic View for MIR146A Gene

Genes around MIR146A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR146A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR146A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR146A Gene

Proteins for MIR146A Gene

Post-translational modifications for MIR146A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR146A Gene

Domains & Families for MIR146A Gene

Gene Families for MIR146A Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR146A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR146A Gene

Function for MIR146A Gene

Phenotypes From GWAS Catalog for MIR146A Gene

Animal Model Products

CRISPR Products

Clone Products

  • Applied Biological Materials Clones for MIR146A
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR146A Gene

Localization for MIR146A Gene

Gene Ontology (GO) - Cellular Components for MIR146A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 18766170
genes like me logo Genes that share ontologies with MIR146A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR146A Gene

Pathways & Interactions for MIR146A Gene

genes like me logo Genes that share pathways with MIR146A: view

Pathways by source for MIR146A Gene

1 BioSystems pathway for MIR146A Gene
1 KEGG pathway for MIR146A Gene

Interacting Proteins for MIR146A Gene

Gene Ontology (GO) - Biological Process for MIR146A Gene

None

No data available for SIGNOR curated interactions for MIR146A Gene

Drugs & Compounds for MIR146A Gene

No Compound Related Data Available

Transcripts for MIR146A Gene

mRNA/cDNA for MIR146A Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Clone Products

  • Applied Biological Materials Clones for MIR146A
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for MIR146A Gene

No ASD Table

Relevant External Links for MIR146A Gene

GeneLoc Exon Structure for
MIR146A
ECgene alternative splicing isoforms for
MIR146A

Expression for MIR146A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR146A Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR146A Gene:

MIR146A
genes like me logo Genes that share expression patterns with MIR146A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR146A Gene

Orthologs for MIR146A Gene

Evolution for MIR146A Gene

ENSEMBL:
Gene Tree for MIR146A (if available)
TreeFam:
Gene Tree for MIR146A (if available)

No data available for Orthologs for MIR146A Gene

Paralogs for MIR146A Gene

No data available for Paralogs for MIR146A Gene

Variants for MIR146A Gene

Sequence variations from dbSNP and Humsavar for MIR146A Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000515369 -- 160,485,681(+) TACTC(A/G)TTTAC nc-transcript-variant, downstream-variant-500B
rs1002867611 -- 160,485,572(+) TTCCT(A/G)TGAGA nc-transcript-variant, downstream-variant-500B
rs1003082502 -- 160,484,995(+) CTGTG(G/T)CCCAG intron-variant, upstream-variant-2KB
rs1003409971 -- 160,483,379(+) ATCCA(C/T)GAGAA intron-variant, upstream-variant-2KB
rs1003422377 -- 160,485,283(+) TTTCA(C/T)TCTTG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR146A Gene

Variant ID Type Subtype PubMed ID
esv3607372 CNV gain 21293372
nsv1015634 CNV gain 25217958
nsv1026980 CNV gain 25217958

Relevant External Links for MIR146A Gene

Human Gene Mutation Database (HGMD)
MIR146A
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR146A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR146A Gene

Disorders for MIR146A Gene

MalaCards: The human disease database

(3) MalaCards diseases for MIR146A Gene - From: HGMD and GeneCards

Disorder Aliases PubMed IDs
postpartum psychosis
  • puerperal psychosis
coronary restenosis
peripartum cardiomyopathy
  • meadows' syndrome
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for MIR146A

Genetic Association Database (GAD)
MIR146A
Human Genome Epidemiology (HuGE) Navigator
MIR146A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR146A
genes like me logo Genes that share disorders with MIR146A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR146A Gene

Publications for MIR146A Gene

  1. A functional polymorphism in Pre-miR-146a gene is associated with prostate cancer risk and mature miR-146a expression in vivo. (PMID: 19902466) Xu B … Wu HF (The Prostate 2010) 3 45 60
  2. Common genetic variants in pre-microRNAs are associated with risk of coal workers' pneumoconiosis. (PMID: 19881472) Wang M … Ni C (Journal of human genetics 2010) 3 45 60
  3. Evaluation of SNPs in miR-146a, miR196a2 and miR-499 as low-penetrance alleles in German and Italian familial breast cancer cases. (PMID: 19847796) Catucci I … Peterlongo P (Human mutation 2010) 3 45 60
  4. Novel genetic variants in microRNA genes and familial breast cancer. (PMID: 19048628) Shen J … Zhao H (International journal of cancer 2009) 3 45 60
  5. Functional variant in microRNA-196a2 contributes to the susceptibility of congenital heart disease in a Chinese population. (PMID: 19514064) Xu J … Chen Y (Human mutation 2009) 3 45 60

Products for MIR146A Gene

Sources for MIR146A Gene

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