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Aliases for MIR146A Gene

Subcategory (RNA class) for MIR146A Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR146A Gene

  • MicroRNA 146a 2 3
  • MicroRNA 146 2
  • Hsa-Mir-146a 3
  • Hsa-Mir-146 3
  • MiRNA146A 3
  • MiR-146a 3
  • MIRN146A 3
  • MIRN146 3

External Ids for MIR146A Gene

ORGUL Members for MIR146A Gene

Previous HGNC Symbols for MIR146A Gene

  • MIRN146
  • MIRN146A

Previous GeneCards Identifiers for MIR146A Gene

  • GC05P159848
  • GC05P159912
  • GC05P159896

Summaries for MIR146A Gene

Entrez Gene Summary for MIR146A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. Some of the targets of the encoded miRNA are the transcripts for tumor necrosis factor, interleukin 1 receptor-associated kinase 1, interleukin 1-beta, TNF receptor-associated factor 6, and complement factor H. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2015]

GeneCards Summary for MIR146A Gene

MIR146A (MicroRNA 146a) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR146A include enthesitis-related arthritis and peripartum cardiomyopathy. Among its related pathways are MicroRNAs in cancer.

Gene Wiki entry for MIR146A Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR146A Gene

Genomics for MIR146A Gene

Genomic Location for MIR146A Gene

Chromosome:
5
Start:
160,485,352 bp from pter
End:
160,485,450 bp from pter
Size:
99 bases
Orientation:
Plus strand

Genomic View for MIR146A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR146A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR146A Gene

No data available for Regulatory Elements for MIR146A Gene

Proteins for MIR146A Gene

Post-translational modifications for MIR146A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR146A Gene

Domains & Families for MIR146A Gene

Gene Families for MIR146A Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR146A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR146A Gene

Function for MIR146A Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR146A Gene

Localization for MIR146A Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR146A Gene

Pathways & Interactions for MIR146A Gene

SuperPathways for MIR146A Gene

Superpath Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR146A: view

Pathways by source for MIR146A Gene

1 KEGG pathway for MIR146A Gene

Interacting Proteins for MIR146A Gene

Gene Ontology (GO) - Biological Process for MIR146A Gene

None

No data available for SIGNOR curated interactions for MIR146A Gene

Drugs & Compounds for MIR146A Gene

No Compound Related Data Available

Transcripts for MIR146A Gene

mRNA/cDNA for MIR146A Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR146A Gene

No ASD Table

Relevant External Links for MIR146A Gene

GeneLoc Exon Structure for
MIR146A
ECgene alternative splicing isoforms for
MIR146A

Expression for MIR146A Gene

mRNA expression in normal human tissues for MIR146A Gene

genes like me logo Genes that share expression patterns with MIR146A: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MIR146A Gene

Orthologs for MIR146A Gene

Evolution for MIR146A Gene

ENSEMBL:
Gene Tree for MIR146A (if available)
TreeFam:
Gene Tree for MIR146A (if available)

No data available for Orthologs for MIR146A Gene

Paralogs for MIR146A Gene

No data available for Paralogs for MIR146A Gene

Variants for MIR146A Gene

Relevant External Links for MIR146A Gene

HapMap Linkage Disequilibrium report
MIR146A
Human Gene Mutation Database (HGMD)
MIR146A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR146A Gene

Disorders for MIR146A Gene

MalaCards: The human disease database

(3) MalaCards diseases for MIR146A Gene - From: GeneCards

Disorder Aliases PubMed IDs
enthesitis-related arthritis
  • era
peripartum cardiomyopathy
  • antepartum peripartum cardiomyopathy
familial breast cancer
  • breast cancer, familial
- elite association

Relevant External Links for MIR146A

Genetic Association Database (GAD)
MIR146A
Human Genome Epidemiology (HuGE) Navigator
MIR146A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR146A
genes like me logo Genes that share disorders with MIR146A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR146A Gene

Publications for MIR146A Gene

  1. Association of miR-146a rs2910164 polymorphism with squamous cell carcinoma risk: a meta-analysis. (PMID: 26214637) Zhang X. … Chen G. (J BUON 2015) 67
  2. Affection of single-nucleotide polymorphisms in miR-27a, miR-124a, and miR-146a on susceptibility to type 2 diabetes mellitus in Chinese Han people. (PMID: 25673459) Wang T.T. … Qiao H. (Chin. Med. J. 2015) 67
  3. The associations of nucleotide polymorphisms in mir-196a2, mir-146a, mir-149 with lung cancer risk. (PMID: 25524943) Xu L. … Tang W. (Cancer Biomark 2015) 67
  4. Brain endothelial miR-146a negatively modulates T-cell adhesion through repressing multiple targets to inhibit NF-I_B activation. (PMID: 25515214) Wu D. … Romero I.A. (J. Cereb. Blood Flow Metab. 2015) 67
  5. Involvement of TLR2-MyD88 in abnormal expression of miR-146a in peripheral blood monocytes of patients with chronic hepatitis C. (PMID: 25877355) Zhang W.J. … Peng C. (J. Huazhong Univ. Sci. Technol. Med. Sci. 2015) 67

Products for MIR146A Gene

Sources for MIR146A Gene

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