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Aliases for MIR146A Gene

Subcategory (RNA class) for MIR146A Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR146A Gene

  • MicroRNA 146a 2 3
  • MIRN146A 3 6
  • MicroRNA 146 2
  • Hsa-Mir-146a 3
  • Hsa-Mir-146 3
  • MiRNA146A 3
  • MiR-146a 3
  • MIRN146 3

External Ids for MIR146A Gene

Previous HGNC Symbols for MIR146A Gene

  • MIRN146
  • MIRN146A

Previous GeneCards Identifiers for MIR146A Gene

  • GC05P159848
  • GC05P159912
  • GC05P159896

Summaries for MIR146A Gene

Entrez Gene Summary for MIR146A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR146A Gene

MIR146A (MicroRNA 146a) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR146A include peripartum cardiomyopathy and oral lichen planus. Among its related pathways are MicroRNAs in cancer.

Gene Wiki entry for MIR146A Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR146A Gene

Genomics for MIR146A Gene

Genomic Location for MIR146A Gene

Start:
160,485,352 bp from pter
End:
160,485,450 bp from pter
Size:
99 bases
Orientation:
Plus strand

Genomic View for MIR146A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR146A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR146A Gene

No data available for Regulatory Elements for MIR146A Gene

Proteins for MIR146A Gene

Post-translational modifications for MIR146A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR146A Gene

Domains for MIR146A Gene

Gene Families for MIR146A Gene

HGNC:
  • MIR :ncRNAs / Micro RNAs

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR146A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR146A Gene

Function for MIR146A Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MIR146A Gene

Localization for MIR146A Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR146A Gene

Pathways for MIR146A Gene

SuperPathways for MIR146A Gene

Superpath Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR146A: view

Pathways by source for MIR146A Gene

1 KEGG pathway for MIR146A Gene

Interacting Proteins for MIR146A Gene

Gene Ontology (GO) - Biological Process for MIR146A Gene

None

Transcripts for MIR146A Gene

mRNA/cDNA for MIR146A Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR146A Gene

No ASD Table

Relevant External Links for MIR146A Gene

GeneLoc Exon Structure for
MIR146A
ECgene alternative splicing isoforms for
MIR146A

Expression for MIR146A Gene

mRNA expression in normal human tissues for MIR146A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

genes like me logo Genes that share expressions with MIR146A: view

No data available for mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for MIR146A Gene

Orthologs for MIR146A Gene

Evolution for MIR146A Gene

ENSEMBL:
Gene Tree for MIR146A (if available)
TreeFam:
Gene Tree for MIR146A (if available)

No data available for Orthologs for MIR146A Gene

Paralogs for MIR146A Gene

No data available for Paralogs for MIR146A Gene

Variants for MIR146A Gene

Sequence variations from dbSNP and Humsavar for MIR146A Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs2910163 -- 160,484,217(+) ACACT(A/G)GCATG upstream-variant-2KB
rs2910164 -- 160,485,411(+) GACCT(C/G)TGAAA nc-transcript-variant
rs2961920 -- 160,484,499(+) tcaca(A/C)ttttg upstream-variant-2KB
rs6869198 -- 160,484,058(+) ctggc(A/G)aattt upstream-variant-2KB
rs6895607 -- 160,484,050(+) cacca(C/T)gcctg upstream-variant-2KB

Relevant External Links for MIR146A Gene

HapMap Linkage Disequilibrium report
MIR146A
Human Gene Mutation Database (HGMD)
MIR146A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MIR146A Gene

Disorders for MIR146A Gene

Relevant External Links for MIR146A

Genetic Association Database (GAD)
MIR146A
Human Genome Epidemiology (HuGE) Navigator
MIR146A
genes like me logo Genes that share disorders with MIR146A: view

No data available for UniProtKB/Swiss-Prot for MIR146A Gene

Publications for MIR146A Gene

  1. A functional polymorphism in Pre-miR-146a gene is associated with prostate cancer risk and mature miR-146a expression in vivo. (PMID: 19902466) Xu B. … Wu H.F. (Prostate 2010) 3 48
  2. Novel genetic variants in microRNA genes and familial breast cancer. (PMID: 19048628) Shen J. … Zhao H. (Int. J. Cancer 2009) 3 48
  3. Genetic variations in microRNA-related genes are novel susceptibility loci for esophageal cancer risk. (PMID: 19138993) Ye Y. … Wu X. (Cancer Prev Res (Phila) 2008) 3 48
  4. Functional variant in microRNA-196a2 contributes to the susceptibility of congenital heart disease in a Chinese population. (PMID: 19514064) Xu J. … Chen Y. (Hum. Mutat. 2009) 3 48
  5. Evaluation of SNPs in miR-146a, miR196a2 and miR-499 as low-penetrance alleles in German and Italian familial breast cancer cases. (PMID: 19847796) Catucci I. … Peterlongo P. (Hum. Mutat. 2010) 3 48

Products for MIR146A Gene

  • QIAGEN qRT-PCR Assays for microRNAs that regulate MIR146A
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for MIR146A
    • Block miRNA regulation of MIR146A using miScript Target Protectors

    Sources for MIR146A Gene

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