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Aliases for MIR1469 Gene

Subcategory (RNA class) for MIR1469 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR1469 Gene

  • MicroRNA 1469 2 3
  • Nuclear Receptor Subfamily 2 Group F Member 2 4 5
  • NR2F2 4 5
  • Apolipoprotein A-I Regulatory Protein 1 4
  • COUP Transcription Factor II 4
  • Hsa-Mir-1469 3
  • COUP-TF II 4
  • MIRN1469 3
  • COUP-TF2 4
  • TFCOUP2 4
  • ARP-1 4
  • ARP1 4

External Ids for MIR1469 Gene

Previous HGNC Symbols for MIR1469 Gene

  • MIRN1469

Previous GeneCards Identifiers for MIR1469 Gene

  • GC00U922906
  • GC15P094678
  • GC15P096876

Summaries for MIR1469 Gene

Entrez Gene Summary for MIR1469 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR1469 Gene

MIR1469 (MicroRNA 1469) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR1469 include Congenital Heart Defects, Multiple Types, 4 and Pulmonic Stenosis. Among its related pathways are Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) and Nuclear Receptor transcription pathway. An important paralog of this gene is NR2F1.

UniProtKB/Swiss-Prot for MIR1469 Gene

  • Ligand-activated transcription factor. Activated by high concentrations of 9-cis-retinoic acid and all-trans-retinoic acid, but not by dexamethasone, cortisol or progesterone (in vitro). Regulation of the apolipoprotein A-I gene transcription. Binds to DNA site A.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR1469 Gene

Genomics for MIR1469 Gene

Regulatory Elements for MIR1469 Gene

Enhancers for MIR1469 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15F096363 0.6 ENCODE 11.7 +37.5 37489 0.3 CTCF RNF2 CBX2 NBN CTBP2 MIR1469 NR2F2 NR2F2-AS1 PIR46489 GC15M096366
GH15F096361 0.2 ENCODE 11.7 +36.1 36129 0.2 CBX8 PKNOX1 RNF2 SUZ12 CBX2 CTBP2 EZH2 NR2F2-AS1 MIR1469 NR2F2 PIR46489 GC15M096366
GH15F096362 0.7 ENCODE 11.7 +36.3 36309 0.2 PKNOX1 RNF2 SUZ12 CBX2 CBX8 MLLT1 EZH2 SP7 NR2F2-AS1 MIR1469 NR2F2 PIR46489 GC15M096366
GH15F096364 0.7 ENCODE 11.7 +36.6 36629 0.2 SUZ12 CBX2 POU5F1 MLLT1 SP7 EZH2 MIR1469 NR2F2 NR2F2-AS1 PIR46489 GC15M096366
GH15F096365 0.2 ENCODE 11.7 +36.8 36829 0.2 RNF2 CBX2 CTBP2 POU5F1 MLLT1 SP7 EZH2 MIR1469 NR2F2 NR2F2-AS1 PIR46489 GC15M096366
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR1469 on UCSC Golden Path with GeneCards custom track

Promoters for MIR1469 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000414067 962 4601 PKNOX1 WRNIP1 ARID4B SIN3A ZNF48 ZNF2 ZNF143 SP5 ZHX2 REST

Genomic Location for MIR1469 Gene

Chromosome:
15
Start:
96,325,938 bp from pter
End:
96,340,263 bp from pter
Size:
14,326 bases
Orientation:
Plus strand

Genomic View for MIR1469 Gene

Genes around MIR1469 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR1469 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR1469 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR1469 Gene

Proteins for MIR1469 Gene

  • Protein details for MIR1469 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P24468-COT2_HUMAN
    Recommended name:
    COUP transcription factor 2
    Protein Accession:
    P24468
    Secondary Accessions:
    • B4DQJ2
    • B6ZGU1
    • Q03754
    • Q3KQR7

    Protein attributes for MIR1469 Gene

    Size:
    414 amino acids
    Molecular mass:
    45571 Da
    Quaternary structure:
    • Interacts with SQSTM1 (By similarity). Binds DNA as a dimer; homodimer or heterodimer with NR2F6. Interacts with NCOA1, NCOA2, NCOA3 and PPARGC1A. Interacts with ZFPM2 (By similarity).
    • Interacts with SQSTM1 (By similarity). Binds DNA as a dimer; homodimer or heterodimer with NR2F6. Interacts with NCOA1, NCOA2, NCOA3 and PPARGC1A. Interacts with ZFPM2 (By similarity).

    Three dimensional structures from OCA and Proteopedia for MIR1469 Gene

    Alternative splice isoforms for MIR1469 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MIR1469 Gene

Post-translational modifications for MIR1469 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MIR1469 Gene

No data available for DME Specific Peptides for MIR1469 Gene

Domains & Families for MIR1469 Gene

Gene Families for MIR1469 Gene

Graphical View of Domain Structure for InterPro Entry

P24468

UniProtKB/Swiss-Prot:

COT2_HUMAN :
  • Contains 1 nuclear receptor DNA-binding domain.
  • Belongs to the nuclear hormone receptor family. NR2 subfamily.
Domain:
  • Contains 1 nuclear receptor DNA-binding domain.
Family:
  • Belongs to the nuclear hormone receptor family. NR2 subfamily.
genes like me logo Genes that share domains with MIR1469: view

No data available for Suggested Antigen Peptide Sequences for MIR1469 Gene

Function for MIR1469 Gene

Molecular function for MIR1469 Gene

UniProtKB/Swiss-Prot Function:
Ligand-activated transcription factor. Activated by high concentrations of 9-cis-retinoic acid and all-trans-retinoic acid, but not by dexamethasone, cortisol or progesterone (in vitro). Regulation of the apolipoprotein A-I gene transcription. Binds to DNA site A.

Gene Ontology (GO) - Molecular Function for MIR1469 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001972 retinoic acid binding IDA --
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA --
GO:0003707 steroid hormone receptor activity IEA --
GO:0003714 transcription corepressor activity TAS --
genes like me logo Genes that share ontologies with MIR1469: view

Animal Model Products

Transcription Factor Targets for MIR1469 Gene

Selected GeneGlobe predicted Target genes for MIR1469

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA and HOMER Transcription for MIR1469 Gene

Localization for MIR1469 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIR1469 Gene

Gene Ontology (GO) - Cellular Components for MIR1469 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with MIR1469: view

No data available for Subcellular locations from COMPARTMENTS for MIR1469 Gene

Pathways & Interactions for MIR1469 Gene

genes like me logo Genes that share pathways with MIR1469: view

Pathways by source for MIR1469 Gene

1 BioSystems pathway for MIR1469 Gene

Gene Ontology (GO) - Biological Process for MIR1469 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001701 in utero embryonic development IEA --
GO:0001764 neuron migration IEA --
GO:0001893 maternal placenta development IEA --
GO:0001937 negative regulation of endothelial cell proliferation IMP --
GO:0001945 lymph vessel development IEA --
genes like me logo Genes that share ontologies with MIR1469: view

No data available for SIGNOR curated interactions for MIR1469 Gene

Transcripts for MIR1469 Gene

mRNA/cDNA for MIR1469 Gene

(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR1469 Gene

No ASD Table

Relevant External Links for MIR1469 Gene

GeneLoc Exon Structure for
MIR1469
ECgene alternative splicing isoforms for
MIR1469

Expression for MIR1469 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR1469 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR1469 Gene:

MIR1469

mRNA Expression by UniProt/SwissProt for MIR1469 Gene:

P24468-COT2_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with MIR1469: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for MIR1469 Gene

Orthologs for MIR1469 Gene

This gene was present in the common ancestor of animals.

Orthologs for MIR1469 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NR2F2 35
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nr2f2 35
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NR2F2 35
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NR2F2 35
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NR2F2 35
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NR2F2 35
  • 89 (a)
OneToOne
chicken
(Gallus gallus)
Aves NR2F2 35
  • 95 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NR2F2 35
  • 74 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii nr2f2 35
  • 86 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Hr51 35
  • 25 (a)
ManyToMany
Species where no ortholog for MIR1469 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR1469 Gene

ENSEMBL:
Gene Tree for MIR1469 (if available)
TreeFam:
Gene Tree for MIR1469 (if available)

Paralogs for MIR1469 Gene

Paralogs for MIR1469 Gene

genes like me logo Genes that share paralogs with MIR1469: view

Variants for MIR1469 Gene

Sequence variations from dbSNP and Humsavar for MIR1469 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs587777373 Pathogenic 96,332,329(+) CAGCA(-/GCA)ACACA intron-variant, upstream-variant-2KB, cds-indel
rs551936462 Likely benign 96,332,234(+) ACGCC(C/G)GGCCA intron-variant, upstream-variant-2KB, reference, synonymous-codon
rs111316474 -- 96,331,691(+) AGAGA(-/T)TTTTT intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs112110943 -- 96,331,665(+) GAGAG(C/T)GAGAG intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs112438450 -- 96,331,703(+) TTTTT(C/G/T)CCTCC intron-variant, upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for MIR1469 Gene

Variant ID Type Subtype PubMed ID
dgv448n67 CNV gain 20364138
nsv1141674 CNV deletion 24896259
nsv827449 CNV gain 20364138
nsv827450 CNV gain 20364138

Relevant External Links for MIR1469 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR1469

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR1469 Gene

Disorders for MIR1469 Gene

MalaCards: The human disease database

(3) MalaCards diseases for MIR1469 Gene - From: GeneCards

Disorder Aliases PubMed IDs
congenital heart defects, multiple types, 4
  • chtd4
pulmonic stenosis
  • valvular pulmonic stenosis
transposition of the great arteries
  • transposition of the great arteries, dextro-looped 1
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

COT2_HUMAN
  • Congenital heart defects, multiple types, 4 (CHTD4) [MIM:615779]: A disorder characterized by congenital developmental abnormalities involving structures of the heart. Common defects include transposition of the great arteries, aortic stenosis, atrial septal defect, ventricular septal defect, pulmonic stenosis, and patent ductus arteriosus. Some patients also have cardiac arrhythmias, which may be due to the anatomic defect itself or to surgical interventions. {ECO:0000269 PubMed:24702954}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for MIR1469

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR1469
genes like me logo Genes that share disorders with MIR1469: view

No data available for Genatlas for MIR1469 Gene

Publications for MIR1469 Gene

  1. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 4 64
  2. Rare variants in NR2F2 cause congenital heart defects in humans. (PMID: 24702954) Al Turki S. … Hurles M.E. (Am. J. Hum. Genet. 2014) 4 64
  3. Initial characterization of the human central proteome. (PMID: 21269460) Burkard T.R. … Colinge J. (BMC Syst. Biol. 2011) 4 64
  4. Hidden layers of human small RNAs. (PMID: 18402656) Kawaji H. … Hayashizaki Y. (BMC Genomics 2008) 3 64
  5. DNA-binding profiling of human hormone nuclear receptors via fluorescence correlation spectroscopy in a cell-free system. (PMID: 18619963) Kobayashi T. … Sawasaki T. (FEBS Lett. 2008) 4 64

Products for MIR1469 Gene

Sources for MIR1469 Gene

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