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Aliases for MIR1469 Gene

Subcategory (RNA class) for MIR1469 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR1469 Gene

  • MicroRNA 1469 2 3 5
  • Hsa-Mir-1469 3
  • MIRN1469 3

External Ids for MIR1469 Gene

Previous HGNC Symbols for MIR1469 Gene

  • MIRN1469

Previous GeneCards Identifiers for MIR1469 Gene

  • GC00U922906
  • GC15P094678
  • GC15P096876

Summaries for MIR1469 Gene

Entrez Gene Summary for MIR1469 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR1469 Gene

MIR1469 (MicroRNA 1469) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR1469 include Congenital Heart Defects, Multiple Types, 4 and Pulmonic Stenosis. Among its related pathways are Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) and Ectoderm Differentiation.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR1469 Gene

Genomics for MIR1469 Gene

Regulatory Elements for MIR1469 Gene

Enhancers for MIR1469 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15G096260 1.8 FANTOM5 Ensembl ENCODE dbSUPER 10.8 -69.8 -69824 5.9 FOXA2 PKNOX1 MLX ZFP64 ARID4B SIN3A FEZF1 ZNF48 GATA2 FOS NR2F2 NR2F2-AS1 MIR1469 GC15M096250 GC15P096285
GH15G096052 1.3 Ensembl ENCODE 10.3 -279.9 -279890 2.3 PKNOX1 FOXA2 ARNT FEZF1 ZNF2 YY1 ZNF592 SREBF1 ZNF610 SMARCA4 NR2F2 NR2F2-AS1 MIR1469 LOC105370998 ENSG00000259702
GH15G096284 1.2 Ensembl ENCODE dbSUPER 9.8 -47.5 -47456 2.8 L3MBTL2 BHLHE40 MAX ATF2 ZFHX2 JUND EGR1 ZNF157 GLIS1 CREB1 NR2F2 NR2F2-AS1 MIR1469 ENSG00000279645 GC15P096285
GH15G096392 1 ENCODE dbSUPER 10.6 +59.5 59496 0.2 BCOR IRF2 TEAD4 BACH1 ZMYM3 ZNF316 NCOR1 ADNP NFE2 MAFK MIR1469 NR2F2 NR2F2-AS1 LOC100289303 ENSG00000259542
GH15G096362 0.9 ENCODE dbSUPER 11.7 +29.0 28986 0.2 PKNOX1 RNF2 SUZ12 NR2F1 CBX2 CBX8 MLLT1 SP7 EZH2 MIR1469 NR2F2-AS1 NR2F2 PIR46489 GC15M096366
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR1469 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR1469 Gene

Chromosome:
15
Start:
96,333,261 bp from pter
End:
96,333,307 bp from pter
Size:
47 bases
Orientation:
Plus strand

Genomic View for MIR1469 Gene

Genes around MIR1469 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR1469 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR1469 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR1469 Gene

Proteins for MIR1469 Gene

Post-translational modifications for MIR1469 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR1469 Gene

Domains & Families for MIR1469 Gene

Gene Families for MIR1469 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR1469: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR1469 Gene

Function for MIR1469 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR1469 Gene

Localization for MIR1469 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR1469 Gene

Pathways & Interactions for MIR1469 Gene

genes like me logo Genes that share pathways with MIR1469: view

Pathways by source for MIR1469 Gene

Interacting Proteins for MIR1469 Gene

Gene Ontology (GO) - Biological Process for MIR1469 Gene

None

No data available for SIGNOR curated interactions for MIR1469 Gene

Drugs & Compounds for MIR1469 Gene

No Compound Related Data Available

Transcripts for MIR1469 Gene

mRNA/cDNA for MIR1469 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR1469 Gene

No ASD Table

Relevant External Links for MIR1469 Gene

GeneLoc Exon Structure for
MIR1469
ECgene alternative splicing isoforms for
MIR1469

Expression for MIR1469 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR1469 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR1469 Gene:

MIR1469
genes like me logo Genes that share expression patterns with MIR1469: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR1469 Gene

Orthologs for MIR1469 Gene

Evolution for MIR1469 Gene

ENSEMBL:
Gene Tree for MIR1469 (if available)
TreeFam:
Gene Tree for MIR1469 (if available)

No data available for Orthologs for MIR1469 Gene

Paralogs for MIR1469 Gene

No data available for Paralogs for MIR1469 Gene

Variants for MIR1469 Gene

Sequence variations from dbSNP and Humsavar for MIR1469 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs587777373 Pathogenic 96,332,329(+) CAGCA(-/GCA)ACACA intron-variant, upstream-variant-2KB, cds-indel
rs551936462 Likely benign 96,332,234(+) ACGCC(C/G)GGCCA intron-variant, upstream-variant-2KB, reference, synonymous-codon
rs1000101256 -- 96,332,126(+) AGCAC(A/G)TGGCG intron-variant, upstream-variant-2KB, reference, synonymous-codon
rs1000695447 -- 96,331,282(+) GGGCA(C/G)GCGGC intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1001729842 -- 96,333,049(+) CAGCG(C/T)TCATG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR1469 Gene

Variant ID Type Subtype PubMed ID
dgv448n67 CNV gain 20364138
nsv1141674 CNV deletion 24896259
nsv827449 CNV gain 20364138
nsv827450 CNV gain 20364138

Relevant External Links for MIR1469 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR1469

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR1469 Gene

Disorders for MIR1469 Gene

MalaCards: The human disease database

(3) MalaCards diseases for MIR1469 Gene - From: GeneCards

Disorder Aliases PubMed IDs
congenital heart defects, multiple types, 4
  • chtd4
pulmonic stenosis
  • valvular pulmonic stenosis
transposition of the great arteries
  • dextro-looped transposition of the great arteries
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for MIR1469

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR1469
genes like me logo Genes that share disorders with MIR1469: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR1469 Gene

Publications for MIR1469 Gene

  1. Hidden layers of human small RNAs. (PMID: 18402656) Kawaji H. … Hayashizaki Y. (BMC Genomics 2008) 3 64
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64

Products for MIR1469 Gene

Sources for MIR1469 Gene

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