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Aliases for MIR145 Gene

Subcategory (RNA class) for MIR145 Gene

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Quality Score for this RNA gene is

3

Aliases for MIR145 Gene

  • MicroRNA 145 2 3 5
  • Hsa-Mir-145 3
  • MiRNA145 3
  • MiR-145 3
  • MIRN145 3

External Ids for MIR145 Gene

ORGUL Members for MIR145 Gene

Previous HGNC Symbols for MIR145 Gene

  • MIRN145

Previous GeneCards Identifiers for MIR145 Gene

  • GC05P148794
  • GC05P148810

Summaries for MIR145 Gene

Entrez Gene Summary for MIR145 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR145 Gene

MIR145 (MicroRNA 145) is an RNA Gene, and is affiliated with the undefined RNA class. Among its related pathways are Heart Development and MicroRNAs in cancer.

Additional gene information for MIR145 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR145 Gene

Genomics for MIR145 Gene

Regulatory Elements for MIR145 Gene

Enhancers for MIR145 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05H149495 2.1 Ensembl ENCODE dbSUPER 11.4 +66.6 66631 4 ZNF362 ZNF664 ZNF316 POLR2A SCRT2 FOS MAFK PRDM1 EMSY SUPT5H ARHGEF37 MIR145 RPL29P14 CSNK1A1 MIR143 RNU6-588P CARMN IL17B PCYOX1L ENSG00000230551
GH05H149319 1.9 FANTOM5 Ensembl ENCODE dbSUPER 11.4 -108.0 -108048 6 HDGF PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 YY1 ZNF766 HMGXB3 PCYOX1L RPL7P1 GRPEL2 ENSG00000251330 ENSG00000253865 GRPEL2-AS1 MIR145 AFAP1L1 MIR143
GH05H149481 1.8 FANTOM5 Ensembl ENCODE dbSUPER 11.6 +56.0 55954 9 PKNOX1 FOXA2 ARID4B SIN3A FEZF1 DMAP1 ZNF2 FOS PAF1 SP5 ARHGEF37 HMGXB3 TIGD6 MIR145 RPL29P14 CSNK1A1 CARMN IL17B MIR143 RNU6-588P
GH05H149513 1.7 dbSUPER 11.3 +86.5 86455 6 ZNF680 L3MBTL2 MAFG FEZF1 ZNF664 PRDM6 ZNF316 MAFF HMBOX1 MAFK ARHGEF37 RPL29P14 CSNK1A1 MIR145 MIR143 RNU6-588P CARMN IL17B PCYOX1L ENSG00000230551
GH05H149466 1.5 Ensembl ENCODE dbSUPER 12.2 +36.0 35970 1 HDGF PKNOX1 ATF1 ARNT ZNF2 TCF12 ZNF121 ZNF766 GLIS2 GATA2 CSNK1A1 MIR145 MIR143 RNU6-588P RPL29P14 ARHGEF37 CARMN IL17B ENSG00000253865 ENSG00000248647
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR145 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR145 Gene

Chromosome:
5
Start:
149,430,646 bp from pter
End:
149,430,733 bp from pter
Size:
88 bases
Orientation:
Plus strand

Genomic View for MIR145 Gene

Genes around MIR145 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR145 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR145 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR145 Gene

Proteins for MIR145 Gene

Post-translational modifications for MIR145 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR145 Gene

Domains & Families for MIR145 Gene

Gene Families for MIR145 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR145: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR145 Gene

Function for MIR145 Gene

Gene Ontology (GO) - Molecular Function for MIR145 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000993 RNA polymerase II core binding IDA 25336585
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 15131085
genes like me logo Genes that share ontologies with MIR145: view

Animal Model Products

CRISPR Products

miRNA Products

Clone Products

  • Applied Biological Materials Clones for MIR145
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR145 Gene

Localization for MIR145 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR145 Gene

Pathways & Interactions for MIR145 Gene

genes like me logo Genes that share pathways with MIR145: view

Pathways by source for MIR145 Gene

Interacting Proteins for MIR145 Gene

Gene Ontology (GO) - Biological Process for MIR145 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006940 regulation of smooth muscle contraction ISS --
GO:0010614 negative regulation of cardiac muscle hypertrophy ISS --
GO:0010667 negative regulation of cardiac muscle cell apoptotic process ISS --
GO:0010668 ectodermal cell differentiation IDA 19409607
GO:0010763 positive regulation of fibroblast migration ISS --
genes like me logo Genes that share ontologies with MIR145: view

No data available for SIGNOR curated interactions for MIR145 Gene

Drugs & Compounds for MIR145 Gene

No Compound Related Data Available

Transcripts for MIR145 Gene

mRNA/cDNA for MIR145 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Clone Products

  • Applied Biological Materials Clones for MIR145
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for MIR145 Gene

No ASD Table

Relevant External Links for MIR145 Gene

GeneLoc Exon Structure for
MIR145
ECgene alternative splicing isoforms for
MIR145

Expression for MIR145 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR145 Gene

mRNA differential expression in normal tissues according to GTEx for MIR145 Gene

This gene is overexpressed in Esophagus - Gastroesophageal Junction (x7.0), Colon - Sigmoid (x6.8), and Esophagus - Muscularis (x5.9).

NURSA nuclear receptor signaling pathways regulating expression of MIR145 Gene:

MIR145
genes like me logo Genes that share expression patterns with MIR145: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR145 Gene

Orthologs for MIR145 Gene

Evolution for MIR145 Gene

ENSEMBL:
Gene Tree for MIR145 (if available)
TreeFam:
Gene Tree for MIR145 (if available)

No data available for Orthologs for MIR145 Gene

Paralogs for MIR145 Gene

No data available for Paralogs for MIR145 Gene

Variants for MIR145 Gene

Sequence variations from dbSNP and Humsavar for MIR145 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1002578845 -- 149,430,369(+) CTGAA(A/T)GGTTG intron-variant, upstream-variant-2KB
rs1003723006 -- 149,431,037(+) CCTCA(A/G)CCCAC intron-variant, downstream-variant-500B
rs1007810229 -- 149,429,654(+) AACAA(C/T)GAGCC intron-variant, upstream-variant-2KB
rs1007842653 -- 149,428,742(+) AGAGA(A/G)AAAAG intron-variant, upstream-variant-2KB
rs1007923471 -- 149,429,477(+) TTTTT(A/G)TATTT intron-variant, downstream-variant-500B, upstream-variant-2KB

Relevant External Links for MIR145 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR145

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR145 Gene

Disorders for MIR145 Gene

Relevant External Links for MIR145

Genetic Association Database (GAD)
MIR145
Human Genome Epidemiology (HuGE) Navigator
MIR145
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR145

No disorders were found for MIR145 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR145 Gene

Publications for MIR145 Gene

  1. Long Noncoding RNA CRNDE Promotes Proliferation of Gastric Cancer Cells by Targeting miR-145. (PMID: 28490034) Hu CE … Huang GJ (Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017) 3 60
  2. An alternative approach in regulation of expression of a transgene by endogenous miR-145 in carcinoma and normal breast cell lines. (PMID: 25923846) Ghanbari Safari M … Hosseinkhani S (Biotechnology and applied biochemistry 2017) 3 60
  3. miR-145 inhibits proliferation and migration of breast cancer cells by directly or indirectly regulating TGF-β1 expression. (PMID: 28393176) Ding Y … Sun X (International journal of oncology 2017) 3 60
  4. Silencing of bach1 gene by small interfering RNA-mediation regulates invasive and expression level of miR-203, miR-145, matrix metalloproteinase-9, and CXCR4 receptor in MDA-MB-468 breast cancer cells. (PMID: 28349828) Mohammadzadeh R … Ale Taha SM (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2017) 3 60
  5. microRNA-145 modulates epithelial-mesenchymal transition and suppresses proliferation, migration and invasion by targeting SIP1 in human cervical cancer cells. (PMID: 27933466) Sathyanarayanan A … Karunagaran D (Cellular oncology (Dordrecht) 2017) 3 60

Products for MIR145 Gene

Sources for MIR145 Gene

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