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Aliases for MIR145 Gene

Subcategory (RNA class) for MIR145 Gene

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Quality Score for this RNA gene is

3

Aliases for MIR145 Gene

  • MicroRNA 145 2 3 5
  • Hsa-Mir-145 3
  • MiRNA145 3
  • MiR-145 3
  • MIRN145 3

External Ids for MIR145 Gene

ORGUL Members for MIR145 Gene

Previous HGNC Symbols for MIR145 Gene

  • MIRN145

Previous GeneCards Identifiers for MIR145 Gene

  • GC05P148794
  • GC05P148810

Summaries for MIR145 Gene

Entrez Gene Summary for MIR145 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR145 Gene

MIR145 (MicroRNA 145) is an RNA Gene, and is affiliated with the undefined RNA class. Among its related pathways are Heart Development and SRF and miRs in Smooth Muscle Differentiation and Proliferation.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR145 Gene

Genomics for MIR145 Gene

Regulatory Elements for MIR145 Gene

Enhancers for MIR145 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F149474 0.9 Ensembl ENCODE 12.2 +43.8 43830 0.7 CTCF ZNF687 ZFP64 NR3C1 TEAD3 OSR2 GLIS2 ZNF341 GLIS1 FOSL2 MIR145 CARMN MIR143 IL17B ENSG00000248647 ENSG00000253406 ENSG00000230551
GH05F149470 1.3 Ensembl ENCODE 12.2 +41.2 41160 2.3 KLF1 ZNF223 KLF17 ZNF48 ZIC2 RFX5 HIC1 ZNF316 GATA3 GLIS2 MIR145 MIR143 CARMN IL17B RNU6-588P LOC105378223 ENSG00000248647 ENSG00000253406 ARHGEF37 ENSG00000230551
GH05F149463 0.8 Ensembl ENCODE 12.2 +34.9 34858 3.4 ATF1 PKNOX1 CREB3L1 ZNF2 ZNF121 GLIS2 GATA2 FOS ZNF263 YY2 CSNK1A1 ARHGEF37 MIR145 MIR143 RNU6-588P RPL29P14 CARMN IL17B LOC105378223 ENSG00000248647
GH05F149399 1.1 Ensembl ENCODE 11.6 -30.0 -30049 1.5 CTCF TFAP4 PKNOX1 SAP130 TAL1 ETS1 NCOR1 ZNF416 ZNF143 NR2F6 CARMN PDGFRB RPL7P1 LOC105378223 MIR145 PCYOX1L AFAP1L1 IL17B LOC101927046
GH05F149481 1.1 FANTOM5 Ensembl ENCODE 11.6 +55.9 55923 9.5 ATF1 PKNOX1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZNF121 GATA2 ZNF416 ARHGEF37 HMGXB3 TIGD6 MIR145 RPL29P14 CSNK1A1 CARMN MIR143 IL17B RNU6-588P
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR145 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR145 Gene

Chromosome:
5
Start:
149,430,646 bp from pter
End:
149,430,733 bp from pter
Size:
88 bases
Orientation:
Plus strand

Genomic View for MIR145 Gene

Genes around MIR145 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR145 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR145 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR145 Gene

Proteins for MIR145 Gene

Post-translational modifications for MIR145 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR145 Gene

Domains & Families for MIR145 Gene

Gene Families for MIR145 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR145: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR145 Gene

Function for MIR145 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR145 Gene

Localization for MIR145 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR145 Gene

Pathways & Interactions for MIR145 Gene

genes like me logo Genes that share pathways with MIR145: view

Pathways by source for MIR145 Gene

Interacting Proteins for MIR145 Gene

Gene Ontology (GO) - Biological Process for MIR145 Gene

None

No data available for SIGNOR curated interactions for MIR145 Gene

Transcripts for MIR145 Gene

mRNA/cDNA for MIR145 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR145 Gene

No ASD Table

Relevant External Links for MIR145 Gene

GeneLoc Exon Structure for
MIR145
ECgene alternative splicing isoforms for
MIR145

Expression for MIR145 Gene

mRNA expression in normal human tissues for MIR145 Gene

mRNA differential expression in normal tissues according to GTEx for MIR145 Gene

This gene is overexpressed in Esophagus - Gastroesophageal Junction (x7.0), Colon - Sigmoid (x6.8), and Esophagus - Muscularis (x5.9).

NURSA nuclear receptor signaling pathways regulating expression of MIR145 Gene:

MIR145
genes like me logo Genes that share expression patterns with MIR145: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR145 Gene

Orthologs for MIR145 Gene

Evolution for MIR145 Gene

ENSEMBL:
Gene Tree for MIR145 (if available)
TreeFam:
Gene Tree for MIR145 (if available)

No data available for Orthologs for MIR145 Gene

Paralogs for MIR145 Gene

No data available for Paralogs for MIR145 Gene

Variants for MIR145 Gene

Sequence variations from dbSNP and Humsavar for MIR145 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs112274740 -- 149,428,700(+) TAAGC(G/T)GTTCT intron-variant, upstream-variant-2KB
rs113013728 -- 149,429,614(+) ATCCA(C/T)TCTTG intron-variant, upstream-variant-2KB
rs113076755 -- 149,430,840(+) TAAGA(A/G)GGCTT intron-variant, downstream-variant-500B
rs1141225 -- 149,428,712(+) GACaa(A/G)aaaag intron-variant, upstream-variant-2KB
rs114213994 -- 149,429,146(+) AAGTT(C/T)CCCTG intron-variant, downstream-variant-500B, upstream-variant-2KB

Relevant External Links for MIR145 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR145

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR145 Gene

Disorders for MIR145 Gene

Relevant External Links for MIR145

Genetic Association Database (GAD)
MIR145
Human Genome Epidemiology (HuGE) Navigator
MIR145
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR145

No disorders were found for MIR145 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR145 Gene

Publications for MIR145 Gene

  1. Role of miR-145 in human laryngeal squamous cell carcinoma. (PMID: 26083661) Karatas O.F. … Ozen M. (Head Neck 2016) 3 64
  2. MiR-345 suppresses proliferation, migration and invasion by targeting Smad1 in human prostate cancer. (PMID: 26227059) Chen Q.G. … Kong C.Z. (J. Cancer Res. Clin. Oncol. 2016) 3 64
  3. Alteration of the Metabolome Profile in Endothelial Cells by Overexpression of miR-143/145. (PMID: 26597530) Wang W. … Liu C. (J. Microbiol. Biotechnol. 2016) 3 64
  4. MicroRNAa89145 inhibits the malignant phenotypes of gastric carcinoma cells via downregulation of fascin 1 expression. (PMID: 26647829) Xue M. … Li G. (Mol Med Rep 2016) 3 64
  5. Targeting oncogenic PLCE1 by miR-145 impairs tumor proliferation and metastasis of esophageal squamous cell carcinoma. (PMID: 26657507) Cui X.B. … Li F. (Oncotarget 2016) 3 64

Products for MIR145 Gene

Sources for MIR145 Gene

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