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Aliases for MIR144 Gene

Subcategory (RNA class) for MIR144 Gene

miRNA

Quality Score for this RNA gene is

9.2

Aliases for MIR144 Gene

  • MicroRNA 144 2 3 5
  • Hsa-Mir-144 3
  • Mir-144 3
  • MIRN144 3

External Ids for MIR144 Gene

Previous HGNC Symbols for MIR144 Gene

  • MIRN144

Previous GeneCards Identifiers for MIR144 Gene

  • GC17M024217
  • GC17M027189
  • GC17M027193
  • GC17M027267
  • GC17M028862
  • GC17M028864

Summaries for MIR144 Gene

Entrez Gene Summary for MIR144 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR144 Gene

MIR144 (MicroRNA 144) is an RNA Gene, and is affiliated with the miRNA class.

fRNAdb sequence ontologies for MIR144 Gene - the ORGUL cluster for this gene includes several descriptions:

  • miRNA: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene. Micro RNAs are produced from precursor molecules (SO:0000647) that can form local hairpin structures, which ordinarily are processed (via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors.

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR144

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR144 Gene

Genomics for MIR144 Gene

Genomic Location for MIR144 Gene

Chromosome:
17
Start:
28,861,533 bp from pter
End:
28,861,618 bp from pter
Size:
86 bases
Orientation:
Minus strand

Genomic View for MIR144 Gene

Genes around MIR144 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR144 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR144 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR144 Gene

ORGUL Member Location for MIR144 Gene

ORGUL Member Location for MIR144 gene

No data available for Regulatory Elements for MIR144 Gene

Proteins for MIR144 Gene

Post-translational modifications for MIR144 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR144 Gene

Domains & Families for MIR144 Gene

Gene Families for MIR144 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR144: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR144 Gene

Function for MIR144 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR144 Gene

Localization for MIR144 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR144 Gene

Pathways & Interactions for MIR144 Gene

SuperPathways for MIR144 Gene

No Data Available

Interacting Proteins for MIR144 Gene

Gene Ontology (GO) - Biological Process for MIR144 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR144 Gene

Drugs & Compounds for MIR144 Gene

No Compound Related Data Available

Transcripts for MIR144 Gene

fRNAdb Secondary structures for MIR144 Gene

  • hsa-miR-144-3p_MIMAT0000436_Homo_sapiens_miR-144-3p_mature
  • hsa-miR-144-5p_MIMAT0004600_Homo_sapiens_miR-144-5p_mature
  • hsa-mir-144_MI0000460_Homo_sapiens_miR-144_stem-loop_hairpin

mRNA/cDNA for MIR144 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR144 Gene

No ASD Table

Relevant External Links for MIR144 Gene

GeneLoc Exon Structure for
MIR144
ECgene alternative splicing isoforms for
MIR144

Expression for MIR144 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR144 Gene:

MIR144
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR144 Gene

Orthologs for MIR144 Gene

Evolution for MIR144 Gene

ENSEMBL:
Gene Tree for MIR144 (if available)
TreeFam:
Gene Tree for MIR144 (if available)

No data available for Orthologs for MIR144 Gene

Paralogs for MIR144 Gene

No data available for Paralogs for MIR144 Gene

Variants for MIR144 Gene

Sequence variations from dbSNP and Humsavar for MIR144 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000736932 -- 28,862,534(+) CTACT(A/G)GGAGA upstream-variant-2KB
rs1000983181 -- 28,861,821(+) CTCAT(A/G)GGGAC downstream-variant-500B, upstream-variant-2KB
rs1001446212 -- 28,863,599(+) TCACC(A/G)TGTTG upstream-variant-2KB
rs1001880847 -- 28,863,066(+) CCTCC(C/T)AAGTA upstream-variant-2KB
rs1002142648 -- 28,863,379(+) TAATA(C/T)ATTTC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR144 Gene

Variant ID Type Subtype PubMed ID
esv3640315 CNV loss 21293372

Relevant External Links for MIR144 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR144

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR144 Gene

Disorders for MIR144 Gene

Relevant External Links for MIR144

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR144

No disorders were found for MIR144 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR144 Gene

Publications for MIR144 Gene

  1. Identification of tissue-specific microRNAs from mouse. (PMID: 12007417) Lagos-Quintana M. … Tuschl T. (Curr. Biol. 2002) 1 3 64
  2. MicroRNA-144 inhibits hepatocellular carcinoma cell proliferation, invasion and migration by targeting ZFX. (PMID: 28229969) Bao H. … Liu Z. (J. Biosci. 2017) 3 64
  3. Possible tumor suppressive role of the miR-144/451 cluster in esophageal carcinoma as determined by principal component regression analysis. (PMID: 27572636) Gao Z. … Pu Y. (Mol Med Rep 2016) 3 64
  4. MiR-144-3p and Its Target Gene I^-Amyloid Precursor Protein Regulate 1-Methyl-4-Phenyl-1,2-3,6-Tetrahydropyridine-Induced Mitochondrial Dysfunction. (PMID: 27329039) Li K. … Wang L. (Mol. Cells 2016) 3 64
  5. MiR-144 inhibits cell proliferation of renal cell carcinoma by targeting MTOR. (PMID: 27072960) Xiang C. … Ke Y. (J. Huazhong Univ. Sci. Technol. Med. Sci. 2016) 3 64

Products for MIR144 Gene

Sources for MIR144 Gene

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