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Aliases for MIR143 Gene

Subcategory (RNA class) for MIR143 Gene

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Quality Score for this RNA gene is

13

Aliases for MIR143 Gene

  • MicroRNA 143 2 3 5
  • Hsa-Mir-143 3
  • Mir-143 3
  • MIRN143 3

External Ids for MIR143 Gene

ORGUL Members for MIR143 Gene

Previous HGNC Symbols for MIR143 Gene

  • MIRN143

Previous GeneCards Identifiers for MIR143 Gene

  • GC05P148793
  • GC05P148808

Summaries for MIR143 Gene

Entrez Gene Summary for MIR143 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR143 Gene

MIR143 (MicroRNA 143) is an RNA Gene, and is affiliated with the undefined RNA class. Among its related pathways are MicroRNAs in cancer and Heart Development.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR143 Gene

Genomics for MIR143 Gene

Regulatory Elements for MIR143 Gene


Promoters for MIR143 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MIR143 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR143 Gene

Chromosome:
5
Start:
149,428,918 bp from pter
End:
149,429,023 bp from pter
Size:
106 bases
Orientation:
Plus strand

Genomic View for MIR143 Gene

Genes around MIR143 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR143 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR143 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR143 Gene

Proteins for MIR143 Gene

Post-translational modifications for MIR143 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR143 Gene

Domains & Families for MIR143 Gene

Gene Families for MIR143 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR143: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR143 Gene

Function for MIR143 Gene

miRNA for MIR143 Gene

miRTarBase miRNAs that target MIR143

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MIR143 Gene

Localization for MIR143 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR143 Gene

Pathways & Interactions for MIR143 Gene

genes like me logo Genes that share pathways with MIR143: view

Pathways by source for MIR143 Gene

Interacting Proteins for MIR143 Gene

Gene Ontology (GO) - Biological Process for MIR143 Gene

None

No data available for SIGNOR curated interactions for MIR143 Gene

Drugs & Compounds for MIR143 Gene

No Compound Related Data Available

Transcripts for MIR143 Gene

mRNA/cDNA for MIR143 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR143 Gene

No ASD Table

Relevant External Links for MIR143 Gene

GeneLoc Exon Structure for
MIR143
ECgene alternative splicing isoforms for
MIR143

Expression for MIR143 Gene

mRNA expression in normal human tissues for MIR143 Gene

mRNA differential expression in normal tissues according to GTEx for MIR143 Gene

This gene is overexpressed in Esophagus - Gastroesophageal Junction (x11.0), Esophagus - Muscularis (x8.3), and Artery - Coronary (x5.3).
genes like me logo Genes that share expression patterns with MIR143: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MIR143 Gene

Orthologs for MIR143 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR143 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia bta-mir-143 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-143 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-143 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir143 36
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-143 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-143 36
  • 99 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 36
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-143 36
  • 91 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-143-2 36
  • 74 (a)
OneToMany
dre-mir-143-2 36
  • 74 (a)
OneToMany
Species with no ortholog for MIR143:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR143 Gene

ENSEMBL:
Gene Tree for MIR143 (if available)
TreeFam:
Gene Tree for MIR143 (if available)

Paralogs for MIR143 Gene

No data available for Paralogs for MIR143 Gene

Variants for MIR143 Gene

Relevant External Links for MIR143 Gene

HapMap Linkage Disequilibrium report
MIR143

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR143 Gene

Disorders for MIR143 Gene

Relevant External Links for MIR143

Genetic Association Database (GAD)
MIR143
Human Genome Epidemiology (HuGE) Navigator
MIR143
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR143

No disorders were found for MIR143 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR143 Gene

Publications for MIR143 Gene

  1. Novel genetic variants in miR-191 gene and familial ovarian cancer. (PMID: 20167074) Shen J. … Zhao H. (BMC Cancer 2010) 3 48 67
  2. Tumor suppressors miR-143 and miR-145 and predicted target proteins API5, ERK5, K-RAS, and IRS-1 are differentially expressed in proximal and distal colon. (PMID: 25477374) Pekow J. … Bissonnette M. (Am. J. Physiol. Gastrointest. Liver Physiol. 2015) 3
  3. Involvement of miR-143 in cisplatin resistance of gastric cancer cells via targeting IGF1R and BCL2. (PMID: 25492481) Zhuang M. … Shu Y. (Tumour Biol. 2015) 3
  4. Role of JAK2 V617F mutation and aberrant expression of microRNA-143 in myeloproliferative neoplasms. (PMID: 25527813) Benati M. … Guidi G.C. (Clin. Chem. Lab. Med. 2015) 3
  5. miR-143 inhibits interleukin-13-induced inflammatory cytokine and mucus production in nasal epithelial cells from allergic rhinitis patients by targeting IL13RI+1. (PMID: 25529447) Teng Y. … Hong Z. (Biochem. Biophys. Res. Commun. 2015) 3

Products for MIR143 Gene

Sources for MIR143 Gene

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