Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MIR143 Gene

Subcategory (RNA class) for MIR143 Gene


Quality Score for this RNA gene is


Aliases for MIR143 Gene

  • MicroRNA 143 2 3 5
  • Hsa-Mir-143 3
  • Mir-143 3
  • MIRN143 3

External Ids for MIR143 Gene

ORGUL Members for MIR143 Gene

Previous HGNC Symbols for MIR143 Gene

  • MIRN143

Previous GeneCards Identifiers for MIR143 Gene

  • GC05P148793
  • GC05P148808
  • GC05P149429

Summaries for MIR143 Gene

Entrez Gene Summary for MIR143 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR143 Gene

MIR143 (MicroRNA 143) is an RNA Gene, and is affiliated with the undefined RNA class. Among its related pathways are MicroRNAs in cancer.

Additional gene information for MIR143 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR143 Gene

Genomics for MIR143 Gene

Regulatory Elements for MIR143 Gene

Enhancers for MIR143 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05H149495 2.1 Ensembl ENCODE dbSUPER 10.6 +68.4 68359 4.1 ZNF362 ZNF664 ZNF316 POLR2A SCRT2 FOS MAFK PRDM1 EMSY SUPT5H ARHGEF37 MIR145 RPL29P14 CSNK1A1 MIR143 RNU6-588P IL17B CARMN PCYOX1L ENSG00000230551
GH05H149319 1.9 FANTOM5 Ensembl ENCODE dbSUPER 11.2 -106.3 -106320 6.6 HDGF PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 YY1 ZNF766 HMGXB3 PCYOX1L RPL7P1 GRPEL2 ENSG00000251330 ENSG00000253865 GRPEL2-AS1 MIR145 AFAP1L1 MIR143
GH05H149513 1.7 dbSUPER 10.4 +88.2 88183 6.4 ZNF680 L3MBTL2 MAFG FEZF1 ZNF664 PRDM6 ZNF316 MAFF HMBOX1 MAFK ARHGEF37 RPL29P14 CSNK1A1 MIR145 MIR143 RNU6-588P CARMN IL17B PCYOX1L ENSG00000230551
GH05H149466 1.5 Ensembl ENCODE dbSUPER 11.4 +37.7 37698 1.2 HDGF PKNOX1 ATF1 ARNT ZNF2 TCF12 ZNF121 ZNF766 GLIS2 GATA2 CSNK1A1 MIR145 MIR143 RNU6-588P RPL29P14 ARHGEF37 CARMN IL17B ENSG00000253865 ENSG00000253406
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR143 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR143 Gene

Genomic Locations for MIR143 Gene
106 bases
Plus strand

Genomic View for MIR143 Gene

Genes around MIR143 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR143 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR143 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR143 Gene

Proteins for MIR143 Gene

Post-translational modifications for MIR143 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR143 Gene

Domains & Families for MIR143 Gene

Gene Families for MIR143 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR143: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR143 Gene

Function for MIR143 Gene

Phenotypes From GWAS Catalog for MIR143 Gene

Animal Model Products

miRNA for MIR143 Gene

miRTarBase miRNAs that target MIR143

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MIR143 Gene

Localization for MIR143 Gene

Gene Ontology (GO) - Cellular Components for MIR143 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 26646931
GO:0070062 extracellular exosome IDA 26311719
genes like me logo Genes that share ontologies with MIR143: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR143 Gene

Pathways & Interactions for MIR143 Gene

SuperPathways for MIR143 Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR143: view

Pathways by source for MIR143 Gene

1 KEGG pathway for MIR143 Gene

Interacting Proteins for MIR143 Gene

Gene Ontology (GO) - Biological Process for MIR143 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006940 regulation of smooth muscle contraction ISS --
GO:0030036 actin cytoskeleton organization ISS --
GO:0032148 activation of protein kinase B activity ISS --
GO:0038166 angiotensin-activated signaling pathway ISS --
GO:0043536 positive regulation of blood vessel endothelial cell migration IDA 26311719
genes like me logo Genes that share ontologies with MIR143: view

No data available for SIGNOR curated interactions for MIR143 Gene

Drugs & Compounds for MIR143 Gene

No Compound Related Data Available

Transcripts for MIR143 Gene

mRNA/cDNA for MIR143 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR143 Gene

No ASD Table

Relevant External Links for MIR143 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR143 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR143 Gene

mRNA differential expression in normal tissues according to GTEx for MIR143 Gene

This gene is overexpressed in Esophagus - Gastroesophageal Junction (x11.0), Esophagus - Muscularis (x8.3), and Artery - Coronary (x5.3).

NURSA nuclear receptor signaling pathways regulating expression of MIR143 Gene:

genes like me logo Genes that share expression patterns with MIR143: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR143 Gene

Orthologs for MIR143 Gene

Evolution for MIR143 Gene

Gene Tree for MIR143 (if available)
Gene Tree for MIR143 (if available)

No data available for Orthologs for MIR143 Gene

Paralogs for MIR143 Gene

No data available for Paralogs for MIR143 Gene

Variants for MIR143 Gene

Sequence variations from dbSNP and Humsavar for MIR143 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1001897687 -- 149,428,154(+) CATCT(A/G)TGAGC intron-variant, upstream-variant-2KB
rs1002245280 -- 149,427,813(+) GTGGT(A/G)AAACC intron-variant, upstream-variant-2KB
rs1004803422 -- 149,427,129(+) ATATG(C/T)CATCC intron-variant, upstream-variant-2KB
rs1005457089 -- 149,427,769(+) GGTGG(A/G)TCACC intron-variant, upstream-variant-2KB
rs1007842653 -- 149,428,742(+) AGAGA(A/G)AAAAG intron-variant, upstream-variant-2KB

Relevant External Links for MIR143 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR143 Gene

Disorders for MIR143 Gene

Relevant External Links for MIR143

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MIR143 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR143 Gene

Publications for MIR143 Gene

  1. Novel genetic variants in miR-191 gene and familial ovarian cancer. (PMID: 20167074) Shen J … Zhao H (BMC cancer 2010) 3 45 60
  2. MicroRNA-143 inhibits colorectal cancer cell proliferation by targeting MMP7. (PMID: 27827523) Yu B … Chang H (Minerva medica 2017) 3 60
  3. Diagnostic value of microRNA-143 in predicting in-stent restenosis for patients with lower extremity arterial occlusive disease. (PMID: 28057086) Yu ZH … Tu C (European journal of medical research 2017) 3 60
  4. miR-143 Induces the Apoptosis of Prostate Cancer LNCap Cells by Suppressing Bcl-2 Expression. (PMID: 28109198) Ma Z … Qiu M (Medical science monitor : international medical journal of experimental and clinical research 2017) 3 60
  5. MiR-143 Targeting TAK1 Attenuates Pancreatic Ductal Adenocarcinoma Progression via MAPK and NF-κB Pathway In Vitro. (PMID: 28194669) Huang FT … Zhang SN (Digestive diseases and sciences 2017) 3 60

Products for MIR143 Gene

Sources for MIR143 Gene

Loading form....