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Aliases for MIR143 Gene

Subcategory (RNA class) for MIR143 Gene

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Quality Score for this RNA gene is

13

Aliases for MIR143 Gene

  • MicroRNA 143 2 3 5
  • Hsa-Mir-143 3
  • Mir-143 3
  • MIRN143 3

External Ids for MIR143 Gene

ORGUL Members for MIR143 Gene

Previous HGNC Symbols for MIR143 Gene

  • MIRN143

Previous GeneCards Identifiers for MIR143 Gene

  • GC05P148793
  • GC05P148808
  • GC05P149429

Summaries for MIR143 Gene

Entrez Gene Summary for MIR143 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR143 Gene

MIR143 (MicroRNA 143) is an RNA Gene, and is affiliated with the undefined RNA class. Among its related pathways are MicroRNAs in cancer.

Additional gene information for MIR143 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR143 Gene

Genomics for MIR143 Gene

Regulatory Elements for MIR143 Gene

Enhancers for MIR143 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05H149495 2.1 Ensembl ENCODE dbSUPER 10.6 +68.4 68359 4 ZNF362 ZNF664 ZNF316 POLR2A SCRT2 FOS MAFK PRDM1 EMSY SUPT5H ARHGEF37 MIR145 RPL29P14 CSNK1A1 MIR143 RNU6-588P CARMN IL17B PCYOX1L ENSG00000230551
GH05H149319 1.9 FANTOM5 Ensembl ENCODE dbSUPER 11.2 -106.3 -106320 6 HDGF PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 YY1 ZNF766 HMGXB3 PCYOX1L RPL7P1 GRPEL2 ENSG00000251330 ENSG00000253865 GRPEL2-AS1 MIR145 AFAP1L1 MIR143
GH05H149481 1.8 FANTOM5 Ensembl ENCODE dbSUPER 10.8 +57.7 57682 9 PKNOX1 FOXA2 ARID4B SIN3A FEZF1 DMAP1 ZNF2 FOS PAF1 SP5 ARHGEF37 HMGXB3 TIGD6 MIR145 RPL29P14 CSNK1A1 CARMN IL17B MIR143 RNU6-588P
GH05H149513 1.7 dbSUPER 10.4 +88.2 88183 6 ZNF680 L3MBTL2 MAFG FEZF1 ZNF664 PRDM6 ZNF316 MAFF HMBOX1 MAFK ARHGEF37 RPL29P14 CSNK1A1 MIR145 MIR143 RNU6-588P CARMN IL17B PCYOX1L ENSG00000230551
GH05H149559 1.5 Ensembl ENCODE dbSUPER 11.4 +133.6 133611 5 HDGF ZNF2 ETS1 ZNF121 ATF7 FOS REST SMARCB1 ZNF592 MEF2D MIR143 RNU6-588P MIR145 IL17B CARMN ARHGEF37 ENSG00000248647 ENSG00000253406
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR143 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR143 Gene

Chromosome:
5
Start:
149,428,918 bp from pter
End:
149,429,023 bp from pter
Size:
106 bases
Orientation:
Plus strand

Genomic View for MIR143 Gene

Genes around MIR143 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR143 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR143 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR143 Gene

Proteins for MIR143 Gene

Post-translational modifications for MIR143 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR143 Gene

Domains & Families for MIR143 Gene

Gene Families for MIR143 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR143: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR143 Gene

Function for MIR143 Gene

Phenotypes From GWAS Catalog for MIR143 Gene

Animal Model Products

CRISPR Products

miRNA for MIR143 Gene

miRTarBase miRNAs that target MIR143

miRNA Products

Clone Products

  • Applied Biological Materials Clones for MIR143
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MIR143 Gene

Localization for MIR143 Gene

Gene Ontology (GO) - Cellular Components for MIR143 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 26646931
GO:0070062 extracellular exosome IDA 26311719
genes like me logo Genes that share ontologies with MIR143: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR143 Gene

Pathways & Interactions for MIR143 Gene

SuperPathways for MIR143 Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR143: view

Pathways by source for MIR143 Gene

1 KEGG pathway for MIR143 Gene

Interacting Proteins for MIR143 Gene

Gene Ontology (GO) - Biological Process for MIR143 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006940 regulation of smooth muscle contraction ISS --
GO:0030036 actin cytoskeleton organization ISS --
GO:0032148 activation of protein kinase B activity ISS --
GO:0038166 angiotensin-activated signaling pathway ISS --
GO:0043536 positive regulation of blood vessel endothelial cell migration IDA 26311719
genes like me logo Genes that share ontologies with MIR143: view

No data available for SIGNOR curated interactions for MIR143 Gene

Drugs & Compounds for MIR143 Gene

No Compound Related Data Available

Transcripts for MIR143 Gene

mRNA/cDNA for MIR143 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Clone Products

  • Applied Biological Materials Clones for MIR143
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for MIR143 Gene

No ASD Table

Relevant External Links for MIR143 Gene

GeneLoc Exon Structure for
MIR143
ECgene alternative splicing isoforms for
MIR143

Expression for MIR143 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR143 Gene

mRNA differential expression in normal tissues according to GTEx for MIR143 Gene

This gene is overexpressed in Esophagus - Gastroesophageal Junction (x11.0), Esophagus - Muscularis (x8.3), and Artery - Coronary (x5.3).

NURSA nuclear receptor signaling pathways regulating expression of MIR143 Gene:

MIR143
genes like me logo Genes that share expression patterns with MIR143: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR143 Gene

Orthologs for MIR143 Gene

Evolution for MIR143 Gene

ENSEMBL:
Gene Tree for MIR143 (if available)
TreeFam:
Gene Tree for MIR143 (if available)

No data available for Orthologs for MIR143 Gene

Paralogs for MIR143 Gene

No data available for Paralogs for MIR143 Gene

Variants for MIR143 Gene

Sequence variations from dbSNP and Humsavar for MIR143 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1001897687 -- 149,428,154(+) CATCT(A/G)TGAGC intron-variant, upstream-variant-2KB
rs1002245280 -- 149,427,813(+) GTGGT(A/G)AAACC intron-variant, upstream-variant-2KB
rs1004803422 -- 149,427,129(+) ATATG(C/T)CATCC intron-variant, upstream-variant-2KB
rs1005457089 -- 149,427,769(+) GGTGG(A/G)TCACC intron-variant, upstream-variant-2KB
rs1007842653 -- 149,428,742(+) AGAGA(A/G)AAAAG intron-variant, upstream-variant-2KB

Relevant External Links for MIR143 Gene

Human Gene Mutation Database (HGMD)
MIR143
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR143

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR143 Gene

Disorders for MIR143 Gene

Relevant External Links for MIR143

Genetic Association Database (GAD)
MIR143
Human Genome Epidemiology (HuGE) Navigator
MIR143
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR143

No disorders were found for MIR143 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR143 Gene

Publications for MIR143 Gene

  1. Novel genetic variants in miR-191 gene and familial ovarian cancer. (PMID: 20167074) Shen J … Zhao H (BMC cancer 2010) 3 45 60
  2. Diagnostic value of microRNA-143 in predicting in-stent restenosis for patients with lower extremity arterial occlusive disease. (PMID: 28057086) Yu ZH … Tu C (European journal of medical research 2017) 3 60
  3. MiR-143 inhibits cell proliferation and invasion by targeting DNMT3A in gastric cancer. (PMID: 28718369) Zhang Q … Yang J (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2017) 3 60
  4. Comprehensive functional screening of miRNAs involved in fat cell insulin sensitivity among women. (PMID: 28270439) Dahlman I … Kulyté A (American journal of physiology. Endocrinology and metabolism 2017) 3 60
  5. Effects of miRNA-143 and the non-coding RNA MALAT1 on the pathogenesis and metastasis of HeLa cells. (PMID: 28252165) Zhang L … Bao YX (Genetics and molecular research : GMR 2017) 3 60

Products for MIR143 Gene

Sources for MIR143 Gene

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