microRNA 142 MIRN142 )
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Aliasesfor MIR142 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Subcategory (RNA class): miRNAQuality score for this RNA gene is 9.2 Aliases MicroRNA 142 1 2 MIRN1421 2 Hsa-Mir-1421 Mir-1421
External Ids: HGNC: 31529 1 Entrez Gene: 406934 2 Ensembl: ENSG00000207567 7 Export aliases for MIR142 gene to outside databases Previous GC identifer: GC17M053766
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Summariesfor MIR142 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for MIR142 : microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. (provided by RefSeq, Sep 2009) fRNAdb sequence ontologies for MIR142 - the ORGUL cluster for this gene includes several descriptions: microRNA mir-142 - nc_conserved_region - Non-coding region of sequence similarity by descent from a common ancestor.View fRNAdb secondary structures for MIR142
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Genomic Viewsfor MIR142 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,miRBase ,UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section Regulatory elements: Search SABiosciences Regulatory transcription factor binding sites for MIR142 Other transcription factors Search SABiosciences Chromatin IP Primers for MIR142 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MIR142
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 17q22 Ensembl cytogenetic band: 17q22 HGNC cytogenetic band: 17q22 MIR142 Gene in genomic location: bands according to Ensembl, locations according to
Entrez Gene Ensembl GeneLoc information about chromosome 17 GeneLoc Exon Structure
GeneLoc location for GC17M056409: view genomic region miRBase )
(about GC identifiers )
Start: 56,408,593 bp from pter End:
56,408,679 bp from pter
Size: 87 bases Orientation:
minus strand
ORGUL member locations:Legend (see complete legend)
hsa-mir-142_hairpin FR0111987 RF01896 hsa-miR-142-3p_mature hsa-miR-142-5p_mature
56408592 56408640 56408688 chr17
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Proteinsfor MIR142 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB: --
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Protein
Domains /for MIR142 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Functionfor MIR142 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section
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Pathways & Interactionsfor MIR142 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MIR142
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Drugs & Compoundsfor MIR142 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for MIR142 MIR142
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Transcriptsfor MIR142 gene (Secondary structures according to
fRNAdb ,Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC , GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,EMD Millipore ,
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section 1 fRNAdb Secondary structure: 1 Ensembl transcript including schematic representation, and UCSC links where relevant : ENST00000384835(miRNA) GeneLoc Exon Structure
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Expression for MIR142 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section Expression evidence for MIR142:miRBase
MIR142 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: --
About this image SABiosciences Custom PCR Arrays for MIR142 Primer Browse OriGene genome-wide validated SYBR primer pairs Browse OriGene validated miRNA SYBR primer pairs Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat MIR142 Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MIR142 Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MIR142
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Orthologsfor MIR142 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
ENSEMBL Gene Tree for MIR142 (if available)TreeFam Gene Tree for MIR142 (if available)
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Paralogsfor MIR142 gene (Paralogs according to
1 HomoloGene ,2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section
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Genomic Variantsfor MIR142 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical Chr 17 pos Sequence # AA Type More # Allele Pop Total More
HapMap Linkage Disequilibrium report for MIR142 (56408593 - 56408679 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 11 variations for MIR142 11 CNVs 49896 49899 49893 49897 49900 49898 49892 4410 49895 49891 49894
SABiosciences Cancer Mutation PCR Assays
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Disorders
/ Diseasesfor MIR142 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section About GeneDecksing 5 : About MalaCards squamous cell carcinoma hepatocellular carcinoma pancreatic cancer pancreatitis carcinoma Export disorders for MIR142 gene to outside databases
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Publicationsfor MIR142 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for MIR142 gene, integrated from 9 sources (see all 17 ):(articles sorted by number of sources associating them with MIR142) Utopia : connect your pdf to the dynamic
MicroRNA-29a and microRNA-142-3p are regulators of mye loid differentiation and acute myeloid leukemia. (PubMed id 22493297) 1 (2012) miR-29a and miR-142-3p downregulation and diagnostic i mplication in human acute myeloid leukemia. (PubMed id 21678057) 1 (2012) Decreased microRNA-142-3p/5p expression causes CD4+ T cell activation and B cell hyperstimulation in systemic lupus erythematosus. (PubMed id 22549634) 1 (2012) An oncogenic role of miR-142-3p in human T-cell acute lymphoblastic leukemia (T-ALL) by targeting glucocorticoid receptor-a and cAMP/P KA pathways. (PubMed id 21979877) 1 (2012) MiR-142-3p as a potential prognostic biomarker for es ophageal squamous cell carcinoma. (PubMed id 21882196) 1 (2012) Repression of miR-142 by p300 and MAPK is required for survival signalling via gp130 during adaptive hypertrophy. (PubMed id 22367739) 1 (2012) MicroRNA-142-3p, a new regulator of RAC1, suppresses the migration and invasion of hepatocellular carcinoma cells. (PubMed id 21482222) 1 (2011) MicroRNA expression as a predictive marker for gemcit abine response after surgical resection of pancreatic cancer. (PubMed id 21347785) 1 (2011) miR-223 and miR-142 attenuate hematopoietic cell prol iferation, and miR-223 positively regulates miR-142 through LMO2 isoforms and C EBP-I^. (PubMed id 20856265) 1 (2010) Downregulation of microRNA-142 by proto-oncogene LMO2 and its co-factors. (PubMed id 17972953) 1 (2008)
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External Searches for MIR142 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing MIR142 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing MIR142 gene
(According to HUGE )
About This Section --
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Specialized Databases showing MIR142 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description PharmGKB entry for MIR142 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for MIR142 gene: MIR142 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor MIR142 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MIR142 Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MIR142 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MIR142 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human mouse rat Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MIR142 Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MIR142
Search Tocris compounds for MIR142
Search ThermoFisher Antibodies for MIR142
Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MIR142
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