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Aliases for MIR141 Gene

Subcategory (RNA class) for MIR141 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR141 Gene

  • MicroRNA 141 2 3
  • MIRN141 3 6
  • Hsa-Mir-141 3

External Ids for MIR141 Gene

ORGUL Members for MIR141 Gene

Previous Symbols for MIR141 Gene

  • MIRN141

Summaries for MIR141 Gene

Entrez Gene Summary for MIR141 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR141 Gene

MIR141 (MicroRNA 141) is a RNA Gene, and belongs to miRNA RNA class. Diseases associated with MIR141 include hepatitis c virus. Among its related pathways are MicroRNAs in cancer.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR141 Gene

Genomics for MIR141 Gene

Genomic Location for MIR141 Gene

Start:
6,964,097 bp from pter
End:
6,964,191 bp from pter
Size:
95 bases
Orientation:
Plus strand

Genomic View for MIR141 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR141 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR141 Gene

No data available for Regulatory Elements for MIR141 Gene

Proteins for MIR141 Gene

Post-translational modifications for MIR141 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR141 Gene

Domains for MIR141 Gene

Gene Families for MIR141 Gene

HGNC:
  • MIR :ncRNAs / Micro RNAs
genes like me logo Genes that share domains with MIR141: view

No data available for Protein Domains and UniProtKB/Swiss-Prot for MIR141 Gene

Function for MIR141 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MIR141 Gene

Localization for MIR141 Gene

No data available for Gene Ontology (GO) - Cellular Components for MIR141 Gene

Pathways for MIR141 Gene

SuperPathways for MIR141 Gene

Superpath Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR141: view

Pathways by source for MIR141 Gene

1 KEGG pathway for MIR141 Gene

Interacting Proteins for MIR141 Gene

Gene Ontology (GO) - Biological Process for MIR141 Gene

None

Transcripts for MIR141 Gene

mRNA/cDNA for MIR141 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR141 Gene

No ASD Table

Relevant External Links for MIR141 Gene

GeneLoc Exon Structure for
MIR141
ECgene alternative splicing isoforms for
MIR141

Expression for MIR141 Gene

mRNA expression in normal human tissues for MIR141 Gene

genes like me logo Genes that share expressions with MIR141: view

Orthologs for MIR141 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR141 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-141-1 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-141 37
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-141 37
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir141 37
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-141 37
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-200a 37
  • 41 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-200a 37
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-200a 37
  • 63 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-141 37
  • 60 (a)
OneToMany
dre-mir-200a 37
  • 63 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea csa-mir-141 37
  • 49 (a)
OneToMany
Species with no ortholog for MIR141:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR141 Gene

ENSEMBL:
Gene Tree for MIR141 (if available)
TreeFam:
Gene Tree for MIR141 (if available)

Paralogs for MIR141 Gene

No data available for Paralogs for MIR141 Gene

Variants for MIR141 Gene

Sequence variations from dbSNP and Humsavar for MIR141 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs16933011 -- 6,964,642(+) TCCTG(G/T)ACATA downstream-variant-500B
rs74642626 -- 6,964,652(+) ACTTT(G/T)CACCT downstream-variant-500B
rs112516557 -- 6,964,395(+) TGGGA(A/G)CATGA downstream-variant-500B
rs115367070 -- 6,964,665(+) GTTTT(C/G)TCTGA downstream-variant-500B
rs115891778 -- 6,964,590(+) AACCC(A/G)GTCCC downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for MIR141 Gene

Variant ID Type Subtype PubMed ID
nsv898641 CNV Loss 21882294
nsv509453 CNV Insertion 20534489

Relevant External Links for MIR141 Gene

HapMap Linkage Disequilibrium report
MIR141

Disorders for MIR141 Gene

(1) MalaCards Diseases for MIR141 Gene

Search for MIR141 Gene in MalaCards »
genes like me logo Genes that share disorders with MIR141: view

No data available for UniProtKB/Swiss-Prot for MIR141 Gene

Publications for MIR141 Gene

  1. Identification of tissue-specific microRNAs from mouse. (PMID: 12007417) Lagos-Quintana M. … Tuschl T. (Curr. Biol. 2002) 3
  2. Reduced accumulation of specific microRNAs in colorectal neoplasia. (PMID: 14573789) Michael M.Z. … James R.J. (Mol. Cancer Res. 2003) 3
  3. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3
  4. A mammalian microRNA expression atlas based on small RNA library sequencing. (PMID: 17604727) Landgraf P. … Tuschl T. (Cell 2007) 3
  5. Patterns of known and novel small RNAs in human cervical cancer. (PMID: 17616659) Lui W.O. … Fire A. (Cancer Res. 2007) 3

Products for MIR141 Gene

Sources for MIR141 Gene

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