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Aliases for MIR141 Gene

Subcategory (RNA class) for MIR141 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR141 Gene

  • MicroRNA 141 2 3 5
  • Hsa-Mir-141 3
  • Mir-141 3
  • MIRN141 3

External Ids for MIR141 Gene

ORGUL Members for MIR141 Gene

Previous HGNC Symbols for MIR141 Gene

  • MIRN141

Previous GeneCards Identifiers for MIR141 Gene

  • GC12P006972
  • GC12P006976
  • GC12P007073
  • GC12P007035
  • GC12P007178
  • GC12P007225
  • GC12P007278
  • GC12P007320
  • GC12P007375

Summaries for MIR141 Gene

Entrez Gene Summary for MIR141 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR141 Gene

MIR141 (MicroRNA 141) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are miRNA targets in ECM and membrane receptors and Mesodermal Commitment Pathway.

Additional gene information for MIR141 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR141 Gene

Genomics for MIR141 Gene

Regulatory Elements for MIR141 Gene

Enhancers for MIR141 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12H006923 1.7 FANTOM5 ENCODE dbSUPER 11.8 -36.9 -36947 6 HDGF ARID4B SIN3A ZNF2 YY1 ZNF143 FOS DEK PAF1 SP3 ZNF384 CHD4 ENSG00000219410 LRRC23 ENSG00000247853 SCARNA12 EMG1 PHB2 RPL13P5 NCAPD2
GH12H006930 0.2 dbSUPER 11.8 -33.0 -33040 0 MIR141 MIR200CHG MIR200C PHB2 SCARNA12 EMG1 SPSB2 RPL13P5 LRRC23 TPI1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR141 on UCSC Golden Path with GeneCards custom track

Promoters for MIR141 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000048377 -597 1001 GTF2F1 NFIB SIN3A RELA HIC1 POLR2A MAZ ZNF740 NFIA NRF1

Genomic Location for MIR141 Gene

Chromosome:
12
Start:
6,964,097 bp from pter
End:
6,964,191 bp from pter
Size:
95 bases
Orientation:
Plus strand

Genomic View for MIR141 Gene

Genes around MIR141 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR141 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR141 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR141 Gene

Proteins for MIR141 Gene

Post-translational modifications for MIR141 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR141 Gene

Domains & Families for MIR141 Gene

Gene Families for MIR141 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR141: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR141 Gene

Function for MIR141 Gene

Gene Ontology (GO) - Molecular Function for MIR141 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 15131085
genes like me logo Genes that share ontologies with MIR141: view

Animal Model Products

CRISPR Products

miRNA Products

Clone Products

  • Applied Biological Materials Clones for MIR141
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR141 Gene

Localization for MIR141 Gene

Gene Ontology (GO) - Cellular Components for MIR141 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 26646931
genes like me logo Genes that share ontologies with MIR141: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR141 Gene

Pathways & Interactions for MIR141 Gene

genes like me logo Genes that share pathways with MIR141: view

Pathways by source for MIR141 Gene

Interacting Proteins for MIR141 Gene

Gene Ontology (GO) - Biological Process for MIR141 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008284 positive regulation of cell proliferation IMP 16762633
GO:0035195 gene silencing by miRNA IMP 16762633
GO:0050728 negative regulation of inflammatory response ISS --
GO:1904995 negative regulation of leukocyte adhesion to vascular endothelial cell IGI 26371161
genes like me logo Genes that share ontologies with MIR141: view

No data available for SIGNOR curated interactions for MIR141 Gene

Drugs & Compounds for MIR141 Gene

No Compound Related Data Available

Transcripts for MIR141 Gene

mRNA/cDNA for MIR141 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Clone Products

  • Applied Biological Materials Clones for MIR141
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for MIR141 Gene

No ASD Table

Relevant External Links for MIR141 Gene

GeneLoc Exon Structure for
MIR141
ECgene alternative splicing isoforms for
MIR141

Expression for MIR141 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR141 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR141 Gene:

MIR141
genes like me logo Genes that share expression patterns with MIR141: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR141 Gene

Orthologs for MIR141 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR141 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-141-1 34
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-141 34
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir141 34
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-141 34
  • 89 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-141 34
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-200a 34
  • 41 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-200a 34
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-200a 34
  • 63 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-200a 34
  • 63 (a)
OneToMany
dre-mir-141 34
  • 60 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea csa-mir-141 34
  • 49 (a)
OneToMany
Species where no ortholog for MIR141 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR141 Gene

ENSEMBL:
Gene Tree for MIR141 (if available)
TreeFam:
Gene Tree for MIR141 (if available)

Paralogs for MIR141 Gene

No data available for Paralogs for MIR141 Gene

Variants for MIR141 Gene

Sequence variations from dbSNP and Humsavar for MIR141 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1001110105 -- 6,963,829(+) GCAGC(A/C)CCCTC intron-variant, downstream-variant-500B, upstream-variant-2KB
rs1001273984 -- 6,964,080(+) AGCGC(A/G)CACCG intron-variant, downstream-variant-500B, upstream-variant-2KB
rs1001417130 -- 6,963,487(+) GCCGA(C/T)GGTCG intron-variant, upstream-variant-2KB
rs1005625574 -- 6,963,031(+) CTAGG(C/T)AGGTT nc-transcript-variant, upstream-variant-2KB
rs1005677858 -- 6,963,176(+) TGTGC(G/T)CAGGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR141 Gene

Variant ID Type Subtype PubMed ID
nsv1035811 CNV gain 25217958
nsv1047373 CNV gain 25217958
nsv509453 CNV insertion 20534489

Relevant External Links for MIR141 Gene

Human Gene Mutation Database (HGMD)
MIR141
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR141

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR141 Gene

Disorders for MIR141 Gene

Relevant External Links for MIR141

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR141

No disorders were found for MIR141 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR141 Gene

Publications for MIR141 Gene

  1. Lnc-ATB contributes to gastric cancer growth through a MiR-141-3p/TGFβ2 feedback loop. (PMID: 28115163) Lei K … Liu J (Biochemical and biophysical research communications 2017) 3 60
  2. MicroRNA-141 inhibits tumor growth and minimizes therapy resistance in colorectal cancer. (PMID: 28112364) Ye J … Huang J (Molecular medicine reports 2017) 3 60
  3. MicroRNA-141 enhances anoikis resistance in metastatic progression of ovarian cancer through targeting KLF12/Sp1/survivin axis. (PMID: 28095864) Mak CS … Chan DW (Molecular cancer 2017) 3 60
  4. MiR-141-3p promotes prostate cancer cell proliferation through inhibiting kruppel-like factor-9 expression. (PMID: 27956179) Li JZ … Wang YJ (Biochemical and biophysical research communications 2017) 3 60
  5. miRNA-141 attenuates UV-induced oxidative stress via activating Keap1-Nrf2 signaling in human retinal pigment epithelium cells and retinal ganglion cells. (PMID: 28061435) Cheng LB … Wu ZF (Oncotarget 2017) 3 60

Products for MIR141 Gene

Sources for MIR141 Gene

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