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Aliases for MIR140 Gene

Subcategory (RNA class) for MIR140 Gene


Quality Score for this RNA gene is


Aliases for MIR140 Gene

  • MicroRNA 140 2 3
  • Hsa-Mir-140 3
  • MiRNA140 3
  • Mir-140 3
  • MIRN140 3

External Ids for MIR140 Gene

ORGUL Members for MIR140 Gene

Previous HGNC Symbols for MIR140 Gene

  • MIRN140

Previous GeneCards Identifiers for MIR140 Gene

  • GC16P068527
  • GC16P069966

Summaries for MIR140 Gene

Entrez Gene Summary for MIR140 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR140 Gene

MIR140 (MicroRNA 140) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR140 include spinal chordoma. Among its related pathways are MicroRNAs in cardiomyocyte hypertrophy.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR140 Gene

Genomics for MIR140 Gene

Genomic Location for MIR140 Gene

69,933,073 bp from pter
69,933,182 bp from pter
110 bases
Plus strand

Genomic View for MIR140 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR140 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR140 Gene

No data available for Regulatory Elements for MIR140 Gene

Proteins for MIR140 Gene

Post-translational modifications for MIR140 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR140 Gene

Domains & Families for MIR140 Gene

Gene Families for MIR140 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR140: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR140 Gene

Function for MIR140 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR140 Gene

Localization for MIR140 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR140 Gene

Pathways & Interactions for MIR140 Gene

genes like me logo Genes that share pathways with MIR140: view

Pathways by source for MIR140 Gene

1 BioSystems pathway for MIR140 Gene

Interacting Proteins for MIR140 Gene

Gene Ontology (GO) - Biological Process for MIR140 Gene


No data available for SIGNOR curated interactions for MIR140 Gene

Drugs & Compounds for MIR140 Gene

No Compound Related Data Available

Transcripts for MIR140 Gene

mRNA/cDNA for MIR140 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR140 Gene

No ASD Table

Relevant External Links for MIR140 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR140 Gene

mRNA expression in normal human tissues for MIR140 Gene

genes like me logo Genes that share expression patterns with MIR140: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MIR140 Gene

Orthologs for MIR140 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR140 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia bta-mir-140 36
  • 100 (a)
(Canis familiaris)
Mammalia cfa-mir-140 36
  • 100 (a)
(Monodelphis domestica)
Mammalia mdo-mir-140 36
  • 100 (a)
(Mus musculus)
Mammalia Mir140 36
  • 100 (a)
(Ornithorhynchus anatinus)
Mammalia oan-mir-140 36
  • 76 (a)
(Pan troglodytes)
Mammalia ptr-mir-140 36
  • 100 (a)
(Gallus gallus)
Aves gga-mir-140 36
  • 95 (a)
(Anolis carolinensis)
Reptilia aca-mir-140 36
  • 100 (a)
(Danio rerio)
Actinopterygii mir140 36
  • 82 (a)
Species with no ortholog for MIR140:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR140 Gene

Gene Tree for MIR140 (if available)
Gene Tree for MIR140 (if available)

Paralogs for MIR140 Gene

No data available for Paralogs for MIR140 Gene

Variants for MIR140 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR140 Gene

Variant ID Type Subtype PubMed ID
dgv895e1 CNV Complex 17122850
nsv509630 CNV Insertion 20534489
nsv1853 CNV Loss 18451855

Relevant External Links for MIR140 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Variation tolerance for MIR140 Gene

Disorders for MIR140 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIR140 Gene - From: GeneCards

Disorder Aliases PubMed IDs
spinal chordoma
  • chordoma of spine
- elite association

Relevant External Links for MIR140

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with MIR140: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR140 Gene

Publications for MIR140 Gene

  1. RANKL expression in myeloma cells is regulated by a network involving RANKL promoter methylation, DNMT1, microRNA and TNFI+ in the microenvironment. (PMID: 24875904) Yuan L. … Chim C.S. (Biochim. Biophys. Acta 2014) 67
  2. Downregulation of miR-140 promotes cancer stem cell formation in basal-like early stage breast cancer. (PMID: 23752191) Li Q. … Zhou Q. (Oncogene 2014) 67
  3. miR-140-5p suppresses BMP2-mediated osteogenesis in undifferentiated human mesenchymal stem cells. (PMID: 24928442) Hwang S. … Suh N. (FEBS Lett. 2014) 67
  4. microRNA-140 targets RALA and regulates chondrogenic differentiation of human mesenchymal stem cells by translational enhancement of SOX9 and ACAN. (PMID: 24063364) Karlsen T.A. … Brinchmann J.E. (Stem Cells Dev. 2014) 67
  5. Identification of miR-140-3p as a marker associated with poor prognosis in spinal chordoma. (PMID: 25197358) Zou M.X. … Deng Y.W. (Int J Clin Exp Pathol 2014) 67

Products for MIR140 Gene

Sources for MIR140 Gene

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