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Aliases for MIR140 Gene

Subcategory (RNA class) for MIR140 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR140 Gene

  • MicroRNA 140 2 3 5
  • Hsa-Mir-140 3
  • MiRNA140 3
  • Mir-140 3
  • MIRN140 3

External Ids for MIR140 Gene

ORGUL Members for MIR140 Gene

Previous HGNC Symbols for MIR140 Gene

  • MIRN140

Previous GeneCards Identifiers for MIR140 Gene

  • GC16P068527
  • GC16P069966

Summaries for MIR140 Gene

Entrez Gene Summary for MIR140 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR140 Gene

MIR140 (MicroRNA 140) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR140 include Spinal Chordoma. Among its related pathways are MicroRNAs in cardiomyocyte hypertrophy.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR140 Gene

Genomics for MIR140 Gene

Regulatory Elements for MIR140 Gene

Enhancers for MIR140 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MIR140 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR140 Gene

Chromosome:
16
Start:
69,933,073 bp from pter
End:
69,933,182 bp from pter
Size:
110 bases
Orientation:
Plus strand

Genomic View for MIR140 Gene

Genes around MIR140 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR140 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR140 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR140 Gene

Proteins for MIR140 Gene

Post-translational modifications for MIR140 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR140 Gene

Domains & Families for MIR140 Gene

Gene Families for MIR140 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR140: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR140 Gene

Function for MIR140 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR140 Gene

Localization for MIR140 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR140 Gene

Pathways & Interactions for MIR140 Gene

genes like me logo Genes that share pathways with MIR140: view

Pathways by source for MIR140 Gene

1 BioSystems pathway for MIR140 Gene

Interacting Proteins for MIR140 Gene

Gene Ontology (GO) - Biological Process for MIR140 Gene

None

No data available for SIGNOR curated interactions for MIR140 Gene

Drugs & Compounds for MIR140 Gene

No Compound Related Data Available

Transcripts for MIR140 Gene

mRNA/cDNA for MIR140 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR140 Gene

No ASD Table

Relevant External Links for MIR140 Gene

GeneLoc Exon Structure for
MIR140
ECgene alternative splicing isoforms for
MIR140

Expression for MIR140 Gene

mRNA expression in normal human tissues for MIR140 Gene

genes like me logo Genes that share expression patterns with MIR140: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MIR140 Gene

Orthologs for MIR140 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR140 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia bta-mir-140 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-140 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-140 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir140 36
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-140 36
  • 76 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-140 36
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-140 36
  • 95 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-140 36
  • 100 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii mir140 36
  • 82 (a)
OneToOne
Species with no ortholog for MIR140:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR140 Gene

ENSEMBL:
Gene Tree for MIR140 (if available)
TreeFam:
Gene Tree for MIR140 (if available)

Paralogs for MIR140 Gene

No data available for Paralogs for MIR140 Gene

Variants for MIR140 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR140 Gene

Variant ID Type Subtype PubMed ID
dgv895e1 CNV Complex 17122850
nsv509630 CNV Insertion 20534489
nsv1853 CNV Loss 18451855

Relevant External Links for MIR140 Gene

Human Gene Mutation Database (HGMD)
MIR140

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Variation tolerance for MIR140 Gene

Disorders for MIR140 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIR140 Gene - From: GeneCards

Disorder Aliases PubMed IDs
spinal chordoma
  • chordoma of spine
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for MIR140

Genetic Association Database (GAD)
MIR140
Human Genome Epidemiology (HuGE) Navigator
MIR140
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR140
genes like me logo Genes that share disorders with MIR140: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR140 Gene

Publications for MIR140 Gene

  1. Single nucleotide polymorphisms in miRNA binding sites and miRNA genes as breast/ovarian cancer risk modifiers in Jewish high-risk women. (PMID: 19950226) Kontorovich T. … Friedman E. (Int. J. Cancer 2010) 3 48 67
  2. Identification of a novel FGFRL1 MicroRNA target site polymorphism for bone mineral density in meta-analyses of genome-wide association studies. (PMID: 25941324) Niu T. … Deng H.W. (Hum. Mol. Genet. 2015) 3
  3. NRF2/miR-140 signaling confers radioprotection to human lung fibroblasts. (PMID: 26300493) Duru N. … Zhou Q. (Cancer Lett. 2015) 3
  4. Role of miR-140 in embryonic bone development and cancer. (PMID: 26318829) Green D. … Fraser W.D. (Clin. Sci. 2015) 3
  5. Downregulation of miR-140 promotes cancer stem cell formation in basal-like early stage breast cancer. (PMID: 23752191) Li Q. … Zhou Q. (Oncogene 2014) 3

Products for MIR140 Gene

Sources for MIR140 Gene

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