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Aliases for MIR139 Gene

Subcategory (RNA class) for MIR139 Gene

miRNA

Quality Score for this RNA gene is

8

Aliases for MIR139 Gene

  • MicroRNA 139 2 3 5
  • Hsa-Mir-139 3
  • MIR139-3p 3
  • Mir-139 3
  • MIRN139 3

External Ids for MIR139 Gene

Previous HGNC Symbols for MIR139 Gene

  • MIRN139

Previous GeneCards Identifiers for MIR139 Gene

  • GC11M072006
  • GC11M072326

Summaries for MIR139 Gene

Entrez Gene Summary for MIR139 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR139 Gene

MIR139 (MicroRNA 139) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR139 include bladder carcinoma in situ.

fRNAdb sequence ontologies for MIR139 Gene

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR139

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR139 Gene

Genomics for MIR139 Gene

Genomic Location for MIR139 Gene

Chromosome:
11
Start:
72,615,063 bp from pter
End:
72,615,130 bp from pter
Size:
68 bases
Orientation:
Minus strand

Genomic View for MIR139 Gene

Genes around MIR139 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR139 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR139 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR139 Gene

ORGUL Member Location for MIR139 Gene

ORGUL Member Location for MIR139 gene

No data available for Regulatory Elements for MIR139 Gene

Proteins for MIR139 Gene

Post-translational modifications for MIR139 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR139 Gene

Domains & Families for MIR139 Gene

Gene Families for MIR139 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR139: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR139 Gene

Function for MIR139 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR139 Gene

Localization for MIR139 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR139 Gene

Pathways & Interactions for MIR139 Gene

SuperPathways for MIR139 Gene

No Data Available

Interacting Proteins for MIR139 Gene

Gene Ontology (GO) - Biological Process for MIR139 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR139 Gene

Drugs & Compounds for MIR139 Gene

No Compound Related Data Available

Transcripts for MIR139 Gene

fRNAdb Secondary structures for MIR139 Gene

  • hsa-miR-139-3p_MIMAT0004552_Homo_sapiens_miR-139-3p_mature

mRNA/cDNA for MIR139 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR139 Gene

No ASD Table

Relevant External Links for MIR139 Gene

GeneLoc Exon Structure for
MIR139
ECgene alternative splicing isoforms for
MIR139

Expression for MIR139 Gene

mRNA expression in normal human tissues for MIR139 Gene

genes like me logo Genes that share expression patterns with MIR139: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MIR139 Gene

Orthologs for MIR139 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR139 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-139 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-139 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-139 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir139 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-139 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-139 36
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-139 36
  • 66 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-139 36
  • 81 (a)
OneToOne
Species with no ortholog for MIR139:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR139 Gene

ENSEMBL:
Gene Tree for MIR139 (if available)
TreeFam:
Gene Tree for MIR139 (if available)

Paralogs for MIR139 Gene

No data available for Paralogs for MIR139 Gene

Variants for MIR139 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR139 Gene

Variant ID Type Subtype PubMed ID
nsv832207 CNV Loss 17160897
nsv468633 CNV Loss 19166990
nsv523601 CNV Loss 19592680
nsv825991 CNV Gain 20364138

Relevant External Links for MIR139 Gene

HapMap Linkage Disequilibrium report
MIR139

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Variation tolerance for MIR139 Gene

Disorders for MIR139 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIR139 Gene - From: GeneCards

Disorder Aliases PubMed IDs
bladder carcinoma in situ
  • bladder ca in situ
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for MIR139

Genetic Association Database (GAD)
MIR139
Human Genome Epidemiology (HuGE) Navigator
MIR139
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR139
genes like me logo Genes that share disorders with MIR139: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR139 Gene

Publications for MIR139 Gene

  1. Novel genetic variants in miR-191 gene and familial ovarian cancer. (PMID: 20167074) Shen J. … Zhao H. (BMC Cancer 2010) 3 48 67
  2. Identification of tissue-specific microRNAs from mouse. (PMID: 12007417) Lagos-Quintana M. … Tuschl T. (Curr. Biol. 2002) 1 3
  3. miR-139-5p inhibits epithelial-mesenchymal transition, migration and invasion of hepatocellular carcinoma cells by targeting ZEB1 and ZEB2. (PMID: 26022123) Qiu G. … Wu D. (Biochem. Biophys. Res. Commun. 2015) 3
  4. MicroRNAs targeting the immunomodulatory HLA-G gene: a new survey searching for microRNAs with potential to regulate HLA-G. (PMID: 25700346) Porto I.O. … Castelli E.C. (Mol. Immunol. 2015) 3
  5. MiR-139-5p: promising biomarker for cancer. (PMID: 25691250) Zhang H.D. … Tang J.H. (Tumour Biol. 2015) 3

Products for MIR139 Gene

Sources for MIR139 Gene

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