Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MIR139 Gene

Subcategory (RNA class) for MIR139 Gene


Quality Score for this RNA gene is


Aliases for MIR139 Gene

  • MicroRNA 139 2 3
  • MIR139-3p 3 6
  • Hsa-Mir-139 3
  • MIRN139 3

External Ids for MIR139 Gene

Previous HGNC Symbols for MIR139 Gene

  • MIRN139

Previous GeneCards Identifiers for MIR139 Gene

  • GC11M072006
  • GC11M072326

Summaries for MIR139 Gene

Entrez Gene Summary for MIR139 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR139 Gene

MIR139 (MicroRNA 139) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR139 include bladder carcinoma in situ.

fRNAdb sequence ontologies for MIR139 Gene

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR139

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR139 Gene

Genomics for MIR139 Gene

Genomic Location for MIR139 Gene

72,615,063 bp from pter
72,615,130 bp from pter
68 bases
Minus strand

Genomic View for MIR139 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR139 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR139 Gene

ORGUL Member Location for MIR139 Gene

ORGUL Member Location for MIR139 gene

No data available for Regulatory Elements for MIR139 Gene

Proteins for MIR139 Gene

Post-translational modifications for MIR139 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR139 Gene

Domains for MIR139 Gene

Gene Families for MIR139 Gene

  • MIR :ncRNAs / Micro RNAs

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR139: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR139 Gene

Function for MIR139 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MIR139 Gene

Localization for MIR139 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR139 Gene

Pathways for MIR139 Gene

SuperPathways for MIR139 Gene

No Data Available

Interacting Proteins for MIR139 Gene

Gene Ontology (GO) - Biological Process for MIR139 Gene


No data available for Pathways by source for MIR139 Gene

Transcripts for MIR139 Gene

fRNAdb Secondary structures for MIR139 Gene

  • hsa-miR-139-3p_MIMAT0004552_Homo_sapiens_miR-139-3p_mature

mRNA/cDNA for MIR139 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR139 Gene

No ASD Table

Relevant External Links for MIR139 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR139 Gene

mRNA expression in normal human tissues for MIR139 Gene

genes like me logo Genes that share expressions with MIR139: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for MIR139 Gene

Orthologs for MIR139 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR139 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia bta-mir-139 36
  • 99 (a)
(Canis familiaris)
Mammalia cfa-mir-139 36
  • 96 (a)
(Monodelphis domestica)
Mammalia mdo-mir-139 36
  • 83 (a)
(Mus musculus)
Mammalia Mir139 36
  • 100 (a)
(Ornithorhynchus anatinus)
Mammalia oan-mir-139 36
  • 60 (a)
(Pan troglodytes)
Mammalia ptr-mir-139 36
  • 100 (a)
(Anolis carolinensis)
Reptilia aca-mir-139 36
  • 66 (a)
(Danio rerio)
Actinopterygii dre-mir-139 36
  • 81 (a)
Species with no ortholog for MIR139:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR139 Gene

Gene Tree for MIR139 (if available)
Gene Tree for MIR139 (if available)

Paralogs for MIR139 Gene

No data available for Paralogs for MIR139 Gene

Variants for MIR139 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR139 Gene

Variant ID Type Subtype PubMed ID
nsv832207 CNV Loss 17160897
nsv468633 CNV Loss 19166990
nsv523601 CNV Loss 19592680
nsv825991 CNV Gain 20364138

Relevant External Links for MIR139 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for MIR139 Gene

Disorders for MIR139 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for MIR139 Gene in MalaCards »

(1) Diseases for MIR139 Gene including...

Relevant External Links for MIR139

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with MIR139: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for MIR139 Gene

Publications for MIR139 Gene

  1. Novel genetic variants in miR-191 gene and familial ovarian cancer. (PMID: 20167074) Shen J. … Zhao H. (BMC Cancer 2010) 3 48
  2. Genetic polymorphisms in the precursor MicroRNA flanking region and non-small cell lung cancer survival. (PMID: 20889907) Hu Z. … Shen H. (Am. J. Respir. Crit. Care Med. 2011) 3
  3. The microRNA miR-139 suppresses metastasis and progression of hepatocellular carcinoma by down-regulating Rho-kinase 2. (PMID: 20951699) Wong C.C. … Ng I.O. (Gastroenterology 2011) 3
  4. Differential expression of microRNA-675, microRNA-139-3p and microRNA-335 in benign and malignant adrenocortical tumours. (PMID: 21471143) Schmitz K.J. … Schmid K.W. (J. Clin. Pathol. 2011) 3
  5. HER2 interacts with CD44 to up-regulate CXCR4 via epigenetic silencing of microRNA-139 in gastric cancer cells. (PMID: 21925125) Bao W. … Yang A.G. (Gastroenterology 2011) 3

Products for MIR139 Gene

Sources for MIR139 Gene

Back to Top