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Aliases for MIR139 Gene

Subcategory (RNA class) for MIR139 Gene

miRNA

Quality Score for this RNA gene is

8

Aliases for MIR139 Gene

  • MicroRNA 139 2 3 5
  • Hsa-Mir-139 3
  • MIR139-3p 3
  • Mir-139 3
  • MIRN139 3

External Ids for MIR139 Gene

Previous HGNC Symbols for MIR139 Gene

  • MIRN139

Previous GeneCards Identifiers for MIR139 Gene

  • GC11M072006
  • GC11M072326

Summaries for MIR139 Gene

Entrez Gene Summary for MIR139 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR139 Gene

MIR139 (MicroRNA 139) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR139 include Bladder Carcinoma In Situ and Primary Biliary Cholangitis. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins..

fRNAdb sequence ontologies for MIR139 Gene

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR139

Additional gene information for MIR139 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR139 Gene

Genomics for MIR139 Gene

GeneHancer (GH) Regulatory Elements for MIR139 Gene

Promoters and enhancers for MIR139 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I072615 Enhancer 0.9 ENCODE dbSUPER 550.8 +0.9 948 0.2 MAX CTBP1 POLR2A EGR1 VEZF1 IKZF2 RUNX3 NFE2L2 L3MBTL2 CBFA2T3 GC11M072616 MIR139 LOC105369377 PDE2A
GH11I072614 Enhancer 0.5 dbSUPER 550.8 -0.4 -449 1.3 ZFHX2 PRDM10 ZNF398 EGR2 MIR139 GC11M072616 ENSG00000256148 STARD10 RNU7-105P LOC105369377 PDE2A
GH11I072652 Enhancer 0.8 ENCODE dbSUPER 12.2 -38.0 -37952 0.2 HDAC1 MXI1 RFX1 MAX CBFA2T3 SIN3A ZEB2 POLR2A HDAC2 ZSCAN29 ARAP1 PDE2A MIR139 ARAP1-AS1 RNU7-105P LOC105369379
GH11I072550 Enhancer 0.6 ENCODE 11.6 +62.7 62724 3.2 MEIS2 CTCF PKNOX1 MAX MAFG REST RAD21 MITF MAFF ZNF316 LOC100421204 LOC105369378 MIR139 PDE2A ARAP1-AS1 ARAP1 ENSG00000256403 STARD10 ENSG00000274664
GH11I072547 Enhancer 0.5 ENCODE 11.5 +66.2 66247 2.7 STAT3 CEBPB EP300 BRCA1 LINC01537 LOC105369378 MIR139 PDE2A ARAP1-AS1 ARAP1 ENSG00000256403 ZNF705E ART2P STARD10
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR139 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR139 Gene

Genomic Locations for MIR139 Gene
chr11:72,615,063-72,615,130
(GRCh38/hg38)
Size:
68 bases
Orientation:
Minus strand
chr11:72,326,107-72,326,174
(GRCh37/hg19)

Genomic View for MIR139 Gene

Genes around MIR139 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR139 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR139 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR139 Gene

ORGUL Member Location for MIR139 Gene

ORGUL Member Location for MIR139 gene

Proteins for MIR139 Gene

Post-translational modifications for MIR139 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR139 Gene

Domains & Families for MIR139 Gene

Gene Families for MIR139 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR139: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR139 Gene

Function for MIR139 Gene

Gene Ontology (GO) - Molecular Function for MIR139 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000993 RNA polymerase II core binding IDA 25336585
genes like me logo Genes that share ontologies with MIR139: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR139 Gene

Localization for MIR139 Gene

Gene Ontology (GO) - Cellular Components for MIR139 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 26646931
genes like me logo Genes that share ontologies with MIR139: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR139 Gene

Pathways & Interactions for MIR139 Gene

genes like me logo Genes that share pathways with MIR139: view

Pathways by source for MIR139 Gene

1 BioSystems pathway for MIR139 Gene

Interacting Proteins for MIR139 Gene

Gene Ontology (GO) - Biological Process for MIR139 Gene

None

No data available for SIGNOR curated interactions for MIR139 Gene

Drugs & Compounds for MIR139 Gene

No Compound Related Data Available

Transcripts for MIR139 Gene

fRNAdb Secondary structures for MIR139 Gene

  • hsa-miR-139-3p_MIMAT0004552_Homo_sapiens_miR-139-3p_mature

mRNA/cDNA for MIR139 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR139 Gene

No ASD Table

Relevant External Links for MIR139 Gene

GeneLoc Exon Structure for
MIR139
ECgene alternative splicing isoforms for
MIR139

Expression for MIR139 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR139 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR139 Gene:

MIR139
genes like me logo Genes that share expression patterns with MIR139: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR139 Gene

Orthologs for MIR139 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR139 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Mir139 34
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-139 34
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-139 34
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-139 34
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-139 34
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-139 34
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-139 34
  • 66 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-139 34
  • 81 (a)
OneToOne
Species where no ortholog for MIR139 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR139 Gene

ENSEMBL:
Gene Tree for MIR139 (if available)
TreeFam:
Gene Tree for MIR139 (if available)

Paralogs for MIR139 Gene

No data available for Paralogs for MIR139 Gene

Variants for MIR139 Gene

Sequence variations from dbSNP and Humsavar for MIR139 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000838175 -- 72,615,674(-) G/A upstream_transcript_variant
rs1000949542 -- 72,616,166(-) G/C upstream_transcript_variant
rs1001023057 -- 72,615,821(-) T/C upstream_transcript_variant
rs1001354769 -- 72,614,649(-) C/T downstream_transcript_variant
rs1001841523 -- 72,614,564(-) C/G downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR139 Gene

Variant ID Type Subtype PubMed ID
dgv2005n54 CNV loss 21841781
nsv1042182 CNV gain 25217958
nsv468633 CNV loss 19166990
nsv523601 CNV loss 19592680
nsv825991 CNV gain 20364138
nsv832207 CNV loss 17160897

Additional Variant Information for MIR139 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR139

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR139 Gene

Disorders for MIR139 Gene

MalaCards: The human disease database

(2) MalaCards diseases for MIR139 Gene - From: GeneCards

Disorder Aliases PubMed IDs
bladder carcinoma in situ
  • bladder ca in situ
primary biliary cholangitis
  • pbc
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR139

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MIR139: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR139 Gene

Publications for MIR139 Gene

  1. Novel genetic variants in miR-191 gene and familial ovarian cancer. (PMID: 20167074) Shen J … Zhao H (BMC cancer 2010) 3 44 58
  2. Identification of tissue-specific microRNAs from mouse. (PMID: 12007417) Lagos-Quintana M … Tuschl T (Current biology : CB 2002) 1 3 58
  3. MicroRNA-139 inhibits the proliferation and migration of osteosarcoma cells via targeting forkhead-box P2. (PMID: 28993144) Zhong C … Zheng J (Life sciences 2017) 3 58
  4. MicroRNA-139-5p inhibits bladder cancer proliferation and self-renewal by targeting the Bmi1 oncogene. (PMID: 28720065) Luo H … Xu C (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2017) 3 58
  5. miR-139-5p Represses BMSC Osteogenesis via Targeting Wnt/β-Catenin Signaling Pathway. (PMID: 28622009) Long H … Zhu J (DNA and cell biology 2017) 3 58

Products for MIR139 Gene

Sources for MIR139 Gene

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