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Aliases for MIR138-2 Gene

Subcategory (RNA class) for MIR138-2 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR138-2 Gene

  • MicroRNA 138-2 2 3 5
  • Hsa-Mir-138-2 3
  • Mir-138-2 3
  • MIRN138-2 3

External Ids for MIR138-2 Gene

ORGUL Members for MIR138-2 Gene

Previous HGNC Symbols for MIR138-2 Gene

  • MIRN138-2

Previous GeneCards Identifiers for MIR138-2 Gene

  • GC16P055452
  • GC16P056892

Summaries for MIR138-2 Gene

Entrez Gene Summary for MIR138-2 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR138-2 Gene

MIR138-2 (MicroRNA 138-2) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins..

Additional gene information for MIR138-2 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR138-2 Gene

Genomics for MIR138-2 Gene

Regulatory Elements for MIR138-2 Gene

Enhancers for MIR138-2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16H056914 1.9 FANTOM5 Ensembl ENCODE dbSUPER 11.4 +58.8 58779 5.6 HDGF PKNOX1 FOXA2 ATF1 MLX ARID4B DMAP1 YBX1 ZNF121 SLC30A9 HERPUD1 MIR138-2 ENSG00000261270 MT1X NLRC5 RPS24P17
GH16H056604 2 FANTOM5 Ensembl ENCODE dbSUPER 9.9 -248.4 -248363 10.8 HDGF PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 RSPRY1 BBS2 MT1A MT1F MT1H MT1G MT3 MT1DP MT1CP MT1B
GH16H056908 1.8 FANTOM5 Ensembl ENCODE dbSUPER 10.5 +52.9 52853 5.5 HDGF FOXA2 TBL1XR1 RB1 BMI1 BATF EGR1 SCRT2 ATF7 ETV6 HERPUD1 MIR138-2 MT1G MT1H ENSG00000261270 NLRC5 RPS24P17
GH16H056811 1.2 Ensembl ENCODE 10.8 -44.5 -44479 5 FOXA2 MLX ARNT ARID4B DMAP1 FOS SP5 ZHX2 MXD4 MIER2 NUP93 MT1G MT1H MIR138-2 GC16P056858
GH16H056616 0.9 ENCODE dbSUPER 9.8 -240.7 -240688 1.9 POLR2A SUZ12 TAF1 MAX CTBP2 REST RAD21 EZH2 YY1 MT1A MT1F MT1G MT1H MT1CP MT1DP MT1B MT3 MT1E MT1X
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR138-2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR138-2 Gene

Genomic Locations for MIR138-2 Gene
chr16:56,858,518-56,858,601
(GRCh38/hg38)
Size:
84 bases
Orientation:
Plus strand
chr16:56,892,430-56,892,513
(GRCh37/hg19)

Genomic View for MIR138-2 Gene

Genes around MIR138-2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR138-2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR138-2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR138-2 Gene

Proteins for MIR138-2 Gene

Post-translational modifications for MIR138-2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR138-2 Gene

Domains & Families for MIR138-2 Gene

Gene Families for MIR138-2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR138-2: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR138-2 Gene

Function for MIR138-2 Gene

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR138-2 Gene

Localization for MIR138-2 Gene

Gene Ontology (GO) - Cellular Components for MIR138-2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 25336585
GO:0005737 cytoplasm IDA 25336585
genes like me logo Genes that share ontologies with MIR138-2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR138-2 Gene

Pathways & Interactions for MIR138-2 Gene

genes like me logo Genes that share pathways with MIR138-2: view

Pathways by source for MIR138-2 Gene

1 BioSystems pathway for MIR138-2 Gene

Interacting Proteins for MIR138-2 Gene

Gene Ontology (GO) - Biological Process for MIR138-2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IDA 25336585
genes like me logo Genes that share ontologies with MIR138-2: view

No data available for SIGNOR curated interactions for MIR138-2 Gene

Drugs & Compounds for MIR138-2 Gene

No Compound Related Data Available

Transcripts for MIR138-2 Gene

mRNA/cDNA for MIR138-2 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR138-2 Gene

No ASD Table

Relevant External Links for MIR138-2 Gene

GeneLoc Exon Structure for
MIR138-2
ECgene alternative splicing isoforms for
MIR138-2

Expression for MIR138-2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR138-2 Gene

genes like me logo Genes that share expression patterns with MIR138-2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR138-2 Gene

Orthologs for MIR138-2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR138-2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia bta-mir-138-2 34
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-138 34
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-138b 34
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir138-2 34
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-138 34
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-138-2 34
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-138-2 34
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-138-1 34
  • 82 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-138 34
  • 75 (a)
OneToOne
Species where no ortholog for MIR138-2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR138-2 Gene

ENSEMBL:
Gene Tree for MIR138-2 (if available)
TreeFam:
Gene Tree for MIR138-2 (if available)

Paralogs for MIR138-2 Gene

No data available for Paralogs for MIR138-2 Gene

Variants for MIR138-2 Gene

Sequence variations from dbSNP and Humsavar for MIR138-2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000433296 -- 56,856,974(+) AAGAA(A/T)GTAAA upstream-variant-2KB
rs1001706062 -- 56,858,431(+) CATTG(G/T)TTGGG upstream-variant-2KB
rs1002115703 -- 56,858,148(+) AAAGT(G/T)CTGGG upstream-variant-2KB
rs1004178618 -- 56,856,557(+) TAGTT(C/G)GGTGT upstream-variant-2KB
rs1005903419 -- 56,857,722(+) GCTGG(C/G)AGTTC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR138-2 Gene

Variant ID Type Subtype PubMed ID
nsv1059098 CNV gain 25217958
esv33108 CNV loss 17666407

Relevant External Links for MIR138-2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR138-2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR138-2 Gene

Disorders for MIR138-2 Gene

Relevant External Links for MIR138-2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR138-2

No disorders were found for MIR138-2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR138-2 Gene

Publications for MIR138-2 Gene

  1. MiR-138: A promising therapeutic target for cancer. (PMID: 28378633) Sha HH … Feng JF (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2017) 3 60
  2. MicroRNAs regulate KDM5 histone demethylases in breast cancer cells. (PMID: 26621457) Denis H … Deplus R (Molecular bioSystems 2016) 3 60
  3. Derepression of MicroRNA-138 Contributes to Loss of the Human Articular Chondrocyte Phenotype. (PMID: 26359943) Seidl CI … Murphy CL (Arthritis & rheumatology (Hoboken, N.J.) 2016) 3 60
  4. Tumor suppressive microRNA-138 inhibits metastatic potential via the targeting of focal adhesion kinase in Ewing's sarcoma cells. (PMID: 26782922) Tanaka K … Tsumura H (International journal of oncology 2016) 3 60
  5. MiR-138 Acts as a Tumor Suppressor by Targeting EZH2 and Enhances Cisplatin-Induced Apoptosis in Osteosarcoma Cells. (PMID: 27019355) Zhu Z … Zhou X (PloS one 2016) 3 60

Products for MIR138-2 Gene

Sources for MIR138-2 Gene

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