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Aliases for MIR138-2 Gene

Subcategory (RNA class) for MIR138-2 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR138-2 Gene

  • MicroRNA 138-2 2 3 5
  • Hsa-Mir-138-2 3
  • Mir-138-2 3
  • MIRN138-2 3

External Ids for MIR138-2 Gene

ORGUL Members for MIR138-2 Gene

Previous HGNC Symbols for MIR138-2 Gene

  • MIRN138-2

Previous GeneCards Identifiers for MIR138-2 Gene

  • GC16P055452
  • GC16P056892

Summaries for MIR138-2 Gene

Entrez Gene Summary for MIR138-2 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR138-2 Gene

MIR138-2 (MicroRNA 138-2) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR138-2 Gene

Genomics for MIR138-2 Gene

Regulatory Elements for MIR138-2 Gene

Enhancers for MIR138-2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MIR138-2 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR138-2 Gene

Chromosome:
16
Start:
56,858,507 bp from pter
End:
56,858,616 bp from pter
Size:
110 bases
Orientation:
Plus strand

Genomic View for MIR138-2 Gene

Genes around MIR138-2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR138-2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR138-2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR138-2 Gene

Proteins for MIR138-2 Gene

Post-translational modifications for MIR138-2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR138-2 Gene

Domains & Families for MIR138-2 Gene

Gene Families for MIR138-2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR138-2: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR138-2 Gene

Function for MIR138-2 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR138-2 Gene

Localization for MIR138-2 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR138-2 Gene

Pathways & Interactions for MIR138-2 Gene

SuperPathways for MIR138-2 Gene

No Data Available

Interacting Proteins for MIR138-2 Gene

Gene Ontology (GO) - Biological Process for MIR138-2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR138-2 Gene

Drugs & Compounds for MIR138-2 Gene

No Compound Related Data Available

Transcripts for MIR138-2 Gene

mRNA/cDNA for MIR138-2 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR138-2 Gene

No ASD Table

Relevant External Links for MIR138-2 Gene

GeneLoc Exon Structure for
MIR138-2
ECgene alternative splicing isoforms for
MIR138-2

Expression for MIR138-2 Gene

mRNA expression in normal human tissues for MIR138-2 Gene

genes like me logo Genes that share expression patterns with MIR138-2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MIR138-2 Gene

Orthologs for MIR138-2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR138-2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia bta-mir-138-2 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-138b 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-138 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir138-2 36
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-138-2 36
  • 68 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-138 36
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-138-2 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-138-1 36
  • 82 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-138 36
  • 75 (a)
OneToOne
Species with no ortholog for MIR138-2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR138-2 Gene

ENSEMBL:
Gene Tree for MIR138-2 (if available)
TreeFam:
Gene Tree for MIR138-2 (if available)

Paralogs for MIR138-2 Gene

No data available for Paralogs for MIR138-2 Gene

Variants for MIR138-2 Gene

Sequence variations from dbSNP and Humsavar for MIR138-2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs12934563 -- 56,857,455(+) tttga(A/G)acaag upstream-variant-2KB
rs12934576 -- 56,857,467(+) tctca(A/G)actgg upstream-variant-2KB
rs9928011 -- 56,857,021(+) GTTGT(A/G)CTTTC upstream-variant-2KB
rs78936631 -- 56,856,745(+) CGAGT(C/T)CTTGG upstream-variant-2KB
rs28603292 -- 56,857,594(+) TAAAA(A/T)TTTTT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR138-2 Gene

Variant ID Type Subtype PubMed ID
esv33108 CNV Loss 17666407

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Variation tolerance and Relevant External Links for MIR138-2 Gene

Disorders for MIR138-2 Gene

Relevant External Links for MIR138-2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR138-2

No disorders were found for MIR138-2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR138-2 Gene

Publications for MIR138-2 Gene

  1. MicroRNA-138-5p regulates pancreatic cancer cell growth through targeting FOXC1. (PMID: 25875420) Yu C. … Sun C. (Cell Oncol (Dordr) 2015) 3 67
  2. MicroRNA-138 promotes tau phosphorylation by targeting retinoic acid receptor alpha. (PMID: 25680531) Wang X. … Sun Z. (FEBS Lett. 2015) 3
  3. Profiling peripheral microRNAs in obesity and type 2 diabetes mellitus. (PMID: 25912229) Wu L. … Xi W. (APMIS 2015) 3
  4. BCR-ABL/GATA1/miR-138 mini circuitry contributes to the leukemogenesis of chronic myeloid leukemia. (PMID: 23208504) Xu C. … Yu L. (Oncogene 2014) 3
  5. Induction of microRNA-138 by pro-inflammatory cytokines causes endothelial cell dysfunction. (PMID: 24486907) Sen A. … Peppel K. (FEBS Lett. 2014) 3

Products for MIR138-2 Gene

Sources for MIR138-2 Gene

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