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Aliases for MIR138-2 Gene

Subcategory (RNA class) for MIR138-2 Gene


Quality Score for this RNA gene is


Aliases for MIR138-2 Gene

  • MicroRNA 138-2 2 3
  • Hsa-Mir-138-2 3
  • Mir-138-2 3
  • MIRN138-2 3

External Ids for MIR138-2 Gene

ORGUL Members for MIR138-2 Gene

Previous HGNC Symbols for MIR138-2 Gene

  • MIRN138-2

Previous GeneCards Identifiers for MIR138-2 Gene

  • GC16P055452
  • GC16P056892

Summaries for MIR138-2 Gene

Entrez Gene Summary for MIR138-2 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR138-2 Gene

MIR138-2 (MicroRNA 138-2) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR138-2 Gene

Genomics for MIR138-2 Gene

Genomic Location for MIR138-2 Gene

56,858,507 bp from pter
56,858,616 bp from pter
110 bases
Plus strand

Genomic View for MIR138-2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR138-2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR138-2 Gene

No data available for Regulatory Elements for MIR138-2 Gene

Proteins for MIR138-2 Gene

Post-translational modifications for MIR138-2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR138-2 Gene

Domains & Families for MIR138-2 Gene

Gene Families for MIR138-2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR138-2: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR138-2 Gene

Function for MIR138-2 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR138-2 Gene

Localization for MIR138-2 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR138-2 Gene

Pathways & Interactions for MIR138-2 Gene

SuperPathways for MIR138-2 Gene

No Data Available

Interacting Proteins for MIR138-2 Gene

Gene Ontology (GO) - Biological Process for MIR138-2 Gene


No data available for Pathways by source and SIGNOR curated interactions for MIR138-2 Gene

Drugs & Compounds for MIR138-2 Gene

No Compound Related Data Available

Transcripts for MIR138-2 Gene

mRNA/cDNA for MIR138-2 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR138-2 Gene

No ASD Table

Relevant External Links for MIR138-2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR138-2 Gene

mRNA expression in normal human tissues for MIR138-2 Gene

genes like me logo Genes that share expression patterns with MIR138-2: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MIR138-2 Gene

Orthologs for MIR138-2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR138-2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia bta-mir-138-2 36
  • 100 (a)
(Canis familiaris)
Mammalia cfa-mir-138b 36
  • 99 (a)
(Monodelphis domestica)
Mammalia mdo-mir-138 36
  • 95 (a)
(Mus musculus)
Mammalia Mir138-2 36
  • 99 (a)
(Ornithorhynchus anatinus)
Mammalia oan-mir-138-2 36
  • 68 (a)
(Pan troglodytes)
Mammalia ptr-mir-138 36
  • 100 (a)
(Gallus gallus)
Aves gga-mir-138-2 36
  • 90 (a)
(Anolis carolinensis)
Reptilia aca-mir-138-1 36
  • 82 (a)
(Danio rerio)
Actinopterygii dre-mir-138 36
  • 75 (a)
Species with no ortholog for MIR138-2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR138-2 Gene

Gene Tree for MIR138-2 (if available)
Gene Tree for MIR138-2 (if available)

Paralogs for MIR138-2 Gene

No data available for Paralogs for MIR138-2 Gene

Variants for MIR138-2 Gene

Sequence variations from dbSNP and Humsavar for MIR138-2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs1529930 -- 56,856,988(+) CACTC(G/T)TTCAT upstream-variant-2KB
rs8061693 -- 56,857,431(+) tcttt(C/T)ttttt upstream-variant-2KB
rs9928011 -- 56,857,021(+) GTTGT(A/G)CTTTC upstream-variant-2KB
rs12444347 -- 56,858,101(+) gctgg(G/T)cttga upstream-variant-2KB
rs12917889 -- 56,857,686(+) aagct(C/T)tggga upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR138-2 Gene

Variant ID Type Subtype PubMed ID
esv33108 CNV Loss 17666407

Relevant External Links for MIR138-2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR138-2 Gene

Disorders for MIR138-2 Gene

Relevant External Links for MIR138-2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with MIR138-2: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR138-2 Gene

Publications for MIR138-2 Gene

  1. Profiling peripheral microRNAs in obesity and type 2 diabetes mellitus. (PMID: 25912229) Wu L. … Xi W. (APMIS 2015) 67
  2. MicroRNA-138 promotes tau phosphorylation by targeting retinoic acid receptor alpha. (PMID: 25680531) Wang X. … Sun Z. (FEBS Lett. 2015) 67
  3. Induction of microRNA-138 by pro-inflammatory cytokines causes endothelial cell dysfunction. (PMID: 24486907) Sen A. … Peppel K. (FEBS Lett. 2014) 67
  4. BCR-ABL/GATA1/miR-138 mini circuitry contributes to the leukemogenesis of chronic myeloid leukemia. (PMID: 23208504) Xu C. … Yu L. (Oncogene 2014) 67
  5. MiR-138 inhibits tumor growth through repression of EZH2 in non-small cell lung cancer. (PMID: 23343715) Zhang H. … Fei K. (Cell. Physiol. Biochem. 2013) 67

Products for MIR138-2 Gene

Sources for MIR138-2 Gene

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