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Aliases for MIR138-1 Gene

Subcategory (RNA class) for MIR138-1 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR138-1 Gene

  • MicroRNA 138-1 2 3
  • MIRN138-1 3 6
  • Hsa-Mir-138-1 3

External Ids for MIR138-1 Gene

ORGUL Members for MIR138-1 Gene

Previous Symbols for MIR138-1 Gene

  • MIRN138-1

Summaries for MIR138-1 Gene

Entrez Gene Summary for MIR138-1 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR138-1 Gene

MIR138-1 (MicroRNA 138-1) is a RNA Gene, and belongs to miRNA RNA class. Diseases associated with MIR138-1 include renal cell carcinoma and clear cell renal cell carcinoma.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR138-1 Gene

Genomics for MIR138-1 Gene

Genomic Location for MIR138-1 Gene

Start:
44,114,212 bp from pter
End:
44,114,310 bp from pter
Size:
99 bases
Orientation:
Plus strand

Genomic View for MIR138-1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR138-1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR138-1 Gene

No data available for Regulatory Elements for MIR138-1 Gene

Proteins for MIR138-1 Gene

Post-translational modifications for MIR138-1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR138-1 Gene

Domains for MIR138-1 Gene

Gene Families for MIR138-1 Gene

HGNC:
  • MIR :ncRNAs / Micro RNAs
genes like me logo Genes that share domains with MIR138-1: view

No data available for Protein Domains and UniProtKB/Swiss-Prot for MIR138-1 Gene

Function for MIR138-1 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MIR138-1 Gene

Localization for MIR138-1 Gene

No data available for Gene Ontology (GO) - Cellular Components for MIR138-1 Gene

Pathways for MIR138-1 Gene

SuperPathways for MIR138-1 Gene

No Data Available

Interacting Proteins for MIR138-1 Gene

Gene Ontology (GO) - Biological Process for MIR138-1 Gene

None

No data available for Pathways by source for MIR138-1 Gene

Transcripts for MIR138-1 Gene

mRNA/cDNA for MIR138-1 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR138-1 Gene

No ASD Table

Relevant External Links for MIR138-1 Gene

GeneLoc Exon Structure for
MIR138-1
ECgene alternative splicing isoforms for
MIR138-1

Expression for MIR138-1 Gene

mRNA expression in normal human tissues for MIR138-1 Gene

genes like me logo Genes that share expressions with MIR138-1: view

Orthologs for MIR138-1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR138-1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia bta-mir-138-1 37
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-138a 37
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir138-1 37
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-138-1 37
  • 42 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-138-1 37
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-138-2 37
  • 84 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii CABZ01061343.1 37
  • 74 (a)
OneToOne
Species with no ortholog for MIR138-1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR138-1 Gene

ENSEMBL:
Gene Tree for MIR138-1 (if available)
TreeFam:
Gene Tree for MIR138-1 (if available)

Paralogs for MIR138-1 Gene

No data available for Paralogs for MIR138-1 Gene

Variants for MIR138-1 Gene

Sequence variations from dbSNP and Humsavar for MIR138-1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs7616808 -- 44,113,413(+) GAAGG(A/G)CAGGC upstream-variant-2KB
rs7621857 -- 44,113,923(+) ATTTA(C/T)TGAAG upstream-variant-2KB
rs35031859 -- 44,114,612(+) AACTG(-/C)AACAT downstream-variant-500B
rs35717003 -- 44,113,653(+) GCCTT(-/G)GGAGG upstream-variant-2KB
rs72869235 -- 44,112,390(+) ACTAG(C/T)GGATT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR138-1 Gene

Variant ID Type Subtype PubMed ID
nsv834674 CNV Gain 17160897

Relevant External Links for MIR138-1 Gene

HapMap Linkage Disequilibrium report
MIR138-1

Disorders for MIR138-1 Gene

genes like me logo Genes that share disorders with MIR138-1: view

No data available for UniProtKB/Swiss-Prot for MIR138-1 Gene

Publications for MIR138-1 Gene

  1. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3
  2. A mammalian microRNA expression atlas based on small RNA library sequencing. (PMID: 17604727) Landgraf P. … Tuschl T. (Cell 2007) 3
  3. Patterns of known and novel small RNAs in human cervical cancer. (PMID: 17616659) Lui W.O. … Fire A. (Cancer Res. 2007) 3
  4. MicroRNA-138 suppresses invasion and promotes apoptosis in head and neck squamous cell carcinoma cell lines. (PMID: 19540661) Liu X. … Zhou X. (Cancer Lett. 2009) 3
  5. Identification and experimental validation of G protein alpha inhibiting activity polypeptide 2 (GNAI2) as a microRNA-138 target in tongue squamous cell carcinoma. (PMID: 21079996) Jiang L. … Zhou X. (Hum. Genet. 2011) 3

Products for MIR138-1 Gene

  • QIAGEN qRT-PCR Assays for microRNAs that regulate MIR138-1
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for MIR138-1
    • Block miRNA regulation of MIR138-1 using miScript Target Protectors

    Sources for MIR138-1 Gene

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