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Aliases for MIR137 Gene

Subcategory (RNA class) for MIR137 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR137 Gene

  • MicroRNA 137 2 3
  • MIR137 Host Gene 5
  • Hsa-Mir-137 3
  • MIR137HG 5
  • MiR-137 3
  • MIRN137 3

External Ids for MIR137 Gene

Previous HGNC Symbols for MIR137 Gene

  • MIRN137

Previous GeneCards Identifiers for MIR137 Gene

  • GC01M098284
  • GC01M098511

Summaries for MIR137 Gene

Entrez Gene Summary for MIR137 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR137 Gene

MIR137 (MicroRNA 137) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR137 include Schizophrenia. Among its related pathways are MicroRNAs in cancer.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR137 Gene

Genomics for MIR137 Gene

Regulatory Elements for MIR137 Gene

Enhancers for MIR137 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F097998 0.5 ENCODE 10.4 +50.3 50287 2.4 JUND JUN MAFK MIR137 MIR137HG MIR2682 GC01P098016 ENSG00000259946
GH01F098052 1.3 FANTOM5 Ensembl ENCODE 0.8 -4.1 -4070 2.9 CTCF JUN SIN3A RAD21 POLR2A EGR1 ZNF143 SMC3 FOS ZNF202 MIR137 MIR2682 MIR137HG NFU1P2
GH01F098048 0.9 ENCODE 0.8 +1.4 1424 0.2 ELF3 ARID4B SIN3A ZNF48 ZSCAN9 RAD21 ZBTB40 RARA ZNF143 RCOR1 GC01M098047 MIR137HG MIR2682 MIR137
GH01F098051 0.7 ENCODE 0.8 -1.4 -1397 0.2 CTCF ZNF654 TEAD4 TRIM22 MIER2 RAD21 RFX5 TEAD3 SMARCA4 ZNF143 MIR2682 MIR137 MIR137HG NFU1P2
GH01F098047 0.3 FANTOM5 0.8 +2.4 2436 0.3 ENSG00000259946 GC01M098047 MIR137 MIR2682 MIR137HG
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR137 on UCSC Golden Path with GeneCards custom track

Promoters for MIR137 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001522841 1163 1001 ELF3 SIN3A ZNF48 ZSCAN9 RAD21 ZBTB40 RARA ZNF143 RCOR1 ZNF202

Genomic Location for MIR137 Gene

Chromosome:
1
Start:
97,986,740 bp from pter
End:
98,049,863 bp from pter
Size:
63,124 bases
Orientation:
Minus strand

Genomic View for MIR137 Gene

Genes around MIR137 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR137 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR137 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR137 Gene

Proteins for MIR137 Gene

Post-translational modifications for MIR137 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR137 Gene

Domains & Families for MIR137 Gene

Gene Families for MIR137 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR137: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR137 Gene

Function for MIR137 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR137 Gene

Localization for MIR137 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR137 Gene

Pathways & Interactions for MIR137 Gene

SuperPathways for MIR137 Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR137: view

Pathways by source for MIR137 Gene

1 KEGG pathway for MIR137 Gene

Interacting Proteins for MIR137 Gene

Gene Ontology (GO) - Biological Process for MIR137 Gene

None

No data available for SIGNOR curated interactions for MIR137 Gene

Transcripts for MIR137 Gene

mRNA/cDNA for MIR137 Gene

(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR137 Gene

No ASD Table

Relevant External Links for MIR137 Gene

GeneLoc Exon Structure for
MIR137
ECgene alternative splicing isoforms for
MIR137

Expression for MIR137 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR137 Gene:

MIR137
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR137 Gene

Orthologs for MIR137 Gene

Evolution for MIR137 Gene

ENSEMBL:
Gene Tree for MIR137 (if available)
TreeFam:
Gene Tree for MIR137 (if available)

No data available for Orthologs for MIR137 Gene

Paralogs for MIR137 Gene

No data available for Paralogs for MIR137 Gene

Variants for MIR137 Gene

Sequence variations from dbSNP and Humsavar for MIR137 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs111459339 -- 98,046,785(+) ATGGA(A/G)AATAA intron-variant, upstream-variant-2KB
rs11165946 -- 98,047,974(+) GCAAT(A/C)GTCTA intron-variant, upstream-variant-2KB
rs112693582 -- 98,045,869(+) CCCCG(C/T)CCATC intron-variant, downstream-variant-500B, upstream-variant-2KB
rs112984663 -- 98,045,861(+) CTTCC(A/G)CTCCC intron-variant, downstream-variant-500B, upstream-variant-2KB
rs113227460 -- 98,046,887(+) AATGA(-/T)TTTTA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR137 Gene

Variant ID Type Subtype PubMed ID
nsv470729 CNV loss 18288195
nsv546874 CNV loss 21841781
nsv830736 CNV gain 17160897

Relevant External Links for MIR137 Gene

Human Gene Mutation Database (HGMD)
MIR137
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR137

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR137 Gene

Disorders for MIR137 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIR137 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
schizophrenia
  • schizophrenia 12
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for MIR137

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR137
genes like me logo Genes that share disorders with MIR137: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR137 Gene

Publications for MIR137 Gene

  1. Epigenetic silencing of miR-137 is a frequent event in gastric carcinogenesis. (PMID: 25663388) Steponaitiene R. … Link A. (Mol. Carcinog. 2016) 3 64
  2. MicroRNA-137 is downregulated in human osteosarcoma and regulates cell proliferation and migration through targeting FXYD6. (PMID: 26302771) Li Z.M. … Wang W.B. (J Drug Target 2016) 3 64
  3. The SNP rs1625579 in miR-137 gene and risk of schizophrenia in Chinese population: A meta-analysis. (PMID: 27095331) Zhang P. … Tang Z. (Compr Psychiatry 2016) 3 64
  4. miR-137 Modulates a Tumor Suppressor Network-Inducing Senescence in Pancreatic Cancer Cells. (PMID: 26904954) Neault M. … Richard S. (Cell Rep 2016) 3 64
  5. Polymorphisms in MIR137HG and microRNA-137-regulated genes influence gray matter structure in schizophrenia. (PMID: 26836412) Wright C. … Turner J.A. (Transl Psychiatry 2016) 3 64

Products for MIR137 Gene

Sources for MIR137 Gene

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