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Aliases for MIR137 Gene

Subcategory (RNA class) for MIR137 Gene

miRNA

Quality Score for this RNA gene is

3.2

Aliases for MIR137 Gene

  • MicroRNA 137 2 3
  • MIRN137 3 6
  • Hsa-Mir-137 3
  • MiR-137 3

External Ids for MIR137 Gene

Previous HGNC Symbols for MIR137 Gene

  • MIRN137

Previous GeneCards Identifiers for MIR137 Gene

  • GC01M098284
  • GC01M098511

Summaries for MIR137 Gene

Entrez Gene Summary for MIR137 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR137 Gene

MIR137 (MicroRNA 137) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR137 include 1p21.3 microdeletion syndrome and oral squamous cell carcinoma. Among its related pathways are MicroRNAs in cancer.

fRNAdb sequence ontologies for MIR137 Gene - the ORGUL cluster for this gene includes several descriptions:

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

View fRNAdb secondary structures for MIR137

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR137 Gene

Genomics for MIR137 Gene

Genomic Location for MIR137 Gene

Start:
98,046,070 bp from pter
End:
98,046,171 bp from pter
Size:
102 bases
Orientation:
Minus strand

Genomic View for MIR137 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR137 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR137 Gene

ORGUL Member Location for MIR137 Gene

ORGUL Member Location for MIR137 gene

No data available for Regulatory Elements for MIR137 Gene

Proteins for MIR137 Gene

Post-translational modifications for MIR137 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR137 Gene

Domains for MIR137 Gene

Gene Families for MIR137 Gene

HGNC:
  • MIR :ncRNAs / Micro RNAs

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR137: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR137 Gene

Function for MIR137 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MIR137 Gene

Localization for MIR137 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR137 Gene

Pathways for MIR137 Gene

SuperPathways for MIR137 Gene

Superpath Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR137: view

Pathways by source for MIR137 Gene

1 KEGG pathway for MIR137 Gene

Interacting Proteins for MIR137 Gene

Gene Ontology (GO) - Biological Process for MIR137 Gene

None

Transcripts for MIR137 Gene

fRNAdb Secondary structures for MIR137 Gene

  • hsa-mir-137_MI0000454_Homo_sapiens_miR-137_stem-loop_hairpin

mRNA/cDNA for MIR137 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR137 Gene

No ASD Table

Relevant External Links for MIR137 Gene

GeneLoc Exon Structure for
MIR137
ECgene alternative splicing isoforms for
MIR137

Expression for MIR137 Gene

No Expression Related Data Available

In Situ Assay Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for MIR137 Gene

Orthologs for MIR137 Gene

Evolution for MIR137 Gene

ENSEMBL:
Gene Tree for MIR137 (if available)
TreeFam:
Gene Tree for MIR137 (if available)

No data available for Orthologs for MIR137 Gene

Paralogs for MIR137 Gene

No data available for Paralogs for MIR137 Gene

Variants for MIR137 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR137 Gene

Variant ID Type Subtype PubMed ID
nsv871625 CNV Loss 21882294
nsv871077 CNV Loss 21882294
nsv871230 CNV Loss 21882294
nsv470729 CNV Loss 18288195
nsv830736 CNV Gain 17160897

Relevant External Links for MIR137 Gene

HapMap Linkage Disequilibrium report
MIR137
Human Gene Mutation Database (HGMD)
MIR137

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for MIR137 Gene

Disorders for MIR137 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for MIR137 Gene including...

Search for MIR137 Gene in MalaCards »
genes like me logo Genes that share disorders with MIR137: view

No data available for UniProtKB/Swiss-Prot for MIR137 Gene

Publications for MIR137 Gene

  1. Identification of tissue-specific microRNAs from mouse. (PMID: 12007417) Lagos-Quintana M. … Tuschl T. (Curr. Biol. 2002) 3
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3
  3. A mammalian microRNA expression atlas based on small RNA library sequencing. (PMID: 17604727) Landgraf P. … Tuschl T. (Cell 2007) 3
  4. MicroRNA-137 targets microphthalmia-associated transcription factor in melanoma cell lines. (PMID: 18316599) Bemis L.T. … Robinson W.A. (Cancer Res. 2008) 3
  5. Micro-RNAs miR125b and miR137 are frequently upregulated in response to capecitabine chemoradiotherapy of rectal cancer. (PMID: 18695884) Svoboda M. … Dvorak J. (Int. J. Oncol. 2008) 3

Products for MIR137 Gene

Sources for MIR137 Gene

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