Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MIR137 Gene

Subcategory (RNA class) for MIR137 Gene

miRNA

Quality Score for this RNA gene is

3.2

Aliases for MIR137 Gene

  • MicroRNA 137 2 3 5
  • Hsa-Mir-137 3
  • MiR-137 3
  • MIRN137 3

External Ids for MIR137 Gene

Previous HGNC Symbols for MIR137 Gene

  • MIRN137

Previous GeneCards Identifiers for MIR137 Gene

  • GC01M098284
  • GC01M098511

Summaries for MIR137 Gene

Entrez Gene Summary for MIR137 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR137 Gene

MIR137 (MicroRNA 137) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer.

fRNAdb sequence ontologies for MIR137 Gene - the ORGUL cluster for this gene includes several descriptions:

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

View fRNAdb secondary structures for MIR137

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR137 Gene

Genomics for MIR137 Gene

Regulatory Elements for MIR137 Gene

Enhancers for MIR137 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G097998 0.5 ENCODE 10.4 +46.6 46595 2.4 JUND JUN MAFK MIR137 MIR137HG GC01P098016 ENSG00000259946
GH01G097885 0.4 dbSUPER 10.2 +159.8 159785 2.1 HNF4A DPYD MIR137 MIR137HG LOC100419654
GH01G098048 0.9 ENCODE 0.7 -2.3 -2269 0.2 ELF3 ARID4B SIN3A ZNF48 ZSCAN9 RAD21 ZBTB40 RARA ZNF143 RCOR1 MIR137 MIR137HG
GH01G098044 0.6 ENCODE 0.7 +0.8 799 2.6 PHF8 SUZ12 SIN3A CBX2 RAD21 ZNF316 HDAC2 POLR2A ZBTB20 EZH2 MIR2682 MIR137
GH01G098047 0.3 FANTOM5 0.7 -1.3 -1257 0.3 ENSG00000259946 MIR137 MIR137HG
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR137 on UCSC Golden Path with GeneCards custom track

Promoters for MIR137 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000010436 271 1001 PHF8 SUZ12 SIN3A CBX2 RAD21 ZNF316 HDAC2 POLR2A ZBTB20 EZH2

Genomic Location for MIR137 Gene

Chromosome:
1
Start:
98,046,070 bp from pter
End:
98,046,171 bp from pter
Size:
102 bases
Orientation:
Minus strand

Genomic View for MIR137 Gene

Genes around MIR137 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR137 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR137 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR137 Gene

ORGUL Member Location for MIR137 Gene

ORGUL Member Location for MIR137 gene

Proteins for MIR137 Gene

Post-translational modifications for MIR137 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR137 Gene

Domains & Families for MIR137 Gene

Gene Families for MIR137 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR137: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR137 Gene

Function for MIR137 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR137 Gene

Localization for MIR137 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR137 Gene

Pathways & Interactions for MIR137 Gene

SuperPathways for MIR137 Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR137: view

Pathways by source for MIR137 Gene

1 KEGG pathway for MIR137 Gene

Interacting Proteins for MIR137 Gene

Gene Ontology (GO) - Biological Process for MIR137 Gene

None

No data available for SIGNOR curated interactions for MIR137 Gene

Drugs & Compounds for MIR137 Gene

No Compound Related Data Available

Transcripts for MIR137 Gene

fRNAdb Secondary structures for MIR137 Gene

  • hsa-mir-137_MI0000454_Homo_sapiens_miR-137_stem-loop_hairpin

mRNA/cDNA for MIR137 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR137 Gene

No ASD Table

Relevant External Links for MIR137 Gene

GeneLoc Exon Structure for
MIR137
ECgene alternative splicing isoforms for
MIR137

Expression for MIR137 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR137 Gene:

MIR137
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR137 Gene

Orthologs for MIR137 Gene

Evolution for MIR137 Gene

ENSEMBL:
Gene Tree for MIR137 (if available)
TreeFam:
Gene Tree for MIR137 (if available)

No data available for Orthologs for MIR137 Gene

Paralogs for MIR137 Gene

No data available for Paralogs for MIR137 Gene

Variants for MIR137 Gene

Sequence variations from dbSNP and Humsavar for MIR137 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000823142 -- 98,045,967(+) CAGTG(A/C)GAAAA intron-variant, downstream-variant-500B, upstream-variant-2KB
rs1001182415 -- 98,046,574(+) CTGGT(A/C)TCGGC nc-transcript-variant, upstream-variant-2KB
rs1001318285 -- 98,046,313(+) AATCC(A/G)TAACT nc-transcript-variant, upstream-variant-2KB
rs1001918108 -- 98,046,650(+) AGTTA(A/C)CCACA intron-variant, upstream-variant-2KB
rs1002993497 -- 98,047,671(+) GAATT(C/T)TAGGT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR137 Gene

Variant ID Type Subtype PubMed ID
nsv470729 CNV loss 18288195
nsv546874 CNV loss 21841781
nsv830736 CNV gain 17160897

Relevant External Links for MIR137 Gene

Human Gene Mutation Database (HGMD)
MIR137
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR137

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR137 Gene

Disorders for MIR137 Gene

Relevant External Links for MIR137

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR137

No disorders were found for MIR137 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR137 Gene

Publications for MIR137 Gene

  1. Identification of tissue-specific microRNAs from mouse. (PMID: 12007417) Lagos-Quintana M. … Tuschl T. (Curr. Biol. 2002) 1 3 64
  2. MicroRNA-137 chemosensitizes colon cancer cells to the chemotherapeutic drug oxaliplatin (OXA) by targeting YBX1. (PMID: 28035913) Guo Y. … Wang Y. (Cancer Biomark 2017) 3 64
  3. MicroRNAs regulate KDM5 histone demethylases in breast cancer cells. (PMID: 26621457) Denis H. … Deplus R. (Mol Biosyst 2016) 3 64
  4. No evidence of an association between MIR137 rs1625579 and schizophrenia in Asians: a meta-analysis in 30a88843 individuals. (PMID: 27096222) Pu X. … Xiao X. (Psychiatr. Genet. 2016) 3 64
  5. miR-137 suppresses tumor growth of malignant melanoma by targeting aurora kinase A. (PMID: 27233613) Chang X. … Zhu W. (Biochem. Biophys. Res. Commun. 2016) 3 64

Products for MIR137 Gene

Sources for MIR137 Gene

Content
Loading form....