Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MIR136 Gene

Subcategory (RNA class) for MIR136 Gene

undefined

Quality Score for this RNA gene is

3

Aliases for MIR136 Gene

  • MicroRNA 136 2 3 5
  • Hsa-Mir-136 3
  • MiRNA136 3
  • Mir-136 3
  • MIRN136 3

External Ids for MIR136 Gene

ORGUL Members for MIR136 Gene

Previous HGNC Symbols for MIR136 Gene

  • MIRN136

Previous GeneCards Identifiers for MIR136 Gene

  • GC14P100495
  • GC14P100865
  • GC14P101351
  • GC14P101081
  • GC14P101287
  • GC14P101916
  • GC14P102224

Summaries for MIR136 Gene

Entrez Gene Summary for MIR136 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR136 Gene

MIR136 (MicroRNA 136) is an RNA Gene, and is affiliated with the undefined RNA class. Among its related pathways are Parkinsons Disease Pathway and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins..

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR136 Gene

Genomics for MIR136 Gene

Regulatory Elements for MIR136 Gene

Enhancers for MIR136 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14F100833 0.8 Ensembl ENCODE 11.2 -45.9 -45907 10.6 BCOR ESRRA ZMYM3 ZIC2 TEAD3 ZFHX2 SCRT2 FOS NFE2 ZNF600 MEG3 MIR493 MIR337 MIR127 MIR431 MIR433 MIR136 RTL1 SNORD112 MIR370
GH14F100819 1 FANTOM5 ENCODE 10.7 -58.2 -58167 13.4 PKNOX1 ATF1 MLX ZFP64 ARID4B DMAP1 ZNF48 YY1 SLC30A9 CBX5 DLK1 MEG3 MIR493 MIR337 MIR431 RTL1 MIR127 MIR136 MIR433 SNORD112
GH14F100788 0.9 ENCODE 10.6 -94.0 -93965 5.5 HDAC1 ATF1 NFRKB RAD21 GATA2 CREM CEBPB NR2F2 MBD2 TFDP1 DLK1 MIR493 MIR337 MIR127 MIR136 MIR431 MIR433 RTL1 BEGAIN MEG3
GH14F100691 1 FANTOM5 Ensembl ENCODE 10 -191.2 -191220 4.2 ELF3 TBP MLX INSM2 KLF17 NFXL1 ZNF48 RAD21 DNMT3B RARA DLK1 MIR493 MIR337 MIR136 RTL1 MIR127 MIR431 MIR433 LINC00523 LOC105370668
GH14F100688 1.2 Ensembl ENCODE 10 -195.8 -195777 1.4 GATAD2A ELF3 KLF1 ZIC2 RARA ZFHX2 JUND ZNF366 SCRT2 SMAD4 DLK1 MIR493 MIR127 MIR431 MIR433 MIR337 RTL1 MIR136 LOC105370668 LOC105370669
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR136 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR136 Gene

Chromosome:
14
Start:
100,884,702 bp from pter
End:
100,884,783 bp from pter
Size:
82 bases
Orientation:
Plus strand

Genomic View for MIR136 Gene

Genes around MIR136 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR136 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR136 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR136 Gene

Proteins for MIR136 Gene

Post-translational modifications for MIR136 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR136 Gene

Domains & Families for MIR136 Gene

Gene Families for MIR136 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR136: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR136 Gene

Function for MIR136 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR136 Gene

Localization for MIR136 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR136 Gene

Pathways & Interactions for MIR136 Gene

genes like me logo Genes that share pathways with MIR136: view

Pathways by source for MIR136 Gene

2 BioSystems pathways for MIR136 Gene

Interacting Proteins for MIR136 Gene

Gene Ontology (GO) - Biological Process for MIR136 Gene

None

No data available for SIGNOR curated interactions for MIR136 Gene

Transcripts for MIR136 Gene

mRNA/cDNA for MIR136 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR136 Gene

No ASD Table

Relevant External Links for MIR136 Gene

GeneLoc Exon Structure for
MIR136
ECgene alternative splicing isoforms for
MIR136

Expression for MIR136 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR136 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR136 Gene:

MIR136
genes like me logo Genes that share expression patterns with MIR136: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR136 Gene

Orthologs for MIR136 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR136 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-136 35
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-136 35
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir136 35
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-136 35
  • 98 (a)
OneToOne
Species where no ortholog for MIR136 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR136 Gene

ENSEMBL:
Gene Tree for MIR136 (if available)
TreeFam:
Gene Tree for MIR136 (if available)

Paralogs for MIR136 Gene

No data available for Paralogs for MIR136 Gene

Variants for MIR136 Gene

Sequence variations from dbSNP and Humsavar for MIR136 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs111477324 -- 100,884,344(+) AGGAG(C/T)CTCCT upstream-variant-2KB, reference, missense
rs112643451 -- 100,884,051(+) AAGCC(A/G)GACAG upstream-variant-2KB, reference, synonymous-codon
rs139938584 -- 100,884,384(+) GCCTC(C/T)TGTTC upstream-variant-2KB, reference, synonymous-codon
rs142029300 -- 100,883,594(+) GACTT(C/T)GCTGG upstream-variant-2KB, reference, missense
rs142437873 -- 100,882,836(+) AGTTC(C/T)GGAAT upstream-variant-2KB, reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for MIR136 Gene

Variant ID Type Subtype PubMed ID
esv3635518 CNV gain 21293372
nsv509549 CNV insertion 20534489

Relevant External Links for MIR136 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR136

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR136 Gene

Disorders for MIR136 Gene

Relevant External Links for MIR136

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR136

No disorders were found for MIR136 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR136 Gene

Publications for MIR136 Gene

  1. TNF-I+-mediated microRNA-136 induces differentiation of myeloid cells by targeting NFIA. (PMID: 26329426) Mei S. … Yang R. (J. Leukoc. Biol. 2016) 3 64
  2. Expression of miR-136 is associated with the primary cisplatin resistance of human epithelial ovarian cancer. (PMID: 25482209) Zhao H. … Cui S. (Oncol. Rep. 2015) 3 64
  3. miR-136 modulates TGF-I^1-induced proliferation arrest by targeting PPP2R2A in keratinocytes. (PMID: 25654102) Zhang D. … Pang X. (Biomed Res Int 2015) 3 64
  4. Identification of cellular microRNA-136 as a dual regulator of RIG-I-mediated innate immunity that antagonizes H5N1 IAV replication in A549 cells. (PMID: 26450567) Zhao L. … Jin M. (Sci Rep 2015) 3 64
  5. Upregulation of miR-136 in human non-small cell lung cancer cells promotes Erk1/2 activation by targeting PPP2R2A. (PMID: 23959478) Shen S. … Wang J. (Tumour Biol. 2014) 3 64

Products for MIR136 Gene

Sources for MIR136 Gene

Content
Loading form....