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Aliases for MIR135B Gene

Subcategory (RNA class) for MIR135B Gene

miRNA

Quality Score for this RNA gene is

10.2

Aliases for MIR135B Gene

  • MicroRNA 135b 2 3 5
  • Hsa-Mir-135b 3
  • Mir-135b 3
  • MIRN135B 3

External Ids for MIR135B Gene

Previous HGNC Symbols for MIR135B Gene

  • MIRN135B

Previous GeneCards Identifiers for MIR135B Gene

  • GC01M203685
  • GC01M205417

Summaries for MIR135B Gene

Entrez Gene Summary for MIR135B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR135B Gene

MIR135B (MicroRNA 135b) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer.

fRNAdb sequence ontologies for MIR135B Gene - the ORGUL cluster for this gene includes several descriptions:

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

View fRNAdb secondary structures for MIR135B

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR135B Gene

Genomics for MIR135B Gene

Regulatory Elements for MIR135B Gene

Promoters for MIR135B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MIR135B on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR135B Gene

Chromosome:
1
Start:
205,448,291 bp from pter
End:
205,448,403 bp from pter
Size:
113 bases
Orientation:
Minus strand

Genomic View for MIR135B Gene

Genes around MIR135B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR135B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR135B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR135B Gene

ORGUL Member Location for MIR135B Gene

ORGUL Member Location for MIR135B gene

Proteins for MIR135B Gene

Post-translational modifications for MIR135B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR135B Gene

Domains & Families for MIR135B Gene

Gene Families for MIR135B Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR135B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR135B Gene

Function for MIR135B Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR135B Gene

Localization for MIR135B Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR135B Gene

Pathways & Interactions for MIR135B Gene

SuperPathways for MIR135B Gene

Superpath Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR135B: view

Pathways by source for MIR135B Gene

1 KEGG pathway for MIR135B Gene

Interacting Proteins for MIR135B Gene

Gene Ontology (GO) - Biological Process for MIR135B Gene

None

No data available for SIGNOR curated interactions for MIR135B Gene

Drugs & Compounds for MIR135B Gene

No Compound Related Data Available

Transcripts for MIR135B Gene

fRNAdb Secondary structures for MIR135B Gene

  • hsa-miR-135b-3p_MIMAT0004698_Homo_sapiens_miR-135b-3p_mature
  • FR074368

mRNA/cDNA for MIR135B Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR135B Gene

No ASD Table

Relevant External Links for MIR135B Gene

GeneLoc Exon Structure for
MIR135B
ECgene alternative splicing isoforms for
MIR135B

Expression for MIR135B Gene

mRNA expression in normal human tissues for MIR135B Gene

genes like me logo Genes that share expression patterns with MIR135B: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MIR135B Gene

Orthologs for MIR135B Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR135B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-135b 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-135b 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-135b 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir135b 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-135b 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-135b-1 36
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-135a-3 36
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-135-3 36
  • 89 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-135c-1 36
  • 71 (a)
OneToOne
Species with no ortholog for MIR135B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR135B Gene

ENSEMBL:
Gene Tree for MIR135B (if available)
TreeFam:
Gene Tree for MIR135B (if available)

Paralogs for MIR135B Gene

No data available for Paralogs for MIR135B Gene

Variants for MIR135B Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR135B Gene

Variant ID Type Subtype PubMed ID
nsv832381 CNV Gain 17160897

Relevant External Links for MIR135B Gene

HapMap Linkage Disequilibrium report
MIR135B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Variation tolerance for MIR135B Gene

Disorders for MIR135B Gene

Relevant External Links for MIR135B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR135B

No disorders were found for MIR135B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR135B Gene

Publications for MIR135B Gene

  1. New human and mouse microRNA genes found by homology search. (PMID: 15634332) Weber M.J. (FEBS J. 2005) 1 3
  2. Identification of many microRNAs that copurify with polyribosomes in mammalian neurons. (PMID: 14691248) Kim J. … Ruvkun G. (Proc. Natl. Acad. Sci. U.S.A. 2004) 1 3
  3. MicroRNA-135b suppresses extravillous trophoblast-derived HTR-8/SVneo cell invasion by directly down regulating CXCL12 underA low oxygen conditions. (PMID: 25896762) Tamaru S. … Itakura A. (Biochem. Biophys. Res. Commun. 2015) 3
  4. MiR-135b promotes proliferation and invasion of osteosarcoma cells via targeting FOXO1. (PMID: 25416447) Pei H. … Guo W. (Mol. Cell. Biochem. 2015) 3
  5. MiR-135b is a direct PAX6 target and specifies human neuroectoderm by inhibiting TGF-I^/BMP signaling. (PMID: 24802670) Bhinge A. … Stanton L.W. (EMBO J. 2014) 3

Products for MIR135B Gene

Sources for MIR135B Gene

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