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Aliases for MIR135B Gene

Subcategory (RNA class) for MIR135B Gene

miRNA

Quality Score for this RNA gene is

10.2

Aliases for MIR135B Gene

  • MicroRNA 135b 2 3 5
  • Hsa-Mir-135b 3
  • Mir-135b 3
  • MIRN135B 3

External Ids for MIR135B Gene

Previous HGNC Symbols for MIR135B Gene

  • MIRN135B

Previous GeneCards Identifiers for MIR135B Gene

  • GC01M203685
  • GC01M205417

Summaries for MIR135B Gene

Entrez Gene Summary for MIR135B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR135B Gene

MIR135B (MicroRNA 135b) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer.

fRNAdb sequence ontologies for MIR135B Gene - the ORGUL cluster for this gene includes several descriptions:

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

View fRNAdb secondary structures for MIR135B

Additional gene information for MIR135B Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR135B Gene

Genomics for MIR135B Gene

GeneHancer (GH) Regulatory Elements for MIR135B Gene

Promoters and enhancers for MIR135B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I205444 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 550.8 +0.0 13 8.5 HDGF PKNOX1 FOXA2 ARID4B SIN3A ZNF48 ETS1 ZNF143 SP5 REST MIR135B LEMD1 BLACAT1 LOC105371698 GC01M205361
GH01I205479 Enhancer 1.2 FANTOM5 Ensembl ENCODE 11.4 -32.7 -32744 3 HDGF PKNOX1 RB1 BMI1 ZNF121 SCRT2 ZNF143 ATF7 IKZF2 CEBPB CDK18 LEMD1 LOC284577 MIR135B KLHDC8A LEMD1-AS1 NUAK2 MFSD4A RAB29 CNTN2
GH01I205370 Enhancer 1.2 Ensembl ENCODE dbSUPER 10.9 +74.4 74392 6.4 FOXA2 KLF17 SIN3A FEZF1 ZNF335 ELK1 ZNF366 ZSCAN5C SCRT2 ZNF391 LEMD1-AS1 KLHDC8A MIR135B CDK18 MFSD4A LOC105371698 GC01M205361
GH01I205485 Enhancer 1 ENCODE 11.4 -37.3 -37260 0.2 FOXA2 MLX ARID4B SIN3A DMAP1 ZNF2 ZNF48 GLIS2 GATA2 ARID2 LEMD1 LOC284577 MIR135B KLHDC8A LEMD1-AS1 NUAK2 MFSD4A TRK-TTT8-1 CDK18 GC01M205361
GH01I205339 Enhancer 0.6 dbSUPER 11.6 +108.7 108667 0.4 SRF JUNB EBF1 DPF2 BATF IRF4 BCL11A MLLT1 BCLAF1 RUNX3 MIR135B CDK18 MFSD4A SNRPGP10 KLHDC8A NUAK2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR135B on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR135B Gene

Genomic Locations for MIR135B Gene
chr1:205,448,302-205,448,398
(GRCh38/hg38)
Size:
97 bases
Orientation:
Minus strand
chr1:205,417,430-205,417,526
(GRCh37/hg19)

Genomic View for MIR135B Gene

Genes around MIR135B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR135B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR135B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR135B Gene

ORGUL Member Location for MIR135B Gene

ORGUL Member Location for MIR135B gene

Proteins for MIR135B Gene

Post-translational modifications for MIR135B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR135B Gene

Domains & Families for MIR135B Gene

Gene Families for MIR135B Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR135B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR135B Gene

Function for MIR135B Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR135B Gene

Localization for MIR135B Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR135B Gene

Pathways & Interactions for MIR135B Gene

SuperPathways for MIR135B Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR135B: view

Pathways by source for MIR135B Gene

1 KEGG pathway for MIR135B Gene

Interacting Proteins for MIR135B Gene

Gene Ontology (GO) - Biological Process for MIR135B Gene

None

No data available for SIGNOR curated interactions for MIR135B Gene

Drugs & Compounds for MIR135B Gene

No Compound Related Data Available

Transcripts for MIR135B Gene

fRNAdb Secondary structures for MIR135B Gene

  • hsa-miR-135b-3p_MIMAT0004698_Homo_sapiens_miR-135b-3p_mature
  • FR074368

mRNA/cDNA for MIR135B Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR135B Gene

No ASD Table

Relevant External Links for MIR135B Gene

GeneLoc Exon Structure for
MIR135B
ECgene alternative splicing isoforms for
MIR135B

Expression for MIR135B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR135B Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR135B Gene:

MIR135B
genes like me logo Genes that share expression patterns with MIR135B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR135B Gene

Orthologs for MIR135B Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR135B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-135b 34
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-135b 34
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir135b 34
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-135b 34
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-135b 34
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-135b-1 34
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-135a-3 34
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-135-3 34
  • 89 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-135c-1 34
  • 71 (a)
OneToOne
Species where no ortholog for MIR135B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR135B Gene

ENSEMBL:
Gene Tree for MIR135B (if available)
TreeFam:
Gene Tree for MIR135B (if available)

Paralogs for MIR135B Gene

No data available for Paralogs for MIR135B Gene

Variants for MIR135B Gene

Sequence variations from dbSNP and Humsavar for MIR135B Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000371276 -- 205,449,244(-) AAAA/AAA upstream_transcript_variant
rs1000911825 -- 205,450,008(-) C/T upstream_transcript_variant
rs1000983437 -- 205,449,830(-) T/C upstream_transcript_variant
rs1001993270 -- 205,448,132(-) G/A downstream_transcript_variant
rs1002847553 -- 205,450,242(-) C/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR135B Gene

Variant ID Type Subtype PubMed ID
nsv1068038 CNV deletion 25765185
nsv832381 CNV gain 17160897
nsv952643 CNV deletion 24416366

Additional Variant Information for MIR135B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR135B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR135B Gene

Disorders for MIR135B Gene

Additional Disease Information for MIR135B

No disorders were found for MIR135B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR135B Gene

Publications for MIR135B Gene

  1. New human and mouse microRNA genes found by homology search. (PMID: 15634332) Weber MJ (The FEBS journal 2005) 1 3 58
  2. Identification of many microRNAs that copurify with polyribosomes in mammalian neurons. (PMID: 14691248) Kim J … Ruvkun G (Proceedings of the National Academy of Sciences of the United States of America 2004) 1 3 58
  3. miR-182 and miR-135b Mediate the Tumorigenesis and Invasiveness of Colorectal Cancer Cells via Targeting ST6GALNAC2 and PI3K/AKT Pathway. (PMID: 29030743) Jia L … Zhou H (Digestive diseases and sciences 2017) 3 58
  4. A miR-135b-TAZ positive feedback loop promotes epithelial-mesenchymal transition (EMT) and tumorigenesis in osteosarcoma. (PMID: 28823959) Shen S … Ma J (Cancer letters 2017) 3 58
  5. Upregulation of microRNA-135b and microRNA-182 promotes chemoresistance of colorectal cancer by targeting ST6GALNAC2 via PI3K/AKT pathway. (PMID: 28767179) Liu B … Jia L (Molecular carcinogenesis 2017) 3 58

Products for MIR135B Gene

Sources for MIR135B Gene

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