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Aliases for MIR135B Gene

Subcategory (RNA class) for MIR135B Gene

miRNA

Quality Score for this RNA gene is

10.2

Aliases for MIR135B Gene

  • MicroRNA 135b 2 3 5
  • Hsa-Mir-135b 3
  • Mir-135b 3
  • MIRN135B 3

External Ids for MIR135B Gene

Previous HGNC Symbols for MIR135B Gene

  • MIRN135B

Previous GeneCards Identifiers for MIR135B Gene

  • GC01M203685
  • GC01M205417

Summaries for MIR135B Gene

Entrez Gene Summary for MIR135B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR135B Gene

MIR135B (MicroRNA 135b) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer.

fRNAdb sequence ontologies for MIR135B Gene - the ORGUL cluster for this gene includes several descriptions:

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

View fRNAdb secondary structures for MIR135B

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR135B Gene

Genomics for MIR135B Gene

Regulatory Elements for MIR135B Gene

Enhancers for MIR135B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G205479 1.6 FANTOM5 Ensembl ENCODE 11.4 -32.7 -32745 3.0 HDGF PKNOX1 ARID4B DMAP1 ZNF48 ZNF121 ZNF143 SP5 TBX21 ETV4 CDK18 LEMD1 LOC284577 MIR135B KLHDC8A LEMD1-AS1 NUAK2 MFSD4A RAB29 CNTN2
GH01G205370 1.5 Ensembl ENCODE dbSUPER 10.9 +74.4 74393 6.4 FOXA2 FEZF1 ZNF2 TCF12 GLIS2 ELK1 FOS DEK ZNF263 SP3 KLHDC8A MIR135B CDK18 MFSD4A LEMD1-AS1 LOC105371698
GH01G205485 1 ENCODE 11.4 -37.3 -37260 0.3 FOXA2 MLX ARID4B SIN3A DMAP1 ZNF2 ZNF48 GLIS2 GATA2 ZNF143 LOC284577 LEMD1 MIR135B KLHDC8A LEMD1-AS1 NUAK2 MFSD4A TRK-TTT8-1 CDK18
GH01G205359 0.7 ENCODE dbSUPER 11.3 +87.9 87926 1.7 CTCF SMARCA4 ZNF341 KLHDC8A MIR135B CDK18 NUAK2 MFSD4A LEMD1-AS1
GH01G205339 0.6 dbSUPER 11.6 +108.7 108668 0.4 SRF JUND JUNB MLLT1 EBF1 DPF2 TBX21 MIR135B CDK18 MFSD4A SNRPGP10 NUAK2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR135B on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR135B Gene

Chromosome:
1
Start:
205,448,302 bp from pter
End:
205,448,398 bp from pter
Size:
97 bases
Orientation:
Minus strand

Genomic View for MIR135B Gene

Genes around MIR135B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR135B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR135B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR135B Gene

ORGUL Member Location for MIR135B Gene

ORGUL Member Location for MIR135B gene

Proteins for MIR135B Gene

Post-translational modifications for MIR135B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR135B Gene

Domains & Families for MIR135B Gene

Gene Families for MIR135B Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR135B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR135B Gene

Function for MIR135B Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR135B Gene

Localization for MIR135B Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR135B Gene

Pathways & Interactions for MIR135B Gene

SuperPathways for MIR135B Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR135B: view

Pathways by source for MIR135B Gene

1 KEGG pathway for MIR135B Gene

Interacting Proteins for MIR135B Gene

Gene Ontology (GO) - Biological Process for MIR135B Gene

None

No data available for SIGNOR curated interactions for MIR135B Gene

Transcripts for MIR135B Gene

fRNAdb Secondary structures for MIR135B Gene

  • hsa-miR-135b-3p_MIMAT0004698_Homo_sapiens_miR-135b-3p_mature
  • FR074368

mRNA/cDNA for MIR135B Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR135B Gene

No ASD Table

Relevant External Links for MIR135B Gene

GeneLoc Exon Structure for
MIR135B
ECgene alternative splicing isoforms for
MIR135B

Expression for MIR135B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR135B Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR135B Gene:

MIR135B
genes like me logo Genes that share expression patterns with MIR135B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR135B Gene

Orthologs for MIR135B Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR135B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-135b 35
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-135b 35
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir135b 35
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-135b 35
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-135b 35
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-135b-1 35
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-135a-3 35
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-135-3 35
  • 89 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-135c-1 35
  • 71 (a)
OneToOne
Species where no ortholog for MIR135B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR135B Gene

ENSEMBL:
Gene Tree for MIR135B (if available)
TreeFam:
Gene Tree for MIR135B (if available)

Paralogs for MIR135B Gene

No data available for Paralogs for MIR135B Gene

Variants for MIR135B Gene

Sequence variations from dbSNP and Humsavar for MIR135B Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000371276 -- 205,449,244(+) CCTGG(-/A)AAAGG intron-variant, upstream-variant-2KB
rs1000911825 -- 205,450,008(+) TCCTC(C/T)CTCCC intron-variant, upstream-variant-2KB
rs1000983437 -- 205,449,830(+) AGGGA(C/T)GCTGG intron-variant, upstream-variant-2KB
rs1001993270 -- 205,448,132(+) AGAGT(A/G)AGGAA intron-variant, downstream-variant-500B
rs1002847553 -- 205,450,242(+) ACTGG(C/G)TTTTG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR135B Gene

Variant ID Type Subtype PubMed ID
nsv1068038 CNV deletion 25765185
nsv832381 CNV gain 17160897
nsv952643 CNV deletion 24416366

Relevant External Links for MIR135B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR135B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR135B Gene

Disorders for MIR135B Gene

Relevant External Links for MIR135B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR135B

No disorders were found for MIR135B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR135B Gene

Publications for MIR135B Gene

  1. New human and mouse microRNA genes found by homology search. (PMID: 15634332) Weber M.J. (FEBS J. 2005) 1 3 64
  2. Identification of many microRNAs that copurify with polyribosomes in mammalian neurons. (PMID: 14691248) Kim J. … Ruvkun G. (Proc. Natl. Acad. Sci. U.S.A. 2004) 1 3 64
  3. miR-135b- and miR-146b-dependent silencing of calcium-sensing receptor expression in colorectal tumors. (PMID: 26178670) Fetahu I.S. … KA!llay E. (Int. J. Cancer 2016) 3 64
  4. miR-135b, upregulated in breast cancer, promotes cell growth and disrupts the cell cycle by regulating LATS2. (PMID: 26934863) Hua K. … Fang L. (Int. J. Oncol. 2016) 3 64
  5. hsa-miR-29c and hsa-miR-135b differential expression as potential biomarker of gastric carcinogenesis. (PMID: 26877610) Vidal A.F. … Ribeiro-dos-Santos A.8. (World J. Gastroenterol. 2016) 3 64

Products for MIR135B Gene

Sources for MIR135B Gene

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