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Aliases for MIR135A2 Gene

Subcategory (RNA class) for MIR135A2 Gene

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Quality Score for this RNA gene is

3

Aliases for MIR135A2 Gene

  • MicroRNA 135a-2 2 3 5
  • MicroRNA 135-2 2 3
  • Hsa-Mir-135a-2 3
  • Hsa-Mir-135-2 3
  • Mir-135a-2 3
  • MIRN135-2 3
  • MIRN135A2 3

External Ids for MIR135A2 Gene

ORGUL Members for MIR135A2 Gene

Previous HGNC Symbols for MIR135A2 Gene

  • MIRN135-2
  • MIRN135A2

Previous GeneCards Identifiers for MIR135A2 Gene

  • GC12P096481
  • GC12P097957

Summaries for MIR135A2 Gene

Entrez Gene Summary for MIR135A2 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR135A2 Gene

MIR135A2 (MicroRNA 135a-2) is an RNA Gene, and is affiliated with the undefined RNA class. Among its related pathways are MicroRNAs in cancer and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins..

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR135A2 Gene

Genomics for MIR135A2 Gene

Regulatory Elements for MIR135A2 Gene

Enhancers for MIR135A2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G097535 0.6 dbSUPER 10.7 -28.1 -28105 1.2 ZNF217 MBD2 GATA3 CEBPG DPF2 FOXA1 MIR135A2 MIR1251 RMST ENSG00000274819 ENSG00000251844
GH12G097536 0.6 dbSUPER 10.7 -26.1 -26051 2.4 DPF2 RAD21 FOXA1 ZNF217 MBD2 JUND GATA3 CTBP1 SMARCA4 MIR135A2 MIR1251 RMST ENSG00000274819 ENSG00000251844
GH12G097534 0.4 dbSUPER 10.7 -29.1 -29120 0.7 ZNF316 MAFK MIR135A2 MIR1251 RMST ENSG00000274819 ENSG00000251844
GH12G097503 0.4 ENCODE 10.2 -60.6 -60555 0.2 HNF4A ENSG00000251844 MIR135A2 ENSG00000273570 ENSG00000275971
GH12G097538 0.2 dbSUPER 10.4 -24.2 -24218 1.2 MIR135A2 MIR1251 RMST ENSG00000274819 ENSG00000251844
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR135A2 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR135A2 Gene

Chromosome:
12
Start:
97,563,812 bp from pter
End:
97,563,911 bp from pter
Size:
100 bases
Orientation:
Plus strand

Genomic View for MIR135A2 Gene

Genes around MIR135A2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR135A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR135A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR135A2 Gene

Proteins for MIR135A2 Gene

Post-translational modifications for MIR135A2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR135A2 Gene

Domains & Families for MIR135A2 Gene

Gene Families for MIR135A2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR135A2: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR135A2 Gene

Function for MIR135A2 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR135A2 Gene

Localization for MIR135A2 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR135A2 Gene

Pathways & Interactions for MIR135A2 Gene

genes like me logo Genes that share pathways with MIR135A2: view

Pathways by source for MIR135A2 Gene

1 BioSystems pathway for MIR135A2 Gene
1 KEGG pathway for MIR135A2 Gene

Interacting Proteins for MIR135A2 Gene

Gene Ontology (GO) - Biological Process for MIR135A2 Gene

None

No data available for SIGNOR curated interactions for MIR135A2 Gene

Drugs & Compounds for MIR135A2 Gene

No Compound Related Data Available

Transcripts for MIR135A2 Gene

mRNA/cDNA for MIR135A2 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR135A2 Gene

No ASD Table

Relevant External Links for MIR135A2 Gene

GeneLoc Exon Structure for
MIR135A2
ECgene alternative splicing isoforms for
MIR135A2

Expression for MIR135A2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR135A2 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR135A2 Gene:

MIR135A2
genes like me logo Genes that share expression patterns with MIR135A2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR135A2 Gene

Orthologs for MIR135A2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR135A2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia bta-mir-135a-2 35
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-135a-2 35
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-135a-2 35
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir135a-2 35
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-135a 35
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-135a 35
  • 91 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-135a-2 35
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-135-2 35
  • 91 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-135a 35
  • 70 (a)
OneToOne
Species where no ortholog for MIR135A2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR135A2 Gene

ENSEMBL:
Gene Tree for MIR135A2 (if available)
TreeFam:
Gene Tree for MIR135A2 (if available)

Paralogs for MIR135A2 Gene

No data available for Paralogs for MIR135A2 Gene

Variants for MIR135A2 Gene

Sequence variations from dbSNP and Humsavar for MIR135A2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000502800 -- 97,563,558(+) AATTC(A/T)TCCCA upstream-variant-2KB
rs1000791627 -- 97,564,197(+) GGCAG(C/T)ATTCA downstream-variant-500B
rs1002407826 -- 97,562,980(+) GATAG(A/G)CACCT upstream-variant-2KB
rs1004137174 -- 97,562,025(+) AGTGC(A/G)CCACA upstream-variant-2KB
rs1004357411 -- 97,564,355(+) TCAAC(A/T)CCTCC downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for MIR135A2 Gene

Variant ID Type Subtype PubMed ID
nsv7234 OTHER inversion 18451855
nsv9001 CNV loss 18304495

Relevant External Links for MIR135A2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR135A2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR135A2 Gene

Disorders for MIR135A2 Gene

Relevant External Links for MIR135A2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR135A2

No disorders were found for MIR135A2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR135A2 Gene

Publications for MIR135A2 Gene

  1. Serum microRNA-135a downregulation as a prognostic marker of non-small cell lung cancer. (PMID: 27525941) Zhang Y.K. … Sui G. (Genet. Mol. Res. 2016) 3 64
  2. miR-135 family members mediate podocyte injury through the activation of Wnt/I^-catenin signaling. (PMID: 26134897) Yang X. … Li G. (Int. J. Mol. Med. 2015) 3 64
  3. MiR-135 post-transcriptionally regulates FOXO1 expression and promotes cell proliferation in human malignant melanoma cells. (PMID: 26261511) Ren J.W. … Tu C. (Int J Clin Exp Pathol 2015) 3 64
  4. Mir-135a enhances cellular proliferation through post-transcriptionally regulating PHLPP2 and FOXO1 in human bladder cancer. (PMID: 25888950) Mao X.P. … Chen J.X. (J Transl Med 2015) 3 64
  5. Targeting of Runx2 by miR-135 and miR-203 Impairs Progression of Breast Cancer and Metastatic Bone Disease. (PMID: 25634212) TaipaleenmAoki H. … Lian J.B. (Cancer Res. 2015) 3 64

Products for MIR135A2 Gene

Sources for MIR135A2 Gene

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